Pedrini S et al. |
Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK. |
2005 |
PLoS Med. |
pmid:15647781
|
Deshpande G et al. |
Ggamma1, a downstream target for the hmgcr-isoprenoid biosynthetic pathway, is required for releasing the Hedgehog ligand and directing germ cell migration. |
2009 |
PLoS Genet. |
pmid:19132091
|
Maurer-Stroh S et al. |
Towards complete sets of farnesylated and geranylgeranylated proteins. |
2007 |
PLoS Comput. Biol. |
pmid:17411337
|
Hardman R and Fazli FR |
Labelled steroidal sapogenins and hydrocarbons from Trigonella foenumgraecum by acetate, mevalonate and cholesterol feeds to seeds. |
1972 |
Planta Med. |
pmid:5018497
|
Okada K et al. |
Antisense and chemical suppression of the nonmevalonate pathway affects ent-kaurene biosynthesis in Arabidopsis. |
2002 |
Planta |
pmid:12029484
|
Nagata N et al. |
Mevalonic acid partially restores chloroplast and etioplast development in Arabidopsis lacking the non-mevalonate pathway. |
2002 |
Planta |
pmid:12447549
|
Zeidler J and Lichtenthaler HK |
Biosynthesis of 2-methyl-3-buten-2-ol emitted from needles of Pinus ponderosa via the non-mevalonate DOXP/MEP pathway of isoprenoid formation. |
2001 |
Planta |
pmid:11469599
|
Wu S et al. |
Engineering triterpene metabolism in tobacco. |
2012 |
Planta |
pmid:22729821
|
Simkin AJ et al. |
Peroxisomal localisation of the final steps of the mevalonic acid pathway in planta. |
2011 |
Planta |
pmid:21655959
|
Schwender J et al. |
Chlorophyta exclusively use the 1-deoxyxylulose 5-phosphate/2-C-methylerythritol 4-phosphate pathway for the biosynthesis of isoprenoids. |
2001 |
Planta |
pmid:11289606
|
Clastre M et al. |
Subcellular evidence for the involvement of peroxisomes in plant isoprenoid biosynthesis. |
2011 |
Plant Signal Behav |
pmid:22080790
|
Henriquez MA et al. |
Effects of glucans and eicosapentaenoic acid on differential regulation of phenylpropanoid and mevalonic pathways during potato response to Phytophthora infestans. |
2012 |
Plant Physiol. Biochem. |
pmid:22922112
|
RodrÃguez-Concepción M and Boronat A |
Elucidation of the methylerythritol phosphate pathway for isoprenoid biosynthesis in bacteria and plastids. A metabolic milestone achieved through genomics. |
2002 |
Plant Physiol. |
pmid:12427975
|
Li Z et al. |
Effect of temperature on postillumination isoprene emission in oak and poplar. |
2011 |
Plant Physiol. |
pmid:21177471
|
Che P et al. |
Metabolic and environmental regulation of 3-methylcrotonyl-coenzyme A carboxylase expression in Arabidopsis. |
2002 |
Plant Physiol. |
pmid:12068107
|
Sharkey TD et al. |
Isoprene increases thermotolerance of fosmidomycin-fed leaves. |
2001 |
Plant Physiol. |
pmid:11299379
|
Ruiz-Sola MÃ et al. |
A Single Arabidopsis Gene Encodes Two Differentially Targeted Geranylgeranyl Diphosphate Synthase Isoforms. |
2016 |
Plant Physiol. |
pmid:27707890
|
Huchelmann A et al. |
S-carvone suppresses cellulase-induced capsidiol production in Nicotiana tabacum by interfering with protein isoprenylation. |
2014 |
Plant Physiol. |
pmid:24367019
|
Bouvier-Navé P et al. |
Involvement of the phospholipid sterol acyltransferase1 in plant sterol homeostasis and leaf senescence. |
2010 |
Plant Physiol. |
pmid:19923239
|
Jiang Z et al. |
Engineering Triterpene and Methylated Triterpene Production in Plants Provides Biochemical and Physiological Insights into Terpene Metabolism. |
2016 |
Plant Physiol. |
pmid:26603654
|
Mertens J et al. |
