Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Peutz-Jeghers Syndrome D010580 2 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Biliary Fistula D001658 13 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Refsum Disease D012035 19 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Glioblastoma D005909 27 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Hypothyroidism D007037 32 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Thrombosis D013927 49 associated lipids
Leukemia D007938 74 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Glioma D005910 112 associated lipids
Hypertension D006973 115 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Adenocarcinoma D000230 166 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 | Total 25

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All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
Saha RN and Pahan K Regulation of inducible nitric oxide synthase gene in glial cells. 2006 May-Jun Antioxid. Redox Signal. pmid:16771683
Tamura G et al. Production of mevalonic acid by fermentation. 1968 Appl Microbiol pmid:5664126
Baadhe RR et al. Development of petri net-based dynamic model for improved production of farnesyl pyrophosphate by integrating mevalonate and methylerythritol phosphate pathways in yeast. 2012 Appl. Biochem. Biotechnol. pmid:22350871
Wang J et al. Engineering of a Highly Efficient Escherichia coli Strain for Mevalonate Fermentation through Chromosomal Integration. 2016 Appl. Environ. Microbiol. pmid:27736790
Hagler WM et al. Biosynthesis of radiolabeled T-2 toxin by Fusarium tricinctum. 1981 Appl. Environ. Microbiol. pmid:7235702
Rossoni L et al. The Putative mevalonate diphosphate decarboxylase from Picrophilus torridus is in reality a mevalonate-3-kinase with high potential for bioproduction of isobutene. 2015 Appl. Environ. Microbiol. pmid:25636853
Rico J et al. Enhanced production of a plant monoterpene by overexpression of the 3-hydroxy-3-methylglutaryl coenzyme A reductase catalytic domain in Saccharomyces cerevisiae. 2010 Appl. Environ. Microbiol. pmid:20675444
Withers ST et al. Identification of isopentenol biosynthetic genes from Bacillus subtilis by a screening method based on isoprenoid precursor toxicity. 2007 Appl. Environ. Microbiol. pmid:17693564
Yoon SH et al. Engineering the lycopene synthetic pathway in E. coli by comparison of the carotenoid genes of Pantoea agglomerans and Pantoea ananatis. 2007 Appl. Microbiol. Biotechnol. pmid:17115209
Morrone D et al. Increasing diterpene yield with a modular metabolic engineering system in E. coli: comparison of MEV and MEP isoprenoid precursor pathway engineering. 2010 Appl. Microbiol. Biotechnol. pmid:19777230
Seker T et al. Analysis of acyl CoA ester intermediates of the mevalonate pathway in Saccharomyces cerevisiae. 2005 Appl. Microbiol. Biotechnol. pmid:15448940
Panda T and Devi VA Regulation and degradation of HMGCo-A reductase. 2004 Appl. Microbiol. Biotechnol. pmid:15558272
Guan Z et al. Metabolic engineering of Bacillus subtilis for terpenoid production. 2015 Appl. Microbiol. Biotechnol. pmid:26373726
Tisch D and Schmoll M Light regulation of metabolic pathways in fungi. 2010 Appl. Microbiol. Biotechnol. pmid:19915832
Kim YS et al. Increase of lycopene production by supplementing auxiliary carbon sources in metabolically engineered Escherichia coli. 2011 Appl. Microbiol. Biotechnol. pmid:21246354
Zhuge B et al. Bioconversion of lovastatin to a novel statin by Amycolatopsis sp. 2008 Appl. Microbiol. Biotechnol. pmid:18368405
Mokashi V et al. Supernatant protein factor stimulates HMG-CoA reductase in cell culture and in vitro. 2005 Arch. Biochem. Biophys. pmid:15581604
