Mevalonic acid is a lipid of Fatty Acyls (FA) class.
We collected disease MeSH terms mapped to the references associated with Mevalonic acid
Authors | Title | Published | Journal | PubMed Link |
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Loregger A et al. | Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis. | 2017 | Arterioscler. Thromb. Vasc. Biol. | pmid:28882874 |
Yamashita Y et al. | A 6-year-old girl diagnosed with mevalonate kinase deficiency who had hydrops fetalis and neonatal-onset cholestasis. | 2017 | Nihon Rinsho Meneki Gakkai Kaishi | pmid:28603204 |
Ye L et al. | Type IIs restriction based combinatory modulation technique for metabolic pathway optimization. | 2017 | Microb. Cell Fact. | pmid:28302121 |
Agabiti SS et al. | Geranylgeranyl diphosphate synthase inhibition induces apoptosis that is dependent upon GGPP depletion, ERK phosphorylation and caspase activation. | 2017 | Cell Death Dis | pmid:28300835 |
Kuzuyama T | Biosynthetic studies on terpenoids produced by Streptomyces. | 2017 | J. Antibiot. | pmid:28196976 |
Cheng T et al. | Enzymatic process optimization for the in vitro production of isoprene from mevalonate. | 2017 | Microb. Cell Fact. | pmid:28068985 |
Chen Q et al. | Molecular Cloning, Characterization, and Functional Analysis of Acetyl-CoA C-Acetyltransferase and Mevalonate Kinase Genes Involved in Terpene Trilactone Biosynthesis from Ginkgo biloba. | 2017 | Molecules | pmid:28045448 |
Kosek V et al. | High resolution mass spectrometry based method applicable for a wide range of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors in blood serum including intermediates and products of the cholesterol biosynthetic pathway. | 2017 | J Chromatogr A | pmid:28209347 |
Ding Y et al. | Gamma-tocotrienol reverses multidrug resistance of breast cancer cells with a mechanism distinct from that of atorvastatin. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27864002 |
Moutinho M et al. | The mevalonate pathway in neurons: It's not just about cholesterol. | 2017 | Exp. Cell Res. | pmid:28232115 |
Tricarico PM et al. | 25-Hydroxycholesterol and inflammation in Lovastatin-deregulated mevalonate pathway. | 2017 | Int. J. Biochem. Cell Biol. | pmid:28918367 |
Montero-Villegas S et al. | Inhibition of Mevalonate Pathway and Synthesis of the Storage Lipids in Human Liver-Derived and Non-liver Cell Lines by Lippia alba Essential Oils. | 2017 | Lipids | pmid:27905068 |
Feitosa AO et al. | Lethality of cytochalasin B and other compounds isolated from fungus Aspergillus sp. (Trichocomaceae) endophyte of Bauhinia guianensis (Fabaceae). | 2016 Jul - Sep | Rev. Argent. Microbiol. | pmid:27567521 |
Fessler MB | The Intracellular Cholesterol Landscape: Dynamic Integrator of the Immune Response. | 2016 | Trends Immunol. | pmid:27692616 |
Kim JH et al. | Isoprene production by Escherichia coli through the exogenous mevalonate pathway with reduced formation of fermentation byproducts. | 2016 | Microb. Cell Fact. | pmid:28010736 |
Senkowski W et al. | Large-Scale Gene Expression Profiling Platform for Identification of Context-Dependent Drug Responses in Multicellular Tumor Spheroids. | 2016 | Cell Chem Biol | pmid:27984028 |
Ye L et al. | Combinatory optimization of chromosomal integrated mevalonate pathway for β-carotene production in Escherichia coli. | 2016 | Microb. Cell Fact. | pmid:27905930 |
Goldman AR et al. | The Primary Effect on the Proteome of ARID1A-mutated Ovarian Clear Cell Carcinoma is Downregulation of the Mevalonate Pathway at the Post-transcriptional Level. | 2016 | Mol. Cell Proteomics | pmid:27654507 |