The bHLH Transcription Factors TSAR1 and TSAR2 Regulate Triterpene Saponin Biosynthesis in Medicago truncatula. |
2016 |
Plant Physiol. |
pmid:26589673
|
Wang WQ et al. |
Proteomic analysis of lettuce seed germination and thermoinhibition by sampling of individual seeds at germination and removal of storage proteins by polyethylene glycol fractionation. |
2015 |
Plant Physiol. |
pmid:25736209
|
Koch T et al. |
Differential induction of plant volatile biosynthesis in the lima bean by early and late intermediates of the octadecanoid-signaling pathway. |
1999 |
Plant Physiol. |
pmid:10482670
|
Shimada Y et al. |
Organ-specific expression of brassinosteroid-biosynthetic genes and distribution of endogenous brassinosteroids in Arabidopsis. |
2003 |
Plant Physiol. |
pmid:12529536
|
Sapir-Mir M et al. |
Peroxisomal localization of Arabidopsis isopentenyl diphosphate isomerases suggests that part of the plant isoprenoid mevalonic acid pathway is compartmentalized to peroxisomes. |
2008 |
Plant Physiol. |
pmid:18988695
|
Galichet A et al. |
Farnesylation directs AtIPT3 subcellular localization and modulates cytokinin biosynthesis in Arabidopsis. |
2008 |
Plant Physiol. |
pmid:18184738
|
Bede JC et al. |
Biosynthetic pathway of insect juvenile hormone III in cell suspension cultures of the sedge Cyperus iria. |
2001 |
Plant Physiol. |
pmid:11598232
|
Huang M et al. |
Variation of herbivore-induced volatile terpenes among Arabidopsis ecotypes depends on allelic differences and subcellular targeting of two terpene synthases, TPS02 and TPS03. |
2010 |
Plant Physiol. |
pmid:20463089
|
Lange BM et al. |
Isoprenoid biosynthesis. Metabolite profiling of peppermint oil gland secretory cells and application to herbicide target analysis. |
2001 |
Plant Physiol. |
pmid:11553758
|
Angaman DM et al. |
Precursor uptake assays and metabolic analyses in isolated tomato fruit chromoplasts. |
2012 |
Plant Methods |
pmid:22243738
|
Masferrer A et al. |
Overexpression of Arabidopsis thaliana farnesyl diphosphate synthase (FPS1S) in transgenic Arabidopsis induces a cell death/senescence-like response and reduced cytokinin levels. |
2002 |
Plant J. |
pmid:12000449
|
Suzuki M et al. |
Loss of function of 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 (HMG1) in Arabidopsis leads to dwarfing, early senescence and male sterility, and reduced sterol levels. |
2004 |
Plant J. |
pmid:14871314
|
Re EB et al. |
Co-expression of native and introduced genes reveals cryptic regulation of HMG CoA reductase expression in Arabidopsis. |
1995 |
Plant J. |
pmid:7773308
|
Towler MJ and Weathers PJ |
Evidence of artemisinin production from IPP stemming from both the mevalonate and the nonmevalonate pathways. |
2007 |
Plant Cell Rep. |
pmid:17710406
|
Flores-Sánchez IJ et al. |
Biosynthesis of sterols and triterpenes in cell suspension cultures of Uncaria tomentosa. |
2002 |
Plant Cell Physiol. |
pmid:12514247
|
Miyazawa Y et al. |
Amyloplast formation in cultured tobacco BY-2 cells requires a high cytokinin content. |
2002 |
Plant Cell Physiol. |
pmid:12514251
|
Okada K et al. |
Genetic evidence for the role of isopentenyl diphosphate isomerases in the mevalonate pathway and plant development in Arabidopsis. |
2008 |
Plant Cell Physiol. |
pmid:18303110
|
Mongélard G et al. |
Measurement of carbon flux through the MEP pathway for isoprenoid synthesis by (31)P-NMR spectroscopy after specific inhibition of 2-C-methyl-d-erythritol 2,4-cyclodiphosphate reductase. Effect of light and temperature. |
