Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Carcinoma, Hepatocellular D006528 140 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Hypertension D006973 115 associated lipids
Hypothyroidism D007037 32 associated lipids
Leukemia D007938 74 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Peutz-Jeghers Syndrome D010580 2 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
Paradisi M et al. Dermal fibroblasts in Hutchinson-Gilford progeria syndrome with the lamin A G608G mutation have dysmorphic nuclei and are hypersensitive to heat stress. 2005 BMC Cell Biol. pmid:15982412
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pmid:15996638
pmid:16019076
pmid:16019130
Saiki A et al. Pitavastatin enhanced lipoprotein lipase expression in 3T3-L1 preadipocytes. 2005 J. Atheroscler. Thromb. pmid:16020917
Baker SK and Tarnopolsky MA Statin-associated neuromyotoxicity. 2005 Drugs Today pmid:16034491
Donovan JM et al. Effects of colesevelam HC1 on sterol and bile acid excretion in patients with type IIa hypercholesterolemia. 2005 Dig. Dis. Sci. pmid:16047465
Hargreaves IP et al. The effect of HMG-CoA reductase inhibitors on coenzyme Q10: possible biochemical/clinical implications. 2005 Drug Saf pmid:16048353
Luckman SP et al. JBMR anniversary classic. Nitrogen-containing biophosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. Originally published in Volume 7, number 4, pp 581-9 (1998). 2005 J. Bone Miner. Res. pmid:16050006
pmid:16051251
Bocci G et al. Fluvastatin synergistically enhances the antiproliferative effect of gemcitabine in human pancreatic cancer MIAPaCa-2 cells. 2005 Br. J. Cancer pmid:16052215
van Heusden GP et al. Increased cholesterol synthesis in Chinese hamster ovary cells deficient in peroxisomes. 1992 Biochim. Biophys. Acta pmid:1606178
Tucker DE et al. Group IVC cytosolic phospholipase A2gamma is farnesylated and palmitoylated in mammalian cells. 2005 J. Lipid Res. pmid:16061942
Caruso MG and Notarnicola M Biochemical changes of mevalonate pathway in human colorectal cancer. 2005 Sep-Oct Anticancer Res. pmid:16101154
Girlanda S et al. MICA expressed by multiple myeloma and monoclonal gammopathy of undetermined significance plasma cells Costimulates pamidronate-activated gammadelta lymphocytes. 2005 Cancer Res. pmid:16103105
Duncan RE et al. Statins and cancer development. 2005 Cancer Epidemiol. Biomarkers Prev. pmid:16103434
Luebker DJ et al. Neonatal mortality from in utero exposure to perfluorooctanesulfonate (PFOS) in Sprague-Dawley rats: dose-response, and biochemical and pharamacokinetic parameters. 2005 Toxicology pmid:16129535
Subden RE and Renaud RL Isolation of 4 alpha-methyl-5 alpha-ergosta-8,24(28)-dien-3 beta-ol from ester fractions of nutritionally deprived Neurospora crassa. 1979 Steroids pmid:161433
Viereck V et al. Atorvastatin stimulates the production of osteoprotegerin by human osteoblasts. 2005 J. Cell. Biochem. pmid:16152630
Zeng L et al. HMG CoA reductase inhibition modulates VEGF-induced endothelial cell hyperpermeability by preventing RhoA activation and myosin regulatory light chain phosphorylation. 2005 FASEB J. pmid:16160062
van Beek E et al. Independent pathways in the modulation of osteoclastic resorption by intermediates of the mevalonate biosynthetic pathway: the role of the retinoic acid receptor. 2006 Bone pmid:16165408
pmid:1616923
Thompson K et al. Alkylamines cause Vgamma9Vdelta2 T-cell activation and proliferation by inhibiting the mevalonate pathway. 2006 Blood pmid:16179378
Graber SG et al. Expression of functional G protein beta gamma dimers of defined subunit composition using a baculovirus expression system. 1992 J. Biol. Chem. pmid:1618813
