Mevalonic acid is a lipid of Fatty Acyls (FA) class.
We collected disease MeSH terms mapped to the references associated with Mevalonic acid
Authors | Title | Published | Journal | PubMed Link |
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Hao M et al. | Direct effect of cholesterol on insulin secretion: a novel mechanism for pancreatic beta-cell dysfunction. | 2007 | Diabetes | pmid:17575085 |
Hargreaves IP | Coenzyme Q10 in phenylketonuria and mevalonic aciduria. | 2007 | Mitochondrion | pmid:17442628 |
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Kutrzeba L et al. | Biosynthesis of salvinorin A proceeds via the deoxyxylulose phosphate pathway. | 2007 | Phytochemistry | pmid:17574635 |
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Loiseau L et al. | ErpA, an iron sulfur (Fe S) protein of the A-type essential for respiratory metabolism in Escherichia coli. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17698959 |
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Habib A et al. | Modulation of COX-2 expression by statins in human monocytic cells. | 2007 | FASEB J. | pmid:17317725 |
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Haratake A et al. | Acceleration of de novo cholesterol synthesis in the epidermis influences desquamation of the stratum corneum in aged mice. | 2006 | Skin Pharmacol Physiol | pmid:16778459 |
Dincer M et al. | Statins may decrease skeletal-related events in breast cancer patients with bone metastases. | 2006 | Med. Hypotheses | pmid:16844315 |
Kwintkiewicz J et al. | Mevastatin inhibits proliferation of rat ovarian theca-interstitial cells by blocking the mitogen-activated protein kinase pathway. | 2006 | Fertil. Steril. | pmid:16963032 |
Pozo M et al. | Simvastatin inhibits the migration and adhesion of monocytic cells and disorganizes the cytoskeleton of activated endothelial cells. | 2006 | Eur. J. Pharmacol. | pmid:16973154 |
Piotrowski PC et al. | Statins inhibit growth of human endometrial stromal cells independently of cholesterol availability. | 2006 | Biol. Reprod. | pmid:16571871 |
Sakoda K et al. | Simvastatin decreases IL-6 and IL-8 production in epithelial cells. | 2006 | J. Dent. Res. | pmid:16723648 |
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Polo MP and de Bravo MG | Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2. | 2006 | Biochem. Cell Biol. | pmid:16462894 |
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Sjögren B et al. | Cholesterol depletion reduces serotonin binding and signaling via human 5-HT(7(a)) receptors. | 2006 | Eur. J. Pharmacol. | pmid:17064686 |
Ohm TG and Meske V | Cholesterol, statins and tau. | 2006 | Acta Neurol. Scand., Suppl.c | pmid:16866917 |
Crisby M | The role of pleiotropic effects of statins in dementia. | 2006 | Acta Neurol. Scand., Suppl.c | pmid:16866920 |
Chana RS and Brunskill NJ | Thiazolidinediones inhibit albumin uptake by proximal tubular cells through a mechanism independent of peroxisome proliferator activated receptor gamma. | 2006 | Am. J. Nephrol. | pmid:16508249 |
Macreadie IG et al. | Growth inhibition of Candida species and Aspergillus fumigatus by statins. | 2006 | FEMS Microbiol. Lett. | pmid:16907733 |
Kosztáczky B et al. | Neuropeptides induced a pronounced and statin-sensitive dysregulation of mevalonate cycle in human monocytes of patients with hypercholesterolemia. | 2006 | Neuropeptides | pmid:17049599 |
Ridsdale A et al. | Cholesterol is required for efficient endoplasmic reticulum-to-Golgi transport of secretory membrane proteins. | 2006 | Mol. Biol. Cell | pmid:16452637 |
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Kotti TJ et al. | Brain cholesterol turnover required for geranylgeraniol production and learning in mice. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16505352 |
Sato M et al. | Effects of exogenous mevalonic acid on sterol lipid classes in Larix kaempferi callus. | 2006 | J Oleo Sci | pmid:17693695 |
Kuzina V et al. | Relationships among the biosyntheses of ubiquinone, carotene, sterols, and triacylglycerols in Zygomycetes. | 2006 | Arch. Microbiol. | pmid:17009023 |
Li JQ et al. | Atorvastatin reduces plasminogen activator inhibitor-1 expression in adipose tissue of atherosclerotic rabbits. | 2006 | Clin. Chim. Acta | pmid:16507303 |
Parsons RB et al. | Statins inhibit the dimerization of beta-secretase via both isoprenoid- and cholesterol-mediated mechanisms. | 2006 | Biochem. J. | pmid:16803455 |
