Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Carcinoma, Hepatocellular D006528 140 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Hypertension D006973 115 associated lipids
Hypothyroidism D007037 32 associated lipids
Leukemia D007938 74 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Peutz-Jeghers Syndrome D010580 2 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

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Per page 10 20 50 100 | Total 2899
Authors Title Published Journal PubMed Link
Faas FH et al. Unsaturated fatty acyl-CoA inhibition of cholesterol synthesis in vitro. 1977 Biochim. Biophys. Acta pmid:861236
pmid:8617335
Meigs TE et al. Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation by the nonsterol mevalonate metabolite farnesol in vivo. 1996 J. Biol. Chem. pmid:8626470
Alaei P et al. Inhibition of protein prenylation down-regulates signalling by inflammatory mediators in human keratinocytes. 1996 Biochem. Biophys. Res. Commun. pmid:8630058
McTaggart F et al. Inhibition of squalene synthase of rat liver by novel 3' substituted quinuclidines. 1996 Biochem. Pharmacol. pmid:8630089
James G et al. Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells. 1996 Proc. Natl. Acad. Sci. U.S.A. pmid:8633088
Carlberg M and Larsson O Stimulatory effect of PDGF on HMG-CoA reductase activity and N-linked glycosylation contributes to increased expression of IGF-1 receptors in human fibroblasts. 1996 Exp. Cell Res. pmid:8635486
Keller RK et al. Farnesol is not the nonsterol regulator mediating degradation of HMG-CoA reductase in rat liver. 1996 Arch. Biochem. Biophys. pmid:8645011
Grönroos E et al. Leukotriene D4-induced mobilization of intracellular Ca2+ in epithelial cells is critically dependent on activation of the small GTP-binding protein Rho. 1996 Biochem. J. pmid:8645211
Rostas JA et al. Selective labelling of two phases of axonal transport of cholesterol in the chick optic system. 1979 J. Neurochem. pmid:86598
Carlberg M et al. Mevalonic acid is limiting for N-linked glycosylation and translocation of the insulin-like growth factor-1 receptor to the cell surface. Evidence for a new link between 3-hydroxy-3-methylglutaryl-coenzyme a reductase and cell growth. 1996 J. Biol. Chem. pmid:8663239
Konrad M and Merz WE Long-term effect of cyclic AMP on N-glycosylation is caused by an increase in the activity of the cis-prenyltransferase. 1996 Biochem. J. pmid:8687403
pmid:8692019
Fogelman AM et al. Cholesterol biosynthesis in human lymphocytes, monocytes, and granulocytes. 1977 Biochem. Biophys. Res. Commun. pmid:869944
pmid:8702422
Brown GR et al. Synthesis and activity of a novel series of 3-biarylquinuclidine squalene synthase inhibitors. 1996 J. Med. Chem. pmid:8709131
Scoppola A et al. Effects of insulin on cholesterol synthesis in type II diabetes patients. 1995 Diabetes Care pmid:8721938
Thompson GR et al. Role of cholesterol in regulating apolipoprotein B secretion by the liver. 1996 J. Lipid Res. pmid:8728309
Naoumova RP et al. Acute hyperinsulinaemia decreases cholesterol synthesis less in subjects with non-insulin-dependent diabetes mellitus than in non-diabetic subjects. 1996 Eur. J. Clin. Invest. pmid:8732493
Goto S et al. Species specificity in the blood cholesterol-lowering effect of YM-16638. 1996 Br. J. Pharmacol. pmid:8733592
Hebbachi AM and Gibbons GF Retention of orotic acid effect on very low density lipoproteins secretion in cultured hepatocytes. 1996 Biochem. Soc. Trans. pmid:8736835