Havel CM and Watson JA Isopentenoid synthesis in isolated embryonic Drosophila cells: absolute, basal mevalonate synthesis rate determination. 1992 Arch. Biochem. Biophys. pmid:1567218
TSAI SC et al. TESTICULAR STEROLS. 1. INCORPORATION OF MEVALONATE AND ACETATE INTO STEROLS BY TESTICULAR TISSUE FROM RATS. 1964 Arch. Biochem. Biophys. pmid:14186739
Li G and Stahl PD Post-translational processing and membrane association of the two early endosome-associated rab GTP-binding proteins (rab4 and rab5). 1993 Arch. Biochem. Biophys. pmid:8346922
Faust JR et al. Synthesis of ubiquinone and cholesterol in human fibroblasts: regulation of a branched pathway. 1979 Arch. Biochem. Biophys. pmid:219777
Vaidya S et al. Massive production of farnesol-derived dicarboxylic acids in mice treated with the squalene synthase inhibitor zaragozic acid A. 1998 Arch. Biochem. Biophys. pmid:9647670
Merola AJ et al. Effects of estrogens on cholesterol biosynthesis and tissue distribution in rats. 1968 Arch. Biochem. Biophys. pmid:5642605
Bergstrom JD et al. Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase. 2000 Arch. Biochem. Biophys. pmid:10620343
Peffley DM and Gayen AK Inhibition of squalene synthase but not squalene cyclase prevents mevalonate-mediated suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis at a posttranscriptional level. 1997 Arch. Biochem. Biophys. pmid:9016820
Borgford TJ et al. Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and lipid metabolism in a concanavalin A-resistant Chinese hamster ovary cell line. 1986 Arch. Biochem. Biophys. pmid:3947077
Moir NJ et al. Effect of cholestyramine on the terminal reactions of sterol biosynthesis. 1970 Arch. Biochem. Biophys. pmid:4395692
Kabakoff BD et al. Relationships among dolichyl phosphate, glycoprotein synthesis, and cell culture growth. 1990 Arch. Biochem. Biophys. pmid:2407191
Terabe K et al. Simvastatin inhibits CD44 fragmentation in chondrocytes. 2016 Arch. Biochem. Biophys. pmid:27242325
Back P et al. Regulation of cholesterol biosynthesis in rat liver: diurnal changes of activity and influence of bile acids. 1969 Arch. Biochem. Biophys. pmid:5810824
Meigs TE and Simoni RD Farnesol as a regulator of HMG-CoA reductase degradation: characterization and role of farnesyl pyrophosphatase. 1997 Arch. Biochem. Biophys. pmid:9281305
Krishnaiah KV et al. Effect of dietary cholesterol and ubiquinone on isoprene synthesis in rat liver. 1967 Arch. Biochem. Biophys. pmid:6035059
Gonzalez R et al. Two major regulatory steps in cholesterol synthesis by human renal cancer cells. 1979 Arch. Biochem. Biophys. pmid:485166
Beg ZH et al. Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by reversible phosphorylation: modulation of enzymatic activity by low density lipoprotein, sterols, and mevalonolactone. 1986 Arch. Biochem. Biophys. pmid:3004340
Miziorko HM Enzymes of the mevalonate pathway of isoprenoid biosynthesis. 2011 Arch. Biochem. Biophys. pmid:20932952
Rilling HC et al. Differential prenylation of proteins as a function of mevalonate concentration in CHO cells. 1993 Arch. Biochem. Biophys. pmid:8460935
FUMAGALLI R et al. Cholesterol synthesis in rat brain: differential incorporation of mevalonolactone-2-C14 and potassium mevalonate-2-C14. 1962 Arch. Biochem. Biophys. pmid:13960261
Craig MC et al. Comparative effects of dietary regimens on the levels of enzymes regulating the synthesis of fatty acids and cholesterol in rat liver. 1972 Arch. Biochem. Biophys. pmid:5044513
PORTMAN OW and SUGANO M THE HYDROLYSIS AND FATTY ACID EXCHANGE OF CHOLESTEROL ESTERS ADMINISTERED IN LIPOPROTEINS TO CEBUS MONKEYS. 1963 Arch. Biochem. Biophys. pmid:14072510
