Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Hypertension D006973 115 associated lipids
Glioma D005910 112 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Leukemia D007938 74 associated lipids
Thrombosis D013927 49 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Hypothyroidism D007037 32 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Glioblastoma D005909 27 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Refsum Disease D012035 19 associated lipids
Xanthomatosis D014973 17 associated lipids
Celiac Disease D002446 16 associated lipids
Biliary Fistula D001658 13 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Peutz-Jeghers Syndrome D010580 2 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

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Per page 10 20 50 100 | Total 2899
Authors Title Published Journal PubMed Link
Thurnher M et al. Novel aspects of mevalonate pathway inhibitors as antitumor agents. 2012 Clin. Cancer Res. pmid:22529099
Hong SY et al. Isoprene hydrocarbons production upon heterologous transformation of Saccharomyces cerevisiae. 2012 J. Appl. Microbiol. pmid:22519412
Iwata A et al. Inhibitory effect of statins on inflammatory cytokine production from human bronchial epithelial cells. 2012 Clin. Exp. Immunol. pmid:22471285
Murphy LA et al. Propiconazole-enhanced hepatic cell proliferation is associated with dysregulation of the cholesterol biosynthesis pathway leading to activation of Erk1/2 through Ras farnesylation. 2012 Toxicol. Appl. Pharmacol. pmid:22361350
Yasmin S et al. Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus. 2012 Proc. Natl. Acad. Sci. U.S.A. pmid:22106303
Garcia-Ruiz C et al. Statins and protein prenylation in cancer cell biology and therapy. 2012 Anticancer Agents Med Chem pmid:22413970
Hu W et al. Statins synergize dexamethasone-induced adipocyte fatty acid binding protein expression in macrophages. 2012 Atherosclerosis pmid:22503826
Henriquez MA et al. Effects of glucans and eicosapentaenoic acid on differential regulation of phenylpropanoid and mevalonic pathways during potato response to Phytophthora infestans. 2012 Plant Physiol. Biochem. pmid:22922112
Khasnavis S and Pahan K Sodium benzoate, a metabolite of cinnamon and a food additive, upregulates neuroprotective Parkinson disease protein DJ-1 in astrocytes and neurons. 2012 J Neuroimmune Pharmacol pmid:21701815
Drabkin HA and Gemmill RM Cholesterol and the development of clear-cell renal carcinoma. 2012 Curr Opin Pharmacol pmid:22939900
Conrado RJ et al. DNA-guided assembly of biosynthetic pathways promotes improved catalytic efficiency. 2012 Nucleic Acids Res. pmid:22021385
Yokota K et al. Geranylgeranyl-pyrophosphate regulates secretion of pentraxin 3 and monocyte chemoattractant protein-1 from rheumatoid fibroblast-like synoviocytes in distinct manners. 2011 Jan-Feb Clin. Exp. Rheumatol. pmid:21345291
Singh NK et al. 12/15-Lipoxygenase gene knockout severely impairs ischemia-induced angiogenesis due to lack of Rac1 farnesylation. 2011 Blood pmid:21841162
Luo H et al. Analysis of the transcriptome of Panax notoginseng root uncovers putative triterpene saponin-biosynthetic genes and genetic markers. 2011 BMC Genomics pmid:22369100
Youn YN et al. Impact of High-Dose Statin Pretreatment in Patients with Stable Angina during Off-Pump Coronary Artery Bypass. 2011 Korean J Thorac Cardiovasc Surg pmid:22263153
Odom AR Five questions about non-mevalonate isoprenoid biosynthesis. 2011 PLoS Pathog. pmid:22216001
Rauthan M and Pilon M The mevalonate pathway in C. elegans. 2011 Lipids Health Dis pmid:22204706
Emma F et al. Renal mitochondrial cytopathies. 2011 Int J Nephrol pmid:21811680
Ageenko NV et al. Expression of Pigment Cell-Specific Genes in the Ontogenesis of the Sea Urchin Strongylocentrotus intermedius. 2011 Evid Based Complement Alternat Med pmid:21804858
Cheng G et al. Mitochondria-targeted nitroxides exacerbate fluvastatin-mediated cytostatic and cytotoxic effects in breast cancer cells. 2011 Cancer Biol. Ther. pmid:21799303
Katuru R et al. Mevalonate depletion mediates the suppressive impact of geranylgeraniol on murine B16 melanoma cells. 2011 Exp. Biol. Med. (Maywood) pmid:21540247
Peng LF et al. Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits 3-hydroxy-3-methylglutaryl-coenzyme A synthase. 2011 J. Infect. Dis. pmid:21791663
Bajgain P et al. Transcriptome characterization and polymorphism detection between subspecies of big sagebrush (Artemisia tridentata). 2011 BMC Genomics pmid:21767398
