Mevalonic acid is a lipid of Fatty Acyls (FA) class.
We collected disease MeSH terms mapped to the references associated with Mevalonic acid
Authors | Title | Published | Journal | PubMed Link |
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Yang J et al. | Enhancing production of bio-isoprene using hybrid MVA pathway and isoprene synthase in E. coli. | 2012 | PLoS ONE | pmid:22558074 |
Thurnher M et al. | Novel aspects of mevalonate pathway inhibitors as antitumor agents. | 2012 | Clin. Cancer Res. | pmid:22529099 |
Trapani L et al. | 3-hydroxy 3-methylglutaryl coenzyme A reductase inhibition impairs muscle regeneration. | 2012 | J. Cell. Biochem. | pmid:22274883 |
Song AA et al. | Overexpressing 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) in the lactococcal mevalonate pathway for heterologous plant sesquiterpene production. | 2012 | PLoS ONE | pmid:23300671 |
Partow S et al. | Reconstruction and evaluation of the synthetic bacterial MEP pathway in Saccharomyces cerevisiae. | 2012 | PLoS ONE | pmid:23285068 |
Zhang B et al. | Interference in mevalonate pathway ameliorates homocysteine-induced endothelium-dysfunction. | 2012 | Eur. J. Pharmacol. | pmid:22796672 |
Alonso-Gutierrez J et al. | Metabolic engineering of Escherichia coli for limonene and perillyl alcohol production. | 2013 | Metab. Eng. | pmid:23727191 |
Theesfeld CL and Hampton RY | Insulin-induced gene protein (INSIG)-dependent sterol regulation of Hmg2 endoplasmic reticulum-associated degradation (ERAD) in yeast. | 2013 | J. Biol. Chem. | pmid:23306196 |
van der Burgh R et al. | Mevalonate kinase deficiency, a metabolic autoinflammatory disease. | 2013 | Clin. Immunol. | pmid:23110805 |
Hosaka A et al. | Statins reduce amyloid β-peptide production by modulating amyloid precursor protein maturation and phosphorylation through a cholesterol-independent mechanism in cultured neurons. | 2013 | Neurochem. Res. | pmid:23269484 |
Qi XF et al. | HMG-CoA reductase inhibitors induce apoptosis of lymphoma cells by promoting ROS generation and regulating Akt, Erk and p38 signals via suppression of mevalonate pathway. | 2013 | Cell Death Dis | pmid:23449454 |
Tricarico PM et al. | Temperature and drug treatments in mevalonate kinase deficiency: an ex vivo study. | 2013 | Biomed Res Int | pmid:24073415 |
Tyurin M | Gene replacement and elimination using λRed- and FLP-based tool to re-direct carbon flux in acetogen biocatalyst during continuous CO₂/H₂ blend fermentation. | 2013 | J. Ind. Microbiol. Biotechnol. | pmid:23649912 |
MartÃn-Navarro CM et al. | Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and application of statins as a novel effective therapeutic approach against Acanthamoeba infections. | 2013 | Antimicrob. Agents Chemother. | pmid:23114753 |
Zhang J et al. | Statins directly suppress cytokine production in murine intraepithelial lymphocytes. | 2013 | Cytokine | pmid:23290865 |
Rauthan M et al. | The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23530189 |
Citron CA and Dickschat JS | The stereochemical course of tricho-acorenol biosynthesis. | 2013 | Org. Biomol. Chem. | pmid:24084795 |
Blanc M et al. | The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response. | 2013 | Immunity | pmid:23273843 |
Wang C et al. | Engineered heterologous FPP synthases-mediated Z,E-FPP synthesis in E. coli. | 2013 | Metab. Eng. | pmid:23608473 |
Yu W et al. | The mevalonate auxotrophic mutant of Staphylococcus aureus can adapt to mevalonate depletion. | 2013 | Antimicrob. Agents Chemother. | pmid:23959312 |
Szűcs G et al. | Cardioprotection by farnesol: role of the mevalonate pathway. | 2013 | Cardiovasc Drugs Ther | pmid:23673412 |
Ramak P et al. | Inhibition of the mevalonate pathway enhances carvacrol biosynthesis and DXR gene expression in shoot cultures of Satureja khuzistanica Jamzad. | 2013 | J. Plant Physiol. | pmid:23611428 |
Chen X et al. | Statistical experimental design guided optimization of a one-pot biphasic multienzyme total synthesis of amorpha-4,11-diene. | 2013 | PLoS ONE | pmid:24278153 |
Chang WC et al. | Current development in isoprenoid precursor biosynthesis and regulation. | 2013 | Curr Opin Chem Biol | pmid:23891475 |
