Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Thrombosis D013927 49 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Hypothyroidism D007037 32 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Glioblastoma D005909 27 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Refsum Disease D012035 19 associated lipids
Xanthomatosis D014973 17 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

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All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
Pedrini S et al. Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK. 2005 PLoS Med. pmid:15647781
Deshpande G et al. Ggamma1, a downstream target for the hmgcr-isoprenoid biosynthetic pathway, is required for releasing the Hedgehog ligand and directing germ cell migration. 2009 PLoS Genet. pmid:19132091
Maurer-Stroh S et al. Towards complete sets of farnesylated and geranylgeranylated proteins. 2007 PLoS Comput. Biol. pmid:17411337
Hardman R and Fazli FR Labelled steroidal sapogenins and hydrocarbons from Trigonella foenumgraecum by acetate, mevalonate and cholesterol feeds to seeds. 1972 Planta Med. pmid:5018497
Okada K et al. Antisense and chemical suppression of the nonmevalonate pathway affects ent-kaurene biosynthesis in Arabidopsis. 2002 Planta pmid:12029484
Nagata N et al. Mevalonic acid partially restores chloroplast and etioplast development in Arabidopsis lacking the non-mevalonate pathway. 2002 Planta pmid:12447549
Zeidler J and Lichtenthaler HK Biosynthesis of 2-methyl-3-buten-2-ol emitted from needles of Pinus ponderosa via the non-mevalonate DOXP/MEP pathway of isoprenoid formation. 2001 Planta pmid:11469599
Wu S et al. Engineering triterpene metabolism in tobacco. 2012 Planta pmid:22729821
Simkin AJ et al. Peroxisomal localisation of the final steps of the mevalonic acid pathway in planta. 2011 Planta pmid:21655959
Schwender J et al. Chlorophyta exclusively use the 1-deoxyxylulose 5-phosphate/2-C-methylerythritol 4-phosphate pathway for the biosynthesis of isoprenoids. 2001 Planta pmid:11289606
Clastre M et al. Subcellular evidence for the involvement of peroxisomes in plant isoprenoid biosynthesis. 2011 Plant Signal Behav pmid:22080790
Henriquez MA et al. Effects of glucans and eicosapentaenoic acid on differential regulation of phenylpropanoid and mevalonic pathways during potato response to Phytophthora infestans. 2012 Plant Physiol. Biochem. pmid:22922112
Rodríguez-Concepción M and Boronat A Elucidation of the methylerythritol phosphate pathway for isoprenoid biosynthesis in bacteria and plastids. A metabolic milestone achieved through genomics. 2002 Plant Physiol. pmid:12427975
Li Z et al. Effect of temperature on postillumination isoprene emission in oak and poplar. 2011 Plant Physiol. pmid:21177471
Che P et al. Metabolic and environmental regulation of 3-methylcrotonyl-coenzyme A carboxylase expression in Arabidopsis. 2002 Plant Physiol. pmid:12068107
Sharkey TD et al. Isoprene increases thermotolerance of fosmidomycin-fed leaves. 2001 Plant Physiol. pmid:11299379
Ruiz-Sola MÁ et al. A Single Arabidopsis Gene Encodes Two Differentially Targeted Geranylgeranyl Diphosphate Synthase Isoforms. 2016 Plant Physiol. pmid:27707890
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Sapir-Mir M et al. Peroxisomal localization of Arabidopsis isopentenyl diphosphate isomerases suggests that part of the plant isoprenoid mevalonic acid pathway is compartmentalized to peroxisomes. 2008 Plant Physiol. pmid:18988695
Galichet A et al. Farnesylation directs AtIPT3 subcellular localization and modulates cytokinin biosynthesis in Arabidopsis. 2008 Plant Physiol. pmid:18184738
Bede JC et al. Biosynthetic pathway of insect juvenile hormone III in cell suspension cultures of the sedge Cyperus iria. 2001 Plant Physiol. pmid:11598232
Huang M et al. Variation of herbivore-induced volatile terpenes among Arabidopsis ecotypes depends on allelic differences and subcellular targeting of two terpene synthases, TPS02 and TPS03. 2010 Plant Physiol. pmid:20463089
Lange BM et al. Isoprenoid biosynthesis. Metabolite profiling of peppermint oil gland secretory cells and application to herbicide target analysis. 2001 Plant Physiol. pmid:11553758
Angaman DM et al. Precursor uptake assays and metabolic analyses in isolated tomato fruit chromoplasts. 2012 Plant Methods pmid:22243738
