Mevalonic acid is a lipid of Fatty Acyls (FA) class.
We collected disease MeSH terms mapped to the references associated with Mevalonic acid
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Bell FP | Biosynthesis of various sterols, sterol esters, and squalene from [14C]mevalonate by normal swine intima and media in vitro: a comparative study. | 1976 | Exp. Mol. Pathol. | pmid:1001402 |
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pmid:10216221 | ||||
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pmid:10333388 | ||||
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pmid:10369261 | ||||
Girgert R et al. | Growth inhibition of neuroblastoma cells by lovastatin and L-ascorbic acid is based on different mechanisms. | 1999 | Cancer Lett. | pmid:10374838 |
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Bifulco M et al. | Inhibition of farnesylation blocks growth but not differentiation in FRTL-5 thyroid cells. | 1999 | Biochimie | pmid:10401660 |
Rha SY et al. | Modulation of biological phenotypes for tumor growth and metastasis by target-specific biological inhibitors in gastric cancer. | 1999 | Int. J. Mol. Med. | pmid:10402490 |
pmid:10413074 | ||||
Laufs U et al. | 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1). | 1999 | J. Biol. Chem. | pmid:10419514 |
pmid:10423031 | ||||
Ghosh PM et al. | Role of RhoA activation in the growth and morphology of a murine prostate tumor cell line. | 1999 | Oncogene | pmid:10435593 |
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pmid:10460692 | ||||
Parmryd I et al. | Protein prenylation in spinach chloroplasts. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10468564 |
Appelkvist EL et al. | Synthesis of mevalonate pathway lipids in fibroblasts from Zellweger and X-linked ALD patients. | 1999 | Pediatr. Res. | pmid:10473053 |
Agarwal B et al. | Lovastatin augments apoptosis induced by chemotherapeutic agents in colon cancer cells. | 1999 | Clin. Cancer Res. | pmid:10473109 |
Jomaa H et al. | Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. | 1999 | Science | pmid:10477522 |
Koch T et al. | Differential induction of plant volatile biosynthesis in the lima bean by early and late intermediates of the octadecanoid-signaling pathway. | 1999 | Plant Physiol. | pmid:10482670 |
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pmid:10527548 | ||||
pmid:10527849 | ||||
Gardner RG and Hampton RY | A highly conserved signal controls degradation of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase in eukaryotes. | 1999 | J. Biol. Chem. | pmid:10531376 |
Giordano W et al. | Lovastatin inhibits the production of gibberellins but not sterol or carotenoid biosynthesis in Gibberella fujikuroi. | 1999 | Microbiology (Reading, Engl.) | pmid:10537222 |
Shack S et al. | Activation of the cholesterol pathway and Ras maturation in response to stress. | 1999 | Oncogene | pmid:10557091 |
Kaul D and Kaur M | Receptor-Ck regulates the expression of cyclin-dependent kinase inhibitors (p16; p27). | 1999 | Mol. Cell. Biochem. | pmid:10569199 |
Lange BM and Croteau R | Isopentenyl diphosphate biosynthesis via a mevalonate-independent pathway: isopentenyl monophosphate kinase catalyzes the terminal enzymatic step. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10570138 |
Reszka AA et al. | Bisphosphonates act directly on the osteoclast to induce caspase cleavage of mst1 kinase during apoptosis. A link between inhibition of the mevalonate pathway and regulation of an apoptosis-promoting kinase. | 1999 | J. Biol. Chem. | pmid:10574973 |
pmid:10591153 | ||||
Kim DY et al. | Expression and characterization of the HMG-CoA reductase of the thermophilic archaeon Sulfolobus solfataricus. | 1999 | Protein Expr. Purif. | pmid:10600463 |
Keller RK and Fliesler SJ | Mechanism of aminobisphosphonate action: characterization of alendronate inhibition of the isoprenoid pathway. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10600541 |
Liu GC et al. | Measurement of cholesterol synthesis in man by isotope kinetics of squalene. | 1975 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1060141 |
Elkin RG and Yan Z | Relationship between inhibition of mevalonate biosynthesis and reduced fertility in laying hens. | 1999 | J. Reprod. Fertil. | pmid:10615252 |
Kim SI et al. | Lovastatin inhibits transforming growth factor-beta1 expression in diabetic rat glomeruli and cultured rat mesangial cells. | 2000 | J. Am. Soc. Nephrol. | pmid:10616843 |
Bergstrom JD et al. | Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase. | 2000 | Arch. Biochem. Biophys. | pmid:10620343 |
Szkopińska A et al. | The regulation of activity of main mevalonic acid pathway enzymes: farnesyl diphosphate synthase, 3-hydroxy-3-methylglutaryl-CoA reductase, and squalene synthase in yeast Saccharomyces cerevisiae. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10623644 |
Aboushadi N et al. | Characterization of peroxisomal 3-hydroxy-3-methylglutaryl coenzyme A reductase in UT2 cells: sterol biosynthesis, phosphorylation, degradation, and statin inhibition. | 2000 | Biochemistry | pmid:10625499 |