Tuerdi G et al. | Synergistic effect of combined treatment with gamma-tocotrienol and statin on human malignant mesothelioma cells. | 2013 | Cancer Lett. | pmid:23879968 |
Gopalan A et al. | Simvastatin inhibition of mevalonate pathway induces apoptosis in human breast cancer cells via activation of JNK/CHOP/DR5 signaling pathway. | 2013 | Cancer Lett. | pmid:22960596 |
Onono F et al. | Efficient use of exogenous isoprenols for protein isoprenylation by MDA-MB-231 cells is regulated independently of the mevalonate pathway. | 2013 | J. Biol. Chem. | pmid:23908355 |
Gopalan A et al. | Eliminating drug resistant breast cancer stem-like cells with combination of simvastatin and gamma-tocotrienol. | 2013 | Cancer Lett. | pmid:23063651 |
Liu J et al. | Overproduction of geraniol by enhanced precursor supply in Saccharomyces cerevisiae. | 2013 | J. Biotechnol. | pmid:24161921 |
Lee SK and Kim YS | Phosphorylation of eIF2α attenuates statin-induced apoptosis by inhibiting the stabilization and translocation of p53 to the mitochondria. | 2013 | Int. J. Oncol. | pmid:23354132 |
Valente AJ et al. | Interleukin-18 enhances IL-18R/Nox1 binding, and mediates TRAF3IP2-dependent smooth muscle cell migration. Inhibition by simvastatin. | 2013 | Cell. Signal. | pmid:23541442 |
Xiao H et al. | Inhibition of Rho and Rac geranylgeranylation by atorvastatin is critical for preservation of endothelial junction integrity. | 2013 | PLoS ONE | pmid:23555637 |
Villanueva JA et al. | Resveratrol potentiates effect of simvastatin on inhibition of mevalonate pathway in human endometrial stromal cells. | 2013 | J. Clin. Endocrinol. Metab. | pmid:23386644 |
May B et al. | Biosynthesis of sesquiterpenes in grape berry exocarp of Vitis vinifera L.: evidence for a transport of farnesyl diphosphate precursors from plastids to the cytosol. | 2013 | Phytochemistry | pmid:23954075 |
Zeng H et al. | mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function. | 2013 | Nature | pmid:23812589 |
Chen B et al. | Alteration of mevalonate pathway related enzyme expressions in pressure overload-induced cardiac hypertrophy and associated heart failure with preserved ejection fraction. | 2013 | Cell. Physiol. Biochem. | pmid:24356578 |
Dellas N et al. | Discovery of a metabolic alternative to the classical mevalonate pathway. | 2013 | Elife | pmid:24327557 |
Bruzzese F et al. | Panobinostat synergizes with zoledronic acid in prostate cancer and multiple myeloma models by increasing ROS and modulating mevalonate and p38-MAPK pathways. | 2013 | Cell Death Dis | pmid:24157872 |
Dick M et al. | Statin therapy influences endothelial cell morphology and F-actin cytoskeleton structure when exposed to static and laminar shear stress conditions. | 2013 | Life Sci. | pmid:23517776 |
Fang SY et al. | Pleiotropic vascular protective effects of statins in perioperative medicine. | 2013 | Acta Anaesthesiol Taiwan | pmid:24148741 |
Maciejak A et al. | The effects of statins on the mevalonic acid pathway in recombinant yeast strains expressing human HMG-CoA reductase. | 2013 | BMC Biotechnol. | pmid:24128347 |
Polidoro S et al. | Effects of bisphosphonate treatment on DNA methylation in osteonecrosis of the jaw. | 2013 | Mutat. Res. | pmid:23892139 |
Santolaria T et al. | Repeated systemic administrations of both aminobisphosphonates and human Vγ9Vδ2 T cells efficiently control tumor development in vivo. | 2013 | J. Immunol. | pmid:23836057 |
Poggi A et al. | Selective role of mevalonate pathway in regulating perforin but not FasL and TNFalpha release in human Natural Killer cells. | 2013 | PLoS ONE | pmid:23667543 |
Ohukainen P | If the wheel ain't broke, don't reinvent it. | 2013 | Lipids Health Dis | pmid:23577775 |
Werner M et al. | Simvastatin-induced compartmentalisation of doxorubicin sharpens up nuclear topoisomerase II inhibition in human rhabdomyosarcoma cells. | 2013 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:23564041 |
Zhu Y et al. | Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases. | 2013 | Cell Death Dis | pmid:23559002 |
Lee NY and Kang YS | The effects of bisphosphonates on taurine transport in retinal capillary endothelial cells under high glucose conditions. | 2013 | Adv. Exp. Med. Biol. | pmid:23392871 |
