Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Hypertension D006973 115 associated lipids
Glioma D005910 112 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Leukemia D007938 74 associated lipids
Thrombosis D013927 49 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Hypothyroidism D007037 32 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Glioblastoma D005909 27 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Refsum Disease D012035 19 associated lipids
Xanthomatosis D014973 17 associated lipids
Celiac Disease D002446 16 associated lipids
Biliary Fistula D001658 13 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Peutz-Jeghers Syndrome D010580 2 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
Kelley MT et al. Biosynthesis of squalene and cholesterol by cell-free extracts of adult rat brain. 1969 J. Lipid Res. pmid:4305711
Back P et al. Regulation of cholesterol biosynthesis in rat liver: diurnal changes of activity and influence of bile acids. 1969 Arch. Biochem. Biophys. pmid:5810824
Fillios LC et al. Synthesis and distribution of cholesterol, and the effect of diet, at the liver endoplasmic reticula and plasma membranes from lean or obese rats. 1969 J. Nutr. pmid:5784252
De Matteis F Liver cholesterol metabolism following trauma. Evidence for increased rate of cholesterol synthesis and breakdown. 1969 Biochim. Biophys. Acta pmid:5349601
Gautheron C et al. Synthesis of cholesterolinto the central nervous system and its radioautographic localization. 1969 Exp. Neurol. pmid:5811720
Akhtar M et al. The status of C-6, C-7, C-15 and C-16 hydrogen atoms in cholesterol biosynthesis. 1969 Eur. J. Biochem. pmid:5785581
Chevallier F and Gautheron C A method for the study of cholesterol biosynthesis in the central nervous system. Incorporation of [2-14C]mevalonic lactone after intraperitoneal, intracisternal and intraventricular administration in the rat. 1969 J. Neurochem. pmid:5795585
Kandutsch AA and Saucier SE Prevention of cyclic and triton-induced increases in hydroxymethylglutaryl coenzyme A reductase and sterol synthesis by puromycin. 1969 J. Biol. Chem. pmid:4389023
Thorne KJ and Barker DC Bactoprenol, ATPase and acetate activating enzymes of a vesicular fraction from Lactobacillus casei. 1969 Eur. J. Biochem. pmid:4244061
Van Aller RT et al. The mechanism of introduction of alkyl groups at carbon 24 of sterols. 3. The second one-carbon transfer and reduction. 1969 J. Biol. Chem. pmid:5361547
Cornforth JW and Cornforth RH Chemistry of mevalonic acid. 1969 Biochem. J. pmid:5807184
Rudney H The biosynthesis of terpenoid quinones. 1969 Biochem. J. pmid:4308944
Horodysky AG et al. Biosynthesis of methylcyclopentane monoterpenoids. IV. Verbenalin. 1969 J. Biol. Chem. pmid:5792652
Shechter I and West CA Biosynthesis of gibberellins. IV. Biosynthesis of cyclic diterpenes from trans-geranylgeranyl pyrophosphate. 1969 J. Biol. Chem. pmid:4183095
Noddle RC and Robinson DR Biosynthesis of abscisic acid: incorporation of radioactivity from [2-14C]mevalonic acid by intact fruit. 1969 Biochem. J. pmid:4308332
Porcellati G and Giorgini D The effect of alpha-methyl gamma-phenyl butyric acid on sterol biosynthesis in vitro. 1969 Biochem. Pharmacol. pmid:5772592
Goad LJ and Goodwin TW Studies in phytosterol biosynthesis: observations on the biosynthesis of fucosterol in the marine brown alga Fucus spiralis. 1969 Eur. J. Biochem. pmid:5780485
Akhtar M et al. The role of a cholesta-8,14-dien-3-beta-ol system in cholesterol biosynthesis. 1969 Biochem. J. pmid:5783476
Schweppe JS and Jungmann RA Hormones and cholesterol ester metabolism. 1969 J Am Geriatr Soc pmid:4308733
Howe EE et al. The hypolipemic properties of 5 beta-cholanic acid in the mouse and rat. 1969 Arch. Biochem. Biophys. pmid:5773747