Meigs TE and Simoni RD Regulated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in permeabilized cells. 1992 J. Biol. Chem. pmid:1618856
Pandak WM et al. Bile acid synthesis. VI. Regulation of cholesterol 7 alpha-hydroxylase by taurocholate and mevalonate. 1992 J. Lipid Res. pmid:1619360
Hamadmad SN et al. Erythropoietin receptor signal transduction requires protein geranylgeranylation. 2006 J. Pharmacol. Exp. Ther. pmid:16203826
Bevilacqua M et al. Bisphosphonates and atherosclerosis: why? 2005 Lupus pmid:16218486
Murthy S et al. Regulation of fatty acid synthesis by farnesyl pyrophosphate. 2005 J. Biol. Chem. pmid:16221687
Kim J et al. 4,8-Dimethyldecanal, the aggregation pheromone of Tribolium castaneum, is biosynthesized through the fatty acid pathway. 2005 J. Chem. Ecol. pmid:16222778
Balasubramaniam S et al. Regulation of cholesterol synthesis in rat adrenal gland through coordinate control of 3-hydroxy-3-methylglutaryl coenzyme A synthase and reductase activities. 1977 Proc. Natl. Acad. Sci. U.S.A. pmid:16260
Nair AK and Menon KM Regulation of luteinizing hormone receptor expression: evidence of translational suppression in vitro by a hormonally regulated mRNA-binding protein and its endogenous association with luteinizing hormone receptor mRNA in the ovary. 2005 J. Biol. Chem. pmid:16263716
pmid:16268586
Qin W et al. Regulation of HMG-CoA reductase, apoprotein-B and LDL receptor gene expression by the hypocholesterolemic drugs simvastatin and ciprofibrate in Hep G2, human and rat hepatocytes. 1992 Biochim. Biophys. Acta pmid:1627634
Brannan PG et al. 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human hair roots. 1975 J. Lipid Res. pmid:162931
Pronin AN and Gautam N Interaction between G-protein beta and gamma subunit types is selective. 1992 Proc. Natl. Acad. Sci. U.S.A. pmid:1631113
Bejarano ER and Cerdá-Olmedo E Independence of the carotene and sterol pathways of Phycomyces. 1992 FEBS Lett. pmid:1633878
Boyle PJ et al. Role of GH in regulating nocturnal rates of lipolysis and plasma mevalonate levels in normal and diabetic humans. 1992 Am. J. Physiol. pmid:1636694
González-Fernández L et al. Cleavage of focal adhesion proteins and PKCdelta during lovastatin-induced apoptosis in spontaneously immortalized rat brain neuroblasts. 2006 FEBS J. pmid:16367743
Seong K et al. Cryptic promoter activity in the coding region of the HMG-CoA reductase gene in Fusarium graminearum. 2006 Fungal Genet. Biol. pmid:16377218
Rattan R et al. Rho/ROCK pathway as a target of tumor therapy. 2006 J. Neurosci. Res. pmid:16385577
Reimann FM et al. Regulation of cholesterol metabolism and low-density lipoprotein binding in human intestinal Caco-2 cells. 1992 Digestion pmid:1639221
Kanellis J et al. Activators of the energy sensing kinase AMPK inhibit random cell movement and chemotaxis in U937 cells. 2006 Immunol. Cell Biol. pmid:16405649
Christensen M et al. Simvastatin protection against acute immune-mediated glomerulonephritis in mice. 2006 Kidney Int. pmid:16407885
Ramasubbu K and Mann DL The emerging role of statins in the treatment of heart failure. 2006 J. Am. Coll. Cardiol. pmid:16412858
Gómez-Hernández A et al. Atorvastatin reduces the expression of prostaglandin E2 receptors in human carotid atherosclerotic plaques and monocytic cells: potential implications for plaque stabilization. 2006 J. Cardiovasc. Pharmacol. pmid:16424787
pmid:1642695
Henry A et al. Fibric acid derivatives: effects on the synthesis of isoprenoid lipids in cultured human lymphocytes. 1992 Biochim. Biophys. Acta pmid:1643103
pmid:16435209