Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypertension D006973 115 associated lipids
Glioma D005910 112 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Leukemia D007938 74 associated lipids
Thrombosis D013927 49 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Hypothyroidism D007037 32 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Glioblastoma D005909 27 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Refsum Disease D012035 19 associated lipids
Xanthomatosis D014973 17 associated lipids
Celiac Disease D002446 16 associated lipids
Biliary Fistula D001658 13 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Peutz-Jeghers Syndrome D010580 2 associated lipids
Per page 10 20 50 | Total 25

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All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
Bell FP Biosynthesis of various sterols, sterol esters, and squalene from [14C]mevalonate by normal swine intima and media in vitro: a comparative study. 1976 Exp. Mol. Pathol. pmid:1001402
Takeuchi N et al. Feed-back control of cholesterol synthesis in partially hepatectomized rats. 1976 Biochim. Biophys. Acta pmid:974156
Phillips GT and Clifford KH Stereochemistry of a methyl-group rearrangement during the biosynthesis of lanosterol. 1976 Eur. J. Biochem. pmid:1245185
Endo A et al. Inhibition of cholesterol synthesis in vitro and in vivo by ML-236A and ML-236B, competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. 1977 Eur. J. Biochem. pmid:908337
Bernstein BA et al. Inhibition of cholesterol biosynthesis and acetyl-coenzyme A synthetase by bovine milk and orotic acid. 1977 J. Dairy Sci. pmid:23394
Saito Y et al. Animal cell mutants defective in sterol metabolism: a specific selection procedure and partial characterization of defects. 1977 Proc. Natl. Acad. Sci. U.S.A. pmid:269426
Faas FH et al. Unsaturated fatty acyl-CoA inhibition of cholesterol synthesis in vitro. 1977 Biochim. Biophys. Acta pmid:861236
Kandutsch AA and Chen HW Consequences of blocked sterol synthesis in cultured cells. DNA synthesis and membrane composition. 1977 J. Biol. Chem. pmid:833134
Wiley MH et al. The quantitative role of the kidneys in the in vivo metabolism of mevalonate. 1977 J. Biol. Chem. pmid:833143
Langdon R et al. Induction of HMG CoA reductase by the administration of 20,25-diazacholesterol. 1977 J. Lipid Res. pmid:833506
Kekki M et al. Measurement of cholesterol synthesis in kinetically defined pools using fecal steroid analysis and double labeling technique in man. 1977 J. Lipid Res. pmid:833511
Sinensky M Isolation of a mammalian cell mutant resistant to 25-hydroxy cholesterol. 1977 Biochem. Biophys. Res. Commun. pmid:911332
Ramsey RB and Fredericks M Effect of hypocholesterolemic agents on central nervous system cholesterol biosynthesis. II. AY-9944 and AY-9944 plus zuclomiphene. 1977 Biochem. Pharmacol. pmid:70208
Fogelman AM et al. Cholesterol biosynthesis in human lymphocytes, monocytes, and granulocytes. 1977 Biochem. Biophys. Res. Commun. pmid:869944
Lakshmanan MR and Veech RL Measurement of rate of rat liver sterol synthesis in vivo using tritiated water. 1977 J. Biol. Chem. pmid:873910
Sliwowski JK et al. The in vivo biosynthesis of cholesterol from (3RS,2R) [2-14C,2-3H]mevalonic acid in the brains of rats on normal and protein deficient diets. The stereochemistry of tritium atoms at C-7 and C-15. 1977 J. Neurochem. pmid:874493
Cornforth J Symmetry of squalene epoxidation in vivo. 1977 Proc. R. Soc. Lond., B, Biol. Sci. pmid:22855
Bhat CS and Ramasarma T Rhythmic activity of utilization of mevalonate for biogenesis of cholesterol. 1977 Biochem. Biophys. Res. Commun. pmid:836326
Burt VT et al. The formation of menaquinone-4 (vitamin K) and its oxide in some marine invertebrates. 1977 Biochem. J. pmid:849285
Ramsey RB and Fredericks M Effect of hypocholesterolemic agents on central nervous system cholesterol biosynthesis. I. Zuclomiphene. 1977 Biochem. Pharmacol. pmid:889582
Edwards PA et al. Preferential uptake and utilization of mevalonolactone over mevalonate for sterol biosynthesis in isolated rat hepatocytes. 1977 Biochim. Biophys. Acta pmid:901801
Edwards PA et al. Control of 3-hydroxy-3-methylglutaryl coenzyme A reductase by endogenously synthesized sterols in vitro and in vivo. 1977 J. Biol. Chem. pmid:14128