2011 |
Plant Cell Environ. |
pmid:21443577
|
Chang TH et al. |
Structure of a heterotetrameric geranyl pyrophosphate synthase from mint (Mentha piperita) reveals intersubunit regulation. |
2010 |
Plant Cell |
pmid:20139160
|
Doblas VG et al. |
The SUD1 gene encodes a putative E3 ubiquitin ligase and is a positive regulator of 3-hydroxy-3-methylglutaryl coenzyme a reductase activity in Arabidopsis. |
2013 |
Plant Cell |
pmid:23404890
|
RodrÃguez-Concepción M et al. |
Distinct light-mediated pathways regulate the biosynthesis and exchange of isoprenoid precursors during Arabidopsis seedling development. |
2004 |
Plant Cell |
pmid:14660801
|
Randall SK et al. |
Protein isoprenylation in suspension-cultured tobacco cells. |
1993 |
Plant Cell |
pmid:8485402
|
Muñoz-Bertomeu J et al. |
Up-regulation of an N-terminal truncated 3-hydroxy-3-methylglutaryl CoA reductase enhances production of essential oils and sterols in transgenic Lavandula latifolia. |
2007 |
Plant Biotechnol. J. |
pmid:17714440
|
Enfissi EM et al. |
Metabolic engineering of the mevalonate and non-mevalonate isopentenyl diphosphate-forming pathways for the production of health-promoting isoprenoids in tomato. |
2005 |
Plant Biotechnol. J. |
pmid:17168896
|
Asada Y et al. |
Biosynthesis of the dimethylallyl moiety of glabrol in Glycyrrhiza glabra hairy root cultures via a non-mevalonate pathway. |
2000 |
Phytochemistry |
pmid:11117880
|
Cvejić JH and Rohmer M |
CO2 as main carbon source for isoprenoid biosynthesis via the mevalonate-independent methylerythritol 4-phosphate route in the marine diatoms Phaeodactylum tricornutum and Nitzschia ovalis. |
2000 |
Phytochemistry |
pmid:10656403
|
May B et al. |
Biosynthesis of sesquiterpenes in grape berry exocarp of Vitis vinifera L.: evidence for a transport of farnesyl diphosphate precursors from plastids to the cytosol. |
2013 |
Phytochemistry |
pmid:23954075
|
Umlauf D et al. |
Biosynthesis of the irregular monoterpene artemisia ketone, the sesquiterpene germacrene D and other isoprenoids in Tanacetum vulgare L. (Asteraceae). |
2004 |
Phytochemistry |
pmid:15381410
|
Kutrzeba L et al. |
Biosynthesis of salvinorin A proceeds via the deoxyxylulose phosphate pathway. |
2007 |
Phytochemistry |
pmid:17574635
|
Lopes AA et al. |
Biosynthetic origins of the isoprene units of gaudichaudianic acid in Piper gaudichaudianum (Piperaceae). |
2007 |
Phytochemistry |
pmid:17574633
|
Schramek N et al. |
Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study. |
2010 |
Phytochemistry |
pmid:19932496
|
Thiel R and Adam KP |
Incorporation of [1-(13)C]1-deoxy-D-xylulose into isoprenoids of the liverwort Conocephalum conicum. |
2002 |
Phytochemistry |
pmid:11830134
|
De-Eknamkul W and Potduang B |
Biosynthesis of beta-sitosterol and stigmasterol in Croton sublyratus proceeds via a mixed origin of isoprene units. |
2003 |
Phytochemistry |
pmid:12620352
|
Han YS et al. |
Biosynthesis of anthraquinones in cell cultures of Cinchona 'Robusta' proceeds via the methylerythritol 4-phosphate pathway. |
2002 |
Phytochemistry |
pmid:11754943
|
Khandelwal VK et al. |
Oxidative stress plays an important role in zoledronic acid-induced autophagy. |
2014 |
Physiol Res |
pmid:25669691
|
Ohm TG et al. |
Cholesterol and tau protein--findings in Alzheimer's and Niemann Pick C's disease. |
2003 |
Pharmacopsychiatry |
pmid:14574625
|
Chang JJ et al. |