Corcos L and Le Jossic-Corcos C | Statins: perspectives in cancer therapeutics. | 2013 | Dig Liver Dis | pmid:23490341 |
Lesma E et al. | Chromatin remodeling by rosuvastatin normalizes TSC2-/meth cell phenotype through the expression of tuberin. | 2013 | J. Pharmacol. Exp. Ther. | pmid:23426956 |
Doblas VG et al. | The SUD1 gene encodes a putative E3 ubiquitin ligase and is a positive regulator of 3-hydroxy-3-methylglutaryl coenzyme a reductase activity in Arabidopsis. | 2013 | Plant Cell | pmid:23404890 |
Riganti C et al. | Zoledronic acid restores doxorubicin chemosensitivity and immunogenic cell death in multidrug-resistant human cancer cells. | 2013 | PLoS ONE | pmid:23593363 |
Lazzerini PE et al. | Rosuvastatin inhibits spontaneous and IL-1β-induced interleukin-6 production from human cultured osteoblastic cells. | 2013 | Joint Bone Spine | pmid:22999910 |
Mazein A et al. | A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway. | 2013 | Biochem. Pharmacol. | pmid:23583456 |
Capra V and Rovati GE | Rosuvastatin inhibits human airway smooth muscle cells mitogenic response to eicosanoid contractile agents. | 2014 | Pulm Pharmacol Ther | pmid:23806820 |
Bentinger M et al. | Effects of various squalene epoxides on coenzyme Q and cholesterol synthesis. | 2014 | Biochim. Biophys. Acta | pmid:24747199 |
Yuan J and Ching CB | Combinatorial engineering of mevalonate pathway for improved amorpha-4,11-diene production in budding yeast. | 2014 | Biotechnol. Bioeng. | pmid:24122315 |
Sorrentino G et al. | Metabolic control of YAP and TAZ by the mevalonate pathway. | 2014 | Nat. Cell Biol. | pmid:24658687 |
Al-Haidari AA et al. | HMG-CoA reductase regulates CCL17-induced colon cancer cell migration via geranylgeranylation and RhoA activation. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24582560 |
Huchelmann A et al. | S-carvone suppresses cellulase-induced capsidiol production in Nicotiana tabacum by interfering with protein isoprenylation. | 2014 | Plant Physiol. | pmid:24367019 |
Schwarz BH et al. | Kinetic characterization of an oxidative, cooperative HMG-CoA reductase from Burkholderia cenocepacia. | 2014 | Biochim. Biophys. Acta | pmid:24316250 |
Smith R et al. | Simvastatin inhibits glucose metabolism and legumain activity in human myotubes. | 2014 | PLoS ONE | pmid:24416446 |
Liu YP et al. | Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators. | 2014 | J. Clin. Invest. | pmid:24691443 |
Hamid PH et al. | Differential inhibition of host cell cholesterol de novo biosynthesis and processing abrogates Eimeria bovis intracellular development. | 2014 | Parasitol. Res. | pmid:25199551 |
Khandelwal VK et al. | Oxidative stress plays an important role in zoledronic acid-induced autophagy. | 2014 | Physiol Res | pmid:25669691 |
Warita K et al. | Statin-induced mevalonate pathway inhibition attenuates the growth of mesenchymal-like cancer cells that lack functional E-cadherin mediated cell cohesion. | 2014 | Sci Rep | pmid:25534349 |
Yang J and Guo L | Biosynthesis of β-carotene in engineered E. coli using the MEP and MVA pathways. | 2014 | Microb. Cell Fact. | pmid:25403509 |
Larson-Casey JL et al. | Modulation of the mevalonate pathway by akt regulates macrophage survival and development of pulmonary fibrosis. | 2014 | J. Biol. Chem. | pmid:25378391 |
Shimabukuro-Vornhagen A et al. | Inhibition of protein geranylgeranylation specifically interferes with CD40-dependent B cell activation, resulting in a reduced capacity to induce T cell immunity. | 2014 | J. Immunol. | pmid:25311809 |
Chang TI et al. | The effect of statin on epithelial-mesenchymal transition in peritoneal mesothelial cells. | 2014 | PLoS ONE | pmid:25275561 |
Kanugula AK et al. | Fluvastatin mediated breast cancer cell death: a proteomic approach to identify differentially regulated proteins in MDA-MB-231 cells. | 2014 | PLoS ONE | pmid:25268751 |
Sapir A et al. | Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25187565 |
Rodriguez SB and Leyh TS | An enzymatic platform for the synthesis of isoprenoid precursors. | 2014 | PLoS ONE | pmid:25153179 |
Pandyra A et al. | Immediate utility of two approved agents to target both the metabolic mevalonate pathway and its restorative feedback loop. | 2014 | Cancer Res. | pmid:24994712 |