Stout RW The effect of insulin and glucose on sterol synthesis in cultured rat arterial smooth muscle cells. 1977 Atherosclerosis pmid:901624
Chang TY et al. Isolation and partial characterization of a cholesterol-requiring mutant of Chinese hamster ovary cells. 1977 Proc. Natl. Acad. Sci. U.S.A. pmid:265577
McNamara DJ et al. Measurement of daily cholesterol synthesis rates in man by assay of the fractional conversion of mevalonic acid to cholesterol. 1977 Proc. Natl. Acad. Sci. U.S.A. pmid:268653
Gibbons GF Existence of metabolic reservoirs in the later stages of the cholesterol biosynthetic pathway. 1977 Biochem. Biophys. Res. Commun. pmid:861038
Jakoi L and Quarfordt SH Alterations of rat hepatic cholesterogenesis by heterologous lipoproteins. 1977 J. Biol. Chem. pmid:197106
Balasubramaniam S et al. Regulation of cholesterol synthesis in rat adrenal gland through coordinate control of 3-hydroxy-3-methylglutaryl coenzyme A synthase and reductase activities. 1977 Proc. Natl. Acad. Sci. U.S.A. pmid:16260
Wood SG and Gottlieb D Evidence from mycelial studies for differences in the sterol biosynthetic pathway of Rhizoctonia solani and Phytophthora cinnamomi. 1978 Biochem. J. pmid:637849
Wood SG and Gottlieb D Evidence from cell-free systems for differences in the sterol biosynthetic pathway of Rhizoctonia solani and Phytophthora cinnamomi. 1978 Biochem. J. pmid:637850
Takeuchi N et al. Impairment of hepatic cholesterol synthesis from squalene and the function of hepatic sterol carrier protein system by ageing. 1978 Exp. Gerontol. pmid:639893
Amdur BH et al. Presence of squalene in gram-positive bacteria. 1978 J. Bacteriol. pmid:670148
Parker TS et al. Inhibition of liver prenyltransferase by alkyl phosphonates and phosphonophosphates. 1978 Biochim. Biophys. Acta pmid:687653
Keyhani J and Keyhani E Mevalonic acid as a precursor of the alkyl sidechain of heme a of cytochrome c oxidase in yeast Saccharomyces cerevisiae. 1978 FEBS Lett. pmid:213310
Linder JR and Beitz DC Sterol synthesis and CO2 production from mevalonate in calves. 1978 J. Lipid Res. pmid:712243
Bhavnani BR and Woolever CA Formation of steroids by the pregnant mare. VI. Metabolism of [14C]farnesyl pyrophosphate and [3H]dehydroepiandrosterone injected into the fetus. 1978 Endocrinology pmid:155006
Nestel PJ et al. The effect of dietary fat supplements on cholesterol metabolism in ruminants. 1978 J. Lipid Res. pmid:712248
Allen KG and Klevay LM Copper deficiency and cholesterol metabolism in the rat. 1978 Atherosclerosis pmid:718736
Gustafsson J and Sjöstedt S On the stereospecificity of microsomal "26"-hydroxylation in bile acid biosynthesis. 1978 J. Biol. Chem. pmid:618857
Sable-Amplis R et al. Abnormal liver cholesteryl ester storage in a strain of golden hamsters. Possible model for studies on cholesterol metabolism. 1978 Biochim. Biophys. Acta pmid:718971
Bochenek W and Rodgers JB Effects of saturated and unsaturated fats given with and without dietary cholesterol on hepatic cholesterol synthesis and hepatic lipid metabolism. 1978 Biochim. Biophys. Acta pmid:620042
Mills JT and Adamany AM Impairment of dolichyl saccharide synthesis and dolichol-mediated glycoprotein assembly in the aortic smooth muscle cell in culture by inhibitors of cholesterol biosynthesis. 1978 J. Biol. Chem. pmid:670194
Mitropoulos KA et al. On the mechanism for the regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, of cholesterol 7alpha-hydroxylase and of acyl-coenzyme A:cholesterol acyltransferase by free cholesterol. 1978 Biochim. Biophys. Acta pmid:687657
Betteridge DJ et al. Compactin inhibits cholesterol synthesis in lymphocytes and intestinal mucosa from patients with familial hypercholesterolaemia. 1978 Dec 23-30 Lancet pmid:82843
Marshall JD and Heiniger HJ High affinity Concanavalin A binding to sterol-depleted L cells. 1979 J. Cell. Physiol. pmid:489673
Löffler M and Schneider F Unexpectedly low incorporation of isotopic acetate into lipids of Ehrlich ascites tumor cells cultured in lipid-poor medium. 1979 Oncology pmid:37470
Cayen MN and Dvornik D Effect of diosgenin on lipid metabolism in rats. 1979 J. Lipid Res. pmid:438658
