Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Biliary Fistula D001658 13 associated lipids
Body Weight D001835 333 associated lipids
Celiac Disease D002446 16 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Glioblastoma D005909 27 associated lipids
Glioma D005910 112 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Hypertension D006973 115 associated lipids
Hypothyroidism D007037 32 associated lipids
Leukemia D007938 74 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Peutz-Jeghers Syndrome D010580 2 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Refsum Disease D012035 19 associated lipids
Thrombosis D013927 49 associated lipids
Xanthomatosis D014973 17 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

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Per page 10 20 50 100 | Total 2899
Authors Title Published Journal PubMed Link
Nishimura M et al. Collagen secretion and growth of mesangial cells require geranylgeranylpyrophosphate. 1999 Kidney Int. pmid:9987076
pmid:9920100
pmid:990276
pmid:9882513
Fisher JE et al. Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:9874784
pmid:9872842
Petras SF et al. HMG-CoA reductase regulation: use of structurally diverse first half-reaction squalene synthetase inhibitors to characterize the site of mevalonate-derived nonsterol regulator production in cultured IM-9 cells. 1999 J. Lipid Res. pmid:9869647
Holleran AL et al. Effect of tamoxifen on cholesterol synthesis in HepG2 cells and cultured rat hepatocytes. 1998 Metab. Clin. Exp. pmid:9867082
Melichar B et al. Growth inhibitory effects of aromatic fatty acids on ovarian tumor cell lines. 1998 Clin. Cancer Res. pmid:9865922
Wellburn AR and Hampp R Uptake of mevalonate and acetate during plastid development. 1976 Biochem. J. pmid:985424
Shipman CM et al. The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway. 1998 Cancer Res. pmid:9850051
Disch A and Rohmer M On the absence of the glyceraldehyde 3-phosphate/pyruvate pathway for isoprenoid biosynthesis in fungi and yeasts. 1998 FEMS Microbiol. Lett. pmid:9835029
Lamb DC et al. A sterol biosynthetic pathway in Mycobacterium. 1998 FEBS Lett. pmid:9804188
Schedin S et al. Alterations in the biosynthesis of cholesterol, dolichol and dolichyl-P in the genetic cholesterol homeostasis disorder, Niemann-Pick type C disease. 1998 Biochim. Biophys. Acta pmid:9795206
Naoumova RP et al. Cholesterol synthesis is increased in mixed hyperlipidaemia. 1998 Biochim. Biophys. Acta pmid:9795192
Michikawa M and Yanagisawa K Apolipoprotein E4 induces neuronal cell death under conditions of suppressed de novo cholesterol synthesis. 1998 J. Neurosci. Res. pmid:9778150
Ogura M et al. Further studies on the possible compartmentation of the precursor pool of cholesterol for the biosynthesis of cholic acid in the rat. 1976 J. Biochem. pmid:977552
Coxon FP et al. Protein synthesis is required for caspase activation and induction of apoptosis by bisphosphonate drugs. 1998 Mol. Pharmacol. pmid:9765505
Hiramatsu M et al. Enzyme immunoassay of urinary mevalonic acid and its clinical application. 1998 Clin. Chem. pmid:9761249
Aboushadi N and Krisans SK Analysis of isoprenoid biosynthesis in peroxisomal-deficient Pex2 CHO cell lines. 1998 J. Lipid Res. pmid:9741690
Takeuchi N et al. Feed-back control of cholesterol synthesis in partially hepatectomized rats. 1976 Biochim. Biophys. Acta pmid:974156
Harrison LE et al. Phenylacetate inhibits isoprenoid biosynthesis and suppresses growth of human pancreatic carcinoma. 1998 Surgery pmid:9736908
Guijarro C et al. 3-Hydroxy-3-methylglutaryl coenzyme a reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture. 1998 Circ. Res. pmid:9734471
Orihara N et al. Studies on the biosynthesis of terpenoid compounds produced by actinomycetes. 3. Biosynthesis of the isoprenoid side chain of novobiocin via the non-mevalonate pathway in Streptomyces niveus. 1998 J. Antibiot. pmid:9727394
