Mevalonic acid is a lipid of Fatty Acyls (FA) class.
We collected disease MeSH terms mapped to the references associated with Mevalonic acid
Authors | Title | Published | Journal | PubMed Link |
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Björkhem-Bergman L et al. | Lovastatin prevents carcinogenesis in a rat model for liver cancer. Effects of ubiquinone supplementation. | 2010 | Anticancer Res. | pmid:20530415 |
Morrone D et al. | Increasing diterpene yield with a modular metabolic engineering system in E. coli: comparison of MEV and MEP isoprenoid precursor pathway engineering. | 2010 | Appl. Microbiol. Biotechnol. | pmid:19777230 |
Wang C et al. | Farnesol production from Escherichia coli by harnessing the exogenous mevalonate pathway. | 2010 | Biotechnol. Bioeng. | pmid:20552672 |
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Jana S and Shekhawat GS | Anethum graveolens: An Indian traditional medicinal herb and spice. | 2010 | Pharmacogn Rev | pmid:22228959 |
Zheng Z et al. | Improvement of retinal vascular injury in diabetic rats by statins is associated with the inhibition of mitochondrial reactive oxygen species pathway mediated by peroxisome proliferator-activated receptor gamma coactivator 1alpha. | 2010 | Diabetes | pmid:20566666 |
Liu Q et al. | Dynamics of lamin-A processing following precursor accumulation. | 2010 | PLoS ONE | pmid:20526372 |
Aoyama T et al. | Pharmacokinetic/pharmacodynamic modeling and simulation of rosuvastatin using an extension of the indirect response model by incorporating a circadian rhythm. | 2010 | Biol. Pharm. Bull. | pmid:20522984 |
Jameson JM et al. | A role for the mevalonate pathway in the induction of subtype cross-reactive immunity to influenza A virus by human gammadelta T lymphocytes. | 2010 | Cell. Immunol. | pmid:20483407 |
Hughes M et al. | Neurite-like structures induced by mevalonate pathway blockade are due to the stability of cell adhesion foci and are enhanced by the presence of APP. | 2010 | J. Neurochem. | pmid:20477946 |
Targett-Adams P et al. | Lipid metabolism and HCV infection. | 2010 | Viruses | pmid:21994676 |
Palozza P et al. | Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signaling in cancer cell lines. | 2010 | Carcinogenesis | pmid:20699249 |
Kiran U et al. | Structural and functional characterization of HMG-COA reductase from Artemisia annua. | 2010 | Bioinformation | pmid:21364776 |
Domoki F et al. | Rosuvastatin induces delayed preconditioning against L-glutamate excitotoxicity in cultured cortical neurons. | 2010 | Neurochem. Int. | pmid:19931334 |
Tisch D and Schmoll M | Light regulation of metabolic pathways in fungi. | 2010 | Appl. Microbiol. Biotechnol. | pmid:19915832 |
Acquavella N et al. | Effect of simvastatin on endothelial cell apoptosis mediated by Fas and TNF-alpha. | 2010 | Cytokine | pmid:19932975 |
Coscia M et al. | Zoledronic acid repolarizes tumour-associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway. | 2010 | J. Cell. Mol. Med. | pmid:19818098 |
Massaro M et al. | Statins inhibit cyclooxygenase-2 and matrix metalloproteinase-9 in human endothelial cells: anti-angiogenic actions possibly contributing to plaque stability. | 2010 | Cardiovasc. Res. | pmid:19946014 |
Liu YJ et al. | Simvastatin ameliorates rat cerebrovascular remodeling during hypertension via inhibition of volume-regulated chloride channel. | 2010 | Hypertension | pmid:20644009 |
Räikkönen J et al. | Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells. | 2010 | Biochem. Pharmacol. | pmid:19819230 |
Mitrofan LM et al. | Lysosomal-mitochondrial axis in zoledronic acid-induced apoptosis in human follicular lymphoma cells. | 2010 | J. Biol. Chem. | pmid:19875454 |
Barter MJ et al. | Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation. | 2010 | Ann. Rheum. Dis. | pmid:20693272 |
