Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Peutz-Jeghers Syndrome D010580 2 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Biliary Fistula D001658 13 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Refsum Disease D012035 19 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Glioblastoma D005909 27 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Hypothyroidism D007037 32 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Thrombosis D013927 49 associated lipids
Leukemia D007938 74 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Glioma D005910 112 associated lipids
Hypertension D006973 115 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Adenocarcinoma D000230 166 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
Winiarska M et al. Statins impair antitumor effects of rituximab by inducing conformational changes of CD20. 2008 PLoS Med. pmid:18366248
Deshpande G et al. Ggamma1, a downstream target for the hmgcr-isoprenoid biosynthetic pathway, is required for releasing the Hedgehog ligand and directing germ cell migration. 2009 PLoS Genet. pmid:19132091
Maurer-Stroh S et al. Towards complete sets of farnesylated and geranylgeranylated proteins. 2007 PLoS Comput. Biol. pmid:17411337
Hardman R and Fazli FR Labelled steroidal sapogenins and hydrocarbons from Trigonella foenumgraecum by acetate, mevalonate and cholesterol feeds to seeds. 1972 Planta Med. pmid:5018497
Okada K et al. Antisense and chemical suppression of the nonmevalonate pathway affects ent-kaurene biosynthesis in Arabidopsis. 2002 Planta pmid:12029484
Nagata N et al. Mevalonic acid partially restores chloroplast and etioplast development in Arabidopsis lacking the non-mevalonate pathway. 2002 Planta pmid:12447549
Zeidler J and Lichtenthaler HK Biosynthesis of 2-methyl-3-buten-2-ol emitted from needles of Pinus ponderosa via the non-mevalonate DOXP/MEP pathway of isoprenoid formation. 2001 Planta pmid:11469599
Wu S et al. Engineering triterpene metabolism in tobacco. 2012 Planta pmid:22729821
Simkin AJ et al. Peroxisomal localisation of the final steps of the mevalonic acid pathway in planta. 2011 Planta pmid:21655959
Schwender J et al. Chlorophyta exclusively use the 1-deoxyxylulose 5-phosphate/2-C-methylerythritol 4-phosphate pathway for the biosynthesis of isoprenoids. 2001 Planta pmid:11289606
Clastre M et al. Subcellular evidence for the involvement of peroxisomes in plant isoprenoid biosynthesis. 2011 Plant Signal Behav pmid:22080790
Henriquez MA et al. Effects of glucans and eicosapentaenoic acid on differential regulation of phenylpropanoid and mevalonic pathways during potato response to Phytophthora infestans. 2012 Plant Physiol. Biochem. pmid:22922112
Rodríguez-Concepción M and Boronat A Elucidation of the methylerythritol phosphate pathway for isoprenoid biosynthesis in bacteria and plastids. A metabolic milestone achieved through genomics. 2002 Plant Physiol. pmid:12427975
Li Z et al. Effect of temperature on postillumination isoprene emission in oak and poplar. 2011 Plant Physiol. pmid:21177471
Che P et al. Metabolic and environmental regulation of 3-methylcrotonyl-coenzyme A carboxylase expression in Arabidopsis. 2002 Plant Physiol. pmid:12068107
Sharkey TD et al. Isoprene increases thermotolerance of fosmidomycin-fed leaves. 2001 Plant Physiol. pmid:11299379
Ruiz-Sola MÁ et al. A Single Arabidopsis Gene Encodes Two Differentially Targeted Geranylgeranyl Diphosphate Synthase Isoforms. 2016 Plant Physiol. pmid:27707890
Huchelmann A et al. S-carvone suppresses cellulase-induced capsidiol production in Nicotiana tabacum by interfering with protein isoprenylation. 2014 Plant Physiol. pmid:24367019
Bouvier-Navé P et al. Involvement of the phospholipid sterol acyltransferase1 in plant sterol homeostasis and leaf senescence. 2010 Plant Physiol. pmid:19923239
Jiang Z et al. Engineering Triterpene and Methylated Triterpene Production in Plants Provides Biochemical and Physiological Insights into Terpene Metabolism. 2016 Plant Physiol. pmid:26603654
Mertens J et al. The bHLH Transcription Factors TSAR1 and TSAR2 Regulate Triterpene Saponin Biosynthesis in Medicago truncatula. 2016 Plant Physiol. pmid:26589673
Wang WQ et al. Proteomic analysis of lettuce seed germination and thermoinhibition by sampling of individual seeds at germination and removal of storage proteins by polyethylene glycol fractionation. 2015 Plant Physiol. pmid:25736209
Koch T et al. Differential induction of plant volatile biosynthesis in the lima bean by early and late intermediates of the octadecanoid-signaling pathway. 1999 Plant Physiol. pmid:10482670
Shimada Y et al. Organ-specific expression of brassinosteroid-biosynthetic genes and distribution of endogenous brassinosteroids in Arabidopsis. 2003 Plant Physiol. pmid:12529536