Brinkkoetter PT et al. | Atorvastatin interferes with activation of human CD4(+) T cells via inhibition of small guanosine triphosphatase (GTPase) activity and caspase-independent apoptosis. | 2006 | Clin. Exp. Immunol. | pmid:17100774 |
Mandey SH et al. | A role for geranylgeranylation in interleukin-1beta secretion. | 2006 | Arthritis Rheum. | pmid:17075828 |
Ural AU et al. | In vitro synergistic cytoreductive effects of zoledronic acid and radiation on breast cancer cells. | 2006 | Breast Cancer Res. | pmid:16925824 |
van Hellemond JJ and Tielens AG | Adaptations in the lipid metabolism of the protozoan parasite Trypanosoma brucei. | 2006 | FEBS Lett. | pmid:16920110 |
Saini GS et al. | Validation of the LC-MS/MS method for the quantification of mevalonic acid in human plasma and determination of the matrix effect. | 2006 | J. Lipid Res. | pmid:16861623 |
Yi P et al. | The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Ggamma1. | 2006 | Science | pmid:16857902 |
Dimitroulakos J et al. | Strategies to enhance epidermal growth factor inhibition: targeting the mevalonate pathway. | 2006 | Clin. Cancer Res. | pmid:16857822 |
Xu H et al. | HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced "inside-out" signaling to extracellular matrix by preventing RhoA activation. | 2006 | Am. J. Physiol. Renal Physiol. | pmid:16774905 |
Kawasaki T et al. | Biosynthesis of a natural polyketide-isoprenoid hybrid compound, furaquinocin A: identification and heterologous expression of the gene cluster. | 2006 | J. Bacteriol. | pmid:16452404 |
Haas D and Hoffmann GF | Mevalonate kinase deficiencies: from mevalonic aciduria to hyperimmunoglobulinemia D syndrome. | 2006 | Orphanet J Rare Dis | pmid:16722536 |
Solito E et al. | Post-translational modification plays an essential role in the translocation of annexin A1 from the cytoplasm to the cell surface. | 2006 | FASEB J. | pmid:16720734 |
Chemler JA et al. | Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae. | 2006 | Microb. Cell Fact. | pmid:16719921 |
Silvander M et al. | A new water-based topical carrier with polar skin-lipids. | 2006 | Lipids Health Dis | pmid:16672068 |
Coward WR et al. | Statin-induced proinflammatory response in mitogen-activated peripheral blood mononuclear cells through the activation of caspase-1 and IL-18 secretion in monocytes. | 2006 | J. Immunol. | pmid:16621994 |
Neville-Webbe HL et al. | Mechanisms of the synergistic interaction between the bisphosphonate zoledronic acid and the chemotherapy agent paclitaxel in breast cancer cells in vitro. | 2006 | Tumour Biol. | pmid:16582586 |
Rattan R et al. | Rho/ROCK pathway as a target of tumor therapy. | 2006 | J. Neurosci. Res. | pmid:16385577 |
Wang J et al. | Anti-inflammatory effect of pitavastatin on NF-kappaB activated by TNF-alpha in hepatocellular carcinoma cells. | 2006 | Biol. Pharm. Bull. | pmid:16595893 |
Benetka W et al. | Farnesylation or geranylgeranylation? Efficient assays for testing protein prenylation in vitro and in vivo. | 2006 | BMC Biochem. | pmid:16507103 |
Xu L et al. | [Effects of simvastatin on DNA synthesis in rat cardiac fibroblasts]. | 2006 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:16503530 |
Riganti C et al. | Statins revert doxorubicin resistance via nitric oxide in malignant mesothelioma. | 2006 | Int. J. Cancer | pmid:16450390 |
Ramasubbu K and Mann DL | The emerging role of statins in the treatment of heart failure. | 2006 | J. Am. Coll. Cardiol. | pmid:16412858 |
Christensen M et al. | Simvastatin protection against acute immune-mediated glomerulonephritis in mice. | 2006 | Kidney Int. | pmid:16407885 |
González-Fernández L et al. | Cleavage of focal adhesion proteins and PKCdelta during lovastatin-induced apoptosis in spontaneously immortalized rat brain neuroblasts. | 2006 | FEBS J. | pmid:16367743 |
Zahiri HS et al. | Coenzyme Q10 production in recombinant Escherichia coli strains engineered with a heterologous decaprenyl diphosphate synthase gene and foreign mevalonate pathway. | 2006 | Metab. Eng. | pmid:16815062 |
Pappu AS et al. | Increased nonsterol isoprenoids, dolichol and ubiquinone, in the Smith-Lemli-Opitz syndrome: effects of dietary cholesterol. | 2006 | J. Lipid Res. | pmid:16983147 |
Yoon SH et al. | Enhanced lycopene production in Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate. | 2006 | Biotechnol. Bioeng. | pmid:16547999 |