Masferrer A et al. Overexpression of Arabidopsis thaliana farnesyl diphosphate synthase (FPS1S) in transgenic Arabidopsis induces a cell death/senescence-like response and reduced cytokinin levels. 2002 Plant J. pmid:12000449
Suzuki M et al. Loss of function of 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 (HMG1) in Arabidopsis leads to dwarfing, early senescence and male sterility, and reduced sterol levels. 2004 Plant J. pmid:14871314
Re EB et al. Co-expression of native and introduced genes reveals cryptic regulation of HMG CoA reductase expression in Arabidopsis. 1995 Plant J. pmid:7773308
Towler MJ and Weathers PJ Evidence of artemisinin production from IPP stemming from both the mevalonate and the nonmevalonate pathways. 2007 Plant Cell Rep. pmid:17710406
Flores-Sánchez IJ et al. Biosynthesis of sterols and triterpenes in cell suspension cultures of Uncaria tomentosa. 2002 Plant Cell Physiol. pmid:12514247
Miyazawa Y et al. Amyloplast formation in cultured tobacco BY-2 cells requires a high cytokinin content. 2002 Plant Cell Physiol. pmid:12514251
Okada K et al. Genetic evidence for the role of isopentenyl diphosphate isomerases in the mevalonate pathway and plant development in Arabidopsis. 2008 Plant Cell Physiol. pmid:18303110
Mongélard G et al. Measurement of carbon flux through the MEP pathway for isoprenoid synthesis by (31)P-NMR spectroscopy after specific inhibition of 2-C-methyl-d-erythritol 2,4-cyclodiphosphate reductase. Effect of light and temperature. 2011 Plant Cell Environ. pmid:21443577
Chang TH et al. Structure of a heterotetrameric geranyl pyrophosphate synthase from mint (Mentha piperita) reveals intersubunit regulation. 2010 Plant Cell pmid:20139160
Doblas VG et al. The SUD1 gene encodes a putative E3 ubiquitin ligase and is a positive regulator of 3-hydroxy-3-methylglutaryl coenzyme a reductase activity in Arabidopsis. 2013 Plant Cell pmid:23404890
Rodríguez-Concepción M et al. Distinct light-mediated pathways regulate the biosynthesis and exchange of isoprenoid precursors during Arabidopsis seedling development. 2004 Plant Cell pmid:14660801
Randall SK et al. Protein isoprenylation in suspension-cultured tobacco cells. 1993 Plant Cell pmid:8485402
Muñoz-Bertomeu J et al. Up-regulation of an N-terminal truncated 3-hydroxy-3-methylglutaryl CoA reductase enhances production of essential oils and sterols in transgenic Lavandula latifolia. 2007 Plant Biotechnol. J. pmid:17714440
Enfissi EM et al. Metabolic engineering of the mevalonate and non-mevalonate isopentenyl diphosphate-forming pathways for the production of health-promoting isoprenoids in tomato. 2005 Plant Biotechnol. J. pmid:17168896
Asada Y et al. Biosynthesis of the dimethylallyl moiety of glabrol in Glycyrrhiza glabra hairy root cultures via a non-mevalonate pathway. 2000 Phytochemistry pmid:11117880
Cvejić JH and Rohmer M CO2 as main carbon source for isoprenoid biosynthesis via the mevalonate-independent methylerythritol 4-phosphate route in the marine diatoms Phaeodactylum tricornutum and Nitzschia ovalis. 2000 Phytochemistry pmid:10656403
May B et al. Biosynthesis of sesquiterpenes in grape berry exocarp of Vitis vinifera L.: evidence for a transport of farnesyl diphosphate precursors from plastids to the cytosol. 2013 Phytochemistry pmid:23954075
Umlauf D et al. Biosynthesis of the irregular monoterpene artemisia ketone, the sesquiterpene germacrene D and other isoprenoids in Tanacetum vulgare L. (Asteraceae). 2004 Phytochemistry pmid:15381410
Kutrzeba L et al. Biosynthesis of salvinorin A proceeds via the deoxyxylulose phosphate pathway. 2007 Phytochemistry pmid:17574635
Lopes AA et al. Biosynthetic origins of the isoprene units of gaudichaudianic acid in Piper gaudichaudianum (Piperaceae). 2007 Phytochemistry pmid:17574633
Schramek N et al. Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study. 2010 Phytochemistry pmid:19932496
Thiel R and Adam KP Incorporation of [1-(13)C]1-deoxy-D-xylulose into isoprenoids of the liverwort Conocephalum conicum. 2002 Phytochemistry pmid:11830134
De-Eknamkul W and Potduang B Biosynthesis of beta-sitosterol and stigmasterol in Croton sublyratus proceeds via a mixed origin of isoprene units. 2003 Phytochemistry pmid:12620352
Han YS et al. Biosynthesis of anthraquinones in cell cultures of Cinchona 'Robusta' proceeds via the methylerythritol 4-phosphate pathway. 2002 Phytochemistry pmid:11754943
Khandelwal VK et al. Oxidative stress plays an important role in zoledronic acid-induced autophagy. 2014 Physiol Res pmid:25669691
