Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Thrombosis D013927 49 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Hypothyroidism D007037 32 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Glioblastoma D005909 27 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Refsum Disease D012035 19 associated lipids
Xanthomatosis D014973 17 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

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All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
DiNicolantonio JJ CoQ10 and L-carnitine for statin myalgia? 2012 Expert Rev Cardiovasc Ther pmid:23190071
Aliferis KA and Jabaji S FT-ICR/MS and GC-EI/MS metabolomics networking unravels global potato sprout's responses to Rhizoctonia solani infection. 2012 PLoS ONE pmid:22880040
Zaidi N et al. ATP-citrate lyase: a key player in cancer metabolism. 2012 Cancer Res. pmid:22787121
Matsuoka T et al. An ultrasensitive enzymatic method for measuring mevalonic acid in serum. 2012 J. Lipid Res. pmid:22715156
Van Laar TA et al. Effect of levels of acetate on the mevalonate pathway of Borrelia burgdorferi. 2012 PLoS ONE pmid:22675445
Ginestier C et al. Mevalonate metabolism regulates Basal breast cancer stem cells and is a potential therapeutic target. 2012 Stem Cells pmid:22605458
Liu D et al. The genome of Ganoderma lucidum provides insights into triterpenes biosynthesis and wood degradation [corrected]. 2012 PLoS ONE pmid:22567134
Yang J et al. Enhancing production of bio-isoprene using hybrid MVA pathway and isoprene synthase in E. coli. 2012 PLoS ONE pmid:22558074
Shi Z and Ruvkun G The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans. 2012 Proc. Natl. Acad. Sci. U.S.A. pmid:22396595
Thurnher M et al. Novel aspects of mevalonate pathway inhibitors as antitumor agents. 2012 Clin. Cancer Res. pmid:22529099
Hong SY et al. Isoprene hydrocarbons production upon heterologous transformation of Saccharomyces cerevisiae. 2012 J. Appl. Microbiol. pmid:22519412
Iwata A et al. Inhibitory effect of statins on inflammatory cytokine production from human bronchial epithelial cells. 2012 Clin. Exp. Immunol. pmid:22471285
Luvai A et al. Rosuvastatin: a review of the pharmacology and clinical effectiveness in cardiovascular disease. 2012 Clin Med Insights Cardiol pmid:22442638
Lachenmeier DW et al. NMR evaluation of total statin content and HMG-CoA reductase inhibition in red yeast rice (Monascus spp.) food supplements. 2012 Chin Med pmid:22439629
Mosqueda J et al. Current advances in detection and treatment of babesiosis. 2012 Curr. Med. Chem. pmid:22360483
Keizer HG The "Mevalonate hypothesis": a cholesterol-independent alternative for the etiology of atherosclerosis. 2012 Lipids Health Dis pmid:23122424
Angaman DM et al. Precursor uptake assays and metabolic analyses in isolated tomato fruit chromoplasts. 2012 Plant Methods pmid:22243738
Yano K Lipid metabolic pathways as lung cancer therapeutic targets: a computational study. 2012 Int. J. Mol. Med. pmid:22211244
Shimane M et al. Mevalonate-dependent enzymatic synthesis of amorphadiene driven by an ATP-regeneration system using polyphosphate kinase. 2012 Biosci. Biotechnol. Biochem. pmid:22878192
Mans RA et al. Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation. 2012 Neuroscience pmid:22192838
Fu X et al. Plastid structure and carotenogenic gene expression in red- and white-fleshed loquat (Eriobotrya japonica) fruits. 2012 J. Exp. Bot. pmid:21994170
Murphy LA et al. Propiconazole-enhanced hepatic cell proliferation is associated with dysregulation of the cholesterol biosynthesis pathway leading to activation of Erk1/2 through Ras farnesylation. 2012 Toxicol. Appl. Pharmacol. pmid:22361350
Zhou K et al. Metabolite profiling identified methylerythritol cyclodiphosphate efflux as a limiting step in microbial isoprenoid production. 2012 PLoS ONE pmid:23133596
Fuhrmeister J et al. Prooxidative toxicity and selenoprotein suppression by cerivastatin in muscle cells. 2012 Toxicol. Lett. pmid:23092657
