Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Body Weight D001835 333 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypothyroidism D007037 32 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Refsum Disease D012035 19 associated lipids
Leukemia D007938 74 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Hypertension D006973 115 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Glioblastoma D005909 27 associated lipids
Celiac Disease D002446 16 associated lipids
Biliary Fistula D001658 13 associated lipids
Xanthomatosis D014973 17 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Peutz-Jeghers Syndrome D010580 2 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

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Per page 10 20 50 100 | Total 2899
Authors Title Published Journal PubMed Link
Yano K Lipid metabolic pathways as lung cancer therapeutic targets: a computational study. 2012 Int. J. Mol. Med. pmid:22211244
Mans RA et al. Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation. 2012 Neuroscience pmid:22192838
Murphy LA et al. Propiconazole-enhanced hepatic cell proliferation is associated with dysregulation of the cholesterol biosynthesis pathway leading to activation of Erk1/2 through Ras farnesylation. 2012 Toxicol. Appl. Pharmacol. pmid:22361350
Trapani L et al. 3-hydroxy 3-methylglutaryl coenzyme A reductase inhibition impairs muscle regeneration. 2012 J. Cell. Biochem. pmid:22274883
Henriquez MA et al. Effects of glucans and eicosapentaenoic acid on differential regulation of phenylpropanoid and mevalonic pathways during potato response to Phytophthora infestans. 2012 Plant Physiol. Biochem. pmid:22922112
Song AA et al. Overexpressing 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) in the lactococcal mevalonate pathway for heterologous plant sesquiterpene production. 2012 PLoS ONE pmid:23300671
Partow S et al. Reconstruction and evaluation of the synthetic bacterial MEP pathway in Saccharomyces cerevisiae. 2012 PLoS ONE pmid:23285068
Drabkin HA and Gemmill RM Cholesterol and the development of clear-cell renal carcinoma. 2012 Curr Opin Pharmacol pmid:22939900
Rad SA et al. Type 2 IDI performs better than type 1 for improving lycopene production in metabolically engineered E. coli strains. 2012 World J. Microbiol. Biotechnol. pmid:22806807
Campia I et al. Digoxin and ouabain induce the efflux of cholesterol via liver X receptor signalling and the synthesis of ATP in cardiomyocytes. 2012 Biochem. J. pmid:22845468
Zhang B et al. Interference in mevalonate pathway ameliorates homocysteine-induced endothelium-dysfunction. 2012 Eur. J. Pharmacol. pmid:22796672
Yokota K et al. Geranylgeranyl-pyrophosphate regulates secretion of pentraxin 3 and monocyte chemoattractant protein-1 from rheumatoid fibroblast-like synoviocytes in distinct manners. 2011 Jan-Feb Clin. Exp. Rheumatol. pmid:21345291
Redding-Johanson AM et al. Targeted proteomics for metabolic pathway optimization: application to terpene production. 2011 Metab. Eng. pmid:21215324
Huang SH et al. Imaging of zebrafish in vivo with second-harmonic generation reveals shortened sarcomeres associated with myopathy induced by statin. 2011 PLoS ONE pmid:21966365
Ramgolam VS and Markovic-Plese S Regulation of suppressors of cytokine signaling as a therapeutic approach in autoimmune diseases, with an emphasis on multiple sclerosis. 2011 J Signal Transduct pmid:22132325
Cho SH et al. Study on the hypochlolesterolemic and antioxidative effects of tyramine derivatives from the root bark of Lycium chenese Miller. 2011 Nutr Res Pract pmid:22125678
Tijerino A et al. Overexpression of the Trichoderma brevicompactum tri5 gene: effect on the expression of the trichodermin biosynthetic genes and on tomato seedlings. 2011 Toxins (Basel) pmid:22069764
Wang H et al. Indirect stimulation of human Vγ2Vδ2 T cells through alterations in isoprenoid metabolism. 2011 J. Immunol. pmid:22013129
Ali OF et al. Pleiotropic effects of statins in distal human pulmonary artery smooth muscle cells. 2011 Respir. Res. pmid:21999923
Waldron J and Webster C Liquid chromatography-tandem mass spectrometry method for the measurement of serum mevalonic acid: a novel marker of hydroxymethylglutaryl coenzyme A reductase inhibition by statins. 2011 Ann. Clin. Biochem. pmid:21355014
Rossoni LV et al. Acute simvastatin increases endothelial nitric oxide synthase phosphorylation via AMP-activated protein kinase and reduces contractility of isolated rat mesenteric resistance arteries. 2011 Clin. Sci. pmid:21671887
