Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Peutz-Jeghers Syndrome D010580 2 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Biliary Fistula D001658 13 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Refsum Disease D012035 19 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Glioblastoma D005909 27 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Hypothyroidism D007037 32 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Thrombosis D013927 49 associated lipids
Leukemia D007938 74 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Glioma D005910 112 associated lipids
Hypertension D006973 115 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Adenocarcinoma D000230 166 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

Download all related citations
Per page 10 20 50 100 | Total 2899
Authors Title Published Journal PubMed Link
Suri S et al. Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells in vitro by inhibiting the mevalonate pathway: a model of bisphosphonate-induced gastrointestinal toxicity. 2001 Bone pmid:11595616
van Beek E et al. Independent pathways in the modulation of osteoclastic resorption by intermediates of the mevalonate biosynthetic pathway: the role of the retinoic acid receptor. 2006 Bone pmid:16165408
Taylor GW et al. Excursions in biomedical mass spectrometry. 1996 Br J Clin Pharmacol pmid:8807152
Martin PD et al. Pharmacodynamic effects and pharmacokinetics of a new HMG-CoA reductase inhibitor, rosuvastatin, after morning or evening administration in healthy volunteers. 2002 Br J Clin Pharmacol pmid:12445025
Mikulski SM et al. Synergism between a novel amphibian oocyte ribonuclease and lovastatin in inducing cytostatic and cytotoxic effects in human lung and pancreatic carcinoma cell lines. 1992 Br. J. Cancer pmid:1503903
Kawata S et al. Modulation of the mevalonate pathway and cell growth by pravastatin and d-limonene in a human hepatoma cell line (Hep G2). 1994 Br. J. Cancer pmid:8198962
Jiang P et al. In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells. 2014 Br. J. Cancer pmid:25093497
Bocci G et al. Fluvastatin synergistically enhances the antiproliferative effect of gemcitabine in human pancreatic cancer MIAPaCa-2 cells. 2005 Br. J. Cancer pmid:16052215
Jagdev SP et al. The bisphosphonate, zoledronic acid, induces apoptosis of breast cancer cells: evidence for synergy with paclitaxel. 2001 Br. J. Cancer pmid:11308265
Prottey C et al. Lipid synthesis in rat skin. 1972 Br. J. Dermatol. pmid:4648803
Lin Y et al. Differences in propionate-induced inhibition of cholesterol and triacylglycerol synthesis between human and rat hepatocytes in primary culture. 1995 Br. J. Nutr. pmid:7547837
Eberlein M et al. Rho-dependent inhibition of the induction of connective tissue growth factor (CTGF) by HMG CoA reductase inhibitors (statins). 2001 Br. J. Pharmacol. pmid:11487529
Stalker TJ et al. A new HMG-CoA reductase inhibitor, rosuvastatin, exerts anti-inflammatory effects on the microvascular endothelium: the role of mevalonic acid. 2001 Br. J. Pharmacol. pmid:11375257
Takemoto M et al. NK-104, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, reduces osteopontin expression by rat aortic smooth muscle cells. 2001 Br. J. Pharmacol. pmid:11325797
Hausding M et al. Inhibition of small G proteins of the rho family by statins or clostridium difficile toxin B enhances cytokine-mediated induction of NO synthase II. 2000 Br. J. Pharmacol. pmid:11015307
Luo JD et al. Simvastatin inhibits noradrenaline-induced hypertrophy of cultured neonatal rat cardiomyocytes. 2001 Br. J. Pharmacol. pmid:11156573
Goto S et al. Species specificity in the blood cholesterol-lowering effect of YM-16638. 1996 Br. J. Pharmacol. pmid:8733592
Igarashi J et al. Statins induce S1P1 receptors and enhance endothelial nitric oxide production in response to high-density lipoproteins. 2007 Br. J. Pharmacol. pmid:17220911
Minichsdorfer C and Hohenegger M Autocrine amplification loop in statin-induced apoptosis of human melanoma cells. 2009 Br. J. Pharmacol. pmid:19563533
Alvarez De Sotomayor M et al. Characterization of endothelial factors involved in the vasodilatory effect of simvastatin in aorta and small mesenteric artery of the rat. 2000 Br. J. Pharmacol. pmid:11082126