Scalcinati G et al. Combined metabolic engineering of precursor and co-factor supply to increase α-santalene production by Saccharomyces cerevisiae. 2012 Microb. Cell Fact. pmid:22938570
Li X et al. Differential mRNA expression of seven genes involved in cholesterol metabolism and transport in the liver of atherosclerosis-susceptible and -resistant Japanese quail strains. 2012 Genet. Sel. Evol. pmid:22682430
Baadhe RR et al. Development of petri net-based dynamic model for improved production of farnesyl pyrophosphate by integrating mevalonate and methylerythritol phosphate pathways in yeast. 2012 Appl. Biochem. Biotechnol. pmid:22350871
Panicker SP et al. Sterol intermediates of cholesterol biosynthesis inhibit hair growth and trigger an innate immune response in cicatricial alopecia. 2012 PLoS ONE pmid:22685570
Guo H et al. Rosuvastatin may modulate insulin signaling and inhibit atherogenesis beyond its plasma cholesterol-lowering effect in insulin-resistant mice. 2012 Cardiovasc Drugs Ther pmid:22918601
Trapani L et al. 3-hydroxy 3-methylglutaryl coenzyme A reductase inhibition impairs muscle regeneration. 2012 J. Cell. Biochem. pmid:22274883
Hamano T et al. Pitavastatin decreases tau levels via the inactivation of Rho/ROCK. 2012 Neurobiol. Aging pmid:22133277
Nürenberg G and Volmer DA The analytical determination of isoprenoid intermediates from the mevalonate pathway. 2012 Anal Bioanal Chem pmid:21789486
Garcia-Ruiz C et al. Statins and protein prenylation in cancer cell biology and therapy. 2012 Anticancer Agents Med Chem pmid:22413970
Wu S et al. Engineering triterpene metabolism in tobacco. 2012 Planta pmid:22729821
Henriquez MA et al. Effects of glucans and eicosapentaenoic acid on differential regulation of phenylpropanoid and mevalonic pathways during potato response to Phytophthora infestans. 2012 Plant Physiol. Biochem. pmid:22922112
Song AA et al. Overexpressing 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) in the lactococcal mevalonate pathway for heterologous plant sesquiterpene production. 2012 PLoS ONE pmid:23300671
Partow S et al. Reconstruction and evaluation of the synthetic bacterial MEP pathway in Saccharomyces cerevisiae. 2012 PLoS ONE pmid:23285068
Yang D et al. Different roles of the mevalonate and methylerythritol phosphate pathways in cell growth and tanshinone production of Salvia miltiorrhiza hairy roots. 2012 PLoS ONE pmid:23209548
Hussain MS et al. Current approaches toward production of secondary plant metabolites. 2012 J Pharm Bioallied Sci pmid:22368394
Iguchi K [Effect of bisphosphonates on anticancer activity in prostate cancer cells]. 2012 Yakugaku Zasshi pmid:23023419
Haines BE et al. Molecular modeling of the reaction pathway and hydride transfer reactions of HMG-CoA reductase. 2012 Biochemistry pmid:22971202
Coscia M et al. Dysfunctional Vγ9Vδ2 T cells are negative prognosticators and markers of dysregulated mevalonate pathway activity in chronic lymphocytic leukemia cells. 2012 Blood pmid:22932792
Malenda A et al. Statins impair glucose uptake in tumor cells. 2012 Neoplasia pmid:22577346
Garjani A et al. Ambivalent effects of atorvastatin on angiogenesis, epidermal cell proliferation and tumorgenesis in animal models. 2012 Iran. Biomed. J. pmid:22801278
Ginestier C et al. p53 and cancer stem cells: the mevalonate connexion. 2012 Cell Cycle pmid:22751434
Roy A et al. Sodium phenylbutyrate controls neuroinflammatory and antioxidant activities and protects dopaminergic neurons in mouse models of Parkinson's disease. 2012 PLoS ONE pmid:22723850
Ghavami S et al. Apoptosis, autophagy and ER stress in mevalonate cascade inhibition-induced cell death of human atrial fibroblasts. 2012 Cell Death Dis pmid:22717585
Ohsawa M et al. Effect of spinally administered simvastatin on the formalin-induced nociceptive response in mice. 2012 J. Pharmacol. Sci. pmid:22510521
Khasnavis S and Pahan K Sodium benzoate, a metabolite of cinnamon and a food additive, upregulates neuroprotective Parkinson disease protein DJ-1 in astrocytes and neurons. 2012 J Neuroimmune Pharmacol pmid:21701815