Lakshmanan MR and Veech RL Measurement of rate of rat liver sterol synthesis in vivo using tritiated water. 1977 J. Biol. Chem. pmid:873910
Sliwowski JK et al. The in vivo biosynthesis of cholesterol from (3RS,2R) [2-14C,2-3H]mevalonic acid in the brains of rats on normal and protein deficient diets. The stereochemistry of tritium atoms at C-7 and C-15. 1977 J. Neurochem. pmid:874493
pmid:8747489
pmid:8750242
Velázquez OC et al. Butyrate inhibits seeding and growth of colorectal metastases to the liver in mice. 1996 Surgery pmid:8751616
Dimster-Denk D and Rine J Transcriptional regulation of a sterol-biosynthetic enzyme by sterol levels in Saccharomyces cerevisiae. 1996 Mol. Cell. Biol. pmid:8754796
Ku EC Regulation of fatty acid biosynthesis by intermediates of the cholesterol biosynthetic pathway. 1996 Biochem. Biophys. Res. Commun. pmid:8769113
Guyton JR et al. Toxicity of oxidized low density lipoproteins for vascular smooth muscle cells and partial protection by antioxidants. 1995 Atherosclerosis pmid:8770318
Feillet C et al. Comparative effects of simvastatin and pravastatin on cholesterol synthesis in patients with primary hypercholesterolemia. 1995 Atherosclerosis pmid:8770319
Nishio E et al. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor impairs cell p4fferentiation in cultured adipogenic cells (3T3-L1). 1996 Eur. J. Pharmacol. pmid:8773465
Domenech CE et al. Separate compartments for the production of sterols, carotenoids and gibberellins in Gibberella fujikuroi. 1996 Eur. J. Biochem. pmid:8774718
Miquel K et al. Farnesol and geranylgeraniol induce actin cytoskeleton disorganization and apoptosis in A549 lung adenocarcinoma cells. 1996 Biochem. Biophys. Res. Commun. pmid:8780704
Andersson M et al. Age-dependent modifications in the metabolism of mevalonate pathway lipids in rat brain. 1995 Mech. Ageing Dev. pmid:8789251
pmid:8793275
Taylor GW et al. Excursions in biomedical mass spectrometry. 1996 Br J Clin Pharmacol pmid:8807152
pmid:8807496
Naoumova RP et al. Plasma mevalonic acid, an index of cholesterol synthesis in vivo, and responsiveness to HMG-CoA reductase inhibitors in familial hypercholesterolaemia. 1996 Atherosclerosis pmid:8808497
McGee TP et al. Degradation of 3-hydroxy-3-methylglutaryl-CoA reductase in endoplasmic reticulum membranes is accelerated as a result of increased susceptibility to proteolysis. 1996 J. Biol. Chem. pmid:8810339
Knöss W and Reuter B Biosynthesis of [14C]geranylgeranyldiphosphate by a prenyl transferase system from a mutant strain of Gibberella fujikuroi. 1996 Anal. Biochem. pmid:8811910
Nantais DE et al. Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate binding protein, huGBP1. 1996 J. Leukoc. Biol. pmid:8830800
Satoh T et al. The effects of pravastatin, an HMG-CoA reductase inhibitor, on cell viability and DNA production of rat hepatocytes. 1996 Life Sci. pmid:8831797
Reimann FM et al. Reduced cholesterol esterification in CaCo-2 cells by indirect action of pravastatin. 1996 Atherosclerosis pmid:8831928
pmid:8835365
Jones PJ et al. Dietary cholesterol feeding suppresses human cholesterol synthesis measured by deuterium incorporation and urinary mevalonic acid levels. 1996 Arterioscler. Thromb. Vasc. Biol. pmid:8857917
Parmryd I and Dallner G Organization of isoprenoid biosynthesis. 1996 Biochem. Soc. Trans. pmid:8878825
Kurakata S et al. Effects of different inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, pravastatin sodium and simvastatin, on sterol synthesis and immunological functions in human lymphocytes in vitro. 1996 Immunopharmacology pmid:8880225