Walton TJ et al. Biosynthesis of xanthophylls in higher plants: stereochemistry of hydroxylation at C-3. 1969 Biochem. J. pmid:5801311
Klimov AN et al. Inhibition of biosynthesis of cholesterol by salicylate. 1969 Biochem. Pharmacol. pmid:5789791
Smith PF and Smith MR Cholesterol inhibition of isopentenyl pyrophosphate delta3, delta2-isomerase in Mycoplasma laidlawii. 1970 J. Bacteriol. pmid:4316364
Loker E et al. Phenobarbital-induced proliferation of smooth endoplasmic reticulum after administration of triparanol. 1970 Anat. Rec. pmid:5506924
Kyriakides EC et al. Lipid studies in Wolman's disease. 1970 Pediatrics pmid:5468779
Moir NJ et al. Effect of cholestyramine on the terminal reactions of sterol biosynthesis. 1970 Arch. Biochem. Biophys. pmid:4395692
Heinstein PF et al. Biosynthesis of gossypol. Incorporation of mevalonate-2-14C and isoprenyl pyrophosphates. 1970 J. Biol. Chem. pmid:4318479
Gough DP and Hemming FW The characterization and stereochemistry of biosynthesis of dolichols in rat liver. 1970 Biochem. J. pmid:4319540
Flint AP The activity and kinetic properties of mevalonate kinase in superovulated rat ovary. 1970 Biochem. J. pmid:4321929
Eskelson CD et al. Cholesterolgenesis in vitro from ethanol. 1970 Biochem. Pharmacol. pmid:5513929
Coccodrilli GD et al. Effects of dietary protein on blood lipids of the calf with special reference to cholesterol. 1970 J. Dairy Sci. pmid:5485373
O'Brien DE and Rost WJ N-aralkyl-piperidyl carbanilates as hypocholesteremic agents. 1970 J Pharm Sci pmid:5416166
Siperstein MD Cholesterol and cancer. 1970 Trans. Am. Clin. Climatol. Assoc. pmid:4330034
Milborrow BV and Noddle RC Conversion of 5-(1,2-epoxy-2,6,6-trimethylcyclohexyl)-3-methylpenta-cis-2-trans-4-dienoic acid into abscisic acid in plants. 1970 Biochem. J. pmid:5493506
Hammond RK and White DC Inhibition of carotenoid hydroxylation in Staphylococcus aureus by mixed-function oxidase inhibitors. 1970 J. Bacteriol. pmid:5474879
Hammond RK and White DC Inhibition of vitamin K2 and carotenoid synthesis in Staphylococcus aureus by diphenylamine. 1970 J. Bacteriol. pmid:4319835
Bensch WR and Rodwell VW Purification and properties of 3-hydroxy-3-methylglutaryl coenzyme A reductase from Pseudomonas. 1970 J. Biol. Chem. pmid:4321764
Hammond RK and White DC Carotenoid formation by Staphylococcus aureus. 1970 J. Bacteriol. pmid:5423369
Bolger LM et al. Biosynthesis of 24-ethylcholesta-5,22,25-trien-3-beta-ol, a new sterol from Clerodendrum campbellii. 1970 Biochem. J. pmid:5472151
Gough DP et al. The characterization of undecaprenol of Lactobacillus plantarum. 1970 Biochem. J. pmid:5472148
Hamprecht B and Lynen F [Procedure to determine 3-hydroxy-3-methylglutaryl coenzyme A reductase in rat liver]. 1970 Eur. J. Biochem. pmid:4394155
Hornby GM et al. The effects of thiols on cholesterol synthesis by rat liver in vitro. 1970 Biochem. Biophys. Res. Commun. pmid:5492149
Tefft RE et al. Aspects of the stereochemistry of torularhodin biosynthesis. 1970 Biochem. J. pmid:5465554
Durr IF and Habbal MZ Mevalonate metabolism in supernatant fractions of lysates of Lactobacillus plantarum. 1970 J. Bacteriol. pmid:4392896
Castagnoli N et al. Biosynthesis of N-(alpha-hydroxyethyl) lysergamide, a metabolite of Claviceps paspali Stevens and Hall. 1970 Biochem. J. pmid:5419742
Gough DP and Hemming FW The stereochemistry of betulaprenol biosynthesis. 1970 Biochem. J. pmid:4315982
Krishnaiah KV and Ramasarma T Effect of alpha-p-chlorophenoxyisobutyrate on the metabolism of isoprenoid compounds in the rat. 1970 Biochem. J. pmid:5435680
Sloviter HA et al. Biosynthesis of cholesterol in rabbit reticulocytes and its exchange with plasma. 1970 J. Lipid Res. pmid:5418482
Sargent JR et al. Metabolism of mevalonic acid in the liver of the dogfish Scyliorhinus caniculus. 1970 Biochem. J. pmid:5420034
