Mevalonic acid is a lipid of Fatty Acyls (FA) class.
We collected disease MeSH terms mapped to the references associated with Mevalonic acid
Authors | Title | Published | Journal | PubMed Link |
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pmid:8025334 | ||||
Giron MD et al. | Mevalonate-mediated suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase function in alpha-toxin-perforated cells. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8022795 |
Correll CC et al. | Identification of farnesol as the non-sterol derivative of mevalonic acid required for the accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | 1994 | J. Biol. Chem. | pmid:8021239 |
Gebhardt R et al. | Inhibition of cholesterol biosynthesis by allicin and ajoene in rat hepatocytes and HepG2 cells. | 1994 | Biochim. Biophys. Acta | pmid:8011681 |
Hiser L et al. | ERG10 from Saccharomyces cerevisiae encodes acetoacetyl-CoA thiolase. | 1994 | J. Biol. Chem. | pmid:7989303 |
Sinensky M et al. | Expression of prelamin A but not mature lamin A confers sensitivity of DNA biosynthesis to lovastatin on F9 teratocarcinoma cells. | 1994 | J. Cell. Sci. | pmid:7983180 |
Mallat A et al. | Effect of simvastatin, an inhibitor of hydroxy-methylglutaryl coenzyme A reductase, on the growth of human Ito cells. | 1994 | Hepatology | pmid:7982659 |
Hrab RV et al. | Prevention of fluvastatin-induced toxicity, mortality, and cardiac myopathy in pregnant rats by mevalonic acid supplementation. | 1994 | Teratology | pmid:7974251 |
Ortiz JA et al. | Transfection of the ketogenic mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme A synthase cDNA into Mev-1 cells corrects their auxotrophy for mevalonate. | 1994 | J. Biol. Chem. | pmid:7961793 |
Russell-Jones DL et al. | The effect of growth hormone replacement on serum lipids, lipoproteins, apolipoproteins and cholesterol precursors in adult growth hormone deficient patients. | 1994 | Clin. Endocrinol. (Oxf) | pmid:7955441 |
Dimster-Denk D et al. | Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in Saccharomyces cerevisiae. | 1994 | Mol. Biol. Cell | pmid:7949422 |
pmid:7935024 | ||||
pmid:7926659 | ||||
Ness GC et al. | Effect of squalene synthase inhibition on the expression of hepatic cholesterol biosynthetic enzymes, LDL receptor, and cholesterol 7 alpha hydroxylase. | 1994 | Arch. Biochem. Biophys. | pmid:7911291 |
Camp LA and Hofmann SL | Purification and properties of a palmitoyl-protein thioesterase that cleaves palmitate from H-Ras. | 1993 | J. Biol. Chem. | pmid:7901201 |
Johnson KA et al. | In vivo formation of 25-hydroxycholesterol from endogenous cholesterol after a single meal, dietary cholesterol challenge. | 1994 | J. Lipid Res. | pmid:7897321 |
Herold G et al. | Influence of cholesterol supply on cell growth and differentiation in cultured enterocytes (CaCo-2). | 1995 | Digestion | pmid:7895934 |
Pérez-Sala D et al. | Intracellular alkalinization suppresses lovastatin-induced apoptosis in HL-60 cells through the inactivation of a pH-dependent endonuclease. | 1995 | J. Biol. Chem. | pmid:7890761 |
Chiloeches A et al. | Effects of lovastatin on adenylyl cyclase activity and G proteins in GH4C1 cells. | 1995 | FEBS Lett. | pmid:7890038 |
Munro E et al. | Inhibition of human vascular smooth muscle cell proliferation by lovastatin: the role of isoprenoid intermediates of cholesterol synthesis. | 1994 | Eur. J. Clin. Invest. | pmid:7890015 |
Masters BA et al. | In vitro myotoxicity of the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, pravastatin, lovastatin, and simvastatin, using neonatal rat skeletal myocytes. | 1995 | Toxicol. Appl. Pharmacol. | pmid:7878672 |
pmid:7876919 | ||||
Straka MS and Panini SR | Post-transcriptional regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by mevalonate. | 1995 | Arch. Biochem. Biophys. | pmid:7872789 |
Pfohl M et al. | Acute and chronic effects on cholesterol biosynthesis of LDL-apheresis with or without concomitant HMG-CoA reductase inhibitor therapy. | 1994 | J. Lipid Res. | pmid:7868973 |