Appelkvist EL et al. Presence of individual enzymes of cholesterol biosynthesis in rat liver peroxisomes. 1990 Arch. Biochem. Biophys. pmid:2241153
Schulte AE et al. Purification and characterization of mevalonate kinase from suspension-cultured cells of Catharanthus roseus (L.) G. Don. 2000 Arch. Biochem. Biophys. pmid:10860546
Adam KP et al. Involvement of the mevalonic acid pathway and the glyceraldehyde-pyruvate pathway in terpenoid biosynthesis of the liverworts Ricciocarpos natans and Conocephalum conicum. 1998 Arch. Biochem. Biophys. pmid:9633614
Parmryd I and Dallner G In vivo prenylation of rat proteins: modification of proteins with penta- and hexaprenyl groups. 1999 Arch. Biochem. Biophys. pmid:10190969
Skaff DA et al. Inhibition of bacterial mevalonate diphosphate decarboxylase by eriochrome compounds. 2015 Arch. Biochem. Biophys. pmid:25499551
Shimizu S et al. Possible involvement of 3-hydroxymethylglutaryl-CoA reductase in determining the side-chain length of ubiquinone in rat heart. 1991 Arch. Biochem. Biophys. pmid:1846516
GAYLOR JL Biosynthesis of skin sterols. V. Effect of arsenite inhibition and the accumulation of labeled lanosta-7, 24-dien-3 beta-ol in rat skin. 1963 Arch. Biochem. Biophys. pmid:13946925
BEELER DA et al. The biosynthesis of squalene from mevalonic acid-2-C-14 and farnesyl pyrophosphate-4,8,12-C-14 by carrot and tomato enzymes. 1963 Arch. Biochem. Biophys. pmid:13970235
Hulcher FH Inhibition of hepatic cholesterol biosynthesis by 3,5-dihydroxy-3,4,4-trimethylvaleric acid and its site of action. 1971 Arch. Biochem. Biophys. pmid:5114913
Nepokroeff CM et al. Regulation of the diurnal rhythm of rat liver beta-hydroxy-beta-methylglutaryl coenzmye A reductase activity by insulin, glucagon, cyclic AMP and hydrocortisone. 1974 Arch. Biochem. Biophys. pmid:4364764
Yamamoto T et al. Identification of regulatory sites in the biosynthesis of ubiquinone in the perfused rat heart. 1989 Arch. Biochem. Biophys. pmid:2916849
Muroya H et al. Stimulation of hepatic cholesterol biosynthesis by dietary glucose, and its relation to cholesterol gallstone formation in the hamster. 1968 Arch. Biochem. Biophys. pmid:5661591
GARATTINI S et al. Lipid biosynthesis in vivo from acetate-1-C 14 and 2-C 14 and mevalonic-2-C 14 acid. 1959 Arch. Biochem. Biophys. pmid:13826357
SHAH SN et al. The effect of growth hormone administration and dietary protein on the incorporation of sodium acetate-2-C14 and mevalonic acid-2-C14 into liver cholesterol. 1961 Arch. Biochem. Biophys. pmid:13750592
Edwards PA The influence of catecholamines and cyclic AMP on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and lipid biosynthesis in isolated rat hepatocytes. 1975 Arch. Biochem. Biophys. pmid:169744
Straka MS and Panini SR Post-transcriptional regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by mevalonate. 1995 Arch. Biochem. Biophys. pmid:7872789
Giron MD et al. Isopentenoid synthesis in eukaryotic cells. An initiating role for post-translational control of 3-hydroxy-3-methylglutaryl coenzyme A reductase. 1993 Arch. Biochem. Biophys. pmid:8097083
Godinez MH et al. The biosynthesis of isoprenoid lipids including ubiquinone in muscle from normal and genetically dystrophic mice. 1970 Arch. Biochem. Biophys. pmid:5460184
Gayen AK and Peffley DM The length of 5'-untranslated leader sequences influences distribution of 3-hydroxy-3-methylglutaryl-coenzyme A reductase mRNA in polysomes: effects of lovastatin, oxysterols, and mevalonate. 1995 Arch. Biochem. Biophys. pmid:7574724
