Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

Download all related citations
Per page 10 20 50 100 | Total 2899
Authors Title Published Journal PubMed Link
Merry AH et al. Oestrogen-stimulated cholesterol and lipid synthesis in Xenopus laevis liver. 1973 Biochem. Soc. Trans. pmid:4802550
Holstein SA et al. Isoprenoids influence expression of Ras and Ras-related proteins. 2002 Biochemistry pmid:12427032
Zhang B et al. A second target of the antimalarial and antibacterial agent fosmidomycin revealed by cellular metabolic profiling. 2011 Biochemistry pmid:21438569
Vinokur JM et al. Evidence of a novel mevalonate pathway in archaea. 2014 Biochemistry pmid:24914732
Aboushadi N et al. Characterization of peroxisomal 3-hydroxy-3-methylglutaryl coenzyme A reductase in UT2 cells: sterol biosynthesis, phosphorylation, degradation, and statin inhibition. 2000 Biochemistry pmid:10625499
Haines BE et al. Molecular modeling of the reaction pathway and hydride transfer reactions of HMG-CoA reductase. 2012 Biochemistry pmid:22971202
Pomerantz KB et al. G-protein-mediated signaling in cholesterol-enriched arterial smooth muscle cells. 2. Role of protein kinase C-delta in the regulation of eicosanoid production. 1997 Biochemistry pmid:9235999
Andreassi JL et al. Streptococcus pneumoniae isoprenoid biosynthesis is downregulated by diphosphomevalonate: an antimicrobial target. 2004 Biochemistry pmid:15610040
Barta ML et al. Structural basis for nucleotide binding and reaction catalysis in mevalonate diphosphate decarboxylase. 2012 Biochemistry pmid:22734632
Shukolyukov SA and Saakov VS American cockroach (Periplaneta americana) synthesizes carotenoids from the precursor. 2001 Biochemistry Mosc. pmid:11405890
Bassa BV et al. Effect of inhibition of cholesterol synthetic pathway on the activation of Ras and MAP kinase in mesangial cells. 1999 Biochim. Biophys. Acta pmid:10082972
Hrboticky N et al. Increased cellular triglyceride levels in human monocytic and rat smooth muscle cells after lovastatin. 1997 Biochim. Biophys. Acta pmid:9434135
Thelin A et al. Effect of squalestatin 1 on the biosynthesis of the mevalonate pathway lipids. 1994 Biochim. Biophys. Acta pmid:7811707
Pullinger CR and Gibbons GF Effects of oleate and compactin on the metabolism and secretion of cholesterol and cholesteryl ester by rat hepatocytes. 1982 Biochim. Biophys. Acta pmid:6960928
Tang BL et al. Cytostatic effect of antiestrogens in lymphoid cells: relationship to high affinity antiestrogen-binding sites and cholesterol. 1989 Biochim. Biophys. Acta pmid:2819087
Carrol JJ and Pritham GH Effects of sex hormones and of potassium salts of fatty acids on the biosynthesis in vitro of cholesterol from [2-14C]mevalonic acid. 1966 Biochim. Biophys. Acta pmid:5943435
Pascaud A et al. [Liver endoplasmic reticulum and cholesterol biosynthesis]. 1968 Biochim. Biophys. Acta pmid:5641901
Aspbury RA et al. Isoprenylation of polypeptides in the nematode Caenorhabditis elegans. 1998 Biochim. Biophys. Acta pmid:9630668
Veerkamp JH et al. Effects of HMG-CoA reductase inhibitors on growth and differentiation of cultured rat skeletal muscle cells. 1996 Biochim. Biophys. Acta pmid:8611662
Capuzzi DM et al. Rapid modulation of lipogenesis by clofibrate in rat and monkey hepatocytes. 1975 Biochim. Biophys. Acta pmid:810176