Scheller EL et al. Zoledronic acid inhibits macrophage SOCS3 expression and enhances cytokine production. 2011 J. Cell. Biochem. pmid:21751240
Waldron J and Webster C Liquid chromatography-tandem mass spectrometry method for the measurement of serum mevalonic acid: a novel marker of hydroxymethylglutaryl coenzyme A reductase inhibition by statins. 2011 Ann. Clin. Biochem. pmid:21355014
Soliman SS et al. Chemical inhibitors suggest endophytic fungal paclitaxel is derived from both mevalonate and non-mevalonate-like pathways. 2011 J. Nat. Prod. pmid:22103292
Zhang B et al. A second target of the antimalarial and antibacterial agent fosmidomycin revealed by cellular metabolic profiling. 2011 Biochemistry pmid:21438569
Henneman L et al. Inhibition of the isoprenoid biosynthesis pathway; detection of intermediates by UPLC-MS/MS. 2011 Biochim. Biophys. Acta pmid:21237288
Kim RH et al. Bisphosphonates induce senescence in normal human oral keratinocytes. 2011 J. Dent. Res. pmid:21427353
Kyathanahalli CN and Kowluru A A farnesylated G-protein suppresses Akt phosphorylation in INS 832/13 cells and normal rat islets: regulation by pertussis toxin and PGEâ‚‚. 2011 Biochem. Pharmacol. pmid:21406184
Zhao Y et al. Statins downregulate K6a promoter activity: a possible therapeutic avenue for pachyonychia congenita. 2011 J. Invest. Dermatol. pmid:21390048
Blankier S et al. The role of atorvastatin in regulating the immune response leading to vascular damage in a model of Kawasaki disease. 2011 Clin. Exp. Immunol. pmid:21361911
Ghavami S et al. Mevalonate cascade regulation of airway mesenchymal cell autophagy and apoptosis: a dual role for p53. 2011 PLoS ONE pmid:21304979
Ignea C et al. Improving yeast strains using recyclable integration cassettes, for the production of plant terpenoids. 2011 Microb. Cell Fact. pmid:21276210
Tuckow AP et al. Simvastatin represses protein synthesis in the muscle-derived C₂C₁₂ cell line with a concomitant reduction in eukaryotic initiation factor 2B expression. 2011 Am. J. Physiol. Endocrinol. Metab. pmid:21224482
Tsubaki M et al. Blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathways by statins reduces the expression of bFGF, HGF, and TGF-β as angiogenic factors in mouse osteosarcoma. 2011 Cytokine pmid:21292498
Sawai S and Saito K Triterpenoid biosynthesis and engineering in plants. 2011 Front Plant Sci pmid:22639586
Nishikawa Y et al. Host cholesterol synthesis contributes to growth of intracellular Toxoplasma gondii in macrophages. 2011 J. Vet. Med. Sci. pmid:21187676
Tsuyuki R et al. Enhancement of trichothecene production in Fusarium graminearum by cobalt chloride. 2011 J. Agric. Food Chem. pmid:21299216
Nilsson S et al. Mevalonate pathway inhibitors affect anticancer drug-induced cell death and DNA damage response of human sarcoma cells. 2011 Cancer Lett. pmid:21356574
Liu Q et al. Reconstitution of the costunolide biosynthetic pathway in yeast and Nicotiana benthamiana. 2011 PLoS ONE pmid:21858047
Epplen R et al. Differential effects of ibandronate, docetaxel and farnesol treatment alone and in combination on the growth of prostate cancer cell lines. 2011 Acta Oncol pmid:20429730
Jouneau S et al. Anti-inflammatory effect of fluvastatin on IL-8 production induced by Pseudomonas aeruginosa and Aspergillus fumigatus antigens in cystic fibrosis. 2011 PLoS ONE pmid:21826199
Murtola TJ et al. Comparative effects of high and low-dose simvastatin on prostate epithelial cells: the role of LDL. 2011 Eur. J. Pharmacol. pmid:22040920
Issat T et al. Antitumor effects of the combination of cholesterol reducing drugs. 2011 Oncol. Rep. pmid:21491092
Castella B et al. Immune modulation by zoledronic acid in human myeloma: an advantageous cross-talk between Vγ9Vδ2 T cells, αβ CD8+ T cells, regulatory T cells, and dendritic cells. 2011 J. Immunol. pmid:21753152
Kim YS et al. Increase of lycopene production by supplementing auxiliary carbon sources in metabolically engineered Escherichia coli. 2011 Appl. Microbiol. Biotechnol. pmid:21246354
Jang HJ et al. Retinoid production using metabolically engineered Escherichia coli with a two-phase culture system. 2011 Microb. Cell Fact. pmid:21801353
Leichner GS et al. Metabolically regulated endoplasmic reticulum-associated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase: evidence for requirement of a geranylgeranylated protein. 2011 J. Biol. Chem. pmid:21778231
Yanae M et al. Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma. 2011 J. Exp. Clin. Cancer Res. pmid:21831290