Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Biliary Fistula D001658 13 associated lipids
Body Weight D001835 333 associated lipids
Celiac Disease D002446 16 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Glioblastoma D005909 27 associated lipids
Glioma D005910 112 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Hypertension D006973 115 associated lipids
Hypothyroidism D007037 32 associated lipids
Leukemia D007938 74 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Peutz-Jeghers Syndrome D010580 2 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Refsum Disease D012035 19 associated lipids
Thrombosis D013927 49 associated lipids
Xanthomatosis D014973 17 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

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Per page 10 20 50 100 | Total 2899
Authors Title Published Journal PubMed Link
Pomerantz KB et al. G-protein-mediated signaling in cholesterol-enriched arterial smooth muscle cells. 2. Role of protein kinase C-delta in the regulation of eicosanoid production. 1997 Biochemistry pmid:9235999
Paton VG et al. Cloning and subcellular localization of hamster and rat isopentenyl diphosphate dimethylallyl diphosphate isomerase. A PTS1 motif targets the enzyme to peroxisomes. 1997 J. Biol. Chem. pmid:9228075
pmid:9226547
Flint OP et al. HMG CoA reductase inhibitor-induced myotoxicity: pravastatin and lovastatin inhibit the geranylgeranylation of low-molecular-weight proteins in neonatal rat muscle cell culture. 1997 Toxicol. Appl. Pharmacol. pmid:9221829
Flint OP et al. Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro. 1997 Toxicol. Appl. Pharmacol. pmid:9221828
Lasa M et al. Lovastatin decreases prolactin and growth hormone gene expression in GH4C1 cells through a cAMP dependent mechanism. 1997 Mol. Cell. Endocrinol. pmid:9220025
pmid:921298
Spencer TA et al. Feasibility of an immunoassay for mevalonolactone. 1997 Bioorg. Med. Chem. pmid:9208099
Chan PC et al. Lovastatin increases surface low density lipoprotein receptor expression by retarding the receptor internalization rate in proliferating lymphocytes. 1997 Biochem. Biophys. Res. Commun. pmid:9196047
pmid:9191394
Raiteri M et al. Pharmacological control of the mevalonate pathway: effect on arterial smooth muscle cell proliferation. 1997 J. Pharmacol. Exp. Ther. pmid:9190847
Fuhrman B et al. Hypocholesterolemic effect of lycopene and beta-carotene is related to suppression of cholesterol synthesis and augmentation of LDL receptor activity in macrophages. 1997 Biochem. Biophys. Res. Commun. pmid:9168909
He L et al. Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo. 1997 J. Nutr. pmid:9164984
Amin D et al. RPR 107393, a potent squalene synthase inhibitor and orally effective cholesterol-lowering agent: comparison with inhibitors of HMG-CoA reductase. 1997 J. Pharmacol. Exp. Ther. pmid:9152381
Anouja F et al. The cytotoxicity of the parvovirus minute virus of mice nonstructural protein NS1 is related to changes in the synthesis and phosphorylation of cell proteins. 1997 J. Virol. pmid:9151861
Herawati E and Ishizaki A Optimization of the culture medium for growth and the kinetics of lactate fermentation by Pediococcus sp. ISK-1. 1997 Biosci. Biotechnol. Biochem. pmid:9145518
Padayatty SJ et al. Lovastatin-induced apoptosis in prostate stromal cells. 1997 J. Clin. Endocrinol. Metab. pmid:9141529
Tamai I et al. Intestinal brush-border membrane transport of monocarboxylic acids mediated by proton-coupled transport and anion antiport mechanisms. 1997 J. Pharm. Pharmacol. pmid:9120761
Sinensky M Isolation of a mammalian cell mutant resistant to 25-hydroxy cholesterol. 1977 Biochem. Biophys. Res. Commun. pmid:911332
Khan SA and Nyce JW Effects of ubiquinone and mevalonic acid on hepatic peroxisomal enzymes induced by dehydroepiandrosterone. 1997 Pharmacol. Toxicol. pmid:9101583