Tsuchiya M et al. | Cholesterol biosynthesis pathway intermediates and inhibitors regulate glucose-stimulated insulin secretion and secretory granule formation in pancreatic beta-cells. | 2010 | Endocrinology | pmid:20685866 |
Endo A | A historical perspective on the discovery of statins. | 2010 | Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. | pmid:20467214 |
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Clendening JW et al. | Dysregulation of the mevalonate pathway promotes transformation. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20696928 |
Rico J et al. | Enhanced production of a plant monoterpene by overexpression of the 3-hydroxy-3-methylglutaryl coenzyme A reductase catalytic domain in Saccharomyces cerevisiae. | 2010 | Appl. Environ. Microbiol. | pmid:20675444 |
Okamura E et al. | Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20534558 |
Chen CC et al. | Effect of pravastatin on ventricular arrhythmias in infarcted rats: role of connexin43. | 2010 | J. Appl. Physiol. | pmid:20466804 |
Norman KL and Sarnow P | Modulation of hepatitis C virus RNA abundance and the isoprenoid biosynthesis pathway by microRNA miR-122 involves distinct mechanisms. | 2010 | J. Virol. | pmid:19846523 |
Schramek N et al. | Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study. | 2010 | Phytochemistry | pmid:19932496 |
Huang M et al. | Variation of herbivore-induced volatile terpenes among Arabidopsis ecotypes depends on allelic differences and subcellular targeting of two terpene synthases, TPS02 and TPS03. | 2010 | Plant Physiol. | pmid:20463089 |
Weerasinghe S and Samantha Dassanayake R | Simulation of structural and functional properties of mevalonate diphosphate decarboxylase (MVD). | 2010 | J Mol Model | pmid:19653015 |
Kudoh T et al. | Mevalonate analogues as substrates of enzymes in the isoprenoid biosynthetic pathway of Streptococcus pneumoniae. | 2010 | Bioorg. Med. Chem. | pmid:20056424 |
Rydgren T and Sandler S | The protective effect of simvastatin against low dose streptozotocin induced type 1 diabetes in mice is independent of inhibition of HMG-CoA reductase. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19150339 |
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Jauhiainen M et al. | Analysis of endogenous ATP analogs and mevalonate pathway metabolites in cancer cell cultures using liquid chromatography-electrospray ionization mass spectrometry. | 2009 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:19665949 |
Anthony JR et al. | Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene. | 2009 | Metab. Eng. | pmid:18775787 |
Lorenzen W et al. | Isoprenoids are essential for fruiting body formation in Myxococcus xanthus. | 2009 | J. Bacteriol. | pmid:19617362 |
Zhao S et al. | Synthesis and HMG-CoA reductase inhibition of 2-cyclopropyl-4-thiophenyl-quinoline mevalonolactones. | 2009 | Bioorg. Med. Chem. | pmid:19879766 |
Domoki F et al. | Rosuvastatin induces delayed preconditioning against oxygen-glucose deprivation in cultured cortical neurons. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:18971391 |
Xu Q et al. | Comparative transcripts profiling reveals new insight into molecular processes regulating lycopene accumulation in a sweet orange (Citrus sinensis) red-flesh mutant. | 2009 | BMC Genomics | pmid:19922663 |
Rothwell C et al. | Cholesterol biosynthesis modulation regulates dengue viral replication. | 2009 | Virology | pmid:19419745 |
Ledezma E et al. | Potentiated cytotoxic effects of statins and ajoene in murine melanoma cells. | 2009 | Melanoma Res. | pmid:19276863 |
Maeda T and Horiuchi N | Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation. | 2009 | J. Biochem. | pmid:19254925 |
Dje N'Guessan P et al. | Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells. | 2009 | Arterioscler. Thromb. Vasc. Biol. | pmid:19122173 |
