Mevalonic acid is a lipid of Fatty Acyls (FA) class.
We collected disease MeSH terms mapped to the references associated with Mevalonic acid
Authors | Title | Published | Journal | PubMed Link |
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Hu ZY et al. | Neurosteroids: oligodendrocyte mitochondria convert cholesterol to pregnenolone. | 1987 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3479785 |
Forman BM et al. | The orphan nuclear receptor LXRalpha is positively and negatively regulated by distinct products of mevalonate metabolism. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9380679 |
Arebalo RE et al. | In vivo regulation of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A reductase: immunotitration of the enzyme after short-term mevalonate or cholesterol feeding. | 1982 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6948302 |
Pronin AN and Gautam N | Interaction between G-protein beta and gamma subunit types is selective. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1631113 |
Liu GC et al. | Measurement of cholesterol synthesis in man by isotope kinetics of squalene. | 1975 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1060141 |
Kotti T et al. | Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18685105 |
Epstein WW et al. | Quantitation of prenylcysteines by a selective cleavage reaction. | 1991 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1946384 |
Mizuno T et al. | A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21. | 1991 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1907371 |
Roullet JB et al. | Mevalonate availability and cardiovascular functions. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8265617 |
Shi Z and Ruvkun G | The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22396595 |
Parker TS et al. | Mevalonic acid in human plasma: relationship of concentration and circadian rhythm to cholesterol synthesis rates in man. | 1982 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6953446 |
Lange BM and Croteau R | Isopentenyl diphosphate biosynthesis via a mevalonate-independent pathway: isopentenyl monophosphate kinase catalyzes the terminal enzymatic step. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10570138 |
Sinensky M and Logel J | Defective macromolecule biosynthesis and cell-cycle progression in a mammalian cell starved for mevalonate. | 1985 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2582409 |
Rauthan M et al. | The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23530189 |
Tianero MD et al. | Metabolic model for diversity-generating biosynthesis. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26831074 |
Yasmin S et al. | Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22106303 |
Larson RA et al. | Neutrophils are required for the DNA synthetic response of human lymphocytes to mevalonic acid: evidence suggesting that a nonsterol product of mevalonate is involved. | 1982 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6953445 |
Goldstein JL and Brown MS | Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol. | 1973 | Proc. Natl. Acad. Sci. U.S.A. | pmid:4355366 |
Kopito RR and Brunengraber H | (R)-mevalonate excretion in human and rat urines. | 1980 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6255462 |
Quesney-Huneeus V et al. | Essential role for mevalonate synthesis in DNA replication. | 1979 | Proc. Natl. Acad. Sci. U.S.A. | pmid:291922 |
Laffitte BA et al. | LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11149950 |
Henry LK et al. | Orthologs of the archaeal isopentenyl phosphate kinase regulate terpenoid production in plants. | 2015 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26216978 |
Venkateshwaran M et al. | A role for the mevalonate pathway in early plant symbiotic signaling. | 2015 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26199419 |
Giron MD et al. | Mevalonate-mediated suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase function in alpha-toxin-perforated cells. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8022795 |
Parmryd I et al. | Protein prenylation in spinach chloroplasts. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10468564 |
Lai RK et al. | The gamma subunit of transducin is farnesylated. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2217200 |
Sapir A et al. | Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25187565 |
Farnsworth CC et al. | C terminus of the small GTP-binding protein smg p25A contains two geranylgeranylated cysteine residues and a methyl ester. | 1991 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1906176 |
Kinsella BT et al. | Posttranslational modification of Ha-ras p21 by farnesyl versus geranylgeranyl isoprenoids is determined by the COOH-terminal amino acid. | 1991 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1924354 |
Casey PJ et al. | p21ras is modified by a farnesyl isoprenoid. | 1989 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2682646 |
Kawata M et al. | Posttranslationally processed structure of the human platelet protein smg p21B: evidence for geranylgeranylation and carboxyl methylation of the C-terminal cysteine. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2123345 |
Mumby SM et al. | G protein gamma subunits contain a 20-carbon isoprenoid. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2116011 |
Wang Z et al. | Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24367099 |
Khosravi-Far R et al. | Isoprenoid modification of rab proteins terminating in CC or CXC motifs. | 1991 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1648736 |
Ness GC et al. | Stimulation of hepatic beta-hydroxy-beta-methylglutaryl coenzyme A reductase activity in hypophysectomized rats by L-triiodothyronine. | 1973 | Proc. Natl. Acad. Sci. U.S.A. | pmid:4521209 |
Clendening JW et al. | Dysregulation of the mevalonate pathway promotes transformation. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20696928 |
Okamura E et al. | Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20534558 |
Loiseau L et al. | ErpA, an iron sulfur (Fe S) protein of the A-type essential for respiratory metabolism in Escherichia coli. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17698959 |
Rohdich F et al. | Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of IspH (LytB) protein. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11818558 |
Hecht S et al. | Studies on the nonmevalonate pathway to terpenes: the role of the GcpE (IspG) protein. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11752431 |
Kaneda K et al. | An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11158573 |
Ohyama K et al. | Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19139393 |
Lange BM et al. | A family of transketolases that directs isoprenoid biosynthesis via a mevalonate-independent pathway. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9482845 |
Rao S et al. | Lovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10393901 |
Takahashi S et al. | A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9707569 |
Chang TY et al. | Isolation and partial characterization of a cholesterol-requiring mutant of Chinese hamster ovary cells. | 1977 | Proc. Natl. Acad. Sci. U.S.A. | pmid:265577 |
McNamara DJ et al. | Measurement of daily cholesterol synthesis rates in man by assay of the fractional conversion of mevalonic acid to cholesterol. | 1977 | Proc. Natl. Acad. Sci. U.S.A. | pmid:268653 |
James G et al. | Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8633088 |
Balasubramaniam S et al. | Regulation of cholesterol synthesis in rat adrenal gland through coordinate control of 3-hydroxy-3-methylglutaryl coenzyme A synthase and reductase activities. | 1977 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16260 |
Beg ZH et al. | In vivo modulation of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A reductase, reductase kinase, and reductase kinase kinase by mevalonolactone. | 1984 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6594693 |