Kanugula AK et al. | Statin-induced inhibition of breast cancer proliferation and invasion involves attenuation of iron transport: intermediacy of nitric oxide and antioxidant defence mechanisms. | 2014 | FEBS J. | pmid:24964743 |
Workalemahu G et al. | Metabolic engineering of Salmonella vaccine bacteria to boost human Vγ2Vδ2 T cell immunity. | 2014 | J. Immunol. | pmid:24943221 |
Ranji P et al. | Loss of HMG-CoA reductase in C. elegans causes defects in protein prenylation and muscle mitochondria. | 2014 | PLoS ONE | pmid:24918786 |
Vinokur JM et al. | Evidence of a novel mevalonate pathway in archaea. | 2014 | Biochemistry | pmid:24914732 |
Wang Y et al. | 24S,25-Epoxycholesterol in mouse and rat brain. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24832732 |
Xiong M et al. | Scalable production of mechanically tunable block polymers from sugar. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24912182 |
Rivera-Perez C et al. | Metabolic analysis reveals changes in the mevalonate and juvenile hormone synthesis pathways linked to the mosquito reproductive physiology. | 2014 | Insect Biochem. Mol. Biol. | pmid:24833260 |
Song AA et al. | Engineering the lactococcal mevalonate pathway for increased sesquiterpene production. | 2014 | FEMS Microbiol. Lett. | pmid:24828482 |
Tricarico PM et al. | Block of the mevalonate pathway triggers oxidative and inflammatory molecular mechanisms modulated by exogenous isoprenoid compounds. | 2014 | Int J Mol Sci | pmid:24758928 |
Azami Y et al. | (R)-mevalonate 3-phosphate is an intermediate of the mevalonate pathway in Thermoplasma acidophilum. | 2014 | J. Biol. Chem. | pmid:24755225 |
Zheng X et al. | Triterpenoid saponin biosynthetic pathway profiling and candidate gene mining of the Ilex asprella root using RNA-Seq. | 2014 | Int J Mol Sci | pmid:24722569 |
Liu Y et al. | Caenorhabditis elegans pathways that surveil and defend mitochondria. | 2014 | Nature | pmid:24695221 |
Piłsyk S et al. | Overexpression of erg20 gene encoding farnesyl pyrophosphate synthase has contrasting effects on activity of enzymes of the dolichyl and sterol branches of mevalonate pathway in Trichoderma reesei. | 2014 | Gene | pmid:24793581 |
Ghavami S et al. | Airway mesenchymal cell death by mevalonate cascade inhibition: integration of autophagy, unfolded protein response and apoptosis focusing on Bcl2 family proteins. | 2014 | Biochim. Biophys. Acta | pmid:24637330 |
Korman TP et al. | A synthetic biochemistry system for the in vitro production of isoprene from glycolysis intermediates. | 2014 | Protein Sci. | pmid:24623472 |
Yeganeh B et al. | Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease. | 2014 | Pharmacol. Ther. | pmid:24582968 |
Rojo-Arreola L et al. | Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis. | 2014 | PLoS ONE | pmid:24489942 |
Vannice JC et al. | Identification in Haloferax volcanii of phosphomevalonate decarboxylase and isopentenyl phosphate kinase as catalysts of the terminal enzyme reactions in an archaeal alternate mevalonate pathway. | 2014 | J. Bacteriol. | pmid:24375100 |
Wang Z et al. | Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24367099 |
Sánchez-Solana B et al. | Cytosolic functions of MORC2 in lipogenesis and adipogenesis. | 2014 | Biochim. Biophys. Acta | pmid:24286864 |
Pampalakis G et al. | The KLK5 protease suppresses breast cancer by repressing the mevalonate pathway. | 2014 | Oncotarget | pmid:24158494 |
Bentley FK et al. | Heterologous expression of the mevalonic acid pathway in cyanobacteria enhances endogenous carbon partitioning to isoprene. | 2014 | Mol Plant | pmid:24157609 |
Fu Z et al. | Exometabolome analysis reveals hypoxia at the up-scaling of a Saccharomyces cerevisiae high-cell density fed-batch biopharmaceutical process. | 2014 | Microb. Cell Fact. | pmid:24593159 |
Zelcer N et al. | The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway. | 2014 | Mol. Cell. Biol. | pmid:24449766 |
Kiser PD et al. | Chemistry of the retinoid (visual) cycle. | 2014 | Chem. Rev. | pmid:23905688 |
Rachner TD et al. | Dickkopf-1 is regulated by the mevalonate pathway in breast cancer. | 2014 | Breast Cancer Res. | pmid:24528599 |