Mevalonic acid is a lipid of Fatty Acyls (FA) class.
We collected disease MeSH terms mapped to the references associated with Mevalonic acid
Authors | Title | Published | Journal | PubMed Link |
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Capra V and Rovati GE | Rosuvastatin inhibits human airway smooth muscle cells mitogenic response to eicosanoid contractile agents. | 2014 | Pulm Pharmacol Ther | pmid:23806820 |
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Yang J and Guo L | Biosynthesis of β-carotene in engineered E. coli using the MEP and MVA pathways. | 2014 | Microb. Cell Fact. | pmid:25403509 |
Sapir A et al. | Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25187565 |
Rodriguez SB and Leyh TS | An enzymatic platform for the synthesis of isoprenoid precursors. | 2014 | PLoS ONE | pmid:25153179 |
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Sivanandhan G et al. | Enhanced biosynthesis of withanolides by elicitation and precursor feeding in cell suspension culture of Withania somnifera (L.) Dunal in shake-flask culture and bioreactor. | 2014 | PLoS ONE | pmid:25089711 |
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Vinokur JM et al. | Evidence of a novel mevalonate pathway in archaea. | 2014 | Biochemistry | pmid:24914732 |
Wang Y et al. | 24S,25-Epoxycholesterol in mouse and rat brain. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24832732 |
Xiong M et al. | Scalable production of mechanically tunable block polymers from sugar. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24912182 |
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Song AA et al. | Engineering the lactococcal mevalonate pathway for increased sesquiterpene production. | 2014 | FEMS Microbiol. Lett. | pmid:24828482 |
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Zheng X et al. | Triterpenoid saponin biosynthetic pathway profiling and candidate gene mining of the Ilex asprella root using RNA-Seq. | 2014 | Int J Mol Sci | pmid:24722569 |
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Piłsyk S et al. | Overexpression of erg20 gene encoding farnesyl pyrophosphate synthase has contrasting effects on activity of enzymes of the dolichyl and sterol branches of mevalonate pathway in Trichoderma reesei. | 2014 | Gene | pmid:24793581 |
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Korman TP et al. | A synthetic biochemistry system for the in vitro production of isoprene from glycolysis intermediates. | 2014 | Protein Sci. | pmid:24623472 |
Yeganeh B et al. | Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease. | 2014 | Pharmacol. Ther. | pmid:24582968 |
Rojo-Arreola L et al. | Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis. | 2014 | PLoS ONE | pmid:24489942 |
Li J et al. | De novo synthesis of steroids and oxysterols in adipocytes. | 2014 | J. Biol. Chem. | pmid:24280213 |
Sánchez-Solana B et al. | Cytosolic functions of MORC2 in lipogenesis and adipogenesis. | 2014 | Biochim. Biophys. Acta | pmid:24286864 |
González-Caballero N et al. | Expression of the mevalonate pathway enzymes in the Lutzomyia longipalpis (Diptera: Psychodidae) sex pheromone gland demonstrated by an integrated proteomic approach. | 2014 | J Proteomics | pmid:24185139 |
Pampalakis G et al. | The KLK5 protease suppresses breast cancer by repressing the mevalonate pathway. | 2014 | Oncotarget | pmid:24158494 |
Bentley FK et al. | Heterologous expression of the mevalonic acid pathway in cyanobacteria enhances endogenous carbon partitioning to isoprene. | 2014 | Mol Plant | pmid:24157609 |
Fu Z et al. | Exometabolome analysis reveals hypoxia at the up-scaling of a Saccharomyces cerevisiae high-cell density fed-batch biopharmaceutical process. | 2014 | Microb. Cell Fact. | pmid:24593159 |
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Rachner TD et al. | Dickkopf-1 is regulated by the mevalonate pathway in breast cancer. | 2014 | Breast Cancer Res. | pmid:24528599 |
Alonso-Gutierrez J et al. | Metabolic engineering of Escherichia coli for limonene and perillyl alcohol production. | 2013 | Metab. Eng. | pmid:23727191 |