Ness GC et al. Effect of squalene synthase inhibition on the expression of hepatic cholesterol biosynthetic enzymes, LDL receptor, and cholesterol 7 alpha hydroxylase. 1994 Arch. Biochem. Biophys. pmid:7911291
Jedlicki E et al. Stereospecificity of isopentenylpyrophosphate isomerase and prenyl transferase from pinus and citrus. 1972 Arch. Biochem. Biophys. pmid:4635785
Howe EE et al. The hypolipemic properties of 5 beta-cholanic acid in the mouse and rat. 1969 Arch. Biochem. Biophys. pmid:5773747
Jacobsohn GM and Frey MJ Sterol content and metabolism during early growth of Digitalis purpurea. 1968 Arch. Biochem. Biophys. pmid:5698012
Keller RK et al. Farnesol is not the nonsterol regulator mediating degradation of HMG-CoA reductase in rat liver. 1996 Arch. Biochem. Biophys. pmid:8645011
Kandutsch AA and Packie RM Comparison of the effects of some C27-, C21-, and C19-steroids upon hepatic sterol synthesis and hydroxymethylglutaryl-CoA reductase activity. 1970 Arch. Biochem. Biophys. pmid:5460174
Voynova NE et al. Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure. 2008 Arch. Biochem. Biophys. pmid:18823933
Andres DA et al. Expression cloning of a novel farnesylated protein, RDJ2, encoding a DnaJ protein homologue. 1997 Arch. Biochem. Biophys. pmid:9328291
Butterworth PH et al. In vivo incorporation of [2-14-C]-mevalonate into dolichol of rabbit and pig liver. 1966 Arch. Biochem. Biophys. pmid:5944963
Ranganathan S et al. The biosynthesis of ubiquinone in isolated rat heart cells. 1979 Arch. Biochem. Biophys. pmid:518096
Vögeli U and Chappell J Inhibition of a plant sesquiterpene cyclase by mevinolin. 1991 Arch. Biochem. Biophys. pmid:1898013
SUGANO M and PORTMAN OW FATTY ACID SPECIFICITIES AND RATES OF CHOLESTEROL ESTERIFICATION IN VIVO AND IN VITRO. 1964 Arch. Biochem. Biophys. pmid:14224844
Dugan RE et al. Regulation of hepatic beta-hydroxy-beta-methylglutaryl coenzyme A reductase by the interplay of hormones. 1974 Arch. Biochem. Biophys. pmid:4275665
Frenkel J et al. Increased urinary leukotriene E(4) during febrile attacks in the hyperimmunoglobulinaemia D and periodic fever syndrome. 2001 Arch. Dis. Child. pmid:11466192
Raupp P et al. Novel genotype of mevalonic aciduria with fatalities in premature siblings. 2004 Arch. Dis. Child. Fetal Neonatal Ed. pmid:14711867
Kuzina V et al. Relationships among the biosyntheses of ubiquinone, carotene, sterols, and triacylglycerols in Zygomycetes. 2006 Arch. Microbiol. pmid:17009023
Hindy AM et al. Sterol composition and biosynthesis in mouse salivary glands. 1986 Arch. Oral Biol. pmid:3460541
Park SY et al. Inhibitory effect of simvastatin on the TNF-alpha- and angiotensin II-induced monocyte adhesion to endothelial cells is mediated through the suppression of geranylgeranyl isoprenoid-dependent ROS generation. 2008 Arch. Pharm. Res. pmid:18365690
Jarrell KF et al. S-layer glycoproteins and flagellins: reporters of archaeal posttranslational modifications. 2010 Archaea pmid:20721273
Harada-Shiba M et al. Siblings with normal LDL receptor activity and severe hypercholesterolemia. 1992 Arterioscler. Thromb. pmid:1525122
Wagner AH et al. 3-hydroxy-3-methylglutaryl coenzyme A reductase-independent inhibition of CD40 expression by atorvastatin in human endothelial cells. 2002 Arterioscler. Thromb. Vasc. Biol. pmid:12426205
Kwiterovich PO and Motevalli M Differential effect of genistein on the stimulation of cholesterol production by basic protein II in normal and hyperapoB fibroblasts. 1998 Arterioscler. Thromb. Vasc. Biol. pmid:9445257
Masamura K et al. Pitavastatin-induced thrombomodulin expression by endothelial cells acts via inhibition of small G proteins of the Rho family. 2003 Arterioscler. Thromb. Vasc. Biol. pmid:12615662
