Kuroda M et al. |
Sesquiterpene farnesol inhibits recycling of the C55 lipid carrier of the murein monomer precursor contributing to increased susceptibility to beta-lactams in methicillin-resistant Staphylococcus aureus. |
2007 |
J. Antimicrob. Chemother. |
pmid:17242033
|
Tanaka T et al. |
Lipophilic statins suppress cytotoxicity by freshly isolated natural killer cells through modulation of granule exocytosis. |
2007 |
Int. Immunol. |
pmid:17182966
|
Nishimoto T et al. |
Protective effects of a squalene synthase inhibitor, lapaquistat acetate (TAK-475), on statin-induced myotoxicity in guinea pigs. |
2007 |
Toxicol. Appl. Pharmacol. |
pmid:17599378
|
Parsons RB et al. |
A specific inhibitor of cholesterol biosynthesis, BM15.766, reduces the expression of beta-secretase and the production of amyloid-beta in vitro. |
2007 |
J. Neurochem. |
pmid:17472704
|
Araki S et al. |
Simvastatin enhances induction of inducible nitric oxide synthase in 3T3-L1 adipocytes. |
2007 |
Free Radic. Res. |
pmid:17729120
|
Haas D and Hoffmann GF |
Mevalonate kinase deficiency and autoinflammatory disorders. |
2007 |
N. Engl. J. Med. |
pmid:17596600
|
Maurer-Stroh S et al. |
Towards complete sets of farnesylated and geranylgeranylated proteins. |
2007 |
PLoS Comput. Biol. |
pmid:17411337
|
Llorente A et al. |
Cholesterol regulates prostasome release from secretory lysosomes in PC-3 human prostate cancer cells. |
2007 |
Eur. J. Cell Biol. |
pmid:17601634
|
Jahangir T and Sultana S |
Perillyl Alcohol Protects Against Fe-NTA-Induced Nephrotoxicity and Early Tumor Promotional Events in Rat Experimental Model. |
2007 |
Evid Based Complement Alternat Med |
pmid:18227911
|
Li M et al. |
Inhibition of serotonin-induced mitogenesis, migration, and ERK MAPK nuclear translocation in vascular smooth muscle cells by atorvastatin. |
2007 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
pmid:17545489
|
Merrell MA et al. |
Inhibition of the mevalonate pathway and activation of p38 MAP kinase are independently regulated by nitrogen-containing bisphosphonates in breast cancer cells. |
2007 |
Eur. J. Pharmacol. |
pmid:17640631
|
Wong J et al. |
Synthesis of the oxysterol, 24(S), 25-epoxycholesterol, parallels cholesterol production and may protect against cellular accumulation of newly-synthesized cholesterol. |
2007 |
Lipids Health Dis |
pmid:17408498
|
Hunter WN |
The non-mevalonate pathway of isoprenoid precursor biosynthesis. |
2007 |
J. Biol. Chem. |
pmid:17442674
|
Takeda I et al. |
Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. |
2007 |
Cancer Sci. |
pmid:17428261
|
Roelofs AJ et al. |
Apomine enhances the antitumor effects of lovastatin on myeloma cells by down-regulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase. |
2007 |
J. Pharmacol. Exp. Ther. |
pmid:17412884
|
Henriksson LM et al. |
Structures of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase provide new insights into catalysis. |
2007 |
J. Biol. Chem. |
pmid:17491006
|
Towler MJ and Weathers PJ |
Evidence of artemisinin production from IPP stemming from both the mevalonate and the nonmevalonate pathways. |
2007 |
Plant Cell Rep. |
pmid:17710406
|
Habib A et al. |
Modulation of COX-2 expression by statins in human monocytic cells. |
2007 |
FASEB J. |
pmid:17317725
|
Andreassi JL et al. |
Crystal structure of the Streptococcus pneumoniae mevalonate kinase in complex with diphosphomevalonate. |
2007 |
Protein Sci. |
pmid:17400916
|
Lee MH et al. |