The in vitro inhibitory effect of tannin derivatives on 3-hydroxy-3-methylglutaryl-coenzyme a reductase on vero cells. |
2001 |
Pharmacology |
pmid:11359999
|
Khan SA and Nyce JW |
Effects of ubiquinone and mevalonic acid on hepatic peroxisomal enzymes induced by dehydroepiandrosterone. |
1997 |
Pharmacol. Toxicol. |
pmid:9101583
|
Yeganeh B et al. |
Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease. |
2014 |
Pharmacol. Ther. |
pmid:24582968
|
De Leo L et al. |
Targeting farnesyl-transferase as a novel therapeutic strategy for mevalonate kinase deficiency: in vitro and in vivo approaches. |
2010 |
Pharmacol. Res. |
pmid:20206266
|
Corsini A et al. |
Pharmacology of competitive inhibitors of HMG-CoA reductase. |
1995 |
Pharmacol. Res. |
pmid:7784310
|
Jana S and Shekhawat GS |
Anethum graveolens: An Indian traditional medicinal herb and spice. |
2010 |
Pharmacogn Rev |
pmid:22228959
|
Vishnuvardhan D and Beinfeld MC |
Lovastatin is a potent inhibitor of cholecystokinin secretion in endocrine tumor cells in culture. |
2000 |
Peptides |
pmid:10822111
|
Kyriakides EC et al. |
Lipid studies in Wolman's disease. |
1970 |
Pediatrics |
pmid:5468779
|
Hoffmann GF et al. |
Clinical and biochemical phenotype in 11 patients with mevalonic aciduria. |
1993 |
Pediatrics |
pmid:8386351
|
Appelkvist EL et al. |
Synthesis of mevalonate pathway lipids in fibroblasts from Zellweger and X-linked ALD patients. |
1999 |
Pediatr. Res. |
pmid:10473053
|
Mancini J et al. |
Mevalonic aciduria in 3 siblings: a new recognizable metabolic encephalopathy. |
1993 May-Jun |
Pediatr. Neurol. |
pmid:8352861
|
Hamid PH et al. |
Differential inhibition of host cell cholesterol de novo biosynthesis and processing abrogates Eimeria bovis intracellular development. |
2014 |
Parasitol. Res. |
pmid:25199551
|
Haas D and Hoffmann GF |
Mevalonate kinase deficiencies: from mevalonic aciduria to hyperimmunoglobulinemia D syndrome. |
2006 |
Orphanet J Rare Dis |
pmid:16722536
|
Qiu Y and Li D |
Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase. |
2006 |
Org. Lett. |
pmid:16524256
|
Citron CA and Dickschat JS |
The stereochemical course of tricho-acorenol biosynthesis. |
2013 |
Org. Biomol. Chem. |
pmid:24084795
|
Wang T et al. |
Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway. |
2016 |
Oncotarget |
pmid:26565813
|
Pandyra AA et al. |
Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death. |
2015 |
Oncotarget |
pmid:26353928
|
Sharon C et al. |
Inhibition of insulin-like growth factor receptor/AKT/mammalian target of rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate-isoprenoid pathway in vitro and in vivo. |
2015 |
Oncotarget |
pmid:25895029
|
Pampalakis G et al. |
The KLK5 protease suppresses breast cancer by repressing the mevalonate pathway. |
2014 |
Oncotarget |
pmid:24158494
|
Löffler M and Schneider F |
Unexpectedly low incorporation of isotopic acetate into lipids of Ehrlich ascites tumor cells cultured in lipid-poor medium. |
1979 |
Oncology |
pmid:37470
|
Issat T et al. |
Antitumor effects of the combination of cholesterol reducing drugs. |
2011 |
Oncol. Rep. |
pmid:21491092
|
Issat T et al. |
Berberine, a natural cholesterol reducing product, exerts antitumor cytostatic/cytotoxic effects independently from the mevalonate pathway. |
2006 |
Oncol. Rep. |
pmid:17089049
|
Ghosh PM et al. |
Role of RhoA activation in the growth and morphology of a murine prostate tumor cell line. |
1999 |
Oncogene |
pmid:10435593
|
Shack S et al. |
