Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Glioblastoma D005909 27 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Hypothyroidism D007037 32 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Thrombosis D013927 49 associated lipids
Leukemia D007938 74 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Glioma D005910 112 associated lipids
Hypertension D006973 115 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

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Per page 10 20 50 100 | Total 2899
Authors Title Published Journal PubMed Link
Hu ZY et al. Neurosteroids: oligodendrocyte mitochondria convert cholesterol to pregnenolone. 1987 Proc. Natl. Acad. Sci. U.S.A. pmid:3479785
Forman BM et al. The orphan nuclear receptor LXRalpha is positively and negatively regulated by distinct products of mevalonate metabolism. 1997 Proc. Natl. Acad. Sci. U.S.A. pmid:9380679
Arebalo RE et al. In vivo regulation of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A reductase: immunotitration of the enzyme after short-term mevalonate or cholesterol feeding. 1982 Proc. Natl. Acad. Sci. U.S.A. pmid:6948302
Epstein WW et al. Quantitation of prenylcysteines by a selective cleavage reaction. 1991 Proc. Natl. Acad. Sci. U.S.A. pmid:1946384
Parker TS et al. Mevalonic acid in human plasma: relationship of concentration and circadian rhythm to cholesterol synthesis rates in man. 1982 Proc. Natl. Acad. Sci. U.S.A. pmid:6953446
Lange BM and Croteau R Isopentenyl diphosphate biosynthesis via a mevalonate-independent pathway: isopentenyl monophosphate kinase catalyzes the terminal enzymatic step. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10570138
Rauthan M et al. The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23530189
Yasmin S et al. Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus. 2012 Proc. Natl. Acad. Sci. U.S.A. pmid:22106303
Larson RA et al. Neutrophils are required for the DNA synthetic response of human lymphocytes to mevalonic acid: evidence suggesting that a nonsterol product of mevalonate is involved. 1982 Proc. Natl. Acad. Sci. U.S.A. pmid:6953445
Sapir A et al. Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:25187565
Kinsella BT et al. Posttranslational modification of Ha-ras p21 by farnesyl versus geranylgeranyl isoprenoids is determined by the COOH-terminal amino acid. 1991 Proc. Natl. Acad. Sci. U.S.A. pmid:1924354
Casey PJ et al. p21ras is modified by a farnesyl isoprenoid. 1989 Proc. Natl. Acad. Sci. U.S.A. pmid:2682646
Kawata M et al. Posttranslationally processed structure of the human platelet protein smg p21B: evidence for geranylgeranylation and carboxyl methylation of the C-terminal cysteine. 1990 Proc. Natl. Acad. Sci. U.S.A. pmid:2123345
Wang Z et al. Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:24367099
Clendening JW et al. Dysregulation of the mevalonate pathway promotes transformation. 2010 Proc. Natl. Acad. Sci. U.S.A. pmid:20696928
Hecht S et al. Studies on the nonmevalonate pathway to terpenes: the role of the GcpE (IspG) protein. 2001 Proc. Natl. Acad. Sci. U.S.A. pmid:11752431
Kaneda K et al. An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190. 2001 Proc. Natl. Acad. Sci. U.S.A. pmid:11158573
Takahashi S et al. A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9707569
Chang TY et al. Isolation and partial characterization of a cholesterol-requiring mutant of Chinese hamster ovary cells. 1977 Proc. Natl. Acad. Sci. U.S.A. pmid:265577
James G et al. Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells. 1996 Proc. Natl. Acad. Sci. U.S.A. pmid:8633088