Wang J et al. | Engineering of a Highly Efficient Escherichia coli Strain for Mevalonate Fermentation through Chromosomal Integration. | 2016 | Appl. Environ. Microbiol. | pmid:27736790 |
Parrales A et al. | DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway. | 2016 | Nat. Cell Biol. | pmid:27775703 |
Ruiz-Sola MÃ et al. | A Single Arabidopsis Gene Encodes Two Differentially Targeted Geranylgeranyl Diphosphate Synthase Isoforms. | 2016 | Plant Physiol. | pmid:27707890 |
Miettinen TP and Björklund M | Cellular Allometry of Mitochondrial Functionality Establishes the Optimal Cell Size. | 2016 | Dev. Cell | pmid:27720611 |
Yamamoto K et al. | Enhancement of astaxanthin production in Xanthophyllomyces dendrorhous by efficient method for the complete deletion of genes. | 2016 | Microb. Cell Fact. | pmid:27624332 |
Nerdal PT et al. | Butyrophilin 3A/CD277-Dependent Activation of Human γδ T Cells: Accessory Cell Capacity of Distinct Leukocyte Populations. | 2016 | J. Immunol. | pmid:27619996 |
Terabe K et al. | Simvastatin inhibits CD44 fragmentation in chondrocytes. | 2016 | Arch. Biochem. Biophys. | pmid:27242325 |
Agabiti SS et al. | Molecular mechanisms linking geranylgeranyl diphosphate synthase to cell survival and proliferation. | 2016 | Mol. Membr. Biol. | pmid:27537059 |
Rizvi F et al. | Chamber-specific differences in human cardiac fibroblast proliferation and responsiveness toward simvastatin. | 2016 | Am. J. Physiol., Cell Physiol. | pmid:27335167 |
Elsayed M et al. | Synergistic Antiproliferative Effects of Zoledronic Acid and Fluvastatin on Human Pancreatic Cancer Cell Lines: An in Vitro Study. | 2016 | Biol. Pharm. Bull. | pmid:27181081 |
Silva Ramos E et al. | Bioenergetic roles of mitochondrial fusion. | 2016 | Biochim. Biophys. Acta | pmid:27060252 |
Leitmeyer K et al. | Simvastatin Results in a Dose-Dependent Toxic Effect on Spiral Ganglion Neurons in an In Vitro Organotypic Culture Assay. | 2016 | Biomed Res Int | pmid:27051663 |
Hashimoto A et al. | P53- and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance. | 2016 | J. Cell Biol. | pmid:27044891 |
Cheng S et al. | Cloning, Expression Profiling and Functional Analysis of CnHMGS, a Gene Encoding 3-hydroxy-3-Methylglutaryl Coenzyme A Synthase from Chamaemelum nobile. | 2016 | Molecules | pmid:27005600 |
Okin D and Medzhitov R | The Effect of Sustained Inflammation on Hepatic Mevalonate Pathway Results in Hyperglycemia. | 2016 | Cell | pmid:26997483 |
Salunkhe VA et al. | Rosuvastatin Treatment Affects Both Basal and Glucose-Induced Insulin Secretion in INS-1 832/13 Cells. | 2016 | PLoS ONE | pmid:26986474 |
Marcuzzi A et al. | Geranylgeraniol and Neurological Impairment: Involvement of Apoptosis and Mitochondrial Morphology. | 2016 | Int J Mol Sci | pmid:26978350 |
Matsumoto Y et al. | A critical role of mevalonate for peptidoglycan synthesis in Staphylococcus aureus. | 2016 | Sci Rep | pmid:26961421 |
Zhu J et al. | Mevalonate-Farnesal Biosynthesis in Ticks: Comparative Synganglion Transcriptomics and a New Perspective. | 2016 | PLoS ONE | pmid:26959814 |
Pina ES et al. | Mevalonate-derived quinonemethide triterpenoid from in vitro roots of Peritassa laevigata and their localization in root tissue by MALDI imaging. | 2016 | Sci Rep | pmid:26943243 |
Rodriguez S et al. | ATP citrate lyase mediated cytosolic acetyl-CoA biosynthesis increases mevalonate production in Saccharomyces cerevisiae. | 2016 | Microb. Cell Fact. | pmid:26939608 |