Takeuchi N et al. Feed-back control of cholesterol synthesis in partially hepatectomized rats. 1976 Biochim. Biophys. Acta pmid:974156
Bentinger M et al. Effects of various squalene epoxides on coenzyme Q and cholesterol synthesis. 2014 Biochim. Biophys. Acta pmid:24747199
Faas FH et al. Unsaturated fatty acyl-CoA inhibition of cholesterol synthesis in vitro. 1977 Biochim. Biophys. Acta pmid:861236
Mak KM and Trier JS Radioautographic and chemical evidence for (5- 3 H)mevalonate incorporation into cholesterol by rat villous absorptive cells. 1972 Biochim. Biophys. Acta pmid:4642214
Shapiro DJ et al. Micro assay for 3-hydroxy-3-methylglutaryl-CoA reductase in rat liver and in L-cell fibroblasts. 1974 Biochim. Biophys. Acta pmid:4441486
Rasouli M et al. Calmodulin antagonist W-7 inhibits de novo synthesis of cholesterol and suppresses secretion of de novo synthesized and preformed lipids from cultured hepatocytes. 2004 Biochim. Biophys. Acta pmid:15158760
Poznansky MJ and Czekanski S Cholesterol movement between human skin fibroblasts and phosphatidylcholine vesicles. 1982 Biochim. Biophys. Acta pmid:7059600
Parker TS et al. Inhibition of liver prenyltransferase by alkyl phosphonates and phosphonophosphates. 1978 Biochim. Biophys. Acta pmid:687653
Bojesen E et al. Sterol biosynthesis in vitro of rat renal inner medulla. 1973 Biochim. Biophys. Acta pmid:4713153
NICHOLAS HJ and THOMAS BE Intracerebral incorporation of [2-14C]mevalonic acid into adult rat brain squalene and cholesterol. 1959 Biochim. Biophys. Acta pmid:13854106
Swell L and Law MD Release of lipoprotein cholesterol esters by the isolated perfused rat liver. 1971 Biochim. Biophys. Acta pmid:5554903
Silva Ramos E et al. Bioenergetic roles of mitochondrial fusion. 2016 Biochim. Biophys. Acta pmid:27060252
De Matteis F Liver cholesterol metabolism following trauma. Evidence for increased rate of cholesterol synthesis and breakdown. 1969 Biochim. Biophys. Acta pmid:5349601
Goodman ZD and Lequire VS Transfer of esterified cholesterol from serum lipoproteins to the liver. 1975 Biochim. Biophys. Acta pmid:1182142
Schwarz BH et al. Kinetic characterization of an oxidative, cooperative HMG-CoA reductase from Burkholderia cenocepacia. 2014 Biochim. Biophys. Acta pmid:24316250
Naoumova RP et al. Cholesterol synthesis is increased in mixed hyperlipidaemia. 1998 Biochim. Biophys. Acta pmid:9795192
Henneman L et al. Inhibition of the isoprenoid biosynthesis pathway; detection of intermediates by UPLC-MS/MS. 2011 Biochim. Biophys. Acta pmid:21237288
Cohen BI et al. Effects of clofibrate on sterol metabolism in the rat. 1974 Biochim. Biophys. Acta pmid:4418670
Von Holt C et al. Metabolic effects of hypoglycin and methylenecyclopropaneacetic acid. 1966 Biochim. Biophys. Acta pmid:5968584
Kalra VK and Blankenhorn DH Abnormal activation of sterol synthesis in lymphocytes of atherosclerotic-susceptible pigeons and heterozygous familial hypercholesterolemic patients. 1976 Biochim. Biophys. Acta pmid:952994
Beg ZH and Lupien PJ In vitro and in vivo inhibition of hepatic cholesterol synthesis by 3-hydroxy-3-methylglutaric acid. 1972 Biochim. Biophys. Acta pmid:5061662
Grünler J et al. Branch-point reactions in the biosynthesis of cholesterol, dolichol, ubiquinone and prenylated proteins. 1994 Biochim. Biophys. Acta pmid:8199197
Shimizu I et al. Mevalonate synthesis in the mitochondria of yeast. 1973 Biochim. Biophys. Acta pmid:4569545