Rahman R et al. Removal of the 4,4-dimethyl carbons in the enzymic conversion of lanosterol to cholesterol. Initial loss of the 4-alpha-methyl group. 1970 J. Biol. Chem. pmid:5445804
Godinez MH et al. The biosynthesis of isoprenoid lipids including ubiquinone in muscle from normal and genetically dystrophic mice. 1970 Arch. Biochem. Biophys. pmid:5460184
Stokke KT and Norum KR Subcellular distribution of acyl-CoA: cholesterol acyltransferase in rat liver cells. 1970 Biochim. Biophys. Acta pmid:5456044
Zander JM and Caspi E The stereospecificity of the cholesterol delta 22-dehydrogenase of Tetrahymena pyriformis and the origin of the C-22 protons of cholesterol. 1970 J. Biol. Chem. pmid:5438358
Nestel PJ Turnover of plasma esterified cholesterol: influence of dietary fat and carbohydrate and relation to plasma lipids and body weight. 1970 Clin Sci pmid:5428350
Dell'Orco RT and Melnykovych G Lipid composition of heteroploid cells in culture: effects of prednisolone. 1970 J. Cell. Physiol. pmid:5471037
Percy-Robb IW and Boyd GS The synthesis of bile acids in perfused rat liver subjected to chronic biliary drainage. 1970 Biochem. J. pmid:5472179
Kandutsch AA and Packie RM Comparison of the effects of some C27-, C21-, and C19-steroids upon hepatic sterol synthesis and hydroxymethylglutaryl-CoA reductase activity. 1970 Arch. Biochem. Biophys. pmid:5460174
Krishnaiah KV and Ramasarma T Regulation of hepatic cholesterolgenesis by ubiquinone. 1970 Biochim. Biophys. Acta pmid:5442761
Beytia E et al. Purification and mechanism of action of hog liver mevalonic kinase. 1970 J. Biol. Chem. pmid:5469176
Yamamoto M et al. Effects of glycyrrhizin and cortisone on cholesterol metabolism in the rat. 1970 Endocrinol. Jpn. pmid:5537368
Cayen MN Effect of dietary tomatine on cholesterol metabolism in the rat. 1971 J. Lipid Res. pmid:4362143
Swell L and Law MD Release of lipoprotein cholesterol esters by the isolated perfused rat liver. 1971 Biochim. Biophys. Acta pmid:5554903
Menkes JH Lipid metabolism in brain tissue explants. 1971 J. Neurochem. pmid:5092865
Goodfellow RD et al. Dietary sterol effects on mevalonate kinase activity in axenic and non-axenic Sarcophaga bullata (Diptera). 1971 J. Insect Physiol. pmid:5111035
White LW Regulation of hepatic cholesterol biosynthesis by clofibrate administration. 1971 J. Pharmacol. Exp. Ther. pmid:5570460
Maragoudakis ME On the mode of action of lipid-lowering agents. VI. Inhibition of lipogenesis in rat mammary gland cell culture. 1971 J. Biol. Chem. pmid:4327196
Smith AG and Goad LJ Sterol biosynthesis in the starfish Asterias rubens and Henricia sanguinolenta. 1971 Biochem. J. pmid:5126917
Holmlund CE On the mechanism of growth inhibition of Tetrahymena pyriformis by steroids. 1971 Biochim. Biophys. Acta pmid:4108656
Kandutsch AA and Hancock RL Regulation of the rate of sterol synthesis and the level of beta-hydroxy-beta-methylglutaryl coenzyme A reductase activity in mouse liver and hepatomas. 1971 Cancer Res. pmid:4328734
Mulheirn LJ and Caspi E The location of the 4-pro-R protons of mevalonic acid in cholesterol. 1971 J. Biol. Chem. pmid:5561468
Gibbons GF et al. Concerning the role of lanosterol and cycloartenol in steroid biosynthesis. 1971 J. Biol. Chem. pmid:5561470
Johnson DF and Daly JW Biosynthesis of cholesterol and cholesterol acetate in dendrobatid arrow poison frogs. 1971 Biochem. Pharmacol. pmid:5114496
Chida N and Okamura T Increased cholesterol-biosynthesis in familial hypercholesterolemia. 1971 Tohoku J. Exp. Med. pmid:5140375
Fall RR and West CA Purification and properties of kaurene synthetase from Fusarium moniliforme. 1971 J. Biol. Chem. pmid:4331199
Ramsey RB et al. The biosynthesis of cholesterol and other sterols by brain tissue. Distribution in subcellular fractions as a function of time after intracerebral injection of [2-14C]-mevalonic acid. 1971 J. Neurochem. pmid:5092868