Simvastatin suppresses self-renewal of mouse embryonic stem cells by inhibiting RhoA geranylgeranylation. |
2007 |
Stem Cells |
pmid:17464088
|
Nakajima H et al. |
Induction of mitochondria-dependent apoptosis through the inhibition of mevalonate pathway in human breast cancer cells by YM529, a new third generation bisphosphonate. |
2007 |
Cancer Lett. |
pmid:17316980
|
Kinjoh T et al. |
Control of juvenile hormone biosynthesis in Bombyx mori: cloning of the enzymes in the mevalonate pathway and assessment of their developmental expression in the corpora allata. |
2007 |
Insect Biochem. Mol. Biol. |
pmid:17628279
|
Saha RN and Pahan K |
Regulation of inducible nitric oxide synthase gene in glial cells. |
2006 May-Jun |
Antioxid. Redox Signal. |
pmid:16771683
|
Seong K et al. |
Cryptic promoter activity in the coding region of the HMG-CoA reductase gene in Fusarium graminearum. |
2006 |
Fungal Genet. Biol. |
pmid:16377218
|
Haratake A et al. |
Acceleration of de novo cholesterol synthesis in the epidermis influences desquamation of the stratum corneum in aged mice. |
2006 |
Skin Pharmacol Physiol |
pmid:16778459
|
Dincer M et al. |
Statins may decrease skeletal-related events in breast cancer patients with bone metastases. |
2006 |
Med. Hypotheses |
pmid:16844315
|
Kwintkiewicz J et al. |
Mevastatin inhibits proliferation of rat ovarian theca-interstitial cells by blocking the mitogen-activated protein kinase pathway. |
2006 |
Fertil. Steril. |
pmid:16963032
|
Pozo M et al. |
Simvastatin inhibits the migration and adhesion of monocytic cells and disorganizes the cytoskeleton of activated endothelial cells. |
2006 |
Eur. J. Pharmacol. |
pmid:16973154
|
Piotrowski PC et al. |
Statins inhibit growth of human endometrial stromal cells independently of cholesterol availability. |
2006 |
Biol. Reprod. |
pmid:16571871
|
Sakoda K et al. |
Simvastatin decreases IL-6 and IL-8 production in epithelial cells. |
2006 |
J. Dent. Res. |
pmid:16723648
|
Kanellis J et al. |
Activators of the energy sensing kinase AMPK inhibit random cell movement and chemotaxis in U937 cells. |
2006 |
Immunol. Cell Biol. |
pmid:16405649
|
Polo MP and de Bravo MG |
Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2. |
2006 |
Biochem. Cell Biol. |
pmid:16462894
|
Hampel D et al. |
Biosynthesis of mono- and sesquiterpenes in strawberry fruits and foliage: 2H labeling studies. |
2006 |
J. Agric. Food Chem. |
pmid:16478276
|
Ro DK et al. |
Production of the antimalarial drug precursor artemisinic acid in engineered yeast. |
2006 |
Nature |
pmid:16612385
|
Sjögren B et al. |
Cholesterol depletion reduces serotonin binding and signaling via human 5-HT(7(a)) receptors. |
2006 |
Eur. J. Pharmacol. |
pmid:17064686
|
Ohm TG and Meske V |
Cholesterol, statins and tau. |
2006 |
Acta Neurol. Scand., Suppl.c |
pmid:16866917
|
Crisby M |
The role of pleiotropic effects of statins in dementia. |
2006 |
Acta Neurol. Scand., Suppl.c |
pmid:16866920
|
Chana RS and Brunskill NJ |
Thiazolidinediones inhibit albumin uptake by proximal tubular cells through a mechanism independent of peroxisome proliferator activated receptor gamma. |
2006 |
Am. J. Nephrol. |
pmid:16508249
|
Macreadie IG et al. |
Growth inhibition of Candida species and Aspergillus fumigatus by statins. |
2006 |
FEMS Microbiol. Lett. |
pmid:16907733
|
Kosztáczky B et al. |
Neuropeptides induced a pronounced and statin-sensitive dysregulation of mevalonate cycle in human monocytes of patients with hypercholesterolemia. |
2006 |
Neuropeptides |
pmid:17049599
|