Plée-Gautier E et al. Statins increase cytochrome P450 4F3-mediated eicosanoids production in human liver cells: a PXR dependent mechanism. 2012 Biochem. Pharmacol. pmid:22634049
Paintlia AS et al. Interference with RhoA-ROCK signaling mechanism in autoreactive CD4+ T cells enhances the bioavailability of 1,25-dihydroxyvitamin D3 in experimental autoimmune encephalomyelitis. 2012 Am. J. Pathol. pmid:22796435
Drabkin HA and Gemmill RM Cholesterol and the development of clear-cell renal carcinoma. 2012 Curr Opin Pharmacol pmid:22939900
Rad SA et al. Type 2 IDI performs better than type 1 for improving lycopene production in metabolically engineered E. coli strains. 2012 World J. Microbiol. Biotechnol. pmid:22806807
Campia I et al. Digoxin and ouabain induce the efflux of cholesterol via liver X receptor signalling and the synthesis of ATP in cardiomyocytes. 2012 Biochem. J. pmid:22845468
Fatima T et al. Fatty acid composition of developing sea buckthorn (Hippophae rhamnoides L.) berry and the transcriptome of the mature seed. 2012 PLoS ONE pmid:22558083
Zhang B et al. Interference in mevalonate pathway ameliorates homocysteine-induced endothelium-dysfunction. 2012 Eur. J. Pharmacol. pmid:22796672
Conrado RJ et al. DNA-guided assembly of biosynthetic pathways promotes improved catalytic efficiency. 2012 Nucleic Acids Res. pmid:22021385
Roullet JB et al. No evidence for mevalonate shunting in moderately affected children with Smith-Lemli-Opitz syndrome. 2012 J. Inherit. Metab. Dis. pmid:22391996
Barta ML et al. Structural basis for nucleotide binding and reaction catalysis in mevalonate diphosphate decarboxylase. 2012 Biochemistry pmid:22734632
Jiang Q et al. Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide. 2012 Int. J. Cancer pmid:21400505
Li J et al. Atorvastatin inhibits myocardin expression in vascular smooth muscle cells. 2012 Hypertension pmid:22615115
Yokota K et al. Geranylgeranyl-pyrophosphate regulates secretion of pentraxin 3 and monocyte chemoattractant protein-1 from rheumatoid fibroblast-like synoviocytes in distinct manners. 2011 Jan-Feb Clin. Exp. Rheumatol. pmid:21345291
Li Z et al. Effect of temperature on postillumination isoprene emission in oak and poplar. 2011 Plant Physiol. pmid:21177471
Yu F et al. Zingiber zerumbet CYP71BA1 catalyzes the conversion of α-humulene to 8-hydroxy-α-humulene in zerumbone biosynthesis. 2011 Cell. Mol. Life Sci. pmid:20730551
Youn YN et al. Impact of High-Dose Statin Pretreatment in Patients with Stable Angina during Off-Pump Coronary Artery Bypass. 2011 Korean J Thorac Cardiovasc Surg pmid:22263153
Odom AR Five questions about non-mevalonate isoprenoid biosynthesis. 2011 PLoS Pathog. pmid:22216001
Rauthan M and Pilon M The mevalonate pathway in C. elegans. 2011 Lipids Health Dis pmid:22204706
Barrero RA et al. De novo assembly of Euphorbia fischeriana root transcriptome identifies prostratin pathway related genes. 2011 BMC Genomics pmid:22151917
Leszczynska A et al. Different statins produce highly divergent changes in gene expression profiles of human hepatoma cells: a pilot study. 2011 Acta Biochim. Pol. pmid:22132374
Ramgolam VS and Markovic-Plese S Regulation of suppressors of cytokine signaling as a therapeutic approach in autoimmune diseases, with an emphasis on multiple sclerosis. 2011 J Signal Transduct pmid:22132325
Cho SH et al. Study on the hypochlolesterolemic and antioxidative effects of tyramine derivatives from the root bark of Lycium chenese Miller. 2011 Nutr Res Pract pmid:22125678
Cheng G et al. Mitochondria-targeted nitroxides exacerbate fluvastatin-mediated cytostatic and cytotoxic effects in breast cancer cells. 2011 Cancer Biol. Ther. pmid:21799303
Katuru R et al. Mevalonate depletion mediates the suppressive impact of geranylgeraniol on murine B16 melanoma cells. 2011 Exp. Biol. Med. (Maywood) pmid:21540247
Peng LF et al. Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits 3-hydroxy-3-methylglutaryl-coenzyme A synthase. 2011 J. Infect. Dis. pmid:21791663