Hornby GM and Boyd GS The origin of lanosta-7,24-dienol in rat skin. 1971 Biochem. J. pmid:5131739
Mosbach EH et al. Bile acid synthesis in the isolated, perfused rabbit liver. 1971 J. Clin. Invest. pmid:5097576
Richards JB et al. Dolichol phosphates as acceptors of mannose from guanosine diphosphate mannose in liver systems. 1971 Biochem. J. pmid:5131017
Dugan RE and Porter JW Stereospecificity of the transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate in each of the two reductive steps catalyzed by beta-hydroxy-beta-methylglutaryl coenzyme A reductase. 1971 J. Biol. Chem. pmid:4398469
Hulcher FH Inhibition of hepatic cholesterol biosynthesis by 3,5-dihydroxy-3,4,4-trimethylvaleric acid and its site of action. 1971 Arch. Biochem. Biophys. pmid:5114913
Baisted DJ Sterol and triterpene synthesis in the developing and germinating pea seed. 1971 Biochem. J. pmid:5158507
Goldfarb S and Pitot HC Improved assay of 3-hydroxy-3-methylglutaryl coenzyme A reductase. 1971 J. Lipid Res. pmid:5164097
Thorne KJ and Barker DC The bactoprenol content of plasma and mesosome membranes from Lactobacillus casei. 1971 Biochem. J. pmid:5001951
Skilleter DN and Kekwick RG The enzymes forming isopentenyl pyrophosphate from 5-phosphomevalonate (mevalonate 5-phosphate) in the latex of Hevea brasiliensis. 1971 Biochem. J. pmid:4333851
Goodwin TW Biosynthesis of carotenoids and plant triterpenes. 1971 Biochem. J. pmid:4331177
Shapiro DJ and Rodwell VW Regulation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol synthesis. 1971 J. Biol. Chem. pmid:5574396
Bloxham DP and Akhtar M Studies on the control of cholesterol biosynthesis: the adenosine 3':5'-cyclic monophosphate-dependent accumulation of a steroid carboxylic acid. 1971 Biochem. J. pmid:4331371
Green TR and Baisted DJ Development of the squalene-synthesizing system during early stages of pea seed germination. 1971 Biochem. J. pmid:4335540
Goldfarb S and Pitot HC The regulation of beta-hydroxy-beta-methylglutaryl coenzyme A reductase in Morris hepatomas 5123C, 7800, and 9618A. 1971 Cancer Res. pmid:4330433
Aiyar AS et al. Biogenesis of ubiquinone in rats--an alternate origin of the benzoquinone moiety. 1971 Biochem. Biophys. Res. Commun. pmid:5117559
Ramsey RB et al. Formation of methyl sterols in brain cholesterol biosynthesis. Sterol formation in vitro and in vivo in adult rat brain. 1971 J. Biol. Chem. pmid:5132663
Díaz Zagoya JC et al. Studies on the regulation of cholesterol metabolism by the use of the structural analogue, diosgenin. 1971 Biochem. Pharmacol. pmid:5132893
Sodhi HS et al. Effects of chlorophenoxyisobutyrate on the synthesis and metabolism of cholesterol in man. 1971 Metab. Clin. Exp. pmid:5550302
Ono T and Imai Y Effects of steroid hormones on synthesis of cholesterol in vitro. 1971 J. Biochem. pmid:4254538
Mulheirn LJ and Caspi E Mechanism of squalene cyclization. The biosynthesis of fusidic acid. 1971 J. Biol. Chem. pmid:5553407
Yamasaki K et al. Isolation of 3 7 -dihydroxychol-5-en-24-oic acid, an intermediate of chenodeoxycholic acid biogenesis, from fistula bile of the rat and hen. 1971 J. Biochem. pmid:5134665
Mukherjee C et al. In vitro studies on the effect of different dietary fats and different proportions of dietary protein on the synthesis of lipids by rat arterial tissue. 1971 J. Nutr. pmid:5578922
Malhotra HC and Nes WR The mechanism of introduction of alkyl groups at C-24 of sterols. IV. Inhibition by triparanol. 1971 J. Biol. Chem. pmid:5570429
Booth R et al. The effect of dietary cholesterol on cholesterol biosynthesis and other processes in mammalian liver. 1971 Biochem. J. pmid:5124798
Ogura M et al. Studies on the cholesterol pool as the precursor of bile acids in the rat. 1971 J. Biochem. pmid:5144357