Ridsdale A et al. |
Cholesterol is required for efficient endoplasmic reticulum-to-Golgi transport of secretory membrane proteins. |
2006 |
Mol. Biol. Cell |
pmid:16452637
|
Gómez-Hernández A et al. |
Atorvastatin reduces the expression of prostaglandin E2 receptors in human carotid atherosclerotic plaques and monocytic cells: potential implications for plaque stabilization. |
2006 |
J. Cardiovasc. Pharmacol. |
pmid:16424787
|
Kinderlerer AR et al. |
Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis. |
2006 |
Arthritis Res. Ther. |
pmid:16859540
|
Kotti TJ et al. |
Brain cholesterol turnover required for geranylgeraniol production and learning in mice. |
2006 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:16505352
|
Sato M et al. |
Effects of exogenous mevalonic acid on sterol lipid classes in Larix kaempferi callus. |
2006 |
J Oleo Sci |
pmid:17693695
|
Kuzina V et al. |
Relationships among the biosyntheses of ubiquinone, carotene, sterols, and triacylglycerols in Zygomycetes. |
2006 |
Arch. Microbiol. |
pmid:17009023
|
Li JQ et al. |
Atorvastatin reduces plasminogen activator inhibitor-1 expression in adipose tissue of atherosclerotic rabbits. |
2006 |
Clin. Chim. Acta |
pmid:16507303
|
Parsons RB et al. |
Statins inhibit the dimerization of beta-secretase via both isoprenoid- and cholesterol-mediated mechanisms. |
2006 |
Biochem. J. |
pmid:16803455
|
Brinkkoetter PT et al. |
Atorvastatin interferes with activation of human CD4(+) T cells via inhibition of small guanosine triphosphatase (GTPase) activity and caspase-independent apoptosis. |
2006 |
Clin. Exp. Immunol. |
pmid:17100774
|
Mandey SH et al. |
A role for geranylgeranylation in interleukin-1beta secretion. |
2006 |
Arthritis Rheum. |
pmid:17075828
|
Ural AU et al. |
In vitro synergistic cytoreductive effects of zoledronic acid and radiation on breast cancer cells. |
2006 |
Breast Cancer Res. |
pmid:16925824
|
van Hellemond JJ and Tielens AG |
Adaptations in the lipid metabolism of the protozoan parasite Trypanosoma brucei. |
2006 |
FEBS Lett. |
pmid:16920110
|
Saini GS et al. |
Validation of the LC-MS/MS method for the quantification of mevalonic acid in human plasma and determination of the matrix effect. |
2006 |
J. Lipid Res. |
pmid:16861623
|
Yi P et al. |
The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Ggamma1. |
2006 |
Science |
pmid:16857902
|
Dimitroulakos J et al. |
Strategies to enhance epidermal growth factor inhibition: targeting the mevalonate pathway. |
2006 |
Clin. Cancer Res. |
pmid:16857822
|
Xu H et al. |
HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced "inside-out" signaling to extracellular matrix by preventing RhoA activation. |
2006 |
Am. J. Physiol. Renal Physiol. |
pmid:16774905
|
Kawasaki T et al. |
Biosynthesis of a natural polyketide-isoprenoid hybrid compound, furaquinocin A: identification and heterologous expression of the gene cluster. |
2006 |
J. Bacteriol. |
pmid:16452404
|
Haas D and Hoffmann GF |
Mevalonate kinase deficiencies: from mevalonic aciduria to hyperimmunoglobulinemia D syndrome. |
2006 |
Orphanet J Rare Dis |
pmid:16722536
|
Solito E et al. |
Post-translational modification plays an essential role in the translocation of annexin A1 from the cytoplasm to the cell surface. |
2006 |
FASEB J. |
pmid:16720734
|
Chemler JA et al. |
Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae. |
2006 |
Microb. Cell Fact. |
pmid:16719921
|
Silvander M et al. |
A new water-based topical carrier with polar skin-lipids. |