Tabacik C et al. Regulation of cholesterol biosynthesis at a stage after the 3-hydroxy-3-methylglutaryl-CoA reductase step, in normal and leukemic (L2C) guinea pig lymphocytes. 1987 Biochim. Biophys. Acta pmid:3651496
Herold G et al. Cholesterol synthesis and esterification in cultured intestinal mucosa. Evidence for compartmentation. 1984 Biochim. Biophys. Acta pmid:6567470
Gebhardt R et al. Inhibition of cholesterol biosynthesis by allicin and ajoene in rat hepatocytes and HepG2 cells. 1994 Biochim. Biophys. Acta pmid:8011681
Marco C et al. Quantitative role of different embryonic tissues in mevalonate metabolism by sterol and nonsterol pathways. Relationship with enzyme activities of cholesterogenesis. 1986 Biochim. Biophys. Acta pmid:3019412
Hashimoto F and Hayashi H Identification of intermediates after inhibition of cholesterol synthesis by aminotriazole treatment in vivo. 1991 Biochim. Biophys. Acta pmid:1954238
Holmlund CE On the mechanism of growth inhibition of Tetrahymena pyriformis by steroids. 1971 Biochim. Biophys. Acta pmid:4108656
Niemiro R and Fumagalli R Studies on the inhibitory mechanism of some hypocholesterolemic agents on 7-dehydrocholesterol delta-7-bond reductase activity. 1965 Biochim. Biophys. Acta pmid:4284414
Schedin S et al. Alterations in the biosynthesis of cholesterol, dolichol and dolichyl-P in the genetic cholesterol homeostasis disorder, Niemann-Pick type C disease. 1998 Biochim. Biophys. Acta pmid:9795206
Avigan J et al. In vitro biosynthesis of lipids, proteins and deoxyribonucleic acid in aortic tissue and in culture aortic cells. 1972 Biochim. Biophys. Acta pmid:5041430
Cohen LH et al. Regulation of squalene synthetase in human hepatoma cell line Hep G2 by sterols, and not by mevalonate-derived non-sterols. 1989 Biochim. Biophys. Acta pmid:2538145
Scher DS and Rodwell VW 3-Hydroxy-3-methylglutaryl coenzyme A lyase from Pseudomonas mevalonii. 1989 Biochim. Biophys. Acta pmid:2742863
Henze K et al. The effect of hydrocortisone on cholesterol metabolism of cultured human skin fibroblasts. 1981 Biochim. Biophys. Acta pmid:6118180
Hooff GP et al. Isoprenoids, small GTPases and Alzheimer's disease. 2010 Biochim. Biophys. Acta pmid:20382260
MARKLEY K and GURIN S Decarboxylation of mevalonic acid and conversion to squalene; enzyme fractionation and cofactors. 1959 Biochim. Biophys. Acta pmid:13628647
Ghavami S et al. Airway mesenchymal cell death by mevalonate cascade inhibition: integration of autophagy, unfolded protein response and apoptosis focusing on Bcl2 family proteins. 2014 Biochim. Biophys. Acta pmid:24637330
Herscovitz H et al. Bile acid synthesis from HDL cholesterol and cholesterol ester by cultured chick embryo hepatocytes. 1986 Biochim. Biophys. Acta pmid:3756203
Duncan JL and Buckingham L Resistance to streptolysin O in mammalian cells treated with oxygenated derivatives of cholesterol. Cholesterol content of resistant cells and recovery of streptolysin O sensitivity. 1980 Biochim. Biophys. Acta pmid:7459354
Lee CS and O'Sullivan WJ Improved procedures for the synthesis of phosphomevalonate and for the assay and purification of pig liver phosphomevalonate kinase. 1985 Biochim. Biophys. Acta pmid:2983770
Wang SR et al. Lipid and lipoprotein metabolism in Hep G2 cells. 1988 Biochim. Biophys. Acta pmid:3042028
