| MeSH term | MeSH ID | Detail |
|---|---|---|
| Thrombosis | D013927 | 49 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Hypothyroidism | D007037 | 32 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Lipid Metabolism, Inborn Errors | D008052 | 26 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Refsum Disease | D012035 | 19 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Mevalonic acid
Mevalonic acid is a lipid of Fatty Acyls (FA) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.
Here are additional resources we collected from PubChem and MeSH for Mevalonic acid
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Mevalonic acid
PubChem Biomolecular Interactions and Pathways
NCBI Entrez Crosslinks
All references with Mevalonic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lee MH et al. | Simvastatin suppresses self-renewal of mouse embryonic stem cells by inhibiting RhoA geranylgeranylation. | 2007 | Stem Cells | pmid:17464088 |
| Haratake A et al. | Acceleration of de novo cholesterol synthesis in the epidermis influences desquamation of the stratum corneum in aged mice. | 2006 | Skin Pharmacol Physiol | pmid:16778459 |
| Kodaman PH and Duleba AJ | Statins in the treatment of polycystic ovary syndrome. | 2008 | Semin. Reprod. Med. | pmid:18181091 |
| Bellosta S et al. | Statins effect on smooth muscle cell proliferation. | 2004 | Semin Vasc Med | pmid:15861311 |
| Cornforth JW | Asymmetry and enzyme action. | 1976 | Science | pmid:935862 |
| Edmond J et al. | Mevalonate metabolism: role of kidneys. | 1976 | Science | pmid:935865 |
| Farnsworth CC et al. | Identification of geranylgeranyl-modified proteins in HeLa cells. | 1990 | Science | pmid:2296721 |
| MEROLA AJ and ARNOLD A | ESTRONE INHIBITION OF CHOLESTEROL BIOSYNTHESIS AT THE MEVALONIC ACID STAGE. | 1964 | Science | pmid:14169718 |
| FIMOGNARI GM and RODWELL VW | CHOLESTEROL BIOSYNTHESIS: MEVALONATE SYNTHESIS INHIBITED BY BILE SALTS. | 1965 | Science | pmid:14245778 |
| Graebe JE | Isoprenoid biosynthesis in a cell-free system from pea shoots. | 1967 | Science | pmid:4381746 |
| Yi P et al. | The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Ggamma1. | 2006 | Science | pmid:16857902 |
| Galli G et al. | Sterol precursors of cholesterol in adult human brain. | 1968 | Science | pmid:5700071 |
| Jomaa H et al. | Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. | 1999 | Science | pmid:10477522 |
| Matsumoto Y et al. | A critical role of mevalonate for peptidoglycan synthesis in Staphylococcus aureus. | 2016 | Sci Rep | pmid:26961421 |
| Pina ES et al. | Mevalonate-derived quinonemethide triterpenoid from in vitro roots of Peritassa laevigata and their localization in root tissue by MALDI imaging. | 2016 | Sci Rep | pmid:26943243 |
| Kain V et al. | Simvastatin may induce insulin resistance through a novel fatty acid mediated cholesterol independent mechanism. | 2015 | Sci Rep | pmid:26345110 |
| Warita K et al. | Statin-induced mevalonate pathway inhibition attenuates the growth of mesenchymal-like cancer cells that lack functional E-cadherin mediated cell cohesion. | 2014 | Sci Rep | pmid:25534349 |
| Omar SH | Oleuropein in olive and its pharmacological effects. | 2010 Apr-Jun | Sci Pharm | pmid:21179340 |
| Feitosa AO et al. | Lethality of cytochalasin B and other compounds isolated from fungus Aspergillus sp. (Trichocomaceae) endophyte of Bauhinia guianensis (Fabaceae). | 2016 Jul - Sep | Rev. Argent. Microbiol. | pmid:27567521 |
| Ali OF et al. | Pleiotropic effects of statins in distal human pulmonary artery smooth muscle cells. | 2011 | Respir. Res. | pmid:21999923 |
| Schaafsma D et al. | Simvastatin inhibits TGFβ1-induced fibronectin in human airway fibroblasts. | 2011 | Respir. Res. | pmid:21864337 |
| Capra V and Rovati GE | Rosuvastatin inhibits human airway smooth muscle cells mitogenic response to eicosanoid contractile agents. | 2014 | Pulm Pharmacol Ther | pmid:23806820 |
| Olson AL et al. | Substrate induced structural and dynamics changes in human phosphomevalonate kinase and implications for mechanism. | 2009 | Proteins | pmid:18798562 |