Bajgain P et al. Transcriptome characterization and polymorphism detection between subspecies of big sagebrush (Artemisia tridentata). 2011 BMC Genomics pmid:21767398
Scheller EL et al. Zoledronic acid inhibits macrophage SOCS3 expression and enhances cytokine production. 2011 J. Cell. Biochem. pmid:21751240
Sun S and McKenna CE Farnesyl pyrophosphate synthase modulators: a patent review (2006 - 2010). 2011 Expert Opin Ther Pat pmid:21702715
Rizzo WB The role of fatty aldehyde dehydrogenase in epidermal structure and function. 2011 Dermatoendocrinol pmid:21695018
Waldron J and Webster C Liquid chromatography-tandem mass spectrometry method for the measurement of serum mevalonic acid: a novel marker of hydroxymethylglutaryl coenzyme A reductase inhibition by statins. 2011 Ann. Clin. Biochem. pmid:21355014
Tsang A et al. Francisella tularensis 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase: kinetic characterization and phosphoregulation. 2011 PLoS ONE pmid:21694781
Rossoni LV et al. Acute simvastatin increases endothelial nitric oxide synthase phosphorylation via AMP-activated protein kinase and reduces contractility of isolated rat mesenteric resistance arteries. 2011 Clin. Sci. pmid:21671887
Sivy TL et al. Evidence of isoprenoid precursor toxicity in Bacillus subtilis. 2011 Biosci. Biotechnol. Biochem. pmid:22146731
Ghavami S et al. Mevalonate cascade regulation of airway mesenchymal cell autophagy and apoptosis: a dual role for p53. 2011 PLoS ONE pmid:21304979
Ignea C et al. Improving yeast strains using recyclable integration cassettes, for the production of plant terpenoids. 2011 Microb. Cell Fact. pmid:21276210
Tuckow AP et al. Simvastatin represses protein synthesis in the muscle-derived C₂C₁₂ cell line with a concomitant reduction in eukaryotic initiation factor 2B expression. 2011 Am. J. Physiol. Endocrinol. Metab. pmid:21224482
Sawai S and Saito K Triterpenoid biosynthesis and engineering in plants. 2011 Front Plant Sci pmid:22639586
Hong C et al. Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. 2011 J. Lipid Res. pmid:21187453
Nishikawa Y et al. Host cholesterol synthesis contributes to growth of intracellular Toxoplasma gondii in macrophages. 2011 J. Vet. Med. Sci. pmid:21187676
Tsuyuki R et al. Enhancement of trichothecene production in Fusarium graminearum by cobalt chloride. 2011 J. Agric. Food Chem. pmid:21299216
Li YY et al. Zoledronic acid induces cell-cycle prolongation in murine lung cancer cells by perturbing cyclin and Ras expression. 2011 Anticancer Drugs pmid:20926944
Nilsson S et al. Mevalonate pathway inhibitors affect anticancer drug-induced cell death and DNA damage response of human sarcoma cells. 2011 Cancer Lett. pmid:21356574
Issat T et al. Antitumor effects of the combination of cholesterol reducing drugs. 2011 Oncol. Rep. pmid:21491092
Varman AM et al. Statistics-based model for prediction of chemical biosynthesis yield from Saccharomyces cerevisiae. 2011 Microb. Cell Fact. pmid:21689458
Clastre M et al. Subcellular evidence for the involvement of peroxisomes in plant isoprenoid biosynthesis. 2011 Plant Signal Behav pmid:22080790
Castella B et al. Immune modulation by zoledronic acid in human myeloma: an advantageous cross-talk between Vγ9Vδ2 T cells, αβ CD8+ T cells, regulatory T cells, and dendritic cells. 2011 J. Immunol. pmid:21753152
Okada K The biosynthesis of isoprenoids and the mechanisms regulating it in plants. 2011 Biosci. Biotechnol. Biochem. pmid:21737944
Martinez-Moya P et al. Proteomic analysis of the carotenogenic yeast Xanthophyllomyces dendrorhous. 2011 BMC Microbiol. pmid:21669001
Jang HJ et al. Retinoid production using metabolically engineered Escherichia coli with a two-phase culture system. 2011 Microb. Cell Fact. pmid:21801353
Leichner GS et al. Metabolically regulated endoplasmic reticulum-associated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase: evidence for requirement of a geranylgeranylated protein. 2011 J. Biol. Chem. pmid:21778231
Simkin AJ et al. Peroxisomal localisation of the final steps of the mevalonic acid pathway in planta. 2011 Planta pmid:21655959