Ciavatti M et al. Biosynthesis of cholesterol and cholesterol precursors in platelets of female rats treated with oral contraceptives. 1980 Biochim. Biophys. Acta pmid:7437455
Herscovitz H and Tietz A The availability of different sources of cholesterol for bile acid synthesis by cultured chick embryo hepatocytes. 1985 Biochim. Biophys. Acta pmid:4041475
Edwards PA Effect of plasma lipoproteins and lecithin-cholesterol dispersions on the activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase of isolated rat hepatocytes. 1975 Biochim. Biophys. Acta pmid:241422
van Heusden GP et al. Increased cholesterol synthesis in Chinese hamster ovary cells deficient in peroxisomes. 1992 Biochim. Biophys. Acta pmid:1606178
Martínez-Botas J et al. Dose-dependent effects of lovastatin on cell cycle progression. Distinct requirement of cholesterol and non-sterol mevalonate derivatives. 2001 Biochim. Biophys. Acta pmid:11470239
Sable-Amplis R et al. Abnormal liver cholesteryl ester storage in a strain of golden hamsters. Possible model for studies on cholesterol metabolism. 1978 Biochim. Biophys. Acta pmid:718971
Jensen E et al. Cell-density-dependent uptake of chylomicron remnants in rat hepatocyte monolayers. Effects of compactin and mevalonic acid. 1987 Biochim. Biophys. Acta pmid:3790613
Cayen MN The effect of starvation and cholesterol feeding on intestinal cholesterol synthesis in the rat. 1969 Biochim. Biophys. Acta pmid:5364263
Bochenek W and Rodgers JB Effects of saturated and unsaturated fats given with and without dietary cholesterol on hepatic cholesterol synthesis and hepatic lipid metabolism. 1978 Biochim. Biophys. Acta pmid:620042
Tomoda H et al. F-244 specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A synthase. 1987 Biochim. Biophys. Acta pmid:2891379
Stokke KT and Norum KR Subcellular distribution of acyl-CoA: cholesterol acyltransferase in rat liver cells. 1970 Biochim. Biophys. Acta pmid:5456044
Kandutsch AA and Saucier SE Sterol and fatty acid synthesis in developing brains of three myelin-deficient mouse mutants. 1972 Biochim. Biophys. Acta pmid:5012453
Fraser PD et al. Carotenoid biosynthesis in wild type and mutant strains of Mucor circinelloides. 1996 Biochim. Biophys. Acta pmid:8600974
Edwards PA et al. Preferential uptake and utilization of mevalonolactone over mevalonate for sterol biosynthesis in isolated rat hepatocytes. 1977 Biochim. Biophys. Acta pmid:901801
Raicht RF et al. Sterol balance studies in the rat. Effects of dietary cholesterol and beta-sitosterol on sterol balance and rate-limiting enzymes of sterol metabolism. 1975 Biochim. Biophys. Acta pmid:1137717
Kawaguchi A et al. Subcellular distribution of sesterterpene- and sterol-biosynthesizing activities in Cochliobolus heterostrophus. 1973 Biochim. Biophys. Acta pmid:4120185
Perkins SL et al. Linkage of the isoprenoid biosynthetic pathway with induction of DNA synthesis in mouse lymphocytes. Effects of compactin on mitogen-induced lymphocytes in serum-free medium. 1982 Biochim. Biophys. Acta pmid:6279167
Qin W et al. Regulation of HMG-CoA reductase, apoprotein-B and LDL receptor gene expression by the hypocholesterolemic drugs simvastatin and ciprofibrate in Hep G2, human and rat hepatocytes. 1992 Biochim. Biophys. Acta pmid:1627634
Kaliszewski P et al. Rsp5p ubiquitin ligase and the transcriptional activators Spt23p and Mga2p are involved in co-regulation of biosynthesis of end products of the mevalonate pathway and triacylglycerol in yeast Saccharomyces cerevisiae. 2008 Biochim. Biophys. Acta pmid:18771750