Ignea C et al. | Production of the forskolin precursor 11β-hydroxy-manoyl oxide in yeast using surrogate enzymatic activities. | 2016 | Microb. Cell Fact. | pmid:26920948 |
Cárdenas PD et al. | GAME9 regulates the biosynthesis of steroidal alkaloids and upstream isoprenoids in the plant mevalonate pathway. | 2016 | Nat Commun | pmid:26876023 |
Tianero MD et al. | Metabolic model for diversity-generating biosynthesis. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26831074 |
Daguzan C et al. | Aminobisphosphonates Synergize with Human Cytomegalovirus To Activate the Antiviral Activity of Vγ9Vδ2 Cells. | 2016 | J. Immunol. | pmid:26819204 |
Yang J et al. | A novel MVA-mediated pathway for isoprene production in engineered E. coli. | 2016 | BMC Biotechnol. | pmid:26786050 |
Yang L et al. | Combinatorial engineering of hybrid mevalonate pathways in Escherichia coli for protoilludene production. | 2016 | Microb. Cell Fact. | pmid:26785630 |
Kolawole EM et al. | Fluvastatin Suppresses Mast Cell and Basophil IgE Responses: Genotype-Dependent Effects. | 2016 | J. Immunol. | pmid:26773154 |
Huang Y et al. | De Novo Transcriptome and Expression Profile Analysis to Reveal Genes and Pathways Potentially Involved in Cantharidin Biosynthesis in the Blister Beetle Mylabris cichorii. | 2016 | PLoS ONE | pmid:26752526 |
Healey GD et al. | Mevalonate Biosynthesis Intermediates Are Key Regulators of Innate Immunity in Bovine Endometritis. | 2016 | J. Immunol. | pmid:26673142 |
Torabi S and Mo H | Trans, trans-farnesol as a mevalonate-derived inducer of murine 3T3-F442A pre-adipocyte differentiation. | 2016 | Exp. Biol. Med. (Maywood) | pmid:26660152 |
Jiang Z et al. | Engineering Triterpene and Methylated Triterpene Production in Plants Provides Biochemical and Physiological Insights into Terpene Metabolism. | 2016 | Plant Physiol. | pmid:26603654 |
Mertens J et al. | The bHLH Transcription Factors TSAR1 and TSAR2 Regulate Triterpene Saponin Biosynthesis in Medicago truncatula. | 2016 | Plant Physiol. | pmid:26589673 |
Garnett DJ | Caveolae as a target to quench autoinduction of the metastatic phenotype in lung cancer. | 2016 | J. Cancer Res. Clin. Oncol. | pmid:26573510 |
Wang T et al. | Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway. | 2016 | Oncotarget | pmid:26565813 |
Yildirim FI et al. | Aggravating effect of atorvastatin on indomethacin-induced gastric injury: Focus on PGE2, TNF-α, neutrophils and iNOS. | 2015 | Prostaglandins Other Lipid Mediat. | pmid:26201058 |
Surup F et al. | Deconins A-E: Cuparenic and Mevalonic or Propionic Acid Conjugates from the Basidiomycete Deconica sp. 471. | 2015 | J. Nat. Prod. | pmid:25871540 |
York AG et al. | Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling. | 2015 | Cell | pmid:26686653 |
Miettinen TP and Björklund M | Mevalonate Pathway Regulates Cell Size Homeostasis and Proteostasis through Autophagy. | 2015 | Cell Rep | pmid:26686643 |
Gallagher KA and Jensen PR | Genomic insights into the evolution of hybrid isoprenoid biosynthetic gene clusters in the MAR4 marine streptomycete clade. | 2015 | BMC Genomics | pmid:26578069 |
Nyati P et al. | Negative Feedbacks by Isoprenoids on a Mevalonate Kinase Expressed in the Corpora Allata of Mosquitoes. | 2015 | PLoS ONE | pmid:26566274 |
Chen Y et al. | Mevalonate inhibits acid sphingomyelinase activity, increases sphingomyelin levels and inhibits cell proliferation of HepG2 and Caco-2 cells. | 2015 | Lipids Health Dis | pmid:26493087 |
