Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Peutz-Jeghers Syndrome D010580 2 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Biliary Fistula D001658 13 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Refsum Disease D012035 19 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Glioblastoma D005909 27 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Hypothyroidism D007037 32 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Thrombosis D013927 49 associated lipids
Leukemia D007938 74 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Glioma D005910 112 associated lipids
Hypertension D006973 115 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Adenocarcinoma D000230 166 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
Fukunaga M et al. Mast cell death induced by 24(S),25-epoxycholesterol. 2010 Exp. Cell Res. pmid:20854813
Bouvier-Navé P et al. Involvement of the phospholipid sterol acyltransferase1 in plant sterol homeostasis and leaf senescence. 2010 Plant Physiol. pmid:19923239
Deichmann R et al. Coenzyme q10 and statin-induced mitochondrial dysfunction. 2010 Ochsner J pmid:21603349
Hamdy RC Zoledronic acid: clinical utility and patient considerations in osteoporosis and low bone mass. 2010 Drug Des Devel Ther pmid:21151620
Stapleton PA et al. Hypercholesterolemia and microvascular dysfunction: interventional strategies. 2010 J Inflamm (Lond) pmid:21087503
Martin DM et al. Functional annotation, genome organization and phylogeny of the grapevine (Vitis vinifera) terpene synthase gene family based on genome assembly, FLcDNA cloning, and enzyme assays. 2010 BMC Plant Biol. pmid:20964856
González-Candelas L et al. A transcriptomic approach highlights induction of secondary metabolism in citrus fruit in response to Penicillium digitatum infection. 2010 BMC Plant Biol. pmid:20807411
Jarrell KF et al. S-layer glycoproteins and flagellins: reporters of archaeal posttranslational modifications. 2010 Archaea pmid:20721273
Yang L et al. [Effects of clinically effective dose of lovastatin on prostate cancer PC3 cells]. 2010 Beijing Da Xue Xue Bao pmid:20721249
Guella G et al. Structures, biological activities and phylogenetic relationships of terpenoids from marine ciliates of the genus Euplotes. 2010 Mar Drugs pmid:20714425
Jana S and Shekhawat GS Anethum graveolens: An Indian traditional medicinal herb and spice. 2010 Pharmacogn Rev pmid:22228959
Zheng Z et al. Improvement of retinal vascular injury in diabetic rats by statins is associated with the inhibition of mitochondrial reactive oxygen species pathway mediated by peroxisome proliferator-activated receptor gamma coactivator 1alpha. 2010 Diabetes pmid:20566666
Klawitter J et al. Effects of lovastatin on breast cancer cells: a proteo-metabonomic study. 2010 Breast Cancer Res. pmid:20205716
Catros V et al. [Tgammadelta lymphocytes in oncology: unconventional killer lymphocytes]. 2010 Med Sci (Paris) pmid:20188051
Pontillo A et al. The inhibition of mevalonate pathway induces upregulation of NALP3 expression: new insight in the pathogenesis of mevalonate kinase deficiency. 2010 Eur. J. Hum. Genet. pmid:20179743
Yamauchi N The pathway of leucine to mevalonate in halophilic archaea: efficient incorporation of leucine into isoprenoidal lipid with the involvement of isovaleryl-CoA dehydrogenase in Halobacterium salinarum. 2010 Biosci. Biotechnol. Biochem. pmid:20139592
Olson AL et al. NMR dynamics investigation of ligand-induced changes of main and side-chain arginine N-H's in human phosphomevalonate kinase. 2010 J. Am. Chem. Soc. pmid:20112895
Kowluru A et al. Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells. 2010 Diabetes pmid:20071600
Kiran U et al. Structural and functional characterization of HMG-COA reductase from Artemisia annua. 2010 Bioinformation pmid:21364776
Domoki F et al. Rosuvastatin induces delayed preconditioning against L-glutamate excitotoxicity in cultured cortical neurons. 2010 Neurochem. Int. pmid:19931334
De Leo L et al. Targeting farnesyl-transferase as a novel therapeutic strategy for mevalonate kinase deficiency: in vitro and in vivo approaches. 2010 Pharmacol. Res. pmid:20206266
Massaro M et al. Statins inhibit cyclooxygenase-2 and matrix metalloproteinase-9 in human endothelial cells: anti-angiogenic actions possibly contributing to plaque stability. 2010 Cardiovasc. Res. pmid:19946014
Kojima Y et al. Pitavastatin decreases the expression of endothelial lipase both in vitro and in vivo. 2010 Cardiovasc. Res. pmid:20045866