pmid:7851471 | ||||
Soma MR et al. | In vivo enhanced antitumor activity of carmustine [N,N'-bis(2-chloroethyl)-N-nitrosourea] by simvastatin. | 1995 | Cancer Res. | pmid:7834630 |
Shipton CA et al. | Isoprenylation of plant proteins in vivo. Isoprenylated proteins are abundant in the mitochondria and nuclei of spinach. | 1995 | J. Biol. Chem. | pmid:7822281 |
Sekler MS and Simoni RD | Mutation in the lumenal part of the membrane domain of HMG-CoA reductase alters its regulated degradation. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7818519 |
Ortiz MB et al. | Mevalonate dependency of the early cell cycle mitogenic response to epidermal growth factor and prostaglandin F2 alpha in Swiss mouse 3T3 cells. | 1995 | J. Cell. Physiol. | pmid:7814446 |
Cummings MH and Watts GF | Increased hepatic secretion of very-low-density lipoprotein apolipoprotein B-100 in cholesteryl ester storage disease. | 1995 | Clin. Chem. | pmid:7813057 |
Thelin A et al. | Effect of squalestatin 1 on the biosynthesis of the mevalonate pathway lipids. | 1994 | Biochim. Biophys. Acta | pmid:7811707 |
Sagami H et al. | A novel type of protein modification by isoprenoid-derived materials. Diphytanylglycerylated proteins in Halobacteria. | 1995 | J. Biol. Chem. | pmid:7797461 |
Schootemeijer A et al. | Relation between membrane fluidity and signal transduction in the human megakaryoblastic cell line MEG-01. | 1995 | Biochim. Biophys. Acta | pmid:7794941 |
Crick DC et al. | Farnesol is utilized for protein isoprenylation and the biosynthesis of cholesterol in mammalian cells. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7794274 |
Corsini A et al. | Pharmacology of competitive inhibitors of HMG-CoA reductase. | 1995 | Pharmacol. Res. | pmid:7784310 |
Re EB et al. | Co-expression of native and introduced genes reveals cryptic regulation of HMG CoA reductase expression in Arabidopsis. | 1995 | Plant J. | pmid:7773308 |
Aspbury RA et al. | Lipid modification of signal-transducing polypeptides in the free-living nematode Caenorhabditis elegans. | 1995 | Biochem. Soc. Trans. | pmid:7758740 |
Appelkvist EL et al. | Regulation of coenzyme Q biosynthesis. | 1994 | Mol. Aspects Med. | pmid:7752843 |
Dimster-Denk D et al. | Control of RAS mRNA level by the mevalonate pathway. | 1995 | Mol. Biol. Cell | pmid:7749195 |
Sasseville AM and Raymond Y | Lamin A precursor is localized to intranuclear foci. | 1995 | J. Cell. Sci. | pmid:7738105 |
Massey LK et al. | Branched-chain amino acid catabolism in bacteria. | 1976 | Bacteriol Rev | pmid:773366 |
Ishikawa S et al. | Simvastatin inhibits the cellular signaling and proliferative action of arginine vasopressin in cultured rat glomerular mesangial cells. | 1995 | Endocrinology | pmid:7720643 |
Cummings MH et al. | Increased hepatic secretion of very-low-density lipoprotein apolipoprotein B-100 in obesity: a stable isotope study. | 1995 | Clin. Sci. | pmid:7720348 |
Cuthbert JA and Lipsky PE | Suppression of the proliferation of Ras-transformed cells by fluoromevalonate, an inhibitor of mevalonate metabolism. | 1995 | Cancer Res. | pmid:7712482 |
Lala A et al. | The effects of insulin on plasma mevalonate concentrations in man. | 1994 | Ann. Nutr. Metab. | pmid:7710260 |
pmid:7672316 | ||||
Bernini F et al. | HMG-CoA reductase inhibitors reduce acetyl LDL endocytosis in mouse peritoneal macrophages. | 1995 | Arterioscler. Thromb. Vasc. Biol. | pmid:7670949 |
Doerner KC et al. | Regulation of cholesterol 7 alpha-hydroxylase expression by sterols in primary rat hepatocyte cultures. | 1995 | J. Lipid Res. | pmid:7665995 |
Inglese J | Prenylation-dependent targeting of G-protein-coupled receptor kinases. | 1995 | Meth. Enzymol. | pmid:7651147 |
pmid:7651146 | ||||
Cox AD | Mutation and analysis of prenylation signal sequences. | 1995 | Meth. Enzymol. | pmid:7651143 |
Burton PM et al. | Azalanstat (RS-21607), a lanosterol 14 alpha-demethylase inhibitor with cholesterol-lowering activity. | 1995 | Biochem. Pharmacol. | pmid:7646560 |