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Lindenthal B and von Bergmann K | Urinary excretion and serum concentration of mevalonic acid during acute intake of alcohol. | 2000 | Metab. Clin. Exp. | pmid:10647065 |
Kuzuyama T et al. | Cloning and characterization of 1-deoxy-D-xylulose 5-phosphate synthase from Streptomyces sp. Strain CL190, which uses both the mevalonate and nonmevalonate pathways for isopentenyl diphosphate biosynthesis. | 2000 | J. Bacteriol. | pmid:10648511 |
Haratake A et al. | Topical mevalonic acid stimulates de novo cholesterol synthesis and epidermal permeability barrier homeostasis in aged mice. | 2000 | J. Invest. Dermatol. | pmid:10651982 |
Cvejić JH and Rohmer M | CO2 as main carbon source for isoprenoid biosynthesis via the mevalonate-independent methylerythritol 4-phosphate route in the marine diatoms Phaeodactylum tricornutum and Nitzschia ovalis. | 2000 | Phytochemistry | pmid:10656403 |
pmid:10665838 | ||||
Hanley K et al. | Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription. | 2000 | J. Invest. Dermatol. | pmid:10692116 |
Lambert M and Bui ND | Dexamethasone-induced decrease in HMG-CoA reductase and protein-farnesyl transferase activities does not impair ras processing in AR 4-2J cells. | 1999 | Mol. Cell. Biochem. | pmid:10706000 |
pmid:10728920 | ||||
Turunen M et al. | Influence of peroxisome proliferator-activated receptor alpha on ubiquinone biosynthesis. | 2000 | J. Mol. Biol. | pmid:10731415 |
Flach J et al. | The mevalonate/isoprenoid pathway inhibitor apomine (SR-45023A) is antiproliferative and induces apoptosis similar to farnesol. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10733934 |
Hashimoto F et al. | Changes in isoprenoid lipid synthesis by gemfibrozil and clofibric acid in rat hepatocytes. | 2000 | Biochem. Pharmacol. | pmid:10736420 |
Coppens I et al. | Toxoplasma gondii exploits host low-density lipoprotein receptor-mediated endocytosis for cholesterol acquisition. | 2000 | J. Cell Biol. | pmid:10747095 |
Tanaka T et al. | Geranylgeranyl-pyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition. | 2000 | J. Neurosci. | pmid:10751437 |
pmid:10774794 | ||||
Woo JT et al. | Compactin suppresses bone resorption by inhibiting the fusion of prefusion osteoclasts and disrupting the actin ring in osteoclasts. | 2000 | J. Bone Miner. Res. | pmid:10780857 |
Leonardsen L et al. | Effect of inhibition of sterol delta 14-reductase on accumulation of meiosis-activating sterol and meiotic resumption in cumulus-enclosed mouse oocytes in vitro. | 2000 | J. Reprod. Fertil. | pmid:10793639 |
Tasevski V et al. | Mitogenic effect of lithium in FRTL-5 cells can be reversed by blocking de novo cholesterol synthesis and subsequent signal transduction. | 2000 | Thyroid | pmid:10807058 |
pmid:10814523 | ||||
RodrÃguez-Concepción M et al. | Genetic evidence of branching in the isoprenoid pathway for the production of isopentenyl diphosphate and dimethylallyl diphosphate in Escherichia coli. | 2000 | FEBS Lett. | pmid:10818234 |
Vishnuvardhan D and Beinfeld MC | Lovastatin is a potent inhibitor of cholecystokinin secretion in endocrine tumor cells in culture. | 2000 | Peptides | pmid:10822111 |
Ashar HR et al. | Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules. | 2000 | J. Biol. Chem. | pmid:10852915 |
pmid:10856525 | ||||
Raal FJ et al. | Inhibition of cholesterol synthesis by atorvastatin in homozygous familial hypercholesterolaemia. | 2000 | Atherosclerosis | pmid:10856535 |
Schulte AE et al. | Purification and characterization of mevalonate kinase from suspension-cultured cells of Catharanthus roseus (L.) G. Don. | 2000 | Arch. Biochem. Biophys. | pmid:10860546 |
Montalvetti A et al. | Characterization and regulation of Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase. | 2000 | Biochem. J. | pmid:10861207 |
pmid:10872206 | ||||
Stickney JT and Buss JE | Murine guanylate-binding protein: incomplete geranylgeranyl isoprenoid modification of an interferon-gamma-inducible guanosine triphosphate-binding protein. | 2000 | Mol. Biol. Cell | pmid:10888661 |
Takagi M et al. | A gene cluster for the mevalonate pathway from Streptomyces sp. Strain CL190. | 2000 | J. Bacteriol. | pmid:10894721 |
Wilding EI et al. | Identification, evolution, and essentiality of the mevalonate pathway for isopentenyl diphosphate biosynthesis in gram-positive cocci. | 2000 | J. Bacteriol. | pmid:10894743 |
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Hirai N et al. | Biosynthesis of abscisic acid by the non-mevalonate pathway in plants, and by the mevalonate pathway in fungi. | 2000 | Biosci. Biotechnol. Biochem. | pmid:10945263 |
Nilsson A | Increased cholesterol-ester formation during forced cholesterol synthesis in rat hepatocytes. | 1975 | Eur. J. Biochem. | pmid:1097241 |
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Moreau JP et al. | Biosynthesis of sterols by a yeast homogenate. Incorporation of mevalonic acid into cholesta-5,7,24-trien-3beta-ol and 5alpha-cholesta-7,24-dien-3beta-ol. | 1975 | Eur. J. Biochem. | pmid:1100393 |
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Smit A and Mushegian A | Biosynthesis of isoprenoids via mevalonate in Archaea: the lost pathway. | 2000 | Genome Res. | pmid:11042147 |
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