Werner M et al. Mutual amplification of apoptosis by statin-induced mitochondrial stress and doxorubicin toxicity in human rhabdomyosarcoma cells. 2004 Br. J. Pharmacol. pmid:15289292
Naidu A et al. Secretion of apolipoprotein E by brain glia requires protein prenylation and is suppressed by statins. 2002 Brain Res. pmid:12468034
Mellon SH and Deschepper CF Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain. 1993 Brain Res. pmid:8111631
Klawitter J et al. Effects of lovastatin on breast cancer cells: a proteo-metabonomic study. 2010 Breast Cancer Res. pmid:20205716
Ural AU et al. In vitro synergistic cytoreductive effects of zoledronic acid and radiation on breast cancer cells. 2006 Breast Cancer Res. pmid:16925824
Rachner TD et al. Dickkopf-1 is regulated by the mevalonate pathway in breast cancer. 2014 Breast Cancer Res. pmid:24528599
Journe F et al. Farnesol, a mevalonate pathway intermediate, stimulates MCF-7 breast cancer cell growth through farnesoid-X-receptor-mediated estrogen receptor activation. 2008 Breast Cancer Res. Treat. pmid:17333335
Schwartz YSh et al. Cholesterol-induced stimulation of postinflammatory liver fibrosis. 2008 Bull. Exp. Biol. Med. pmid:19110552
Alla S et al. [Mevalonolactone: a volatile compound produced by Psammotettix alienus (Dhb)]. 2002 C. R. Biol. pmid:12481687
Cheng G et al. Mitochondria-targeted nitroxides exacerbate fluvastatin-mediated cytostatic and cytotoxic effects in breast cancer cells. 2011 Cancer Biol. Ther. pmid:21799303
Duncan RE et al. Statins and cancer development. 2005 Cancer Epidemiol. Biomarkers Prev. pmid:16103434
Karlic H et al. Inhibition of the mevalonate pathway affects epigenetic regulation in cancer cells. 2015 Cancer Genet pmid:25978957
Girgert R et al. Growth inhibition of neuroblastoma cells by lovastatin and L-ascorbic acid is based on different mechanisms. 1999 Cancer Lett. pmid:10374838
Tuerdi G et al. Synergistic effect of combined treatment with gamma-tocotrienol and statin on human malignant mesothelioma cells. 2013 Cancer Lett. pmid:23879968
Gopalan A et al. Simvastatin inhibition of mevalonate pathway induces apoptosis in human breast cancer cells via activation of JNK/CHOP/DR5 signaling pathway. 2013 Cancer Lett. pmid:22960596
Gopalan A et al. Eliminating drug resistant breast cancer stem-like cells with combination of simvastatin and gamma-tocotrienol. 2013 Cancer Lett. pmid:23063651
Nilsson S et al. Mevalonate pathway inhibitors affect anticancer drug-induced cell death and DNA damage response of human sarcoma cells. 2011 Cancer Lett. pmid:21356574
Ren Z and Gould MN Inhibition of ubiquinone and cholesterol synthesis by the monoterpene perillyl alcohol. 1994 Cancer Lett. pmid:8149348
Nakajima H et al. Induction of mitochondria-dependent apoptosis through the inhibition of mevalonate pathway in human breast cancer cells by YM529, a new third generation bisphosphonate. 2007 Cancer Lett. pmid:17316980
Grigor MR et al. Cholesterol metabolism in rats bearing Morris hepatoma 7777. 1973 Cancer Res. pmid:4352741
Virtanen SS et al. Alendronate inhibits invasion of PC-3 prostate cancer cells by affecting the mevalonate pathway. 2002 Cancer Res. pmid:11980672
Zaidi N et al. ATP-citrate lyase: a key player in cancer metabolism. 2012 Cancer Res. pmid:22787121
Schulz S et al. Mechanisms of cell growth inhibition and cell cycle arrest in human colonic adenocarcinoma cells by dehydroepiandrosterone: role of isoprenoid biosynthesis. 1992 Cancer Res. pmid:1531325
Larsson O and Johansson BM Mevalonic acid products as mediators of cell proliferation in simian virus 40-transformed 3T3 cells. 1987 Cancer Res. pmid:3040232
George R and Goldfarb S Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in Morris hepatoma 7800 after intravenous injection of mevalonic acid. 1980 Cancer Res. pmid:7438103
Shipman CM et al. The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway. 1998 Cancer Res. pmid:9850051
Eggens I et al. Cytidine 5'-triphosphate-dependent dolichol kinase and dolichol phosphatase activities and levels of dolichyl phosphate in microsomal fractions from highly differentiated human hepatomas. 1988 Cancer Res. pmid:2836054
Schulz S and Nyce JW Inhibition of protein isoprenylation and p21ras membrane association by dehydroepiandrosterone in human colonic adenocarcinoma cells in vitro. 1991 Cancer Res. pmid:1835900