Faust JR et al. Synthesis of ubiquinone and cholesterol in human fibroblasts: regulation of a branched pathway. 1979 Arch. Biochem. Biophys. pmid:219777
Barter PJ and Lally JI The metabolism of esterified cholesterol in rabbit plasma low density lipoproteins. 1979 Biochim. Biophys. Acta pmid:219897
Rostas JA et al. Selective labelling of two phases of axonal transport of cholesterol in the chick optic system. 1979 J. Neurochem. pmid:86598
Calandra S et al. Cholesterol synthesis in isolated rat hepatocytes. In vitro effect os sterols and bile acids. 1979 Exp. Mol. Pathol. pmid:446695
Gonzalez R et al. Two major regulatory steps in cholesterol synthesis by human renal cancer cells. 1979 Arch. Biochem. Biophys. pmid:485166
Wiley MH et al. Sex differences in the sterol and nonsterol metabolism of mevalonate. 1979 J. Biol. Chem. pmid:762097
Quesney-Huneeus V et al. Essential role for mevalonate synthesis in DNA replication. 1979 Proc. Natl. Acad. Sci. U.S.A. pmid:291922
Ahmed AA et al. Effect of milk constituents on hepatic cholesterol-genesis. 1979 Atherosclerosis pmid:465119
Tabacik C et al. Cholesterogenesis induction in human lymphocytes by sterols efflux or phytohemagglutinin stimulation : cellular division as the requirement for efficient cholesterol biosynthesis in lymphocytes. 1979 Biochem. Biophys. Res. Commun. pmid:465064
Wiley MH et al. Conversion of mevalonolactone to its open-chain salt by a serum enzyme. 1979 Biochem. Biophys. Res. Commun. pmid:465057
Ortiz de Montellano PR et al. Regulation of sterol biosynthesis and lysis of cultured hepatoma cells: inhibition of lanosterol demethylation by hydroxysterols. 1979 Biochem. Biophys. Res. Commun. pmid:508352
Shama Bhat C and Ramasarma T Inhibition of rat liver mevalonate pyrophosphate decarboxylase and mevalonate phosphate kinase by phenyl and phenolic compounds. 1979 Biochem. J. pmid:226078
Popják G et al. Determination of mevalonate in blood plasma in man and rat. Mevalonate "tolerance" tests in man. 1979 J. Lipid Res. pmid:226640
Humphries GM and McConnell HM Potent immunosuppression by oxidized cholesterol. 1979 J. Immunol. pmid:368234
Barter PJ and Lally JI In vitro exchanges of esterified cholesterol between serum lipoprotein fractions: studies of humans and rabbits. 1979 Metab. Clin. Exp. pmid:216885
Subden RE and Renaud RL Isolation of 4 alpha-methyl-5 alpha-ergosta-8,24(28)-dien-3 beta-ol from ester fractions of nutritionally deprived Neurospora crassa. 1979 Steroids pmid:161433
Streuli RA et al. Inhibition of human lymphocyte E-rosette formation by oxygenated sterols. 1979 J. Immunol. pmid:501096
Ranganathan S et al. The biosynthesis of ubiquinone in isolated rat heart cells. 1979 Arch. Biochem. Biophys. pmid:518096
Frier BM and Saudek CD Cholesterol metabolism in diabetes: the effect of insulin on the kinetics of plasma squalene. 1979 J. Clin. Endocrinol. Metab. pmid:511973
Hughes PE and Tove SB Synthesis of alpha-tocopherolquinone by the rat and its reduction by mitochondria. 1980 J. Biol. Chem. pmid:7391070
Elliott JG and Lachance PA Effects of vitamin A and ascorbic acid on in vitro cholesterol biosynthesis in the rat. 1980 J. Nutr. pmid:7381607
Kita T et al. Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase. 1980 J. Clin. Invest. pmid:6903572
Brown MS and Goldstein JL Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth. 1980 J. Lipid Res. pmid:6995544
Lehoux JG and Preiss B Regulation of hamster adrenal 3-hydroxy-3-methylglutaryl coenzyme A reductase activity. 1980 Endocrinology pmid:6247136
Kritchevsky D et al. Cholesterol synthesis in tissues of young and old Fisher 344 and Sprague-Dawley rats. 1980 Exp. Gerontol. pmid:7428858
Yachnin S and Hsu R Inhibition of human lymphocyte transformation by oxygenated sterol compounds. 1980 Cell. Immunol. pmid:7363333
Chang TY and Limanek JS Regulation of cytosolic acetoacetyl coenzyme A thiolase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and mevalonate kinase by low density lipoprotein and by 25-hydroxycholesterol in Chinese hamster ovary cells. 1980 J. Biol. Chem. pmid:6105157
Curtiss LK and Edgington TS Differences in the characteristics of inhibition of lymphocyte stimulation by 25-hydroxycholesterol and by the immunoregulatory serum lipoprotein LDL-In. 1980 J. Immunol. pmid:7410845