Iriti M and Faoro F | Chemical diversity and defence metabolism: how plants cope with pathogens and ozone pollution. | 2009 | Int J Mol Sci | pmid:20111684 |
Jawaid S et al. | Kinetic characterization and phosphoregulation of the Francisella tularensis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase). | 2009 | PLoS ONE | pmid:20011597 |
Raemer PC et al. | Statins inhibit NK-cell cytotoxicity by interfering with LFA-1-mediated conjugate formation. | 2009 | Eur. J. Immunol. | pmid:19424968 |
Chang PK et al. | Cyclopiazonic acid biosynthesis of Aspergillus flavus and Aspergillus oryzae. | 2009 | Toxins (Basel) | pmid:22069533 |
Kirmizis D and Chatzidimitriou D | Pleiotropic vasoprotective effects of statins: the chicken or the egg? | 2009 | Drug Des Devel Ther | pmid:19920934 |
Eldor R and Raz I | American Diabetes Association indications for statins in diabetes: is there evidence? | 2009 | Diabetes Care | pmid:19875586 |
Massonnet B et al. | Pharmacological inhibitors of the mevalonate pathway activate pro-IL-1 processing and IL-1 release by human monocytes. | 2009 | Eur. Cytokine Netw. | pmid:19825520 |
Wang W et al. | Global characterization of Artemisia annua glandular trichome transcriptome using 454 pyrosequencing. | 2009 | BMC Genomics | pmid:19818120 |
Brahmachari S et al. | Sodium benzoate, a metabolite of cinnamon and a food additive, reduces microglial and astroglial inflammatory responses. | 2009 | J. Immunol. | pmid:19812204 |
de Souza W and Rodrigues JC | Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs. | 2009 | Interdiscip Perspect Infect Dis | pmid:19680554 |
Zeki AA et al. | Simvastatin inhibits airway hyperreactivity: implications for the mevalonate pathway and beyond. | 2009 | Am. J. Respir. Crit. Care Med. | pmid:19608720 |
Minichsdorfer C and Hohenegger M | Autocrine amplification loop in statin-induced apoptosis of human melanoma cells. | 2009 | Br. J. Pharmacol. | pmid:19563533 |
Perttilä J et al. | OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. | 2009 | J. Mol. Med. | pmid:19554302 |
Montoya CJ et al. | Antiretroviral effect of lovastatin on HIV-1-infected individuals without highly active antiretroviral therapy (The LIVE study): a phase-II randomized clinical trial. | 2009 | Trials | pmid:19538732 |
Li J et al. | Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells. | 2009 | J. Immunol. | pmid:19494338 |
Suzuki M et al. | Complete blockage of the mevalonate pathway results in male gametophyte lethality. | 2009 | J. Exp. Bot. | pmid:19363204 |
Balibar CJ et al. | The mevalonate pathway of Staphylococcus aureus. | 2009 | J. Bacteriol. | pmid:19028897 |
Khan MA et al. | Statins impair CD1d-mediated antigen presentation through the inhibition of prenylation. | 2009 | J. Immunol. | pmid:19342651 |
Alvarez Y et al. | Cyclooxygenase-2 induced by zymosan in human monocyte-derived dendritic cells shows high stability, and its expression is enhanced by atorvastatin. | 2009 | J. Pharmacol. Exp. Ther. | pmid:19318593 |
Niessen J et al. | Human platelets express organic anion-transporting peptide 2B1, an uptake transporter for atorvastatin. | 2009 | Drug Metab. Dispos. | pmid:19237515 |
Lachmann HJ and Hawkins PN | Developments in the scientific and clinical understanding of autoinflammatory disorders. | 2009 | Arthritis Res. Ther. | pmid:19232070 |
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Zeiser R et al. | Regulation of different inflammatory diseases by impacting the mevalonate pathway. | 2009 | Immunology | pmid:19191903 |
Yeger-Lotem E et al. | Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity. | 2009 | Nat. Genet. | pmid:19234470 |
Knight LA et al. | Activity of mevalonate pathway inhibitors against breast and ovarian cancers in the ATP-based tumour chemosensitivity assay. | 2009 | BMC Cancer | pmid:19175937 |
