Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Thrombosis D013927 49 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Hypothyroidism D007037 32 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Glioblastoma D005909 27 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Refsum Disease D012035 19 associated lipids
Xanthomatosis D014973 17 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

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All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
Blomquist GJ et al. Biosynthesis of 3-methylpentacosane in the cockroach Periplaneta americana. 1975 Biochem. Biophys. Res. Commun. pmid:1147933
Al-Haidari AA et al. HMG-CoA reductase regulates CCL17-induced colon cancer cell migration via geranylgeranylation and RhoA activation. 2014 Biochem. Biophys. Res. Commun. pmid:24582560
Fogelman AM et al. Cholesterol biosynthesis in human lymphocytes, monocytes, and granulocytes. 1977 Biochem. Biophys. Res. Commun. pmid:869944
Keller RK and Simonet WS Near normal levels of isoprenoid lipids in severe mevalonic aciduria. 1988 Biochem. Biophys. Res. Commun. pmid:3365255
Fuse M et al. Regulation of geranylgeranyl pyrophosphate synthase in the proliferation of rat FRTL-5 cells: involvement of both cAMP-PKA and PI3-AKT pathways. 2004 Biochem. Biophys. Res. Commun. pmid:14985133
Krishnaiah KV et al. Regulation of steroidogenesis by ubiquinone. 1967 Biochem. Biophys. Res. Commun. pmid:6052477
Hornby GM et al. The effects of thiols on cholesterol synthesis by rat liver in vitro. 1970 Biochem. Biophys. Res. Commun. pmid:5492149
Chan PC et al. Lovastatin increases surface low density lipoprotein receptor expression by retarding the receptor internalization rate in proliferating lymphocytes. 1997 Biochem. Biophys. Res. Commun. pmid:9196047
Szkopińska A et al. The regulation of activity of main mevalonic acid pathway enzymes: farnesyl diphosphate synthase, 3-hydroxy-3-methylglutaryl-CoA reductase, and squalene synthase in yeast Saccharomyces cerevisiae. 2000 Biochem. Biophys. Res. Commun. pmid:10623644
Lee SK et al. Stabilization and translocation of p53 to mitochondria is linked to Bax translocation to mitochondria in simvastatin-induced apoptosis. 2010 Biochem. Biophys. Res. Commun. pmid:20043868
Gibbons GF Existence of metabolic reservoirs in the later stages of the cholesterol biosynthetic pathway. 1977 Biochem. Biophys. Res. Commun. pmid:861038
Ku EC Regulation of fatty acid biosynthesis by intermediates of the cholesterol biosynthetic pathway. 1996 Biochem. Biophys. Res. Commun. pmid:8769113
Aguilera JA et al. Effect of dietary cholesterol on mevalonate metabolism by sterol and nonsterol pathways. 1984 Biochem. Biophys. Res. Commun. pmid:6477574
Polo MP and de Bravo MG Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2. 2006 Biochem. Cell Biol. pmid:16462894
Polo MP et al. Effect of ethanol on cell growth and cholesterol metabolism in cultured Hep G2 cells. 2003 Biochem. Cell Biol. pmid:14663504
Ellsworth JL et al. Evidence for sterol-independent regulation of low-density lipoprotein receptor activity in Hep-G2 cells. 1991 Biochem. J. pmid:1930137
DE WAARD A and POPJAK G Studies on the biosynthesis of cholesterol. 9. Formation of phosphorylated derivatives of mevalonic acid in liver-enzyme preparations. 1959 Biochem. J. pmid:13815126
Henry A et al. Dolichol biosynthesis in human malignant cells. 1991 Biochem. J. pmid:1654890
Smith AG and Goad LJ Sterol biosynthesis by the sea urchin Echinus esculentus. 1974 Biochem. J. pmid:4441383
Rasmussen LM et al. Diverse effects of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase on the expression of VCAM-1 and E-selectin in endothelial cells. 2001 Biochem. J. pmid:11716764
Metz SA et al. Modulation of insulin secretion from normal rat islets by inhibitors of the post-translational modifications of GTP-binding proteins. 1993 Biochem. J. pmid:8216234
