Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Biliary Fistula D001658 13 associated lipids
Body Weight D001835 333 associated lipids
Celiac Disease D002446 16 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Glioblastoma D005909 27 associated lipids
Glioma D005910 112 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Hypertension D006973 115 associated lipids
Hypothyroidism D007037 32 associated lipids
Leukemia D007938 74 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Peutz-Jeghers Syndrome D010580 2 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Refsum Disease D012035 19 associated lipids
Thrombosis D013927 49 associated lipids
Xanthomatosis D014973 17 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

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Per page 10 20 50 100 | Total 2899
Authors Title Published Journal PubMed Link
Chang JJ et al. The in vitro inhibitory effect of tannin derivatives on 3-hydroxy-3-methylglutaryl-coenzyme a reductase on vero cells. 2001 Pharmacology pmid:11359999
pmid:11371670
Stalker TJ et al. A new HMG-CoA reductase inhibitor, rosuvastatin, exerts anti-inflammatory effects on the microvascular endothelium: the role of mevalonic acid. 2001 Br. J. Pharmacol. pmid:11375257
Raicht RF et al. Sterol balance studies in the rat. Effects of dietary cholesterol and beta-sitosterol on sterol balance and rate-limiting enzymes of sterol metabolism. 1975 Biochim. Biophys. Acta pmid:1137717
pmid:11379812
Scoppola A et al. Urinary mevalonate excretion rate in type 2 diabetes: role of metabolic control. 2001 Atherosclerosis pmid:11395032
pmid:11397393
Yasunari K et al. HMG-CoA reductase inhibitors prevent migration of human coronary smooth muscle cells through suppression of increase in oxidative stress. 2001 Arterioscler. Thromb. Vasc. Biol. pmid:11397700
Wong B et al. Statins suppress THP-1 cell migration and secretion of matrix metalloproteinase 9 by inhibiting geranylgeranylation. 2001 J. Leukoc. Biol. pmid:11404382
Shukolyukov SA and Saakov VS American cockroach (Periplaneta americana) synthesizes carotenoids from the precursor. 2001 Biochemistry Mosc. pmid:11405890
pmid:11408165
Altincicek B et al. LytB, a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli. 2001 FEBS Lett. pmid:11418107
McCarty MF Current prospects for controlling cancer growth with non-cytotoxic agents--nutrients, phytochemicals, herbal extracts, and available drugs. 2001 Med. Hypotheses pmid:11425277
pmid:11427897
Fujita T et al. Incadronate and etidronate accelerate phosphate-primed mineralization of MC4 cells via ERK1/2-Cbfa1 signaling pathway in a Ras-independent manner: further involvement of mevalonate-pathway blockade for incadronate. 2001 Jpn. J. Pharmacol. pmid:11430477
Karunagoda RP et al. Labeling patterns of chloroplastidic isoprenoids in cultured cells of liverwort Ptychanthus striatus. 2001 Biosci. Biotechnol. Biochem. pmid:11440120
Frenkel J et al. Increased urinary leukotriene E(4) during febrile attacks in the hyperimmunoglobulinaemia D and periodic fever syndrome. 2001 Arch. Dis. Child. pmid:11466192
Zeidler J and Lichtenthaler HK Biosynthesis of 2-methyl-3-buten-2-ol emitted from needles of Pinus ponderosa via the non-mevalonate DOXP/MEP pathway of isoprenoid formation. 2001 Planta pmid:11469599
Martínez-Botas J et al. Dose-dependent effects of lovastatin on cell cycle progression. Distinct requirement of cholesterol and non-sterol mevalonate derivatives. 2001 Biochim. Biophys. Acta pmid:11470239
Smith AG and Goad LJ Sterol biosynthesis in the echinoderm Asterias rubens. 1975 Biochem. J. pmid:1147897
Blomquist GJ et al. Biosynthesis of 3-methylpentacosane in the cockroach Periplaneta americana. 1975 Biochem. Biophys. Res. Commun. pmid:1147933