Crick DC et al. | Selective inhibition of cholesterol biosynthesis in brain cells by squalestatin 1. | 1995 | J. Neurochem. | pmid:7643114 |
Meigs TE et al. | Farnesyl acetate, a derivative of an isoprenoid of the mevalonate pathway, inhibits DNA replication in hamster and human cells. | 1995 | Exp. Cell Res. | pmid:7641798 |
Watts GF et al. | Direct correlation between cholesterol synthesis and hepatic secretion of apolipoprotein B-100 in normolipidemic subjects. | 1995 | Metab. Clin. Exp. | pmid:7637647 |
Schroeder WA and Johnson EA | Singlet oxygen and peroxyl radicals regulate carotenoid biosynthesis in Phaffia rhodozyma. | 1995 | J. Biol. Chem. | pmid:7629161 |
Kwiterovich PO and Motevalli M | Inhibition of protein tyrosine kinase alters the effect of serum basic protein I on triacylglycerols and cholesterol differently in normal and hyperapoB fibroblasts. | 1995 | Arterioscler. Thromb. Vasc. Biol. | pmid:7627714 |
Wiley MH et al. | Sex differences in the sterol and nonsterol metabolism of mevalonate. | 1979 | J. Biol. Chem. | pmid:762097 |
Schedin S et al. | Changes in the levels of dolichol and dolichyl phosphate in a murine model of Niemann-Pick's type C disease. | 1995 | J. Neurochem. | pmid:7616223 |
Roullet JB et al. | Mevalonate availability affects human and rat resistance vessel function. | 1995 | J. Clin. Invest. | pmid:7615793 |
Dalton MB et al. | The farnesyl protein transferase inhibitor BZA-5B blocks farnesylation of nuclear lamins and p21ras but does not affect their function or localization. | 1995 | Cancer Res. | pmid:7614464 |
Corsini A et al. | Pathogenesis of atherosclerosis and the role of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. | 1995 | Am. J. Cardiol. | pmid:7604791 |
Rogler G et al. | Effects of fluvastatin on growth of porcine and human vascular smooth muscle cells in vitro. | 1995 | Am. J. Cardiol. | pmid:7604784 |
Ranganathan G and Mukkada AJ | Ubiquinone biosynthesis in Leishmania major promastigotes. | 1995 | Int. J. Parasitol. | pmid:7601585 |
pmid:7589240 | ||||
Gayen AK and Peffley DM | The length of 5'-untranslated leader sequences influences distribution of 3-hydroxy-3-methylglutaryl-coenzyme A reductase mRNA in polysomes: effects of lovastatin, oxysterols, and mevalonate. | 1995 | Arch. Biochem. Biophys. | pmid:7574724 |
Lin Y et al. | Differences in propionate-induced inhibition of cholesterol and triacylglycerol synthesis between human and rat hepatocytes in primary culture. | 1995 | Br. J. Nutr. | pmid:7547837 |
Hokland BM et al. | Cyclic AMP stimulates efflux of intracellular sterol from cholesterol-loaded cells. | 1993 | J. Biol. Chem. | pmid:7503979 |
Latruffe N et al. | Stimulation of protein kinase C activity by compactin in vascular smooth muscle cells. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7503722 |
Yu SG et al. | Geraniol, an inhibitor of mevalonate biosynthesis, suppresses the growth of hepatomas and melanomas transplanted to rats and mice. | 1995 | J. Nutr. | pmid:7472655 |
Drevon CA et al. | Secretion of very low density lipoproteins enriched in cholesteryl esters by cultured rat hepatocytes during simulation of intracellular cholesterol esterification. | 1980 | J. Lipid Res. | pmid:7462802 |
Duncan JL and Buckingham L | Resistance to streptolysin O in mammalian cells treated with oxygenated derivatives of cholesterol. Cholesterol content of resistant cells and recovery of streptolysin O sensitivity. | 1980 | Biochim. Biophys. Acta | pmid:7459354 |
Hoffman PC et al. | Effect of oxygenated sterol compounds on human bone marrow granulocytic progenitor cells. | 1981 | Blood | pmid:7448408 |
Subbiah MT | Incorporation of 14C-mevalonate into biliary cholesterol and bile acids by perfused rat liver: effect of plasma and individual lipoproteins. | 1980 | Steroids | pmid:7444999 |
Erickson SK et al. | Rat liver acyl-coenzyme A:cholesterol acyltransferase: its regulation in vivo and some of its properties in vitro. | 1980 | J. Lipid Res. | pmid:7441061 |