George R and Goldfarb S Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in Morris hepatoma 7800 after intravenous injection of mevalonic acid. 1980 Cancer Res. pmid:7438103
Kopito RR and Brunengraber H (R)-mevalonate excretion in human and rat urines. 1980 Proc. Natl. Acad. Sci. U.S.A. pmid:6255462
Turner JA and Prebble JN Protection of cell viability and respiratory quinone levels by carotenoid in Micrococcus lysodeikticus (M. luteus). 1980 J. Gen. Microbiol. pmid:7411117
Raulston DL et al. Cycloheximide inhibits sterol biosynthesis in cell-free preparations of rat liver. 1980 J. Biol. Chem. pmid:7372603
Menon AS et al. Vanadate inhibits mevalonate synthesis and activates NADH oxidation in microsomes. 1980 FEBS Lett. pmid:6900565
Swift IE and Milborrow BV Retention of the 4-pro-R hydrogen atom of mevalonate at C-2,2' of bacterioruberin in Halobacterium halobium. 1980 Biochem. J. pmid:7406867
Cuthbert JA and Lipsky PE Sterol metabolism and lymphocyte function: inhibition of endogenous sterol biosynthesis does not prevent mitogen-induced human T lymphocyte activation. 1980 J. Immunol. pmid:6965969
Feingold KR et al. Sex difference in human mevalonate metabolism. 1980 J. Clin. Invest. pmid:7400320
Sinensky M et al. Somatic cell genetic analysis of regulation of expression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. 1980 Proc. Natl. Acad. Sci. U.S.A. pmid:6935672
Feingold KR et al. Mevalonate metabolism in pregnant rats. 1980 Metab. Clin. Exp. pmid:6774201
Duncan JL and Buckingham L Resistance to streptolysin O in mammalian cells treated with oxygenated derivatives of cholesterol. Cholesterol content of resistant cells and recovery of streptolysin O sensitivity. 1980 Biochim. Biophys. Acta pmid:7459354
Habenicht AJ et al. Relation of cholesterol and mevalonic acid to the cell cycle in smooth muscle and swiss 3T3 cells stimulated to divide by platelet-derived growth factor. 1980 J. Biol. Chem. pmid:6768732
James MJ and Kandutsch AA Elevated dolichol synthesis in mouse testes during spermatogenesis. 1980 J. Biol. Chem. pmid:7350150
Hidaka K et al. Growth of amphotericin B-resistant hamster cell line requires exogenous cholesterol. 1980 Exp. Cell Res. pmid:7408982
Arebalo RE et al. In vivo regulation of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A reductase: enzyme phosphorylation as an early regulatory response after intragastric administration of mevalonolactone. 1980 Proc. Natl. Acad. Sci. U.S.A. pmid:6256737
Hanson RF et al. Stereochemistry of the side chain oxidation of 5 beta-cholestane-3 alpha,7 alpha,12 alpha-triol in man. 1980 J. Biol. Chem. pmid:7354041
Erickson SK et al. Studies on the mechanisms of the rapid modulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in intact liver by mevalonolactone and 25-hydroxycholesterol. 1980 Biochim. Biophys. Acta pmid:7417482
Drevon CA et al. Regulation of cholesterol esterification and biosynthesis in monolayer cultures of normal adult rat hepatocytes. 1980 J. Biol. Chem. pmid:7410416
Shao MJ and Lei KY Conversion of [2-14C] mevalonate into cholesterol, lanosterol and squalene in copper-deficient rats. 1980 J. Nutr. pmid:7373433
Nambudiri AM et al. The role of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in the regulation of ubiquinone synthesis in human fibroblasts. 1980 J. Biol. Chem. pmid:7380842
Shechter I et al. A deficiency of mixed function oxidase activities in the cholesterol biosynthetic pathway of human granulocytes. 1980 J. Lipid Res. pmid:7381322
Erickson SK et al. Rat liver acyl-coenzyme A:cholesterol acyltransferase: its regulation in vivo and some of its properties in vitro. 1980 J. Lipid Res. pmid:7441061
Drevon CA et al. Secretion of very low density lipoproteins enriched in cholesteryl esters by cultured rat hepatocytes during simulation of intracellular cholesterol esterification. 1980 J. Lipid Res. pmid:7462802
Faust JR et al. Synthesis of delta 2-isopentenyl tRNA from mevalonate in cultured human fibroblasts. 1980 J. Biol. Chem. pmid:7391033
Subbiah MT Incorporation of 14C-mevalonate into biliary cholesterol and bile acids by perfused rat liver: effect of plasma and individual lipoproteins. 1980 Steroids pmid:7444999