Swell L et al. Rapid feedback inhibition of endogenous cholic and chenodeoxycholic acid synthesis by exogenous chenodeoxycholic acid in man. 1975 Biochem. Biophys. Res. Commun. pmid:1147960
pmid:11486909
pmid:11486910
Eberlein M et al. Rho-dependent inhibition of the induction of connective tissue growth factor (CTGF) by HMG CoA reductase inhibitors (statins). 2001 Br. J. Pharmacol. pmid:11487529
Diomede L et al. In vivo anti-inflammatory effect of statins is mediated by nonsterol mevalonate products. 2001 Arterioscler. Thromb. Vasc. Biol. pmid:11498461
pmid:11500171
Hamano Y et al. Cloning of a gene cluster encoding enzymes responsible for the mevalonate pathway from a terpenoid-antibiotic-producing Streptomyces strain. 2001 Biosci. Biotechnol. Biochem. pmid:11515548
pmid:11517351
pmid:11518463
Haas D et al. Inherited disorders of cholesterol biosynthesis. 2001 Neuropediatrics pmid:11521206
Lange BM et al. Isoprenoid biosynthesis. Metabolite profiling of peppermint oil gland secretory cells and application to herbicide target analysis. 2001 Plant Physiol. pmid:11553758
Ranganathan S and Ramasarma T The regulation of the biosynthesis of ubiquinone in the rat. 1975 Biochem. J. pmid:1156398
Dairi T et al. Eubacterial diterpene cyclase genes essential for production of the isoprenoid antibiotic terpentecin. 2001 J. Bacteriol. pmid:11567009
Rao AV and Ramakrishnan S Indirect assessment of hydroxymethylglutaryl-CoA reductase (NADPH) activity in liver tissue. 1975 Clin. Chem. pmid:1157326
Rohdich F et al. The non-mevalonate pathway of isoprenoids: genes, enzymes and intermediates. 2001 Curr Opin Chem Biol pmid:11578926
Degraeve F et al. Modulation of COX-2 expression by statins in human aortic smooth muscle cells. Involvement of geranylgeranylated proteins. 2001 J. Biol. Chem. pmid:11591701
Nwokoro NA et al. Genetic disorders of cholesterol biosynthesis in mice and humans. 2001 Sep-Oct Mol. Genet. Metab. pmid:11592808
Suri S et al. Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells in vitro by inhibiting the mevalonate pathway: a model of bisphosphonate-induced gastrointestinal toxicity. 2001 Bone pmid:11595616
Bede JC et al. Biosynthetic pathway of insect juvenile hormone III in cell suspension cultures of the sedge Cyperus iria. 2001 Plant Physiol. pmid:11598232
Gan X et al. Dual mechanisms of ABCA1 regulation by geranylgeranyl pyrophosphate. 2001 J. Biol. Chem. pmid:11641412
Granzow C et al. Synthesis of lipids, cholesterol precursors and cholesterol in glycogen-free and glycogen-synthesizing sublines of the Ehrlich ascites tumor. 1975 Biochem. Biophys. Res. Commun. pmid:1164435
Jones JP et al. The biosynthesis of cholesterol and other sterols by brain tissue: distribution in subcellular fractions as a function of time after injection of (2-14C) mevalonic acid, sodium (2-14C)acetate and (U-14C) glucose into 15-day old rats. 1975 J. Neurochem. pmid:1167373
Hjertman M et al. Characterization of hydrophobic prenyl groups of isoprenylated proteins in human cancer cells. 2001 Biochem. Biophys. Res. Commun. pmid:11676505
Chamberlain LH Inhibition of isoprenoid biosynthesis causes insulin resistance in 3T3-L1 adipocytes. 2001 FEBS Lett. pmid:11696371
Rasmussen LM et al. Diverse effects of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase on the expression of VCAM-1 and E-selectin in endothelial cells. 2001 Biochem. J. pmid:11716764
pmid:11728917
pmid:11730868
Fellermeier M et al. Studies on the nonmevalonate pathway of terpene biosynthesis. The role of 2C-methyl-D-erythritol 2,4-cyclodiphosphate in plants. 2001 Eur. J. Biochem. pmid:11733027
Ichiki T et al. Downregulation of angiotensin II type 1 receptor by hydrophobic 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in vascular smooth muscle cells. 2001 Arterioscler. Thromb. Vasc. Biol. pmid:11742861