Richards JB and Hemming FW Dolichols, ubiquinones, geranylgeraniol and farnesol as the major metabolites of mevalonate in Phytophthora cactorum. 1972 Biochem. J. pmid:4643705
Wellburn AR and Hampp R Uptake of mevalonate and acetate during plastid development. 1976 Biochem. J. pmid:985424
Cohen LH and Griffioen M Regulation of 3-hydroxy-3-methylglutaryl-CoA reductase mRNA contents in human hepatoma cell line Hep G2 by distinct classes of mevalonate-derived metabolites. 1988 Biochem. J. pmid:2848511
Gough DP and Hemming FW The characterization and stereochemistry of biosynthesis of dolichols in rat liver. 1970 Biochem. J. pmid:4319540
Stone KJ and Hemming FW The incorporation of [2-14C, 4R-3H1] mevalonate and [2-14C, 4S-3H1] mevalonate into squalene, ubiquinone and ergosterol of Aspergillus fumigatus Fresenius. 1965 Biochem. J. pmid:4284430
Azrolan NI and Coleman PS A discoordinate increase in the cellular amount of 3-hydroxy-3-methylglutaryl-CoA reductase results in the loss of rate-limiting control over cholesterogenesis in a tumour cell-free system. 1989 Biochem. J. pmid:2705993
Wilton DC The effect of excess mevalonic acid on ubiquinone and tetrahymanol biosynthesis in Tetrahymena pyriformis. 1985 Biochem. J. pmid:3929773
Wilton DC The effect of cholesterol on ubiquinone and tetrahymanol biosynthesis in Tetrahymena pyriformis. 1983 Biochem. J. pmid:6418144
Charlton JM et al. Incorporation of 2-[14C]mevalonic acid into phytoene by isolated chloroplasts. 1967 Biochem. J. pmid:4383323
Disch A et al. Distribution of the mevalonate and glyceraldehyde phosphate/pyruvate pathways for isoprenoid biosynthesis in unicellular algae and the cyanobacterium Synechocystis PCC 6714. 1998 Biochem. J. pmid:9657979
Swift IE and Milborrow BV Retention of the 4-pro-R hydrogen atom of mevalonate at C-2,2' of bacterioruberin in Halobacterium halobium. 1980 Biochem. J. pmid:7406867
Fang TY and Baisted DJ 2,3-Oxidosqualene cyclase and cycloartenol-s-adenosylmethionine methyltransferase activities in vivo in the cotyledon and axis tissues of germinating pea seeds. 1975 Biochem. J. pmid:1212194
Swift IE and Milborrow BV Stereochemistry of allene biosynthesis and the formation of the acetylenic carotenoid diadinoxanthin and peridinin (C37) from neoxanthin. 1981 Biochem. J. pmid:7337715
Jayaram M and Raman TS Metabolism of ergosterol in the larva of the rice moth (Corcyra cephalonica St.). 1972 Biochem. J. pmid:5085614
Nave JF et al. Mechanism of the inhibition of cholesterol biosynthesis by 6-fluoromevalonate. 1985 Biochem. J. pmid:2986604
Smith AG and Goad LJ Sterol biosynthesis in the starfish Asterias rubens and Henricia sanguinolenta. 1971 Biochem. J. pmid:5126917
Moshier SE and Chapman DJ Biosynthetic studies on aromatic carotenoids. Biosynthesis of chlorobactene. 1973 Biochem. J. pmid:4774401
McDermott JC et al. Carotenoid biosynthesis in a Flavobacterium sp.: stereochemistry of hydrogen elimination in the desaturation of phytoene to lycopene, rubixanthin and zeaxanthin. 1973 Biochem. J. pmid:4762756
Ranganathan S and Ramasarma T Inhibition of the biosynthesis of sterols by phenyl and phenolic compounds in rat liver. 1973 Biochem. J. pmid:4749274
Beedle AS et al. Studies on the biosynthesis of tetrahymanol in Tetrahymena pyriformis. The mechanism of inhibition by cholesterol. 1974 Biochem. J. pmid:4140721
Goodwin TW Recent developments in the study of the biosynthesis of carotenoids. 1972 Biochem. J. pmid:5085548
Mitropoulos KA and Myant NB Evidence that the oxidation of the side chain of cholesterol by liver mitochondria is stereospecific, and that the immediate product of cleavage is propionate. 1965 Biochem. J. pmid:5881647
Leijten L et al. Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in mouse uterine epithelial cells. 1987 Biochem. J. pmid:3032158
Hornby GM and Boyd GS The origin of lanosta-7,24-dienol in rat skin. 1971 Biochem. J. pmid:5131739
