Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Hypertension D006973 115 associated lipids
Glioma D005910 112 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Leukemia D007938 74 associated lipids
Thrombosis D013927 49 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Hypothyroidism D007037 32 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Glioblastoma D005909 27 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Refsum Disease D012035 19 associated lipids
Xanthomatosis D014973 17 associated lipids
Celiac Disease D002446 16 associated lipids
Biliary Fistula D001658 13 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Peutz-Jeghers Syndrome D010580 2 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

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Per page 10 20 50 100 | Total 2899
Authors Title Published Journal PubMed Link
Bergès T et al. The Saccharomyces cerevisiae mevalonate diphosphate decarboxylase is essential for viability, and a single Leu-to-Pro mutation in a conserved sequence leads to thermosensitivity. 1997 J. Bacteriol. pmid:9244250
Risé P et al. Effects of simvastatin on the metabolism of polyunsaturated fatty acids and on glycerolipid, cholesterol, and de novo lipid synthesis in THP-1 cells. 1997 J. Lipid Res. pmid:9254057
Naoumova RP et al. Prolonged inhibition of cholesterol synthesis explains the efficacy of atorvastatin. 1997 J. Lipid Res. pmid:9254075
Sakai M et al. HMG-CoA reductase inhibitors suppress macrophage growth induced by oxidized low density lipoprotein. 1997 Atherosclerosis pmid:9258407
Cuthbert JA and Lipsky PE Regulation of proliferation and Ras localization in transformed cells by products of mevalonate metabolism. 1997 Cancer Res. pmid:9270019
Meigs TE and Simoni RD Farnesol as a regulator of HMG-CoA reductase degradation: characterization and role of farnesyl pyrophosphatase. 1997 Arch. Biochem. Biophys. pmid:9281305
El-Sohemy A and Archer MC Regulation of mevalonate synthesis in rat mammary glands by dietary n-3 and n-6 polyunsaturated fatty acids. 1997 Cancer Res. pmid:9288773
Knöss W et al. Biosynthesis of the labdane diterpene marrubiin in Marrubium vulgare via a non-mevalonate pathway. 1997 Biochem. J. pmid:9291117
Ren Z et al. Inhibition of type I and type II geranylgeranyl-protein transferases by the monoterpene perillyl alcohol in NIH3T3 cells. 1997 Biochem. Pharmacol. pmid:9296357
Schwender J et al. Incorporation of 1-deoxy-D-xylulose into isoprene and phytol by higher plants and algae. 1997 FEBS Lett. pmid:9305746
Parmryd I et al. Chloroplastic prenylated proteins. 1997 FEBS Lett. pmid:9323028
Potter D and Miziorko HM Identification of catalytic residues in human mevalonate kinase. 1997 J. Biol. Chem. pmid:9325256
Andres DA et al. Expression cloning of a novel farnesylated protein, RDJ2, encoding a DnaJ protein homologue. 1997 Arch. Biochem. Biophys. pmid:9328291
Hinson DD et al. Identification of an active site alanine in mevalonate kinase through characterization of a novel mutation in mevalonate kinase deficiency. 1997 J. Biol. Chem. pmid:9334262
pmid:9344354
Cornforth JW Asymmetry and enzyme action. 1976 Science pmid:935862
Edmond J et al. Mevalonate metabolism: role of kidneys. 1976 Science pmid:935865
Feillet C et al. Cholesterol biosynthesis in normocholesterolemic patients after cholesterol removal by plasmapheresis. 1997 J Clin Apher pmid:9365862
Hampton RY and Bhakta H Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl-CoA reductase. 1997 Proc. Natl. Acad. Sci. U.S.A. pmid:9371780
Hjertman M et al. Evidence for protein dolichylation. 1997 FEBS Lett. pmid:9373159
Marais AD et al. Decreased production of low density lipoprotein by atorvastatin after apheresis in homozygous familial hypercholesterolemia. 1997 J. Lipid Res. pmid:9374129
Forman BM et al. The orphan nuclear receptor LXRalpha is positively and negatively regulated by distinct products of mevalonate metabolism. 1997 Proc. Natl. Acad. Sci. U.S.A. pmid:9380679
de Chaves EI et al. Role of lipoproteins in the delivery of lipids to axons during axonal regeneration. 1997 J. Biol. Chem. pmid:9388216
pmid:9389491
Pahan K et al. Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages. 1997 J. Clin. Invest. pmid:9389730
