Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Carcinoma, Hepatocellular D006528 140 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Hypertension D006973 115 associated lipids
Hypothyroidism D007037 32 associated lipids
Leukemia D007938 74 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Peutz-Jeghers Syndrome D010580 2 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

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All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
Blomquist GJ et al. Biosynthesis of 3-methylpentacosane in the cockroach Periplaneta americana. 1975 Biochem. Biophys. Res. Commun. pmid:1147933
Natarajan R et al. Molecular cloning of the promoter for rat hepatic neutral cholesterol ester hydrolase: evidence for transcriptional regulation by sterols. 1998 Biochem. Biophys. Res. Commun. pmid:9480812
Fogelman AM et al. Cholesterol biosynthesis in human lymphocytes, monocytes, and granulocytes. 1977 Biochem. Biophys. Res. Commun. pmid:869944
Keller RK and Simonet WS Near normal levels of isoprenoid lipids in severe mevalonic aciduria. 1988 Biochem. Biophys. Res. Commun. pmid:3365255
Krishnaiah KV et al. Regulation of steroidogenesis by ubiquinone. 1967 Biochem. Biophys. Res. Commun. pmid:6052477
Wang Y et al. 24S,25-Epoxycholesterol in mouse and rat brain. 2014 Biochem. Biophys. Res. Commun. pmid:24832732
Hornby GM et al. The effects of thiols on cholesterol synthesis by rat liver in vitro. 1970 Biochem. Biophys. Res. Commun. pmid:5492149
Baisted DJ et al. The effect of cyclic triterpenes on cholesterol synthesis from mevalonate in rat liver homogenates. 1967 Biochem. Biophys. Res. Commun. pmid:6076231
Wiley MH et al. Conversion of mevalonolactone to its open-chain salt by a serum enzyme. 1979 Biochem. Biophys. Res. Commun. pmid:465057
Crick DC et al. Farnesol is utilized for protein isoprenylation and the biosynthesis of cholesterol in mammalian cells. 1995 Biochem. Biophys. Res. Commun. pmid:7794274
Servouse M et al. Isolation and characterization of yeast mutants blocked in mevalonic acid formation. 1984 Biochem. Biophys. Res. Commun. pmid:6148937
Gibbons GF Existence of metabolic reservoirs in the later stages of the cholesterol biosynthetic pathway. 1977 Biochem. Biophys. Res. Commun. pmid:861038
Aguilera JA et al. Effect of dietary cholesterol on mevalonate metabolism by sterol and nonsterol pathways. 1984 Biochem. Biophys. Res. Commun. pmid:6477574
Polo MP and de Bravo MG Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2. 2006 Biochem. Cell Biol. pmid:16462894
Polo MP et al. Effect of ethanol on cell growth and cholesterol metabolism in cultured Hep G2 cells. 2003 Biochem. Cell Biol. pmid:14663504
Silber JR et al. The effect of mevalonic acid deprivation on enzymes of DNA replication in cells emerging from quiescence. 1992 Biochem. J. pmid:1281982
Malathi P and Ganguly J Studies on metabolism of vitamin A. 8. Effect of ascorbate on isoprenoid metabolism in vitamin A-deficient rats. 1964 Biochem. J. pmid:5837438
Ellsworth JL et al. Evidence for sterol-independent regulation of low-density lipoprotein receptor activity in Hep-G2 cells. 1991 Biochem. J. pmid:1930137
Konrad Z and Eichler J Lipid modification of proteins in Archaea: attachment of a mevalonic acid-based lipid moiety to the surface-layer glycoprotein of Haloferax volcanii follows protein translocation. 2002 Biochem. J. pmid:12069685
Wood SG and Gottlieb D Evidence from mycelial studies for differences in the sterol biosynthetic pathway of Rhizoctonia solani and Phytophthora cinnamomi. 1978 Biochem. J. pmid:637849
Wood SG and Gottlieb D Evidence from cell-free systems for differences in the sterol biosynthetic pathway of Rhizoctonia solani and Phytophthora cinnamomi. 1978 Biochem. J. pmid:637850
Henry A et al. Dolichol biosynthesis in human malignant cells. 1991 Biochem. J. pmid:1654890