Deshpande G et al. | Ggamma1, a downstream target for the hmgcr-isoprenoid biosynthetic pathway, is required for releasing the Hedgehog ligand and directing germ cell migration. | 2009 | PLoS Genet. | pmid:19132091 |
Mansouri H et al. | Effects of gibberellic acid on primary terpenoids and delta-tetrahydrocannabinol in Cannabis sativa at flowering stage. | 2009 | J Integr Plant Biol | pmid:19522814 |
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Olson AL et al. | Substrate induced structural and dynamics changes in human phosphomevalonate kinase and implications for mechanism. | 2009 | Proteins | pmid:18798562 |
Sillero MA et al. | Synthesis of ATP derivatives of compounds of the mevalonate pathway (isopentenyl di- and triphosphate; geranyl di- and triphosphate, farnesyl di- and triphosphate, and dimethylallyl diphosphate) catalyzed by T4 RNA ligase, T4 DNA ligase and other ligases Potential relationship with the effect of bisphosphonates on osteoclasts. | 2009 | Biochem. Pharmacol. | pmid:19414000 |
Dueber JE et al. | Synthetic protein scaffolds provide modular control over metabolic flux. | 2009 | Nat. Biotechnol. | pmid:19648908 |
Leszczynska A et al. | Investigating the effects of statins on cellular lipid metabolism using a yeast expression system. | 2009 | PLoS ONE | pmid:20041128 |
Tsuruta H et al. | High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli. | 2009 | PLoS ONE | pmid:19221601 |
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Sun X et al. | Identified biosynthetic pathway of aspergiolide A and a novel strategy to increase its production in a marine-derived fungus Aspergillus glaucus by feeding of biosynthetic precursors and inhibitors simultaneously. | 2009 | Bioresour. Technol. | pmid:19386490 |
Sidorkiewicz M et al. | Mevalonate pathway modulation is associated with hepatitis C virus RNA presence in peripheral blood mononuclear cells. | 2009 | Virus Res. | pmid:19540284 |
Bełtowski J et al. | Adverse effects of statins - mechanisms and consequences. | 2009 | Curr Drug Saf | pmid:19534648 |
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Ohyama K et al. | Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19139393 |
Kroll J et al. | Establishment of a novel anabolism-based addiction system with an artificially introduced mevalonate pathway: complete stabilization of plasmids as universal application in white biotechnology. | 2009 | Metab. Eng. | pmid:19558962 |
Alagna F et al. | Comparative 454 pyrosequencing of transcripts from two olive genotypes during fruit development. | 2009 | BMC Genomics | pmid:19709400 |
Wali VB et al. | Suppression in mevalonate synthesis mediates antitumor effects of combined statin and gamma-tocotrienol treatment. | 2009 | Lipids | pmid:19777282 |
Tekle M et al. | Investigation of coenzyme Q biosynthesis in human fibroblast and HepG2 cells. | 2008 | J. Biochem. Biophys. Methods | pmid:17916383 |
Cornish J et al. | Modulation of osteoclastogenesis by fatty acids. | 2008 | Endocrinology | pmid:18617622 |
Winiarska M et al. | Statins impair antitumor effects of rituximab by inducing conformational changes of CD20. | 2008 | PLoS Med. | pmid:18366248 |
Journe F et al. | Farnesol, a mevalonate pathway intermediate, stimulates MCF-7 breast cancer cell growth through farnesoid-X-receptor-mediated estrogen receptor activation. | 2008 | Breast Cancer Res. Treat. | pmid:17333335 |
Habara K et al. | Pitavastatin up-regulates the induction of iNOS through enhanced stabilization of its mRNA in pro-inflammatory cytokine-stimulated hepatocytes. | 2008 | Nitric Oxide | pmid:17936042 |
Skorupinska-Tudek K et al. | Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of dolichols in plants. | 2008 | J. Biol. Chem. | pmid:18502754 |
Zhang X et al. | Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. | 2008 | J. Immunol. | pmid:18453621 |