Laezza C et al. | p53 regulates the mevalonate pathway in human glioblastoma multiforme. | 2015 | Cell Death Dis | pmid:26469958 |
Rondini EA et al. | Transcriptional Regulation of Cytosolic Sulfotransferase 1C2 by Intermediates of the Cholesterol Biosynthetic Pathway in Primary Cultured Rat Hepatocytes. | 2015 | J. Pharmacol. Exp. Ther. | pmid:26427720 |
Guan Z et al. | Metabolic engineering of Bacillus subtilis for terpenoid production. | 2015 | Appl. Microbiol. Biotechnol. | pmid:26373726 |
Pandyra AA et al. | Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death. | 2015 | Oncotarget | pmid:26353928 |
Kuo KK et al. | Xanthine-based KMUP-1 improves HDL via PPARγ/SR-B1, LDL via LDLRs, and HSL via PKA/PKG for hepatic fat loss. | 2015 | J. Lipid Res. | pmid:26351364 |
Kain V et al. | Simvastatin may induce insulin resistance through a novel fatty acid mediated cholesterol independent mechanism. | 2015 | Sci Rep | pmid:26345110 |
Henry LK et al. | Orthologs of the archaeal isopentenyl phosphate kinase regulate terpenoid production in plants. | 2015 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26216978 |
Zhang Z et al. | Genomic variations of the mevalonate pathway in porokeratosis. | 2015 | Elife | pmid:26202976 |
Venkateshwaran M et al. | A role for the mevalonate pathway in early plant symbiotic signaling. | 2015 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26199419 |
Tricarico PM et al. | Mevalonate Pathway Blockade, Mitochondrial Dysfunction and Autophagy: A Possible Link. | 2015 | Int J Mol Sci | pmid:26184189 |
Kobayashi Y et al. | Mevalonate Pathway Antagonist Suppresses Formation of Serous Tubal Intraepithelial Carcinoma and Ovarian Carcinoma in Mouse Models. | 2015 | Clin. Cancer Res. | pmid:26109099 |
Tricarico PM et al. | Alendronate, a double-edged sword acting in the mevalonate pathway. | 2015 | Mol Med Rep | pmid:26096667 |
Hofberger JA et al. | Large-Scale Evolutionary Analysis of Genes and Supergene Clusters from Terpenoid Modular Pathways Provides Insights into Metabolic Diversification in Flowering Plants. | 2015 | PLoS ONE | pmid:26046541 |
Karlic H et al. | Inhibition of the mevalonate pathway affects epigenetic regulation in cancer cells. | 2015 | Cancer Genet | pmid:25978957 |
Zhou X et al. | Mitogen-activated protein kinase mediates mevalonate-stimulated human mesangial cell proliferation. | 2015 | Mol Med Rep | pmid:25936991 |
Du X et al. | Nitric Oxide Plays a Central Role in Water Stress-Induced Tanshinone Production in Salvia miltiorrhiza Hairy Roots. | 2015 | Molecules | pmid:25919278 |
Chen GP et al. | Alteration of mevalonate pathway in proliferated vascular smooth muscle from diabetic mice: possible role in high-glucose-induced atherogenic process. | 2015 | J Diabetes Res | pmid:25918730 |
Sharon C et al. | Inhibition of insulin-like growth factor receptor/AKT/mammalian target of rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate-isoprenoid pathway in vitro and in vivo. | 2015 | Oncotarget | pmid:25895029 |
Hwang HS et al. | Transcriptomic analysis of Siberian ginseng (Eleutherococcus senticosus) to discover genes involved in saponin biosynthesis. | 2015 | BMC Genomics | pmid:25888223 |
Hirota Y et al. | Functional characterization of the vitamin K2 biosynthetic enzyme UBIAD1. | 2015 | PLoS ONE | pmid:25874989 |