DIPLOCK AT et al. VITAMIN A AND ISOPRENOID SYNTHESIS IN THE RAT. 1965 Biochem. J. pmid:14333548
GOODWIN TW and WILLIAMS RJ A MECHANISM FOR THE CYCLIZATION OF AN ACYCLIC PRECURSOR TO FORM BETA-CAROTENE. 1965 Biochem. J. pmid:14342248
Bolaños JP et al. Inhibition of sterol but not fatty acid synthesis by valproate in developing rat brain in vivo. 1990 Biochem. J. pmid:2264830
Graham JM and Green C The binding of sterols in cellular membranes. 1967 Biochem. J. pmid:6032974
Iglesias J and Gibbons GF Regulation of hepatic cholesterol biosynthesis. Effects of a cytochrome P-450 inhibitor on the formation and metabolism of oxygenated sterol products of lanosterol. 1989 Biochem. J. pmid:2604729
Hitchcock CA et al. Interaction of azole antifungal antibiotics with cytochrome P-450-dependent 14 alpha-sterol demethylase purified from Candida albicans. 1990 Biochem. J. pmid:2180400
Richards JB and Hemming FW Dolichols, ubiquinones, geranylgeraniol and farnesol as the major metabolites of mevalonate in Phytophthora cactorum. 1972 Biochem. J. pmid:4643705
Ranganathan S and Ramasarma T The regulation of the biosynthesis of ubiquinone in the rat. 1975 Biochem. J. pmid:1156398
Smith AG and Goad LJ Sterol biosynthesis in the echinoderm Asterias rubens. 1975 Biochem. J. pmid:1147897
Wellburn AR and Hampp R Uptake of mevalonate and acetate during plastid development. 1976 Biochem. J. pmid:985424
Konrad M and Merz WE Long-term effect of cyclic AMP on N-glycosylation is caused by an increase in the activity of the cis-prenyltransferase. 1996 Biochem. J. pmid:8687403
Flint AP The activity and kinetic properties of mevalonate kinase in superovulated rat ovary. 1970 Biochem. J. pmid:4321929
Walton MJ and Pennock JF Some studies on the biosynthesis of ubiguinone, isoprenoid alcohols, squalene and sterols by marine invertebrates. 1972 Biochem. J. pmid:4403925
Green TR and Baisted DJ Development of the activities of enzymes of the isoprenoid pathway during early stages of pea-seed germination. 1972 Biochem. J. pmid:4348263
Wilton DC The effect of excess mevalonic acid on ubiquinone and tetrahymanol biosynthesis in Tetrahymena pyriformis. 1985 Biochem. J. pmid:3929773
Wilton DC The effect of cholesterol on ubiquinone and tetrahymanol biosynthesis in Tetrahymena pyriformis. 1983 Biochem. J. pmid:6418144
Swift IE and Milborrow BV Retention of the 4-pro-R hydrogen atom of mevalonate at C-2,2' of bacterioruberin in Halobacterium halobium. 1980 Biochem. J. pmid:7406867
Burt VT et al. The formation of menaquinone-4 (vitamin K) and its oxide in some marine invertebrates. 1977 Biochem. J. pmid:849285
Higgins MJ and Kekwick RG An investigation into the role of malonyl-coenzyme A in isoprenoid biosynthesis. 1973 Biochem. J. pmid:4579226
Gibbons GF and Mitropoulos KA The effect of carbon monoxide on the nature of the accumulated 4,4-dimethyl sterol precursors of cholesterol during its biosynthesis from (2-14C)mevalonic acid in vitro. 1973 Biochem. J. pmid:4724584
Swift IE and Milborrow BV Stereochemistry of allene biosynthesis and the formation of the acetylenic carotenoid diadinoxanthin and peridinin (C37) from neoxanthin. 1981 Biochem. J. pmid:7337715
Beedle AS et al. Some properties and a suggested reclassification of mevaldate reductase. 1974 Biochem. J. pmid:4463942
Martin HG and Thorne KJ Synthesis of radioactive dolichol from (4S-3H)mevalonate in the regenerating rat liver. 1974 Biochem. J. pmid:4822733
Gibbons GF and Mitropoulos KA Inhibition of cholesterol biosynthesis by carbon monoxide: accumulation of lanosterol and 24,25-dihydrolanosterol. 1972 Biochem. J. pmid:5073750
Gray JC and Kekwick RG Mevalonate kinase in green leaves and etiolated cotyledons of the french bean Phaseolus vulgaris. 1973 Biochem. J. pmid:4723778
Bassett RA et al. Biosynthesis of ergotamine by Claviceps purpurea (Fr.) Tul. 1973 Biochem. J. pmid:4723222