Theesfeld CL and Hampton RY | Insulin-induced gene protein (INSIG)-dependent sterol regulation of Hmg2 endoplasmic reticulum-associated degradation (ERAD) in yeast. | 2013 | J. Biol. Chem. | pmid:23306196 |
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Hosaka A et al. | Statins reduce amyloid β-peptide production by modulating amyloid precursor protein maturation and phosphorylation through a cholesterol-independent mechanism in cultured neurons. | 2013 | Neurochem. Res. | pmid:23269484 |
Qi XF et al. | HMG-CoA reductase inhibitors induce apoptosis of lymphoma cells by promoting ROS generation and regulating Akt, Erk and p38 signals via suppression of mevalonate pathway. | 2013 | Cell Death Dis | pmid:23449454 |
Tricarico PM et al. | Temperature and drug treatments in mevalonate kinase deficiency: an ex vivo study. | 2013 | Biomed Res Int | pmid:24073415 |
Tyurin M | Gene replacement and elimination using λRed- and FLP-based tool to re-direct carbon flux in acetogen biocatalyst during continuous CO₂/H₂ blend fermentation. | 2013 | J. Ind. Microbiol. Biotechnol. | pmid:23649912 |
MartÃn-Navarro CM et al. | Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and application of statins as a novel effective therapeutic approach against Acanthamoeba infections. | 2013 | Antimicrob. Agents Chemother. | pmid:23114753 |
Zhang J et al. | Statins directly suppress cytokine production in murine intraepithelial lymphocytes. | 2013 | Cytokine | pmid:23290865 |
Rauthan M et al. | The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23530189 |
Citron CA and Dickschat JS | The stereochemical course of tricho-acorenol biosynthesis. | 2013 | Org. Biomol. Chem. | pmid:24084795 |
Blanc M et al. | The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response. | 2013 | Immunity | pmid:23273843 |
Wang C et al. | Engineered heterologous FPP synthases-mediated Z,E-FPP synthesis in E. coli. | 2013 | Metab. Eng. | pmid:23608473 |
Yu W et al. | The mevalonate auxotrophic mutant of Staphylococcus aureus can adapt to mevalonate depletion. | 2013 | Antimicrob. Agents Chemother. | pmid:23959312 |
Szűcs G et al. | Cardioprotection by farnesol: role of the mevalonate pathway. | 2013 | Cardiovasc Drugs Ther | pmid:23673412 |
Ramak P et al. | Inhibition of the mevalonate pathway enhances carvacrol biosynthesis and DXR gene expression in shoot cultures of Satureja khuzistanica Jamzad. | 2013 | J. Plant Physiol. | pmid:23611428 |
Chen X et al. | Statistical experimental design guided optimization of a one-pot biphasic multienzyme total synthesis of amorpha-4,11-diene. | 2013 | PLoS ONE | pmid:24278153 |
Chang WC et al. | Current development in isoprenoid precursor biosynthesis and regulation. | 2013 | Curr Opin Chem Biol | pmid:23891475 |
Tuerdi G et al. | Synergistic effect of combined treatment with gamma-tocotrienol and statin on human malignant mesothelioma cells. | 2013 | Cancer Lett. | pmid:23879968 |
Gopalan A et al. | Simvastatin inhibition of mevalonate pathway induces apoptosis in human breast cancer cells via activation of JNK/CHOP/DR5 signaling pathway. | 2013 | Cancer Lett. | pmid:22960596 |
Onono F et al. | Efficient use of exogenous isoprenols for protein isoprenylation by MDA-MB-231 cells is regulated independently of the mevalonate pathway. | 2013 | J. Biol. Chem. | pmid:23908355 |
Gopalan A et al. | Eliminating drug resistant breast cancer stem-like cells with combination of simvastatin and gamma-tocotrienol. | 2013 | Cancer Lett. | pmid:23063651 |
Liu J et al. | Overproduction of geraniol by enhanced precursor supply in Saccharomyces cerevisiae. | 2013 | J. Biotechnol. | pmid:24161921 |
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Valente AJ et al. | Interleukin-18 enhances IL-18R/Nox1 binding, and mediates TRAF3IP2-dependent smooth muscle cell migration. Inhibition by simvastatin. | 2013 | Cell. Signal. | pmid:23541442 |
Xiao H et al. | Inhibition of Rho and Rac geranylgeranylation by atorvastatin is critical for preservation of endothelial junction integrity. | 2013 | PLoS ONE | pmid:23555637 |