Sapir-Mir M et al. Peroxisomal localization of Arabidopsis isopentenyl diphosphate isomerases suggests that part of the plant isoprenoid mevalonic acid pathway is compartmentalized to peroxisomes. 2008 Plant Physiol. pmid:18988695
Galichet A et al. Farnesylation directs AtIPT3 subcellular localization and modulates cytokinin biosynthesis in Arabidopsis. 2008 Plant Physiol. pmid:18184738
Bede JC et al. Biosynthetic pathway of insect juvenile hormone III in cell suspension cultures of the sedge Cyperus iria. 2001 Plant Physiol. pmid:11598232
Huang M et al. Variation of herbivore-induced volatile terpenes among Arabidopsis ecotypes depends on allelic differences and subcellular targeting of two terpene synthases, TPS02 and TPS03. 2010 Plant Physiol. pmid:20463089
Lange BM et al. Isoprenoid biosynthesis. Metabolite profiling of peppermint oil gland secretory cells and application to herbicide target analysis. 2001 Plant Physiol. pmid:11553758
Angaman DM et al. Precursor uptake assays and metabolic analyses in isolated tomato fruit chromoplasts. 2012 Plant Methods pmid:22243738
Masferrer A et al. Overexpression of Arabidopsis thaliana farnesyl diphosphate synthase (FPS1S) in transgenic Arabidopsis induces a cell death/senescence-like response and reduced cytokinin levels. 2002 Plant J. pmid:12000449
Suzuki M et al. Loss of function of 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 (HMG1) in Arabidopsis leads to dwarfing, early senescence and male sterility, and reduced sterol levels. 2004 Plant J. pmid:14871314
Re EB et al. Co-expression of native and introduced genes reveals cryptic regulation of HMG CoA reductase expression in Arabidopsis. 1995 Plant J. pmid:7773308
Towler MJ and Weathers PJ Evidence of artemisinin production from IPP stemming from both the mevalonate and the nonmevalonate pathways. 2007 Plant Cell Rep. pmid:17710406
Flores-Sánchez IJ et al. Biosynthesis of sterols and triterpenes in cell suspension cultures of Uncaria tomentosa. 2002 Plant Cell Physiol. pmid:12514247
Miyazawa Y et al. Amyloplast formation in cultured tobacco BY-2 cells requires a high cytokinin content. 2002 Plant Cell Physiol. pmid:12514251
Okada K et al. Genetic evidence for the role of isopentenyl diphosphate isomerases in the mevalonate pathway and plant development in Arabidopsis. 2008 Plant Cell Physiol. pmid:18303110
Mongélard G et al. Measurement of carbon flux through the MEP pathway for isoprenoid synthesis by (31)P-NMR spectroscopy after specific inhibition of 2-C-methyl-d-erythritol 2,4-cyclodiphosphate reductase. Effect of light and temperature. 2011 Plant Cell Environ. pmid:21443577
Chang TH et al. Structure of a heterotetrameric geranyl pyrophosphate synthase from mint (Mentha piperita) reveals intersubunit regulation. 2010 Plant Cell pmid:20139160
Doblas VG et al. The SUD1 gene encodes a putative E3 ubiquitin ligase and is a positive regulator of 3-hydroxy-3-methylglutaryl coenzyme a reductase activity in Arabidopsis. 2013 Plant Cell pmid:23404890
Rodríguez-Concepción M et al. Distinct light-mediated pathways regulate the biosynthesis and exchange of isoprenoid precursors during Arabidopsis seedling development. 2004 Plant Cell pmid:14660801
Randall SK et al. Protein isoprenylation in suspension-cultured tobacco cells. 1993 Plant Cell pmid:8485402
Muñoz-Bertomeu J et al. Up-regulation of an N-terminal truncated 3-hydroxy-3-methylglutaryl CoA reductase enhances production of essential oils and sterols in transgenic Lavandula latifolia. 2007 Plant Biotechnol. J. pmid:17714440
Enfissi EM et al. Metabolic engineering of the mevalonate and non-mevalonate isopentenyl diphosphate-forming pathways for the production of health-promoting isoprenoids in tomato. 2005 Plant Biotechnol. J. pmid:17168896
Asada Y et al. Biosynthesis of the dimethylallyl moiety of glabrol in Glycyrrhiza glabra hairy root cultures via a non-mevalonate pathway. 2000 Phytochemistry pmid:11117880
May B et al. Biosynthesis of sesquiterpenes in grape berry exocarp of Vitis vinifera L.: evidence for a transport of farnesyl diphosphate precursors from plastids to the cytosol. 2013 Phytochemistry pmid:23954075
Umlauf D et al. Biosynthesis of the irregular monoterpene artemisia ketone, the sesquiterpene germacrene D and other isoprenoids in Tanacetum vulgare L. (Asteraceae). 2004 Phytochemistry pmid:15381410
Lopes AA et al. Biosynthetic origins of the isoprene units of gaudichaudianic acid in Piper gaudichaudianum (Piperaceae). 2007 Phytochemistry pmid:17574633
Schramek N et al. Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study. 2010 Phytochemistry pmid:19932496
Han YS et al. Biosynthesis of anthraquinones in cell cultures of Cinchona 'Robusta' proceeds via the methylerythritol 4-phosphate pathway. 2002 Phytochemistry pmid:11754943