Gregory KW et al. Diurnal variations in rat liver 3-hydroxy-3-methylglutaryl-Coenzyme A reductase activity in relation to feeding. 1972 Biochem. J. pmid:4656802
Durr IF and Habbal MZ The biosynthesis of C 55 polyprenols by a cell-free preparation of Lactobacillus plantarum. 1972 Biochem. J. pmid:5076663
Kam NT et al. Effect of lovastatin on acyl-CoA: cholesterol O-acyltransferase (ACAT) activity and the basolateral-membrane secretion of newly synthesized lipids by CaCo-2 cells. 1990 Biochem. J. pmid:2268271
GOSSELIN L and POPJAK G Studies on biosynthesis of cholesterol. 8. The effect of Mg2+ and Mn2+ ions and of adenosine triphosphate on enzymic activity of microsomes in sterol biosynthesis from mevalonic acid. 1959 Biochem. J. pmid:13651113
Thorne KJ and Barker DC The bactoprenol content of plasma and mesosome membranes from Lactobacillus casei. 1971 Biochem. J. pmid:5001951
Goodwin TW Biosynthesis of carotenoids and plant triterpenes. 1971 Biochem. J. pmid:4331177
Milborrow BV and Noddle RC Conversion of 5-(1,2-epoxy-2,6,6-trimethylcyclohexyl)-3-methylpenta-cis-2-trans-4-dienoic acid into abscisic acid in plants. 1970 Biochem. J. pmid:5493506
Bloxham DP and Akhtar M Studies on the control of cholesterol biosynthesis: the adenosine 3':5'-cyclic monophosphate-dependent accumulation of a steroid carboxylic acid. 1971 Biochem. J. pmid:4331371
Green TR and Baisted DJ Development of the squalene-synthesizing system during early stages of pea seed germination. 1971 Biochem. J. pmid:4335540
Atkin SD et al. The isolation of 2,3-oxidosqualene from the liver of rats treated with 1-dodecylimidazole, a novel hypocholesterolaemic agent. 1972 Biochem. J. pmid:4655417
Castagnoli N et al. Biosynthesis of N-(alpha-hydroxyethyl) lysergamide, a metabolite of Claviceps paspali Stevens and Hall. 1970 Biochem. J. pmid:5419742
Gough DP and Hemming FW The stereochemistry of betulaprenol biosynthesis. 1970 Biochem. J. pmid:4315982
Krishnaiah KV and Ramasarma T Effect of alpha-p-chlorophenoxyisobutyrate on the metabolism of isoprenoid compounds in the rat. 1970 Biochem. J. pmid:5435680
De Souza NJ et al. Studies on insect moulting hormones: biosynthesis of ponasterone A and ecdysterone from [2-14C] mevalonate in Taxus baccata. 1969 Biochem. J. pmid:5343810
Bolger LM et al. Incorporation of [2-14C] mevalonic acid into 28-isofucosterol by leaves of Pisum sativum. 1969 Biochem. J. pmid:5343809
Sargent JR et al. Metabolism of mevalonic acid in the liver of the dogfish Scyliorhinus caniculus. 1970 Biochem. J. pmid:5420034
Hepper CM and Audley BG Th biosynthesis of rubber from beta-hydroxy-beta-methylgluarylcoenzyme A in Hevea brasiliensis latex. 1969 Biochem. J. pmid:4390212
Buggy MJ et al. Stereochemistry of phytoene biosynthesis by isolated chloroplasts. 1969 Biochem. J. pmid:4309532
Robinson DR and Ryback G Incorporation of tritium from [(4R)-4-3H]mevalonate into abscisic acid. 1969 Biochem. J. pmid:5821014
Rees HH et al. Studies in phytosterol biosynthesis. Mechanism of biosynthesis of cycloartenol. 1968 Biochem. J. pmid:4297048
West CA Gibberellins and their biosynthesis. 1969 Biochem. J. pmid:5810062
Francis MJ and Allcock C Monoterpene beta-D-glucosides in roses: isolation and formation from DL-2-14C mevalonate. 1969 Biochem. J. pmid:5807204
Noddle RC and Robinson DR Biosynthesis of abscisic acid: incorporation of radioactivity from [2-14C]mevalonic acid by intact fruit. 1969 Biochem. J. pmid:4308332
Barr RM and Hemming FW Polyprenol phosphate as an acceptor of mannose from guanosine diphosphate mannose in Aspergillus niger. 1972 Biochem. J. pmid:5073732
Liuzzi A and Foppen FH Sterol-like compound from sensory ganglia. Effect of a nerve growth factor and insulin on its biosynthesis. 1968 Biochem. J. pmid:5641875
Parsons RB et al. Statins inhibit the dimerization of beta-secretase via both isoprenoid- and cholesterol-mediated mechanisms. 2006 Biochem. J. pmid:16803455
Rees HH et al. The biosynthesis of beta-amyrin. Mechanism of squalene cyclization. 1968 Biochem. J. pmid:5639923