Hinson DD et al. Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways. 1997 J. Lipid Res. pmid:9392419
Riches FM et al. Direct association between the hepatic secretion of very-low-density lipoprotein apolipoprotein B-100 and plasma mevalonic acid and lathosterol concentrations in man. 1997 Atherosclerosis pmid:9395276
Ukai M et al. Cholesterol synthesis in germfree and conventional rats. 1976 J. Nutr. pmid:939998
Dunzendorfer S et al. Mevalonate-dependent inhibition of transendothelial migration and chemotaxis of human peripheral blood neutrophils by pravastatin. 1997 Circ. Res. pmid:9400376
Gadbut AP et al. Induction of the cholesterol metabolic pathway regulates the farnesylation of RAS in embryonic chick heart cells: a new role for ras in regulating the expression of muscarinic receptors and G proteins. 1997 EMBO J. pmid:9405354
Goto D et al. Upregulation of low density lipoprotein receptor by gemfibrozil, a hypolipidemic agent, in human hepatoma cells through stabilization of mRNA transcripts. 1997 Arterioscler. Thromb. Vasc. Biol. pmid:9409246
pmid:942445
Tatsuno I et al. Geranylgeranylpyrophosphate, a metabolite of mevalonate, regulates the cell cycle progression and DNA synthesis in human lymphocytes. 1997 Biochem. Biophys. Res. Commun. pmid:9425279
Bianchi C et al. Influence of breast- and formula-feeding on plasma cholesterol precursor sterols throughout the first year of life. 1997 J. Pediatr. pmid:9427904
pmid:9430371
Pfohl M et al. Upregulation of cholesterol synthesis after acute reduction of low density lipoprotein by apheresis in normocholesterolaemic subjects: evidence for a threshold effect. 1997 Atherosclerosis pmid:9430376
Hrboticky N et al. Increased cellular triglyceride levels in human monocytic and rat smooth muscle cells after lovastatin. 1997 Biochim. Biophys. Acta pmid:9434135
Lala A et al. Apolipoprotein E genotype and cholesterogenesis in polygenic hypercholesterolemia. 1998 Metab. Clin. Exp. pmid:9440485
Kwiterovich PO and Motevalli M Differential effect of genistein on the stimulation of cholesterol production by basic protein II in normal and hyperapoB fibroblasts. 1998 Arterioscler. Thromb. Vasc. Biol. pmid:9445257
Kanayama N et al. Genetic evaluation of physiological functions of thiolase isoenzymes in the n-alkalane-assimilating yeast Candida tropicalis. 1998 J. Bacteriol. pmid:9457876
Shamburek RD et al. Intracellular trafficking of the free cholesterol derived from LDL cholesteryl ester is defective in vivo in Niemann-Pick C disease: insights on normal metabolism of HDL and LDL gained from the NP-C mutation. 1997 J. Lipid Res. pmid:9458266
Natarajan R et al. Molecular cloning of the promoter for rat hepatic neutral cholesterol ester hydrolase: evidence for transcriptional regulation by sterols. 1998 Biochem. Biophys. Res. Commun. pmid:9480812
Lange BM et al. A family of transketolases that directs isoprenoid biosynthesis via a mevalonate-independent pathway. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9482845
Ellsworth JL and Starr JR Inhibition of acyl coenzyme A:cholesterol acyltransferase blocks esterification but not uptake of cholesterol in Caco-2 cells. 1998 Metab. Clin. Exp. pmid:9500571
Sul D and Kaneshiro ES Ubiquinone synthesis by Pneumocystis carinii: incorporation of radiolabeled polyprenyl chain and benzoquinone ring precursors. 1997 Nov-Dec J. Eukaryot. Microbiol. pmid:9508445
Rosenthal RS and Rodwell VW Purification and characterization of the heteromeric transcriptional activator MvaT of the Pseudomonas mevalonii mvaAB operon. 1998 Protein Sci. pmid:9514272
Kalra VK and Blankenhorn DH Abnormal activation of sterol synthesis in lymphocytes of atherosclerotic-susceptible pigeons and heterozygous familial hypercholesterolemic patients. 1976 Biochim. Biophys. Acta pmid:952994
Disch A et al. Mevalonate-derived isopentenyl diphosphate is the biosynthetic precursor of ubiquinone prenyl side chain in tobacco BY-2 cells. 1998 Biochem. J. pmid:9531505
Laufs U et al. Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. 1998 Circulation pmid:9537338
Gopalaswamy UV and Aiyar AS Actinomycin D-induced enhancement of ubiquinone biosynthesis in rat. 1976 Chem. Biol. Interact. pmid:954142