Nagashima T et al. | Apoptosis of rheumatoid synovial cells by statins through the blocking of protein geranylgeranylation: a potential therapeutic approach to rheumatoid arthritis. | 2006 | Arthritis Rheum. | pmid:16447234 |
Yokota K et al. | Simvastatin inhibits production of interleukin 6 (IL-6) and IL-8 and cell proliferation induced by tumor necrosis factor-alpha in fibroblast-like synoviocytes from patients with rheumatoid arthritis. | 2006 | J. Rheumatol. | pmid:16511915 |
Grochowski LL et al. | Methanocaldococcus jannaschii uses a modified mevalonate pathway for biosynthesis of isopentenyl diphosphate. | 2006 | J. Bacteriol. | pmid:16621811 |
Alegret M and Silvestre JS | Pleiotropic effects of statins and related pharmacological experimental approaches. | 2006 | Methods Find Exp Clin Pharmacol | pmid:17200729 |
Muñoz-GarcÃa B et al. | Fn14 is upregulated in cytokine-stimulated vascular smooth muscle cells and is expressed in human carotid atherosclerotic plaques: modulation by atorvastatin. | 2006 | Stroke | pmid:16809572 |
Shang F et al. | Simvastatin inhibits lipopolysaccharide-induced tumor necrosis factor-alpha expression in neonatal rat cardiomyocytes: The role of reactive oxygen species. | 2006 | Biochem. Biophys. Res. Commun. | pmid:17094942 |
Issat T et al. | Berberine, a natural cholesterol reducing product, exerts antitumor cytostatic/cytotoxic effects independently from the mevalonate pathway. | 2006 | Oncol. Rep. | pmid:17089049 |
Kuwana M | Potential benefit of statins for vascular disease in systemic sclerosis. | 2006 | Curr Opin Rheumatol | pmid:17053504 |
Thompson K et al. | Alkylamines cause Vgamma9Vdelta2 T-cell activation and proliferation by inhibiting the mevalonate pathway. | 2006 | Blood | pmid:16179378 |
van Beek E et al. | Independent pathways in the modulation of osteoclastic resorption by intermediates of the mevalonate biosynthetic pathway: the role of the retinoic acid receptor. | 2006 | Bone | pmid:16165408 |
Hamadmad SN et al. | Erythropoietin receptor signal transduction requires protein geranylgeranylation. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16203826 |
Qiu Y and Li D | Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase. | 2006 | Org. Lett. | pmid:16524256 |
Qiu Y and Li D | Inhibition of mevalonate 5-diphosphate decarboxylase by fluorinated substrate analogs. | 2006 | Biochim. Biophys. Acta | pmid:16626865 |
Beckman JA and Creager MA | The nonlipid effects of statins on endothelial function. | 2006 | Trends Cardiovasc. Med. | pmid:16781949 |
Caruso MG and Notarnicola M | Biochemical changes of mevalonate pathway in human colorectal cancer. | 2005 Sep-Oct | Anticancer Res. | pmid:16101154 |
Nawarskas JJ | HMG-CoA reductase inhibitors and coenzyme Q10. | 2005 Mar-Apr | Cardiol Rev | pmid:15705257 |
Akiyama K et al. | Antitumor effect of geranylamine derivatives on human hepatoma. | 2005 Jan-Feb | In Vivo | pmid:15796170 |
Han KH et al. | HMG-CoA reductase inhibition reduces monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated monocyte recruitment in vivo. | 2005 | Circulation | pmid:15781755 |
Argmann CA et al. | Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-CoA reductase inhibition: a role for RhoA in ABCA1-mediated cholesterol efflux. | 2005 | J. Biol. Chem. | pmid:15817453 |
Bevilacqua M et al. | Bisphosphonates and atherosclerosis: why? | 2005 | Lupus | pmid:16218486 |
Kim J et al. | 4,8-Dimethyldecanal, the aggregation pheromone of Tribolium castaneum, is biosynthesized through the fatty acid pathway. | 2005 | J. Chem. Ecol. | pmid:16222778 |
Duncan RE et al. | Dietary factors and the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for breast cancer and development. | 2005 | Mol Nutr Food Res | pmid:15617098 |
Okada K and Hase T | Cyanobacterial non-mevalonate pathway: (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase interacts with ferredoxin in Thermosynechococcus elongatus BP-1. | 2005 | J. Biol. Chem. | pmid:15792953 |
Mantha AJ et al. | Targeting the mevalonate pathway inhibits the function of the epidermal growth factor receptor. | 2005 | Clin. Cancer Res. | pmid:15788691 |
McCarey DW et al. | Do the pleiotropic effects of statins in the vasculature predict a role in inflammatory diseases? | 2005 | Arthritis Res. Ther. | pmid:15743490 |
Zeng L et al. | HMG CoA reductase inhibition modulates VEGF-induced endothelial cell hyperpermeability by preventing RhoA activation and myosin regulatory light chain phosphorylation. | 2005 | FASEB J. | pmid:16160062 |