Ohm TG et al. Cholesterol and tau protein--findings in Alzheimer's and Niemann Pick C's disease. 2003 Pharmacopsychiatry pmid:14574625
Chang JJ et al. The in vitro inhibitory effect of tannin derivatives on 3-hydroxy-3-methylglutaryl-coenzyme a reductase on vero cells. 2001 Pharmacology pmid:11359999
Khan SA and Nyce JW Effects of ubiquinone and mevalonic acid on hepatic peroxisomal enzymes induced by dehydroepiandrosterone. 1997 Pharmacol. Toxicol. pmid:9101583
Yeganeh B et al. Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease. 2014 Pharmacol. Ther. pmid:24582968
De Leo L et al. Targeting farnesyl-transferase as a novel therapeutic strategy for mevalonate kinase deficiency: in vitro and in vivo approaches. 2010 Pharmacol. Res. pmid:20206266
Corsini A et al. Pharmacology of competitive inhibitors of HMG-CoA reductase. 1995 Pharmacol. Res. pmid:7784310
Jana S and Shekhawat GS Anethum graveolens: An Indian traditional medicinal herb and spice. 2010 Pharmacogn Rev pmid:22228959
Vishnuvardhan D and Beinfeld MC Lovastatin is a potent inhibitor of cholecystokinin secretion in endocrine tumor cells in culture. 2000 Peptides pmid:10822111
Kyriakides EC et al. Lipid studies in Wolman's disease. 1970 Pediatrics pmid:5468779
Hoffmann GF et al. Clinical and biochemical phenotype in 11 patients with mevalonic aciduria. 1993 Pediatrics pmid:8386351
Appelkvist EL et al. Synthesis of mevalonate pathway lipids in fibroblasts from Zellweger and X-linked ALD patients. 1999 Pediatr. Res. pmid:10473053
Mancini J et al. Mevalonic aciduria in 3 siblings: a new recognizable metabolic encephalopathy. 1993 May-Jun Pediatr. Neurol. pmid:8352861
Hamid PH et al. Differential inhibition of host cell cholesterol de novo biosynthesis and processing abrogates Eimeria bovis intracellular development. 2014 Parasitol. Res. pmid:25199551
Haas D and Hoffmann GF Mevalonate kinase deficiencies: from mevalonic aciduria to hyperimmunoglobulinemia D syndrome. 2006 Orphanet J Rare Dis pmid:16722536
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Citron CA and Dickschat JS The stereochemical course of tricho-acorenol biosynthesis. 2013 Org. Biomol. Chem. pmid:24084795
Wang T et al. Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway. 2016 Oncotarget pmid:26565813
Pandyra AA et al. Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death. 2015 Oncotarget pmid:26353928
Sharon C et al. Inhibition of insulin-like growth factor receptor/AKT/mammalian target of rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate-isoprenoid pathway in vitro and in vivo. 2015 Oncotarget pmid:25895029
Pampalakis G et al. The KLK5 protease suppresses breast cancer by repressing the mevalonate pathway. 2014 Oncotarget pmid:24158494
Löffler M and Schneider F Unexpectedly low incorporation of isotopic acetate into lipids of Ehrlich ascites tumor cells cultured in lipid-poor medium. 1979 Oncology pmid:37470
Issat T et al. Antitumor effects of the combination of cholesterol reducing drugs. 2011 Oncol. Rep. pmid:21491092
Issat T et al. Berberine, a natural cholesterol reducing product, exerts antitumor cytostatic/cytotoxic effects independently from the mevalonate pathway. 2006 Oncol. Rep. pmid:17089049
Ghosh PM et al. Role of RhoA activation in the growth and morphology of a murine prostate tumor cell line. 1999 Oncogene pmid:10435593
Shack S et al. Activation of the cholesterol pathway and Ras maturation in response to stress. 1999 Oncogene pmid:10557091
Deichmann R et al. Coenzyme q10 and statin-induced mitochondrial dysfunction. 2010 Ochsner J pmid:21603349
Cho SH et al. Study on the hypochlolesterolemic and antioxidative effects of tyramine derivatives from the root bark of Lycium chenese Miller. 2011 Nutr Res Pract pmid:22125678
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Habara K et al. Pitavastatin up-regulates the induction of iNOS through enhanced stabilization of its mRNA in pro-inflammatory cytokine-stimulated hepatocytes. 2008 Nitric Oxide pmid:17936042
Yamashita Y et al. A 6-year-old girl diagnosed with mevalonate kinase deficiency who had hydrops fetalis and neonatal-onset cholestasis. 2017 Nihon Rinsho Meneki Gakkai Kaishi pmid:28603204
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Woo IS et al. Farnesyl diphosphate synthase attenuates paclitaxel-induced apoptotic cell death in human glioblastoma U87MG cells. 2010 Neurosci. Lett. pmid:20298756
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