George R and Goldfarb S | Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in Morris hepatoma 7800 after intravenous injection of mevalonic acid. | 1980 | Cancer Res. | pmid:7438103 |
Ciavatti M et al. | Biosynthesis of cholesterol and cholesterol precursors in platelets of female rats treated with oral contraceptives. | 1980 | Biochim. Biophys. Acta | pmid:7437455 |
Kritchevsky D et al. | Cholesterol synthesis in tissues of young and old Fisher 344 and Sprague-Dawley rats. | 1980 | Exp. Gerontol. | pmid:7428858 |
Feingold KR et al. | Influence of thyroid hormone status on mevalonate metabolism in rats. | 1980 | J. Clin. Invest. | pmid:7419712 |
Erickson SK et al. | Studies on the mechanisms of the rapid modulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in intact liver by mevalonolactone and 25-hydroxycholesterol. | 1980 | Biochim. Biophys. Acta | pmid:7417482 |
Turner JA and Prebble JN | Protection of cell viability and respiratory quinone levels by carotenoid in Micrococcus lysodeikticus (M. luteus). | 1980 | J. Gen. Microbiol. | pmid:7411117 |
Curtiss LK and Edgington TS | Differences in the characteristics of inhibition of lymphocyte stimulation by 25-hydroxycholesterol and by the immunoregulatory serum lipoprotein LDL-In. | 1980 | J. Immunol. | pmid:7410845 |
Drevon CA et al. | Regulation of cholesterol esterification and biosynthesis in monolayer cultures of normal adult rat hepatocytes. | 1980 | J. Biol. Chem. | pmid:7410416 |
Hidaka K et al. | Growth of amphotericin B-resistant hamster cell line requires exogenous cholesterol. | 1980 | Exp. Cell Res. | pmid:7408982 |
Swift IE and Milborrow BV | Retention of the 4-pro-R hydrogen atom of mevalonate at C-2,2' of bacterioruberin in Halobacterium halobium. | 1980 | Biochem. J. | pmid:7406867 |
Feingold KR et al. | Sex difference in human mevalonate metabolism. | 1980 | J. Clin. Invest. | pmid:7400320 |
Hughes PE and Tove SB | Synthesis of alpha-tocopherolquinone by the rat and its reduction by mitochondria. | 1980 | J. Biol. Chem. | pmid:7391070 |
Faust JR et al. | Synthesis of delta 2-isopentenyl tRNA from mevalonate in cultured human fibroblasts. | 1980 | J. Biol. Chem. | pmid:7391033 |
Elliott JG and Lachance PA | Effects of vitamin A and ascorbic acid on in vitro cholesterol biosynthesis in the rat. | 1980 | J. Nutr. | pmid:7381607 |
Shechter I et al. | A deficiency of mixed function oxidase activities in the cholesterol biosynthetic pathway of human granulocytes. | 1980 | J. Lipid Res. | pmid:7381322 |
Nambudiri AM et al. | The role of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in the regulation of ubiquinone synthesis in human fibroblasts. | 1980 | J. Biol. Chem. | pmid:7380842 |
Shao MJ and Lei KY | Conversion of [2-14C] mevalonate into cholesterol, lanosterol and squalene in copper-deficient rats. | 1980 | J. Nutr. | pmid:7373433 |
Raulston DL et al. | Cycloheximide inhibits sterol biosynthesis in cell-free preparations of rat liver. | 1980 | J. Biol. Chem. | pmid:7372603 |
pmid:7371916 | ||||
Yachnin S and Hsu R | Inhibition of human lymphocyte transformation by oxygenated sterol compounds. | 1980 | Cell. Immunol. | pmid:7363333 |
Hanson RF et al. | Stereochemistry of the side chain oxidation of 5 beta-cholestane-3 alpha,7 alpha,12 alpha-triol in man. | 1980 | J. Biol. Chem. | pmid:7354041 |
James MJ and Kandutsch AA | Elevated dolichol synthesis in mouse testes during spermatogenesis. | 1980 | J. Biol. Chem. | pmid:7350150 |
Swift IE and Milborrow BV | Stereochemistry of allene biosynthesis and the formation of the acetylenic carotenoid diadinoxanthin and peridinin (C37) from neoxanthin. | 1981 | Biochem. J. | pmid:7337715 |
Feingold KR et al. | The effect of decreased plasma cholesterol concentration on circulatinga mevalonate metabolism in rats. | 1981 | J. Lipid Res. | pmid:7276756 |
Douglass TS et al. | The biosynthesis, absorption, and origin of cholesterol and plant sterols in the Florida land crab. | 1981 | J. Lipid Res. | pmid:7276755 |