Richards JB et al. Dolichol phosphates as acceptors of mannose from guanosine diphosphate mannose in liver systems. 1971 Biochem. J. pmid:5131017
Baisted DJ Sterol and triterpene synthesis in the developing and germinating pea seed. 1971 Biochem. J. pmid:5158507
Skilleter DN and Kekwick RG The enzymes forming isopentenyl pyrophosphate from 5-phosphomevalonate (mevalonate 5-phosphate) in the latex of Hevea brasiliensis. 1971 Biochem. J. pmid:4333851
Milborrow BV and Noddle RC Conversion of 5-(1,2-epoxy-2,6,6-trimethylcyclohexyl)-3-methylpenta-cis-2-trans-4-dienoic acid into abscisic acid in plants. 1970 Biochem. J. pmid:5493506
Bolger LM et al. Biosynthesis of 24-ethylcholesta-5,22,25-trien-3-beta-ol, a new sterol from Clerodendrum campbellii. 1970 Biochem. J. pmid:5472151
Ginger ML et al. Elucidation of carbon sources used for the biosynthesis of fatty acids and sterols in the trypanosomatid Leishmania mexicana. 1999 Biochem. J. pmid:10455027
Gough DP et al. The characterization of undecaprenol of Lactobacillus plantarum. 1970 Biochem. J. pmid:5472148
Olson RJ et al. Alterations in cholesterol and fatty acid biosynthesis in rat liver homogenates by aryloxy acids. 1974 Biochem. J. pmid:4441387
Tefft RE et al. Aspects of the stereochemistry of torularhodin biosynthesis. 1970 Biochem. J. pmid:5465554
Boogaard A et al. Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in human hepatoma cell line Hep G2. Effects of inhibitors of cholesterol synthesis on enzyme activity. 1987 Biochem. J. pmid:3036060
Hepper CM and Audley BG Th biosynthesis of rubber from beta-hydroxy-beta-methylgluarylcoenzyme A in Hevea brasiliensis latex. 1969 Biochem. J. pmid:4390212
Stone KJ and Hemming FW The stereochemistry of hexahydroprenol, ubiquinone and ergosterol biosynthesis in the mycelium of Aspergillus fumigatus Fresenius. 1967 Biochem. J. pmid:4292001
Buggy MJ et al. Stereochemistry of phytoene biosynthesis by isolated chloroplasts. 1969 Biochem. J. pmid:4309532
Robinson DR and Ryback G Incorporation of tritium from [(4R)-4-3H]mevalonate into abscisic acid. 1969 Biochem. J. pmid:5821014
West CA Gibberellins and their biosynthesis. 1969 Biochem. J. pmid:5810062
Francis MJ and Allcock C Monoterpene beta-D-glucosides in roses: isolation and formation from DL-2-14C mevalonate. 1969 Biochem. J. pmid:5807204
Reid WW Effect of SKF7997 and SKF525 on diterpene and sterol biosynthesis in Gibberella fujikori from [2-14C] mevalonate. 1969 Biochem. J. pmid:5807203
Gray JC and Kekwick RG Mevalonate kinase from etiolated cotyledons of French beans. 1969 Biochem. J. pmid:5807202
Austin DG et al. Trisporic acid biosynthesis and carotenogenesis in Blakesleea trispora. 1969 Biochem. J. pmid:5807198
Hill HM and Rogers LJ Conversion of lycopene into beta-carotene by chloroplasts of higher plants. 1969 Biochem. J. pmid:5807194
Cornforth JW and Cornforth RH Chemistry of mevalonic acid. 1969 Biochem. J. pmid:5807184
Rudney H The biosynthesis of terpenoid quinones. 1969 Biochem. J. pmid:4308944
Williams RJ et al. The biosynthesis of cyclic carotenes. 1967 Biochem. J. pmid:6060456
Wieckowski S and Goodwin TW Incorporation of DL-[2-14C]mevalonic acid lactone into beta-carotene and the phytol side chain of chlorophyll in cotyledons of four species of pine seedlings. 1967 Biochem. J. pmid:6060454
Gough DP and Hemming FW The stereochemistry of betulaprenol biosynthesis. 1967 Biochem. J. pmid:6056617
Atkin SD et al. The role of cytochrome P-450 in cholesterol biogenesis and catabolism. 1972 Biochem. J. pmid:5084788
Williams RJ et al. The stereospecific biosynthesis of phytoene and polyunsaturated carotenes. 1967 Biochem. J. pmid:6049923
Wellburn AR and Hemming FW The subcellular distribution and biosynthesis of castaprenols and plastoquinone in the leaves of Aesculus hippocastanum. 1967 Biochem. J. pmid:6068175
Rodwell VW Cholesterol regulation of hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase. 1972 Biochem. J. pmid:5085556
