Mevalonic acid is a lipid of Fatty Acyls (FA) class.
We collected disease MeSH terms mapped to the references associated with Mevalonic acid
Authors | Title | Published | Journal | PubMed Link |
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Ginestier C et al. | Mevalonate metabolism regulates Basal breast cancer stem cells and is a potential therapeutic target. | 2012 | Stem Cells | pmid:22605458 |
Haratake A et al. | Acceleration of de novo cholesterol synthesis in the epidermis influences desquamation of the stratum corneum in aged mice. | 2006 | Skin Pharmacol Physiol | pmid:16778459 |
Kodaman PH and Duleba AJ | Statins in the treatment of polycystic ovary syndrome. | 2008 | Semin. Reprod. Med. | pmid:18181091 |
Bellosta S et al. | Statins effect on smooth muscle cell proliferation. | 2004 | Semin Vasc Med | pmid:15861311 |
Cornforth JW | Asymmetry and enzyme action. | 1976 | Science | pmid:935862 |
Edmond J et al. | Mevalonate metabolism: role of kidneys. | 1976 | Science | pmid:935865 |
Farnsworth CC et al. | Identification of geranylgeranyl-modified proteins in HeLa cells. | 1990 | Science | pmid:2296721 |
MEROLA AJ and ARNOLD A | ESTRONE INHIBITION OF CHOLESTEROL BIOSYNTHESIS AT THE MEVALONIC ACID STAGE. | 1964 | Science | pmid:14169718 |
FIMOGNARI GM and RODWELL VW | CHOLESTEROL BIOSYNTHESIS: MEVALONATE SYNTHESIS INHIBITED BY BILE SALTS. | 1965 | Science | pmid:14245778 |
Graebe JE | Isoprenoid biosynthesis in a cell-free system from pea shoots. | 1967 | Science | pmid:4381746 |
Yi P et al. | The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Ggamma1. | 2006 | Science | pmid:16857902 |
Galli G et al. | Sterol precursors of cholesterol in adult human brain. | 1968 | Science | pmid:5700071 |
Jomaa H et al. | Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. | 1999 | Science | pmid:10477522 |
Matsumoto Y et al. | A critical role of mevalonate for peptidoglycan synthesis in Staphylococcus aureus. | 2016 | Sci Rep | pmid:26961421 |
Pina ES et al. | Mevalonate-derived quinonemethide triterpenoid from in vitro roots of Peritassa laevigata and their localization in root tissue by MALDI imaging. | 2016 | Sci Rep | pmid:26943243 |
Kain V et al. | Simvastatin may induce insulin resistance through a novel fatty acid mediated cholesterol independent mechanism. | 2015 | Sci Rep | pmid:26345110 |
Warita K et al. | Statin-induced mevalonate pathway inhibition attenuates the growth of mesenchymal-like cancer cells that lack functional E-cadherin mediated cell cohesion. | 2014 | Sci Rep | pmid:25534349 |
Omar SH | Oleuropein in olive and its pharmacological effects. | 2010 Apr-Jun | Sci Pharm | pmid:21179340 |
Feitosa AO et al. | Lethality of cytochalasin B and other compounds isolated from fungus Aspergillus sp. (Trichocomaceae) endophyte of Bauhinia guianensis (Fabaceae). | 2016 Jul - Sep | Rev. Argent. Microbiol. | pmid:27567521 |
Ali OF et al. | Pleiotropic effects of statins in distal human pulmonary artery smooth muscle cells. | 2011 | Respir. Res. | pmid:21999923 |
Schaafsma D et al. | Simvastatin inhibits TGFβ1-induced fibronectin in human airway fibroblasts. | 2011 | Respir. Res. | pmid:21864337 |
Capra V and Rovati GE | Rosuvastatin inhibits human airway smooth muscle cells mitogenic response to eicosanoid contractile agents. | 2014 | Pulm Pharmacol Ther | pmid:23806820 |
Olson AL et al. | Substrate induced structural and dynamics changes in human phosphomevalonate kinase and implications for mechanism. | 2009 | Proteins | pmid:18798562 |
Vinokur JM et al. | Structural analysis of mevalonate-3-kinase provides insight into the mechanisms of isoprenoid pathway decarboxylases. | 2015 | Protein Sci. | pmid:25422158 |
Korman TP et al. | A synthetic biochemistry system for the in vitro production of isoprene from glycolysis intermediates. | 2014 | Protein Sci. | pmid:24623472 |
Rosenthal RS and Rodwell VW | Purification and characterization of the heteromeric transcriptional activator MvaT of the Pseudomonas mevalonii mvaAB operon. | 1998 | Protein Sci. | pmid:9514272 |