Keller RK and Vilsaint F Regulation of isoprenoid metabolism in rat liver: near constant chain lengths of dolichyl phosphate and ubiquinone are maintained during greatly altered rates of cholesterogenesis. 1993 Biochim. Biophys. Acta pmid:8399346
Jabalquinto AM and Cardemil E Substrate binding order in mevalonate 5-diphosphate decarboxylase from chicken liver. 1989 Biochim. Biophys. Acta pmid:2752048
Alvear M et al. Inactivation of chicken liver mevalonate 5-diphosphate decarboxylase by sulfhydryl-directed reagents: evidence of a functional dithiol. 1989 Biochim. Biophys. Acta pmid:2909257
Chiew YE et al. Studies on pig liver mevalonate-5-diphosphate decarboxylase. 1987 Biochim. Biophys. Acta pmid:2825791
Schootemeijer A et al. Relation between membrane fluidity and signal transduction in the human megakaryoblastic cell line MEG-01. 1995 Biochim. Biophys. Acta pmid:7794941
Rea TJ et al. Lack of correlation between ACAT mRNA expression and cholesterol esterification in primary liver cells. 1996 Biochim. Biophys. Acta pmid:8555254
Lakshmanan MR et al. Metabolism of ubiquinone in relation to viramin A status in the rat. 1968 Biochim. Biophys. Acta pmid:5707688
Mitropoulos KA et al. On the mechanism for the regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, of cholesterol 7alpha-hydroxylase and of acyl-coenzyme A:cholesterol acyltransferase by free cholesterol. 1978 Biochim. Biophys. Acta pmid:687657
Rao KS and Olson RE The effect of excessive vitamin A upon the metabolism of isoprenoid compounds in rat liver. 1967 Biochim. Biophys. Acta pmid:6049507
Melnykovych G and Clowes KK Suppression of glucocorticoid-induced elevation of alkaline phosphatase in C-4-1 cells by inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and reversal of the suppression by mevalonate. 1983 Biochim. Biophys. Acta pmid:6830849
Williams RJ et al. A possible mechanism for the biosynthesis of eschscholtzxanthin. 1966 Biochim. Biophys. Acta pmid:5966716
HONG L and WRIGHT LD Paper chromatography of mevalonate and acetate. 1957 Biochim. Biophys. Acta pmid:13479486
Krishnaiah KV and Ramasarma T Regulation of hepatic cholesterolgenesis by ubiquinone. 1970 Biochim. Biophys. Acta pmid:5442761
Giroux LM et al. Simvastatin inhibits the oxidation of low-density lipoproteins by activated human monocyte-derived macrophages. 1993 Biochim. Biophys. Acta pmid:8380338
Erickson SK et al. Studies on the mechanisms of the rapid modulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in intact liver by mevalonolactone and 25-hydroxycholesterol. 1980 Biochim. Biophys. Acta pmid:7417482
Seifert SC and Lucas JJ Incorporation of mevalonate into dolichol and other isoprenoids during estrogen-induced chick oviduct differentiation. 1988 Biochim. Biophys. Acta pmid:3416004
Yousef IM and Tuchweber B Effect of lithocholic acid on cholesterol synthesis and transport in the rat liver. 1984 Biochim. Biophys. Acta pmid:6509080
Le Jossic-Corcos C et al. Effects of peroxisome proliferator-activated receptor alpha activation on pathways contributing to cholesterol homeostasis in rat hepatocytes. 2004 Biochim. Biophys. Acta pmid:15238219
Umetani N et al. Lovastatin inhibits gene expression of type-I scavenger receptor in THP-1 human macrophages. 1996 Biochim. Biophys. Acta pmid:8908154