Laufs U and Liao JK Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase. 1998 J. Biol. Chem. pmid:9727051
Hinson DD et al. Hematological abnormalities and cholestatic liver disease in two patients with mevalonate kinase deficiency. 1998 Am. J. Med. Genet. pmid:9714005
Takahashi S et al. A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9707569
pmid:9703948
Pfohl M et al. Use of cholesterol precursors to assess changes in cholesterol synthesis under non-steady-state conditions. 1998 Eur. J. Clin. Invest. pmid:9693942
Kitahara M et al. NK-104, a newly developed HMG-CoA reductase inhibitor, suppresses neointimal thickening by inhibiting smooth muscle cell growth and fibronectin production in balloon-injured rabbit carotid artery. 1998 Jpn. J. Pharmacol. pmid:9681568
Yan D et al. Biochemical characterization and subcellular localization of the mouse retinitis pigmentosa GTPase regulator (mRpgr). 1998 J. Biol. Chem. pmid:9677393
Kashiwagi Y et al. Mechanical stretch activates a pathway linked to mevalonate metabolism in cultured neonatal rat heart cells. 1998 Hypertens. Res. pmid:9661807
Rieder C et al. Biosynthesis of the diterpene verrucosan-2beta-ol in the phototrophic eubacterium Chloroflexus aurantiacus. A retrobiosynthetic NMR study. 1998 J. Biol. Chem. pmid:9660767
Disch A et al. Distribution of the mevalonate and glyceraldehyde phosphate/pyruvate pathways for isoprenoid biosynthesis in unicellular algae and the cyanobacterium Synechocystis PCC 6714. 1998 Biochem. J. pmid:9657979
Nishio E et al. Alpha1-adrenoreceptor stimulation causes vascular smooth muscle cell hypertrophy: a possible role for isoprenoid intermediates. 1998 Eur. J. Pharmacol. pmid:9650858
Vaidya S et al. Massive production of farnesol-derived dicarboxylic acids in mice treated with the squalene synthase inhibitor zaragozic acid A. 1998 Arch. Biochem. Biophys. pmid:9647670
Ramaswamy NK et al. A novel pathway for the synthesis of solanidine in the isolated chloroplast from greening potatoes. 1976 Eur. J. Biochem. pmid:964241
Adam KP et al. Involvement of the mevalonic acid pathway and the glyceraldehyde-pyruvate pathway in terpenoid biosynthesis of the liverworts Ricciocarpos natans and Conocephalum conicum. 1998 Arch. Biochem. Biophys. pmid:9633614
Aspbury RA et al. Isoprenylation of polypeptides in the nematode Caenorhabditis elegans. 1998 Biochim. Biophys. Acta pmid:9630668
Mitropoulos KA and Gibbons GF Effect of triarimol on cholesterol biosynthesis in rat-liver subcellular. 1976 Biochem. Biophys. Res. Commun. pmid:962959
Melnykovych G et al. Inhibition of cholesterol biosynthesis in HeLa cells by glucocorticoids. 1976 Biochem. Biophys. Res. Commun. pmid:962938
Crick DC et al. Geranylgeraniol overcomes the block of cell proliferation by lovastatin in C6 glioma cells. 1998 J. Neurochem. pmid:9603204
Rubins JB et al. Lovastatin induces apoptosis in malignant mesothelioma cells. 1998 Am. J. Respir. Crit. Care Med. pmid:9603146
Singh I et al. Lovastatin and sodium phenylacetate normalize the levels of very long chain fatty acids in skin fibroblasts of X- adrenoleukodystrophy. 1998 FEBS Lett. pmid:9600263
Orihara N et al. Studies on the biosynthesis of terpenoidal compounds produced by actinomycetes. 2. Biosynthesis of carquinostatin B via the non-mevalonate pathway in Streptomyces exfoliatus. 1997 J. Antibiot. pmid:9592576
Visioli F et al. Ethanol enhances cholesterol synthesis and secretion in human hepatomal cells. 1998 Alcohol pmid:9590514
Coutant KD et al. Fluvastatin enhances receptor-stimulated intracellular Ca2+ release in human keratinocytes. 1998 Biochem. Biophys. Res. Commun. pmid:9571146
Kaur M et al. Receptor-Ck-dependent regulation of genes involved in the cell cycle. 1998 Mol. Cell. Biochem. pmid:9562250
Luckman SP et al. Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. 1998 J. Bone Miner. Res. pmid:9556058
Gopalaswamy UV and Aiyar AS Actinomycin D-induced enhancement of ubiquinone biosynthesis in rat. 1976 Chem. Biol. Interact. pmid:954142