Rees HH et al. The biosynthesis of beta-amyrin. Mechanism of squalene cyclization. 1968 Biochem. J. pmid:5639923
Rogers LJ et al. Mevalonate-kinase isoenzymes in plant cells. 1966 Biochem. J. pmid:5968528
Goad LJ and Goodwin TW The biosynthesis of sterols in higher plants. 1966 Biochem. J. pmid:5964970
Rees HH et al. The stereospecific biosynthesis of plant sterols and alpha- and beta-amyrin. 1966 Biochem. J. pmid:5964969
Rogers LJ et al. Intracellular localization of mevalonate-activating enzymes in plant cells. 1966 Biochem. J. pmid:5947149
Treharne KJ et al. Incorporation of [14C] carbon dioxide and [2-14C] mevalonic acid into terpenoids of higher plants during chloroplast development. 1966 Biochem. J. pmid:5965341
Fears R The contribution of the cholesterol biosynthetic pathway to intermediary metabolism and cell function. 1981 Biochem. J. pmid:7039614
Thorne KJ and Kodicek E The structure of bactoprenol, a lipid formed by lactobacilli from mevalonic acid. 1966 Biochem. J. pmid:5965329
Williamson IP and Kekwick RG The formation of 5-phosphomevalonate by mevalonate kinase in Hevea brasiliensis latex. 1965 Biochem. J. pmid:5862423
Molowa DT and Cimis GM Co-ordinate regulation of low-density-lipoprotein receptor and 3-hydroxy-3-methylglutaryl-CoA reductase and synthase gene expression in HepG2 cells. 1989 Biochem. J. pmid:2569863
Shama Bhat C and Ramasarma T Inhibition of rat liver mevalonate pyrophosphate decarboxylase and mevalonate phosphate kinase by phenyl and phenolic compounds. 1979 Biochem. J. pmid:226078
Gavigan SJ and Knight BL The effects of low-density lipoprotein and cholesterol on acyl-coenzyme A: cholesterol acyltransferase activity in membranes from cultured human fibroblasts. 1983 Biochem. J. pmid:6651782
Campos N et al. Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate: a novel system for the genetic analysis of the 2-C-methyl-d-erythritol 4-phosphate pathway for isoprenoid biosynthesis. 2001 Biochem. J. pmid:11115399
Milborrow BV Stereochemical aspects of the formation of double bonds in abscisic acid. 1972 Biochem. J. pmid:4643698
Madyastha KM et al. Carboxyl group methylation of loganic acid by a cell-free enzyme preparation from Vinca rosea. 1972 Biochem. J. pmid:4404427
RAMASARMA T and RAMAKRISHNAN T Incorporation of [2-14C]mevalonic acid and [2-14C]acetic acid into lipids of mycobacteria. 1961 Biochem. J. pmid:14038591
BRAITHWAITE GD and GOODWIN TW Studies in carotenogenesis. 27. Incorporation of [2-14C] acetate, DL-[2-14C] mevalonate and C14-labelled carbon dioxide into carrotroot preparations. 1960 Biochem. J. pmid:13849153
BRAITHWAITE GD and GOODWIN TW Studies in carotenogenesis. 26. The incorporation of [C14] acetate, [C14] mevalonate and C14-labelled carbon dioxide into beta-carotene by the fungus Phycomyces blakesleeanus. 1960 Biochem. J. pmid:13849152
Rohmer M et al. Isoprenoid biosynthesis in bacteria: a novel pathway for the early steps leading to isopentenyl diphosphate. 1993 Biochem. J. pmid:8240251
Disch A et al. Mevalonate-derived isopentenyl diphosphate is the biosynthetic precursor of ubiquinone prenyl side chain in tobacco BY-2 cells. 1998 Biochem. J. pmid:9531505
Goad LJ Sterol biosynthesis. 1969 Biochem. J. pmid:5807186
Percy-Robb IW and Boyd GS The synthesis of bile acids in perfused rat liver subjected to chronic biliary drainage. 1970 Biochem. J. pmid:5472179
Thorne KJ Incorporation of radioactive mevalonate into C50 and C55 phenols by Streptococcus mutans. 1973 Biochem. J. pmid:4772282
Derksen A et al. Non-human primate platelets and arterial tissue cannot convert preformed [14C]lanosterol into[14C]cholesterol in vivo. 1976 Biochem. J. pmid:822845
Goodwin TW and Williams RJ A mechanism for the biosynthesis of alpha-carotene. 1965 Biochem. J. pmid:5881648
Scharf SS and Simpson KL Attempts to detect lycopersene formation in yeast. 1968 Biochem. J. pmid:5753091