Activation of the cholesterol pathway and Ras maturation in response to stress. |
1999 |
Oncogene |
pmid:10557091
|
Deichmann R et al. |
Coenzyme q10 and statin-induced mitochondrial dysfunction. |
2010 |
Ochsner J |
pmid:21603349
|
Cho SH et al. |
Study on the hypochlolesterolemic and antioxidative effects of tyramine derivatives from the root bark of Lycium chenese Miller. |
2011 |
Nutr Res Pract |
pmid:22125678
|
Wilson GJ et al. |
Effects of beta-hydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: A review. |
2008 |
Nutr Metab (Lond) |
pmid:18173841
|
Conrado RJ et al. |
DNA-guided assembly of biosynthetic pathways promotes improved catalytic efficiency. |
2012 |
Nucleic Acids Res. |
pmid:22021385
|
Patel NV and Forman BM |
Linking lipids, Alzheimer's and LXRs? |
2004 |
Nucl Recept Signal |
pmid:16604185
|
Habara K et al. |
Pitavastatin up-regulates the induction of iNOS through enhanced stabilization of its mRNA in pro-inflammatory cytokine-stimulated hepatocytes. |
2008 |
Nitric Oxide |
pmid:17936042
|
Yamashita Y et al. |
A 6-year-old girl diagnosed with mevalonate kinase deficiency who had hydrops fetalis and neonatal-onset cholestasis. |
2017 |
Nihon Rinsho Meneki Gakkai Kaishi |
pmid:28603204
|
Sakai H and Heike T |
[Hyperimmunoglobulinemia D and periodic fever syndrome]. |
2011 |
Nihon Rinsho Meneki Gakkai Kaishi |
pmid:22041426
|
Fabris M et al. |
Tracking the sterol biosynthesis pathway of the diatom Phaeodactylum tricornutum. |
2014 |
New Phytol. |
pmid:24996048
|
Mans RA et al. |
Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation. |
2012 |
Neuroscience |
pmid:22192838
|
Tringali G et al. |
Lovastatin and mevastatin reduce basal and cytokine-stimulated production of prostaglandins from rat microglial cells in vitro: evidence for a mechanism unrelated to the inhibition of hydroxy-methyl-glutaryl CoA reductase. |
2004 |
Neurosci. Lett. |
pmid:14698450
|
Sato-Suzuki I and Murota S |
Simvastatin inhibits the division and induces neurite-like outgrowth in PC12 cells. |
1996 |
Neurosci. Lett. |
pmid:8977139
|
Woo IS et al. |
Farnesyl diphosphate synthase attenuates paclitaxel-induced apoptotic cell death in human glioblastoma U87MG cells. |
2010 |
Neurosci. Lett. |
pmid:20298756
|
Kosztáczky B et al. |
Neuropeptides induced a pronounced and statin-sensitive dysregulation of mevalonate cycle in human monocytes of patients with hypercholesterolemia. |
2006 |
Neuropeptides |
pmid:17049599
|
Haas D et al. |
Inherited disorders of cholesterol biosynthesis. |
2001 |
Neuropediatrics |
pmid:11521206
|
Paoletti P et al. |
Lipid biosynthesis from labelled precursors in an experimental brain tumor-bearing mouse. |
1966 |
Neurochirurgia (Stuttg) |
pmid:5966653
|
Hosaka A et al. |
Statins reduce amyloid β-peptide production by modulating amyloid precursor protein maturation and phosphorylation through a cholesterol-independent mechanism in cultured neurons. |
2013 |
Neurochem. Res. |
pmid:23269484
|
Domoki F et al. |
Rosuvastatin induces delayed preconditioning against L-glutamate excitotoxicity in cultured cortical neurons. |
2010 |
Neurochem. Int. |
pmid:19931334
|
Hamano T et al. |
Pitavastatin decreases tau levels via the inactivation of Rho/ROCK. |
2012 |
Neurobiol. Aging |
pmid:22133277
|
Ikeuchi H et al. |
Fluvastatin reduces renal fibroblast proliferation and production of type III collagen: therapeutic implications for tubulointerstitial fibrosis. |
2004 |
Nephron Exp. Nephrol. |
pmid:15331935
|