Ichiki T et al. Downregulation of angiotensin II type 1 receptor by hydrophobic 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in vascular smooth muscle cells. 2001 Arterioscler. Thromb. Vasc. Biol. pmid:11742861
Diomede L et al. In vivo anti-inflammatory effect of statins is mediated by nonsterol mevalonate products. 2001 Arterioscler. Thromb. Vasc. Biol. pmid:11498461
Yasunari K et al. HMG-CoA reductase inhibitors prevent migration of human coronary smooth muscle cells through suppression of increase in oxidative stress. 2001 Arterioscler. Thromb. Vasc. Biol. pmid:11397700
Martínez-González J et al. 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition prevents endothelial NO synthase downregulation by atherogenic levels of native LDLs: balance between transcriptional and posttranscriptional regulation. 2001 Arterioscler. Thromb. Vasc. Biol. pmid:11348878
Loregger A et al. Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis. 2017 Arterioscler. Thromb. Vasc. Biol. pmid:28882874
O'Neill FH et al. Determinants of variable response to statin treatment in patients with refractory familial hypercholesterolemia. 2001 Arterioscler. Thromb. Vasc. Biol. pmid:11348882
Sakamoto K et al. Fluvastatin prevents vascular hyperplasia by inhibiting phenotype modulation and proliferation through extracellular signal-regulated kinase 1 and 2 and p38 mitogen-activated protein kinase inactivation in organ-cultured artery. 2005 Arterioscler. Thromb. Vasc. Biol. pmid:15591221
Dubuc G et al. Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. 2004 Arterioscler. Thromb. Vasc. Biol. pmid:15178557
Wagner AH et al. Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation. 2000 Arterioscler. Thromb. Vasc. Biol. pmid:10634801
Dje N'Guessan P et al. Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells. 2009 Arterioscler. Thromb. Vasc. Biol. pmid:19122173
Colli S et al. Vastatins inhibit tissue factor in cultured human macrophages. A novel mechanism of protection against atherothrombosis. 1997 Arterioscler. Thromb. Vasc. Biol. pmid:9081680
Monzack EL et al. Efficacy of simvastatin treatment of valvular interstitial cells varies with the extracellular environment. 2009 Arterioscler. Thromb. Vasc. Biol. pmid:19023089
Ferri N et al. Simvastatin reduces MMP1 expression in human smooth muscle cells cultured on polymerized collagen by inhibiting Rac1 activation. 2007 Arterioscler. Thromb. Vasc. Biol. pmid:17303772
Dietzen DJ et al. Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase blunts factor VIIa/tissue factor and prothrombinase activities via effects on membrane phosphatidylserine. 2007 Arterioscler. Thromb. Vasc. Biol. pmid:17185615
Nakata S et al. Statin treatment upregulates vascular neuronal nitric oxide synthase through Akt/NF-kappaB pathway. 2007 Arterioscler. Thromb. Vasc. Biol. pmid:17082483
Wu B et al. Paradoxical effects of statins on aortic valve myofibroblasts and osteoblasts: implications for end-stage valvular heart disease. 2005 Arterioscler. Thromb. Vasc. Biol. pmid:15618546
Kwiterovich PO and Motevalli M Inhibition of protein tyrosine kinase alters the effect of serum basic protein I on triacylglycerols and cholesterol differently in normal and hyperapoB fibroblasts. 1995 Arterioscler. Thromb. Vasc. Biol. pmid:7627714
Bernini F et al. HMG-CoA reductase inhibitors reduce acetyl LDL endocytosis in mouse peritoneal macrophages. 1995 Arterioscler. Thromb. Vasc. Biol. pmid:7670949
Luan Z et al. Statins inhibit secretion of metalloproteinases-1, -2, -3, and -9 from vascular smooth muscle cells and macrophages. 2003 Arterioscler. Thromb. Vasc. Biol. pmid:12663370