Andreassi JL et al. | Crystal structure of the Streptococcus pneumoniae mevalonate kinase in complex with diphosphomevalonate. | 2007 | Protein Sci. | pmid:17400916 |
Hedl M and Rodwell VW | Inhibition of the class II HMG-CoA reductase of Pseudomonas mevalonii. | 2004 | Protein Sci. | pmid:15152097 |
Hedl M and Rodwell VW | Enterococcus faecalis mevalonate kinase. | 2004 | Protein Sci. | pmid:14767074 |
Kim DY et al. | Expression and characterization of the HMG-CoA reductase of the thermophilic archaeon Sulfolobus solfataricus. | 1999 | Protein Expr. Purif. | pmid:10600463 |
Yildirim FI et al. | Aggravating effect of atorvastatin on indomethacin-induced gastric injury: Focus on PGE2, TNF-α, neutrophils and iNOS. | 2015 | Prostaglandins Other Lipid Mediat. | pmid:26201058 |
Kabara JJ | A critical review of brain cholesterol metabolism. | 1973 | Prog. Brain Res. | pmid:4608424 |
Popják G and Meenan A | Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase: search for the enzyme's repressor derived from mevalonate. | 1987 | Proc. R. Soc. Lond., B, Biol. Sci. | pmid:2892200 |
Cornforth J | Symmetry of squalene epoxidation in vivo. | 1977 | Proc. R. Soc. Lond., B, Biol. Sci. | pmid:22855 |
Shi Z and Ruvkun G | The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22396595 |
Saito Y et al. | Animal cell mutants defective in sterol metabolism: a specific selection procedure and partial characterization of defects. | 1977 | Proc. Natl. Acad. Sci. U.S.A. | pmid:269426 |
Cuthbert JA and Lipsky PE | Modulation of human lymphocyte responses by low density lipoproteins (LDL): enhancement but not immunosuppression is mediated by LDL receptors. | 1984 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6087331 |
Huneeus VQ et al. | Isopentenyladenine as a mediator of mevalonate-regulated DNA replication. | 1980 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6934516 |
Kopito RR and Brunengraber H | (R)-mevalonate excretion in human and rat urines. | 1980 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6255462 |
Brown MS and Goldstein JL | Familial hypercholesterolemia: defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity. | 1974 | Proc. Natl. Acad. Sci. U.S.A. | pmid:4362634 |
Polotskaia A et al. | Proteome-wide analysis of mutant p53 targets in breast cancer identifies new levels of gain-of-function that influence PARP, PCNA, and MCM4. | 2015 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25733866 |
Fisher JE et al. | Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9874784 |
Giron MD et al. | Mevalonate-mediated suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase function in alpha-toxin-perforated cells. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8022795 |
Sinensky M et al. | Somatic cell genetic analysis of regulation of expression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | 1980 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6935672 |
Goldstein JL et al. | Genetic heterogeneity in familial hypercholesterolemia: evidence for two different mutations affecting functions of low-density lipoprotein receptor. | 1975 | Proc. Natl. Acad. Sci. U.S.A. | pmid:236556 |
Arebalo RE et al. | In vivo regulation of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A reductase: enzyme phosphorylation as an early regulatory response after intragastric administration of mevalonolactone. | 1980 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6256737 |
Hampton RY and Bhakta H | Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl-CoA reductase. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9371780 |
McNamara DJ et al. | Measurement of daily cholesterol synthesis rates in man by assay of the fractional conversion of mevalonic acid to cholesterol. | 1977 | Proc. Natl. Acad. Sci. U.S.A. | pmid:268653 |
Balasubramaniam S et al. | Regulation of cholesterol synthesis in rat adrenal gland through coordinate control of 3-hydroxy-3-methylglutaryl coenzyme A synthase and reductase activities. | 1977 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16260 |
Zheng YH et al. | Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virions. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12824470 |