Cartwright IJ et al. Investigation of the role of lipids in the assembly of very low density lipoproteins in rabbit hepatocytes. 1997 J. Lipid Res. pmid:9101434
pmid:9089010
Crick DC et al. Geranylgeraniol promotes entry of UT-2 cells into the cell cycle in the absence of mevalonate. 1997 Exp. Cell Res. pmid:9087171
Endo A et al. Inhibition of cholesterol synthesis in vitro and in vivo by ML-236A and ML-236B, competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. 1977 Eur. J. Biochem. pmid:908337
Colli S et al. Vastatins inhibit tissue factor in cultured human macrophages. A novel mechanism of protection against atherothrombosis. 1997 Arterioscler. Thromb. Vasc. Biol. pmid:9081680
pmid:9070894
Scoppola A et al. Plasma mevalonate concentrations in uremic patients. 1997 Kidney Int. pmid:9067929
pmid:9056235
Beytía ED and Porter JW Biochemistry of polyisoprenoid biosynthesis. 1976 Annu. Rev. Biochem. pmid:9026
Edwards PA et al. Preferential uptake and utilization of mevalonolactone over mevalonate for sterol biosynthesis in isolated rat hepatocytes. 1977 Biochim. Biophys. Acta pmid:901801
Peffley DM and Gayen AK Inhibition of squalene synthase but not squalene cyclase prevents mevalonate-mediated suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis at a posttranscriptional level. 1997 Arch. Biochem. Biophys. pmid:9016820
Stout RW The effect of insulin and glucose on sterol synthesis in cultured rat arterial smooth muscle cells. 1977 Atherosclerosis pmid:901624
Lichtenthaler HK et al. Biosynthesis of isoprenoids in higher plant chloroplasts proceeds via a mevalonate-independent pathway. 1997 FEBS Lett. pmid:9009212
pmid:900481
Chiloeches A et al. Effect of mevalonate availability on the association of G-protein alpha-subunits with the plasma membrane in GH4C1 cells. 1997 FEBS Lett. pmid:9003808
Hirai A et al. Geranylgeranylated rho small GTPase(s) are essential for the degradation of p27Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cells. 1997 J. Biol. Chem. pmid:8995216
Spicer LJ et al. Insulin-like growth factor I enhancement of steroidogenesis by bovine granulosa cells and thecal cells: dependence on de novo cholesterol synthesis. 1996 J. Endocrinol. pmid:8994382
Krisans SK Cell compartmentalization of cholesterol biosynthesis. 1996 Ann. N. Y. Acad. Sci. pmid:8993542
Shoda J et al. Simultaneous determination of plasma mevalonate and 7alpha-hydroxy-4-cholesten-3-one levels in hyperlipoproteinemia: convenient indices for estimating hepatic defects of cholesterol and bile acid syntheses and biliary cholesterol supersaturation. 1997 Hepatology pmid:8985259
Sato-Suzuki I and Murota S Simvastatin inhibits the division and induces neurite-like outgrowth in PC12 cells. 1996 Neurosci. Lett. pmid:8977139
Bandoh T et al. Inhibitory effect of fluvastatin at doses insufficient to lower serum lipids on the catheter-induced thickening of intima in rabbit femoral artery. 1996 Eur. J. Pharmacol. pmid:8960862
pmid:8957210
pmid:8946387
Field H et al. Characterisation of protein isoprenylation in procyclic form Trypanosoma brucei. 1996 Mol. Biochem. Parasitol. pmid:8943151
Goalstone ML and Draznin B Effect of insulin on farnesyltransferase activity in 3T3-L1 adipocytes. 1996 J. Biol. Chem. pmid:8910345
Umetani N et al. Lovastatin inhibits gene expression of type-I scavenger receptor in THP-1 human macrophages. 1996 Biochim. Biophys. Acta pmid:8908154
pmid:8907210
Lindenthal B et al. Urinary excretion of mevalonic acid as an indicator of cholesterol synthesis. 1996 J. Lipid Res. pmid:8906596
pmid:8902853
Ramsey RB and Fredericks M Effect of hypocholesterolemic agents on central nervous system cholesterol biosynthesis. I. Zuclomiphene. 1977 Biochem. Pharmacol. pmid:889582