Maekawa T et al. Chronic oral infection with Porphyromonas gingivalis accelerates atheroma formation by shifting the lipid profile. 2011 PLoS ONE pmid:21625524
Jeon JG et al. Natural products in caries research: current (limited) knowledge, challenges and future perspective. 2011 Caries Res. pmid:21576957
Scheller EL et al. Bisphosphonates inhibit expression of p63 by oral keratinocytes. 2011 J. Dent. Res. pmid:21551338
Kishi T Mevalonate pathway is a novel target for hypertension. 2011 Circ. J. pmid:21532185
Sakamoto K et al. Simvastatin suppresses dexamethasone-induced secretion of plasminogen activator inhibitor-1 in human bone marrow adipocytes. 2011 BMC Musculoskelet Disord pmid:21524281
Brock NL et al. Biosynthesis of sesqui- and diterpenes by the gibberellin producer Fusarium fujikuroi. 2011 Chembiochem pmid:21990128
Soliman SS et al. Chemical inhibitors suggest endophytic fungal paclitaxel is derived from both mevalonate and non-mevalonate-like pathways. 2011 J. Nat. Prod. pmid:22103292
Henneman L et al. Inhibition of the isoprenoid biosynthesis pathway; detection of intermediates by UPLC-MS/MS. 2011 Biochim. Biophys. Acta pmid:21237288
Tsubaki M et al. Blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathways by statins reduces the expression of bFGF, HGF, and TGF-β as angiogenic factors in mouse osteosarcoma. 2011 Cytokine pmid:21292498
Cluis CP et al. Identification of bottlenecks in Escherichia coli engineered for the production of CoQ(10). 2011 Metab. Eng. pmid:21986057
Kim KH et al. Generation of human chiral metabolites of simvastatin and lovastatin by bacterial CYP102A1 mutants. 2011 Drug Metab. Dispos. pmid:20962060
Miziorko HM Enzymes of the mevalonate pathway of isoprenoid biosynthesis. 2011 Arch. Biochem. Biophys. pmid:20932952
Tsuyuki R et al. Enhancement of trichothecene production in Fusarium graminearum by cobalt chloride. 2011 J. Agric. Food Chem. pmid:21299216
Kimachi K et al. Zoledronic acid inhibits RANK expression and migration of osteoclast precursors during osteoclastogenesis. 2011 Naunyn Schmiedebergs Arch. Pharmacol. pmid:21225243
Epplen R et al. Differential effects of ibandronate, docetaxel and farnesol treatment alone and in combination on the growth of prostate cancer cell lines. 2011 Acta Oncol pmid:20429730
Lin Y et al. Triterpenic Acids Present in Hawthorn Lower Plasma Cholesterol by Inhibiting Intestinal ACAT Activity in Hamsters. 2011 Evid Based Complement Alternat Med pmid:19228775
Murtola TJ et al. Comparative effects of high and low-dose simvastatin on prostate epithelial cells: the role of LDL. 2011 Eur. J. Pharmacol. pmid:22040920
Sakai H and Heike T [Hyperimmunoglobulinemia D and periodic fever syndrome]. 2011 Nihon Rinsho Meneki Gakkai Kaishi pmid:22041426
Goto T et al. Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist. 2011 Biochem. J. pmid:21605082
Clastre M et al. Subcellular evidence for the involvement of peroxisomes in plant isoprenoid biosynthesis. 2011 Plant Signal Behav pmid:22080790
Soto G et al. Acetoacetyl-CoA thiolase regulates the mevalonate pathway during abiotic stress adaptation. 2011 J. Exp. Bot. pmid:21908473
Wong DH et al. Resveratrol inhibits the mevalonate pathway and potentiates the antiproliferative effects of simvastatin in rat theca-interstitial cells. 2011 Fertil. Steril. pmid:21907337
Kim YS et al. Increase of lycopene production by supplementing auxiliary carbon sources in metabolically engineered Escherichia coli. 2011 Appl. Microbiol. Biotechnol. pmid:21246354
Duke SO and Dayan FE Modes of action of microbially-produced phytotoxins. 2011 Toxins (Basel) pmid:22069756
Banfi C et al. Statins prevent tissue factor induction by protease-activated receptors 1 and 2 in human umbilical vein endothelial cells in vitro. 2011 J. Thromb. Haemost. pmid:21605334
Martinez-Moya P et al. Proteomic analysis of the carotenogenic yeast Xanthophyllomyces dendrorhous. 2011 BMC Microbiol. pmid:21669001
Musso A et al. Relevance of the mevalonate biosynthetic pathway in the regulation of bone marrow mesenchymal stromal cell-mediated effects on T-cell proliferation and B-cell survival. 2011 Haematologica pmid:20884711
Barta ML et al. Crystal structures of Staphylococcus epidermidis mevalonate diphosphate decarboxylase bound to inhibitory analogs reveal new insight into substrate binding and catalysis. 2011 J. Biol. Chem. pmid:21561869
Vallianou I et al. Camphene, a plant-derived monoterpene, reduces plasma cholesterol and triglycerides in hyperlipidemic rats independently of HMG-CoA reductase activity. 2011 PLoS ONE pmid:22073134