| Vinokur JM et al. | Structural analysis of mevalonate-3-kinase provides insight into the mechanisms of isoprenoid pathway decarboxylases. | 2015 | Protein Sci. | pmid:25422158 |
| Korman TP et al. | A synthetic biochemistry system for the in vitro production of isoprene from glycolysis intermediates. | 2014 | Protein Sci. | pmid:24623472 |
| Rosenthal RS and Rodwell VW | Purification and characterization of the heteromeric transcriptional activator MvaT of the Pseudomonas mevalonii mvaAB operon. | 1998 | Protein Sci. | pmid:9514272 |
| Andreassi JL et al. | Crystal structure of the Streptococcus pneumoniae mevalonate kinase in complex with diphosphomevalonate. | 2007 | Protein Sci. | pmid:17400916 |
| Hedl M and Rodwell VW | Inhibition of the class II HMG-CoA reductase of Pseudomonas mevalonii. | 2004 | Protein Sci. | pmid:15152097 |
| Hedl M and Rodwell VW | Enterococcus faecalis mevalonate kinase. | 2004 | Protein Sci. | pmid:14767074 |
| Kim DY et al. | Expression and characterization of the HMG-CoA reductase of the thermophilic archaeon Sulfolobus solfataricus. | 1999 | Protein Expr. Purif. | pmid:10600463 |
| Yildirim FI et al. | Aggravating effect of atorvastatin on indomethacin-induced gastric injury: Focus on PGE2, TNF-α, neutrophils and iNOS. | 2015 | Prostaglandins Other Lipid Mediat. | pmid:26201058 |
| Kabara JJ | A critical review of brain cholesterol metabolism. | 1973 | Prog. Brain Res. | pmid:4608424 |
| Popják G and Meenan A | Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase: search for the enzyme's repressor derived from mevalonate. | 1987 | Proc. R. Soc. Lond., B, Biol. Sci. | pmid:2892200 |
| Cornforth J | Symmetry of squalene epoxidation in vivo. | 1977 | Proc. R. Soc. Lond., B, Biol. Sci. | pmid:22855 |
| Mizuno T et al. | A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21. | 1991 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1907371 |
| Roullet JB et al. | Mevalonate availability and cardiovascular functions. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8265617 |
| Sinensky M and Logel J | Defective macromolecule biosynthesis and cell-cycle progression in a mammalian cell starved for mevalonate. | 1985 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2582409 |
| Quesney-Huneeus V et al. | Essential role for mevalonate synthesis in DNA replication. | 1979 | Proc. Natl. Acad. Sci. U.S.A. | pmid:291922 |
| Laffitte BA et al. | LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11149950 |
| Henry LK et al. | Orthologs of the archaeal isopentenyl phosphate kinase regulate terpenoid production in plants. | 2015 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26216978 |
| Venkateshwaran M et al. | A role for the mevalonate pathway in early plant symbiotic signaling. | 2015 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26199419 |
| Parmryd I et al. | Protein prenylation in spinach chloroplasts. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10468564 |
| Lai RK et al. | The gamma subunit of transducin is farnesylated. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2217200 |
| Sapir A et al. | Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25187565 |
| Farnsworth CC et al. | C terminus of the small GTP-binding protein smg p25A contains two geranylgeranylated cysteine residues and a methyl ester. | 1991 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1906176 |
| Ness GC et al. | Stimulation of hepatic beta-hydroxy-beta-methylglutaryl coenzyme A reductase activity in hypophysectomized rats by L-triiodothyronine. | 1973 | Proc. Natl. Acad. Sci. U.S.A. | pmid:4521209 |
| Okamura E et al. | Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20534558 |
| Ohyama K et al. | Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19139393 |
| Rao S et al. | Lovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10393901 |
| Beg ZH et al. | In vivo modulation of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A reductase, reductase kinase, and reductase kinase kinase by mevalonolactone. | 1984 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6594693 |