Bricker LA et al. Effects of dietary cholesterol on bile acid synthesis in liver and hepatomas. 1974 Cancer Res. pmid:4359874
Kandutsch AA and Hancock RL Regulation of the rate of sterol synthesis and the level of beta-hydroxy-beta-methylglutaryl coenzyme A reductase activity in mouse liver and hepatomas. 1971 Cancer Res. pmid:4328734
Pandyra A et al. Immediate utility of two approved agents to target both the metabolic mevalonate pathway and its restorative feedback loop. 2014 Cancer Res. pmid:24994712
Goldfarb S and Pitot HC The regulation of beta-hydroxy-beta-methylglutaryl coenzyme A reductase in Morris hepatomas 5123C, 7800, and 9618A. 1971 Cancer Res. pmid:4330433
Cuthbert JA and Lipsky PE Regulation of proliferation and Ras localization in transformed cells by products of mevalonate metabolism. 1997 Cancer Res. pmid:9270019
El-Sohemy A and Archer MC Regulation of mevalonate synthesis in rat mammary glands by dietary n-3 and n-6 polyunsaturated fatty acids. 1997 Cancer Res. pmid:9288773
Kotamraju S et al. Statin-induced breast cancer cell death: role of inducible nitric oxide and arginase-dependent pathways. 2007 Cancer Res. pmid:17671209
Cuthbert JA and Lipsky PE Suppression of the proliferation of Ras-transformed cells by fluoromevalonate, an inhibitor of mevalonate metabolism. 1995 Cancer Res. pmid:7712482
Larsson O et al. Abolition of mevinolin-induced growth inhibition in human fibroblasts following transformation by simian virus 40. 1989 Cancer Res. pmid:2551491
TERNER C and KORSH G THE BIOSYNTHESIS OF GLYCERIDES IN HOMOGENATES OF NORMAL LACTATING MAMMARY GLAND AND OF MAMMARY TUMOR TISSUE OF THE MOUSE. 1963 Cancer Res. pmid:14079150
Girlanda S et al. MICA expressed by multiple myeloma and monoclonal gammopathy of undetermined significance plasma cells Costimulates pamidronate-activated gammadelta lymphocytes. 2005 Cancer Res. pmid:16103105
Komori A et al. Canventol inhibits tumor promotion in CD-1 mouse skin through inhibition of tumor necrosis factor alpha release and of protein isoprenylation. 1993 Cancer Res. pmid:8339247
Shoff SM et al. Concentration-dependent increase of murine P388 and B16 population doubling time by the acyclic monoterpene geraniol. 1991 Cancer Res. pmid:1988098
Andela VB Correspondence Re S. S. Virtanen et al., Alendronate inhibits invasion of PC-3 prostate cancer cells by affecting the mevalonate pathway. Cancer Res 2002;62:2708-14. Re K. Sawada et al., Alendronate inhibits lysophosphatidic acid-induced migration of human ovarian cancer cells by attenuating the activation of Rho. Cancer Res 2002;62:6015-20. 2004 Cancer Res. pmid:15087415
Humphries GM Difference in the ability of compactin and oxidized cholesterol, both known inhibitors of cholesterol biosynthesis, to suppress in vitro immune responses. 1981 Cancer Res. pmid:7260948
Dalton MB et al. The farnesyl protein transferase inhibitor BZA-5B blocks farnesylation of nuclear lamins and p21ras but does not affect their function or localization. 1995 Cancer Res. pmid:7614464
Soma MR et al. In vivo enhanced antitumor activity of carmustine [N,N'-bis(2-chloroethyl)-N-nitrosourea] by simvastatin. 1995 Cancer Res. pmid:7834630
Takeda I et al. Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. 2007 Cancer Sci. pmid:17428261
Palozza P et al. Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signaling in cancer cell lines. 2010 Carcinogenesis pmid:20699249
Nawarskas JJ HMG-CoA reductase inhibitors and coenzyme Q10. 2005 Mar-Apr Cardiol Rev pmid:15705257
Liang YJ et al. Simvastatin inhibits C-reactive protein-induced pro-inflammatory changes in endothelial cells by decreasing mevalonate pathway products. 2008 Cardiology pmid:18057884
Szűcs G et al. Cardioprotection by farnesol: role of the mevalonate pathway. 2013 Cardiovasc Drugs Ther pmid:23673412
Guo H et al. Rosuvastatin may modulate insulin signaling and inhibit atherogenesis beyond its plasma cholesterol-lowering effect in insulin-resistant mice. 2012 Cardiovasc Drugs Ther pmid:22918601
Massaro M et al. Statins inhibit cyclooxygenase-2 and matrix metalloproteinase-9 in human endothelial cells: anti-angiogenic actions possibly contributing to plaque stability. 2010 Cardiovasc. Res. pmid:19946014