Autefage H et al. | Sparse feature selection methods identify unexpected global cellular response to strontium-containing materials. | 2015 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25831522 |
Wang WQ et al. | Proteomic analysis of lettuce seed germination and thermoinhibition by sampling of individual seeds at germination and removal of storage proteins by polyethylene glycol fractionation. | 2015 | Plant Physiol. | pmid:25736209 |
Sekiya A et al. | Fluvastatin Upregulates the Expression of Tissue Factor Pathway Inhibitor in Human Umbilical Vein Endothelial Cells. | 2015 | J. Atheroscler. Thromb. | pmid:25735397 |
Polotskaia A et al. | Proteome-wide analysis of mutant p53 targets in breast cancer identifies new levels of gain-of-function that influence PARP, PCNA, and MCM4. | 2015 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25733866 |
de Oliveira LS et al. | New Insights on the terpenome of the red seaweed Laurencia dendroidea (Florideophyceae, Rhodophyta). | 2015 | Mar Drugs | pmid:25675000 |
Rossoni L et al. | The Putative mevalonate diphosphate decarboxylase from Picrophilus torridus is in reality a mevalonate-3-kinase with high potential for bioproduction of isobutene. | 2015 | Appl. Environ. Microbiol. | pmid:25636853 |
Skaff DA et al. | Inhibition of bacterial mevalonate diphosphate decarboxylase by eriochrome compounds. | 2015 | Arch. Biochem. Biophys. | pmid:25499551 |
Kang S et al. | Synthesis of mevalonate- and fluorinated mevalonate prodrugs and their in vitro human plasma stability. | 2015 | Eur J Med Chem | pmid:25461893 |
Matsuo S et al. | Single-dose rosuvastatin ameliorates lung ischemia-reperfusion injury via upregulation of endothelial nitric oxide synthase and inhibition of macrophage infiltration in rats with pulmonary hypertension. | 2015 | J. Thorac. Cardiovasc. Surg. | pmid:25454916 |
Vinokur JM et al. | Structural analysis of mevalonate-3-kinase provides insight into the mechanisms of isoprenoid pathway decarboxylases. | 2015 | Protein Sci. | pmid:25422158 |
Greife A et al. | Establishment and characterization of a bladder cancer cell line with enhanced doxorubicin resistance by mevalonate pathway activation. | 2015 | Tumour Biol. | pmid:25566959 |
Capra V and Rovati GE | Rosuvastatin inhibits human airway smooth muscle cells mitogenic response to eicosanoid contractile agents. | 2014 | Pulm Pharmacol Ther | pmid:23806820 |
Bentinger M et al. | Effects of various squalene epoxides on coenzyme Q and cholesterol synthesis. | 2014 | Biochim. Biophys. Acta | pmid:24747199 |
Smith R et al. | Simvastatin inhibits glucose metabolism and legumain activity in human myotubes. | 2014 | PLoS ONE | pmid:24416446 |
Warita K et al. | Statin-induced mevalonate pathway inhibition attenuates the growth of mesenchymal-like cancer cells that lack functional E-cadherin mediated cell cohesion. | 2014 | Sci Rep | pmid:25534349 |
Yeganeh B et al. | Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease. | 2014 | Pharmacol. Ther. | pmid:24582968 |
Rojo-Arreola L et al. | Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis. | 2014 | PLoS ONE | pmid:24489942 |
Fu Z et al. | Exometabolome analysis reveals hypoxia at the up-scaling of a Saccharomyces cerevisiae high-cell density fed-batch biopharmaceutical process. | 2014 | Microb. Cell Fact. | pmid:24593159 |
Zelcer N et al. | The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway. | 2014 | Mol. Cell. Biol. | pmid:24449766 |
Rachner TD et al. | Dickkopf-1 is regulated by the mevalonate pathway in breast cancer. | 2014 | Breast Cancer Res. | pmid:24528599 |