Liu YJ et al. Simvastatin ameliorates rat cerebrovascular remodeling during hypertension via inhibition of volume-regulated chloride channel. 2010 Hypertension pmid:20644009
Rossi J et al. Laminar shear stress prevents simvastatin-induced adhesion molecule expression in cytokine activated endothelial cells. 2010 Eur. J. Pharmacol. pmid:20863785
Kaneda T et al. Statins inhibited erythropoietin-induced proliferation of rat vascular smooth muscle cells. 2010 Eur. J. Pharmacol. pmid:20851116
Singh RS et al. Expression of 3-hydroxy-3-methylglutaryl-CoA reductase, p-hydroxybenzoate-m-geranyltransferase and genes of phenylpropanoid pathway exhibits positive correlation with shikonins content in arnebia [Arnebia euchroma (Royle) Johnston]. 2010 BMC Mol. Biol. pmid:21092138
Chang TH et al. Structure of a heterotetrameric geranyl pyrophosphate synthase from mint (Mentha piperita) reveals intersubunit regulation. 2010 Plant Cell pmid:20139160
Kassan M et al. In vitro antioxidant activity of pravastatin provides vascular protection. 2010 Eur. J. Pharmacol. pmid:20044990
Kocsis GF et al. Expression of genes related to oxidative/nitrosative stress in mouse hearts: effect of preconditioning and cholesterol diet. 2010 Med. Sci. Monit. pmid:20037483
Clendening JW et al. Dysregulation of the mevalonate pathway promotes transformation. 2010 Proc. Natl. Acad. Sci. U.S.A. pmid:20696928
Kato S et al. Lipophilic but not hydrophilic statins selectively induce cell death in gynaecological cancers expressing high levels of HMGCoA reductase. 2010 J. Cell. Mol. Med. pmid:19432822
Hooff GP et al. Modulation of cholesterol, farnesylpyrophosphate, and geranylgeranylpyrophosphate in neuroblastoma SH-SY5Y-APP695 cells: impact on amyloid beta-protein production. 2010 Mol. Neurobiol. pmid:20405344
Woo IS et al. Farnesyl diphosphate synthase attenuates paclitaxel-induced apoptotic cell death in human glioblastoma U87MG cells. 2010 Neurosci. Lett. pmid:20298756
Asadollahi MA et al. Enhancement of farnesyl diphosphate pool as direct precursor of sesquiterpenes through metabolic engineering of the mevalonate pathway in Saccharomyces cerevisiae. 2010 Biotechnol. Bioeng. pmid:20091767
Lee SK et al. Stabilization and translocation of p53 to mitochondria is linked to Bax translocation to mitochondria in simvastatin-induced apoptosis. 2010 Biochem. Biophys. Res. Commun. pmid:20043868
Kudoh T et al. Mevalonate analogues as substrates of enzymes in the isoprenoid biosynthetic pathway of Streptococcus pneumoniae. 2010 Bioorg. Med. Chem. pmid:20056424
Boo KH et al. Distribution and biosynthesis of 20-hydroxyecdysone in plants of Achyranthes japonica Nakai. 2010 Biosci. Biotechnol. Biochem. pmid:21071854
Lorenzen W et al. Isoprenoids are essential for fruiting body formation in Myxococcus xanthus. 2009 J. Bacteriol. pmid:19617362
Zhao S et al. Synthesis and HMG-CoA reductase inhibition of 2-cyclopropyl-4-thiophenyl-quinoline mevalonolactones. 2009 Bioorg. Med. Chem. pmid:19879766
Eldor R and Raz I American Diabetes Association indications for statins in diabetes: is there evidence? 2009 Diabetes Care pmid:19875586
Massonnet B et al. Pharmacological inhibitors of the mevalonate pathway activate pro-IL-1 processing and IL-1 release by human monocytes. 2009 Eur. Cytokine Netw. pmid:19825520
Wang W et al. Global characterization of Artemisia annua glandular trichome transcriptome using 454 pyrosequencing. 2009 BMC Genomics pmid:19818120
Brahmachari S et al. Sodium benzoate, a metabolite of cinnamon and a food additive, reduces microglial and astroglial inflammatory responses. 2009 J. Immunol. pmid:19812204
Balibar CJ et al. The mevalonate pathway of Staphylococcus aureus. 2009 J. Bacteriol. pmid:19028897
Olson AL et al. Substrate induced structural and dynamics changes in human phosphomevalonate kinase and implications for mechanism. 2009 Proteins pmid:18798562
Fujimoto M et al. Fluvastatin inhibits mast cell degranulation without changing the cytoplasmic Ca2+ level. 2009 Eur. J. Pharmacol. pmid:19059394
García I et al. QSAR and complex network study of the chiral HMGR inhibitor structural diversity. 2009 Bioorg. Med. Chem. pmid:19026553
Ohyama K et al. Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis. 2009 Proc. Natl. Acad. Sci. U.S.A. pmid:19139393
Wali VB et al. Suppression in mevalonate synthesis mediates antitumor effects of combined statin and gamma-tocotrienol treatment. 2009 Lipids pmid:19777282