2006 |
Lipids Health Dis |
pmid:16672068
|
Coward WR et al. |
Statin-induced proinflammatory response in mitogen-activated peripheral blood mononuclear cells through the activation of caspase-1 and IL-18 secretion in monocytes. |
2006 |
J. Immunol. |
pmid:16621994
|
Neville-Webbe HL et al. |
Mechanisms of the synergistic interaction between the bisphosphonate zoledronic acid and the chemotherapy agent paclitaxel in breast cancer cells in vitro. |
2006 |
Tumour Biol. |
pmid:16582586
|
Rattan R et al. |
Rho/ROCK pathway as a target of tumor therapy. |
2006 |
J. Neurosci. Res. |
pmid:16385577
|
Wang J et al. |
Anti-inflammatory effect of pitavastatin on NF-kappaB activated by TNF-alpha in hepatocellular carcinoma cells. |
2006 |
Biol. Pharm. Bull. |
pmid:16595893
|
Benetka W et al. |
Farnesylation or geranylgeranylation? Efficient assays for testing protein prenylation in vitro and in vivo. |
2006 |
BMC Biochem. |
pmid:16507103
|
Xu L et al. |
[Effects of simvastatin on DNA synthesis in rat cardiac fibroblasts]. |
2006 |
Nan Fang Yi Ke Da Xue Xue Bao |
pmid:16503530
|
Riganti C et al. |
Statins revert doxorubicin resistance via nitric oxide in malignant mesothelioma. |
2006 |
Int. J. Cancer |
pmid:16450390
|
Ramasubbu K and Mann DL |
The emerging role of statins in the treatment of heart failure. |
2006 |
J. Am. Coll. Cardiol. |
pmid:16412858
|
Christensen M et al. |
Simvastatin protection against acute immune-mediated glomerulonephritis in mice. |
2006 |
Kidney Int. |
pmid:16407885
|
González-Fernández L et al. |
Cleavage of focal adhesion proteins and PKCdelta during lovastatin-induced apoptosis in spontaneously immortalized rat brain neuroblasts. |
2006 |
FEBS J. |
pmid:16367743
|
Zahiri HS et al. |
Coenzyme Q10 production in recombinant Escherichia coli strains engineered with a heterologous decaprenyl diphosphate synthase gene and foreign mevalonate pathway. |
2006 |
Metab. Eng. |
pmid:16815062
|
Pappu AS et al. |
Increased nonsterol isoprenoids, dolichol and ubiquinone, in the Smith-Lemli-Opitz syndrome: effects of dietary cholesterol. |
2006 |
J. Lipid Res. |
pmid:16983147
|
Yoon SH et al. |
Enhanced lycopene production in Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate. |
2006 |
Biotechnol. Bioeng. |
pmid:16547999
|
Nagashima T et al. |
Apoptosis of rheumatoid synovial cells by statins through the blocking of protein geranylgeranylation: a potential therapeutic approach to rheumatoid arthritis. |
2006 |
Arthritis Rheum. |
pmid:16447234
|
Yokota K et al. |
Simvastatin inhibits production of interleukin 6 (IL-6) and IL-8 and cell proliferation induced by tumor necrosis factor-alpha in fibroblast-like synoviocytes from patients with rheumatoid arthritis. |
2006 |
J. Rheumatol. |
pmid:16511915
|
Grochowski LL et al. |
Methanocaldococcus jannaschii uses a modified mevalonate pathway for biosynthesis of isopentenyl diphosphate. |
2006 |
J. Bacteriol. |
pmid:16621811
|
Alegret M and Silvestre JS |
Pleiotropic effects of statins and related pharmacological experimental approaches. |
2006 |
Methods Find Exp Clin Pharmacol |
pmid:17200729
|
Muñoz-GarcÃa B et al. |
Fn14 is upregulated in cytokine-stimulated vascular smooth muscle cells and is expressed in human carotid atherosclerotic plaques: modulation by atorvastatin. |
2006 |
Stroke |
pmid:16809572
|
Shang F et al. |
Simvastatin inhibits lipopolysaccharide-induced tumor necrosis factor-alpha expression in neonatal rat cardiomyocytes: The role of reactive oxygen species. |
2006 |