Villanueva JA et al. | Resveratrol potentiates effect of simvastatin on inhibition of mevalonate pathway in human endometrial stromal cells. | 2013 | J. Clin. Endocrinol. Metab. | pmid:23386644 |
May B et al. | Biosynthesis of sesquiterpenes in grape berry exocarp of Vitis vinifera L.: evidence for a transport of farnesyl diphosphate precursors from plastids to the cytosol. | 2013 | Phytochemistry | pmid:23954075 |
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Chen B et al. | Alteration of mevalonate pathway related enzyme expressions in pressure overload-induced cardiac hypertrophy and associated heart failure with preserved ejection fraction. | 2013 | Cell. Physiol. Biochem. | pmid:24356578 |
Dellas N et al. | Discovery of a metabolic alternative to the classical mevalonate pathway. | 2013 | Elife | pmid:24327557 |
Bruzzese F et al. | Panobinostat synergizes with zoledronic acid in prostate cancer and multiple myeloma models by increasing ROS and modulating mevalonate and p38-MAPK pathways. | 2013 | Cell Death Dis | pmid:24157872 |
Dick M et al. | Statin therapy influences endothelial cell morphology and F-actin cytoskeleton structure when exposed to static and laminar shear stress conditions. | 2013 | Life Sci. | pmid:23517776 |
Fang SY et al. | Pleiotropic vascular protective effects of statins in perioperative medicine. | 2013 | Acta Anaesthesiol Taiwan | pmid:24148741 |
Maciejak A et al. | The effects of statins on the mevalonic acid pathway in recombinant yeast strains expressing human HMG-CoA reductase. | 2013 | BMC Biotechnol. | pmid:24128347 |
Polidoro S et al. | Effects of bisphosphonate treatment on DNA methylation in osteonecrosis of the jaw. | 2013 | Mutat. Res. | pmid:23892139 |
Santolaria T et al. | Repeated systemic administrations of both aminobisphosphonates and human Vγ9Vδ2 T cells efficiently control tumor development in vivo. | 2013 | J. Immunol. | pmid:23836057 |
Poggi A et al. | Selective role of mevalonate pathway in regulating perforin but not FasL and TNFalpha release in human Natural Killer cells. | 2013 | PLoS ONE | pmid:23667543 |
Ohukainen P | If the wheel ain't broke, don't reinvent it. | 2013 | Lipids Health Dis | pmid:23577775 |
Werner M et al. | Simvastatin-induced compartmentalisation of doxorubicin sharpens up nuclear topoisomerase II inhibition in human rhabdomyosarcoma cells. | 2013 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:23564041 |
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Doblas VG et al. | The SUD1 gene encodes a putative E3 ubiquitin ligase and is a positive regulator of 3-hydroxy-3-methylglutaryl coenzyme a reductase activity in Arabidopsis. | 2013 | Plant Cell | pmid:23404890 |
Riganti C et al. | Zoledronic acid restores doxorubicin chemosensitivity and immunogenic cell death in multidrug-resistant human cancer cells. | 2013 | PLoS ONE | pmid:23593363 |
Lazzerini PE et al. | Rosuvastatin inhibits spontaneous and IL-1β-induced interleukin-6 production from human cultured osteoblastic cells. | 2013 | Joint Bone Spine | pmid:22999910 |
Mazein A et al. | A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway. | 2013 | Biochem. Pharmacol. | pmid:23583456 |
Freed-Pastor WA et al. | Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. | 2012 | Cell | pmid:22265415 |
Angaman DM et al. | Precursor uptake assays and metabolic analyses in isolated tomato fruit chromoplasts. | 2012 | Plant Methods | pmid:22243738 |
Yasmin S et al. | Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22106303 |
Garcia-Ruiz C et al. | Statins and protein prenylation in cancer cell biology and therapy. | 2012 | Anticancer Agents Med Chem | pmid:22413970 |
Hu W et al. | Statins synergize dexamethasone-induced adipocyte fatty acid binding protein expression in macrophages. | 2012 | Atherosclerosis | pmid:22503826 |
Khasnavis S and Pahan K | Sodium benzoate, a metabolite of cinnamon and a food additive, upregulates neuroprotective Parkinson disease protein DJ-1 in astrocytes and neurons. | 2012 | J Neuroimmune Pharmacol | pmid:21701815 |
Conrado RJ et al. | DNA-guided assembly of biosynthetic pathways promotes improved catalytic efficiency. | 2012 | Nucleic Acids Res. | pmid:22021385 |