Kojima Y et al. Pitavastatin decreases the expression of endothelial lipase both in vitro and in vivo. 2010 Cardiovasc. Res. pmid:20045866
Jeon JG et al. Natural products in caries research: current (limited) knowledge, challenges and future perspective. 2011 Caries Res. pmid:21576957
Freed-Pastor WA et al. Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. 2012 Cell pmid:22265415
Okin D and Medzhitov R The Effect of Sustained Inflammation on Hepatic Mevalonate Pathway Results in Hyperglycemia. 2016 Cell pmid:26997483
York AG et al. Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling. 2015 Cell pmid:26686653
Weber C et al. Lovastatin induces differentiation of Mono Mac 6 cells. 1995 Cell Biochem. Funct. pmid:8565148
Bacurau RF et al. Metabolic response of macrophages to injury promoted by the activated complement system. 1999 Cell Biochem. Funct. pmid:10451538
Senkowski W et al. Large-Scale Gene Expression Profiling Platform for Identification of Context-Dependent Drug Responses in Multicellular Tumor Spheroids. 2016 Cell Chem Biol pmid:27984028
Ginestier C et al. p53 and cancer stem cells: the mevalonate connexion. 2012 Cell Cycle pmid:22751434
Agabiti SS et al. Geranylgeranyl diphosphate synthase inhibition induces apoptosis that is dependent upon GGPP depletion, ERK phosphorylation and caspase activation. 2017 Cell Death Dis pmid:28300835
Qi XF et al. HMG-CoA reductase inhibitors induce apoptosis of lymphoma cells by promoting ROS generation and regulating Akt, Erk and p38 signals via suppression of mevalonate pathway. 2013 Cell Death Dis pmid:23449454
Laezza C et al. p53 regulates the mevalonate pathway in human glioblastoma multiforme. 2015 Cell Death Dis pmid:26469958
Bruzzese F et al. Panobinostat synergizes with zoledronic acid in prostate cancer and multiple myeloma models by increasing ROS and modulating mevalonate and p38-MAPK pathways. 2013 Cell Death Dis pmid:24157872
Zhu Y et al. Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases. 2013 Cell Death Dis pmid:23559002
Ghavami S et al. Apoptosis, autophagy and ER stress in mevalonate cascade inhibition-induced cell death of human atrial fibroblasts. 2012 Cell Death Dis pmid:22717585
Khosravi-Far R et al. Protein prenylation: key to ras function and cancer intervention? 1992 Cell Growth Differ. pmid:1419908
Miettinen TP and Björklund M Mevalonate Pathway Regulates Cell Size Homeostasis and Proteostasis through Autophagy. 2015 Cell Rep pmid:26686643
Takii Y et al. Arrest of 3T3 cells in G1 phase by low density lipoprotein. 1983 Cell Struct. Funct. pmid:6671216
Yachnin S and Hsu R Inhibition of human lymphocyte transformation by oxygenated sterol compounds. 1980 Cell. Immunol. pmid:7363333
Jameson JM et al. A role for the mevalonate pathway in the induction of subtype cross-reactive immunity to influenza A virus by human gammadelta T lymphocytes. 2010 Cell. Immunol. pmid:20483407
Bank I et al. Lovastatin and phospholipase Cgamma regulate constitutive and protein kinase C dependent integrin mediated interactions of human T-cells with collagen. 2003 Cell. Immunol. pmid:12914756
Larson RA et al. Neutrophil-assisted DNA synthesis by human lymphocytes in response to mevalonic acid; enhancement by cytochalasin B. 1983 Cell. Immunol. pmid:6640672
Yu F et al. Zingiber zerumbet CYP71BA1 catalyzes the conversion of α-humulene to 8-hydroxy-α-humulene in zerumbone biosynthesis. 2011 Cell. Mol. Life Sci. pmid:20730551
Houten SM et al. Isoprenoid biosynthesis in hereditary periodic fever syndromes and inflammation. 2003 Cell. Mol. Life Sci. pmid:12861380
Chen B et al. Alteration of mevalonate pathway related enzyme expressions in pressure overload-induced cardiac hypertrophy and associated heart failure with preserved ejection fraction. 2013 Cell. Physiol. Biochem. pmid:24356578
Ropero S et al. Cholesterol cell content modulates GTPase activity of G proteins in GH4C1 cell membranes. 2003 Cell. Signal. pmid:12401528
Valente AJ et al. Interleukin-18 enhances IL-18R/Nox1 binding, and mediates TRAF3IP2-dependent smooth muscle cell migration. Inhibition by simvastatin. 2013 Cell. Signal. pmid:23541442
Iguchi T et al. Nitrogen-containing bisphosphonates induce S-phase cell cycle arrest and apoptosis of myeloma cells by activating MAPK pathway and inhibiting mevalonate pathway. 2003 Cell. Signal. pmid:12742232