Rogers LJ et al. Mevalonate-kinase isoenzymes in plant cells. 1966 Biochem. J. pmid:5968528
Goad LJ and Goodwin TW The biosynthesis of sterols in higher plants. 1966 Biochem. J. pmid:5964970
Akhtar M et al. The role of a cholesta-8,14-dien-3-beta-ol system in cholesterol biosynthesis. 1969 Biochem. J. pmid:5783476
De Matteis F Stimulation of liver cholesterol synthesis by actinomycin D. 1968 Biochem. J. pmid:5696865
Rees HH et al. The stereospecific biosynthesis of plant sterols and alpha- and beta-amyrin. 1966 Biochem. J. pmid:5964969
Fears R The contribution of the cholesterol biosynthetic pathway to intermediary metabolism and cell function. 1981 Biochem. J. pmid:7039614
Overton KH and Roberts FM Biosynthesis of trans, trans- and cis, trans-farnesols by soluble enzymes from tissue cultures of Andrographis paniculata. 1974 Biochem. J. pmid:4468823
Joshi VC et al. Biosynthetic relationship between ubichromenol and ubiquinone. 1964 Biochem. J. pmid:5838088
Gavigan SJ and Knight BL The effects of low-density lipoprotein and cholesterol on acyl-coenzyme A: cholesterol acyltransferase activity in membranes from cultured human fibroblasts. 1983 Biochem. J. pmid:6651782
Milborrow BV Stereochemical aspects of the formation of double bonds in abscisic acid. 1972 Biochem. J. pmid:4643698
RAMASARMA T and RAMAKRISHNAN T Incorporation of [2-14C]mevalonic acid and [2-14C]acetic acid into lipids of mycobacteria. 1961 Biochem. J. pmid:14038591
Banthorpe DV et al. Biosynthesis of geraniol and nerol and beta-D-glucosides in Pelargonium graveolens and Rosa dilecta. 1972 Biochem. J. pmid:4348258
Campia I et al. Digoxin and ouabain induce the efflux of cholesterol via liver X receptor signalling and the synthesis of ATP in cardiomyocytes. 2012 Biochem. J. pmid:22845468
Knöss W et al. Biosynthesis of the labdane diterpene marrubiin in Marrubium vulgare via a non-mevalonate pathway. 1997 Biochem. J. pmid:9291117
GOODWIN TW Studies in carotenogenesis. 25. The incorporation of 14CO2, [2-14C] acetate and [2-14C]mevalonate into beta-carotene by illuminated etiolated maize seedings. 1958 Biochem. J. pmid:13607416
Farrell FX et al. Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated. 1993 Biochem. J. pmid:8424780
Goad LJ et al. Incorporation of (2-14C, (5r)-5-3H1) mevalonic acid into cholesterol by a rat liver homogenate and into beta-sitosterol and 28-isofucosterol by larix decidua leaves. 1969 Biochem. J. pmid:5348842
Barr RM and Hemming FW Polyprenols of Aspergillus niger. Their characterization, biosynthesis and subcellular distribution. 1972 Biochem. J. pmid:5073731
Wade DP et al. Independent regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and chylomicron remnant receptor activities in rat liver. 1984 Biochem. J. pmid:6324750
Walton TJ et al. Biosynthesis of xanthophylls in higher plants: stereochemistry of hydroxylation at C-3. 1969 Biochem. J. pmid:5801311
Grönroos E et al. Leukotriene D4-induced mobilization of intracellular Ca2+ in epithelial cells is critically dependent on activation of the small GTP-binding protein Rho. 1996 Biochem. J. pmid:8645211
Scharf SS and Simpson KL Attempts to detect lycopersene formation in yeast. 1968 Biochem. J. pmid:5753091
Booth R et al. The effect of dietary cholesterol on cholesterol biosynthesis and other processes in mammalian liver. 1971 Biochem. J. pmid:5124798
Cohen LH et al. Effects of compactin, mevalonate and low-density lipoprotein on 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity and low-density-lipoprotein-receptor activity in the human hepatoma cell line Hep G2. 1984 Biochem. J. pmid:6089762
Li G et al. Blockade of mevalonate production by lovastatin attenuates bombesin and vasopressin potentiation of nutrient-induced insulin secretion in HIT-T15 cells. Probable involvement of small GTP-binding proteins. 1993 Biochem. J. pmid:8424783