Biochem. Biophys. Res. Commun. |
pmid:17094942
|
Issat T et al. |
Berberine, a natural cholesterol reducing product, exerts antitumor cytostatic/cytotoxic effects independently from the mevalonate pathway. |
2006 |
Oncol. Rep. |
pmid:17089049
|
Kuwana M |
Potential benefit of statins for vascular disease in systemic sclerosis. |
2006 |
Curr Opin Rheumatol |
pmid:17053504
|
Thompson K et al. |
Alkylamines cause Vgamma9Vdelta2 T-cell activation and proliferation by inhibiting the mevalonate pathway. |
2006 |
Blood |
pmid:16179378
|
van Beek E et al. |
Independent pathways in the modulation of osteoclastic resorption by intermediates of the mevalonate biosynthetic pathway: the role of the retinoic acid receptor. |
2006 |
Bone |
pmid:16165408
|
Hamadmad SN et al. |
Erythropoietin receptor signal transduction requires protein geranylgeranylation. |
2006 |
J. Pharmacol. Exp. Ther. |
pmid:16203826
|
Qiu Y and Li D |
Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase. |
2006 |
Org. Lett. |
pmid:16524256
|
Qiu Y and Li D |
Inhibition of mevalonate 5-diphosphate decarboxylase by fluorinated substrate analogs. |
2006 |
Biochim. Biophys. Acta |
pmid:16626865
|
Beckman JA and Creager MA |
The nonlipid effects of statins on endothelial function. |
2006 |
Trends Cardiovasc. Med. |
pmid:16781949
|
Caruso MG and Notarnicola M |
Biochemical changes of mevalonate pathway in human colorectal cancer. |
2005 Sep-Oct |
Anticancer Res. |
pmid:16101154
|
Nawarskas JJ |
HMG-CoA reductase inhibitors and coenzyme Q10. |
2005 Mar-Apr |
Cardiol Rev |
pmid:15705257
|
Akiyama K et al. |
Antitumor effect of geranylamine derivatives on human hepatoma. |
2005 Jan-Feb |
In Vivo |
pmid:15796170
|
Yazawa H et al. |
Simvastatin promotes cell metabolism, proliferation, and osteoblastic differentiation in human periodontal ligament cells. |
2005 |
J. Periodontol. |
pmid:15974856
|
Baker SK and Tarnopolsky MA |
Statin-associated neuromyotoxicity. |
2005 |
Drugs Today |
pmid:16034491
|
Sakamoto K et al. |
Fluvastatin prevents vascular hyperplasia by inhibiting phenotype modulation and proliferation through extracellular signal-regulated kinase 1 and 2 and p38 mitogen-activated protein kinase inactivation in organ-cultured artery. |
2005 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:15591221
|
Seker T et al. |
Analysis of acyl CoA ester intermediates of the mevalonate pathway in Saccharomyces cerevisiae. |
2005 |
Appl. Microbiol. Biotechnol. |
pmid:15448940
|
Neville-Webbe HL et al. |
Sequence- and schedule-dependent enhancement of zoledronic acid induced apoptosis by doxorubicin in breast and prostate cancer cells. |
2005 |
Int. J. Cancer |
pmid:15455384
|
Donovan JM et al. |
Effects of colesevelam HC1 on sterol and bile acid excretion in patients with type IIa hypercholesterolemia. |
2005 |
Dig. Dis. Sci. |
pmid:16047465
|
Cordle A and Landreth G |
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors attenuate beta-amyloid-induced microglial inflammatory responses. |
2005 |
J. Neurosci. |
pmid:15647473
|
Hewitt RE et al. |
The bisphosphonate acute phase response: rapid and copious production of proinflammatory cytokines by peripheral blood gd T cells in response to aminobisphosphonates is inhibited by statins. |
2005 |
Clin. Exp. Immunol. |
pmid:15606619
|
Wu B et al. |
Paradoxical effects of statins on aortic valve myofibroblasts and osteoblasts: implications for end-stage valvular heart disease. |
2005 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:15618546
|