Honda A et al. Effect of YM 9429, a potent teratogen, on cholesterol biosynthesis in cultured cells and rat liver microsomes. 1996 Steroids pmid:8883221
Martín D et al. Inhibition of vitellogenin production by allatostatin in the German cockroach. 1996 Mol. Cell. Endocrinol. pmid:8892320
Ramsey RB and Fredericks M Effect of hypocholesterolemic agents on central nervous system cholesterol biosynthesis. I. Zuclomiphene. 1977 Biochem. Pharmacol. pmid:889582
pmid:8902853
Lindenthal B et al. Urinary excretion of mevalonic acid as an indicator of cholesterol synthesis. 1996 J. Lipid Res. pmid:8906596
pmid:8907210
Umetani N et al. Lovastatin inhibits gene expression of type-I scavenger receptor in THP-1 human macrophages. 1996 Biochim. Biophys. Acta pmid:8908154
Goalstone ML and Draznin B Effect of insulin on farnesyltransferase activity in 3T3-L1 adipocytes. 1996 J. Biol. Chem. pmid:8910345
Field H et al. Characterisation of protein isoprenylation in procyclic form Trypanosoma brucei. 1996 Mol. Biochem. Parasitol. pmid:8943151
pmid:8946387
pmid:8957210
Bandoh T et al. Inhibitory effect of fluvastatin at doses insufficient to lower serum lipids on the catheter-induced thickening of intima in rabbit femoral artery. 1996 Eur. J. Pharmacol. pmid:8960862
Sato-Suzuki I and Murota S Simvastatin inhibits the division and induces neurite-like outgrowth in PC12 cells. 1996 Neurosci. Lett. pmid:8977139
Shoda J et al. Simultaneous determination of plasma mevalonate and 7alpha-hydroxy-4-cholesten-3-one levels in hyperlipoproteinemia: convenient indices for estimating hepatic defects of cholesterol and bile acid syntheses and biliary cholesterol supersaturation. 1997 Hepatology pmid:8985259
Krisans SK Cell compartmentalization of cholesterol biosynthesis. 1996 Ann. N. Y. Acad. Sci. pmid:8993542
Spicer LJ et al. Insulin-like growth factor I enhancement of steroidogenesis by bovine granulosa cells and thecal cells: dependence on de novo cholesterol synthesis. 1996 J. Endocrinol. pmid:8994382
Hirai A et al. Geranylgeranylated rho small GTPase(s) are essential for the degradation of p27Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cells. 1997 J. Biol. Chem. pmid:8995216
Chiloeches A et al. Effect of mevalonate availability on the association of G-protein alpha-subunits with the plasma membrane in GH4C1 cells. 1997 FEBS Lett. pmid:9003808
pmid:900481
Lichtenthaler HK et al. Biosynthesis of isoprenoids in higher plant chloroplasts proceeds via a mevalonate-independent pathway. 1997 FEBS Lett. pmid:9009212
Stout RW The effect of insulin and glucose on sterol synthesis in cultured rat arterial smooth muscle cells. 1977 Atherosclerosis pmid:901624
Peffley DM and Gayen AK Inhibition of squalene synthase but not squalene cyclase prevents mevalonate-mediated suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis at a posttranscriptional level. 1997 Arch. Biochem. Biophys. pmid:9016820
Edwards PA et al. Preferential uptake and utilization of mevalonolactone over mevalonate for sterol biosynthesis in isolated rat hepatocytes. 1977 Biochim. Biophys. Acta pmid:901801
Beytía ED and Porter JW Biochemistry of polyisoprenoid biosynthesis. 1976 Annu. Rev. Biochem. pmid:9026
pmid:9056235
Scoppola A et al. Plasma mevalonate concentrations in uremic patients. 1997 Kidney Int. pmid:9067929
pmid:9070894
Colli S et al. Vastatins inhibit tissue factor in cultured human macrophages. A novel mechanism of protection against atherothrombosis. 1997 Arterioscler. Thromb. Vasc. Biol. pmid:9081680
Endo A et al. Inhibition of cholesterol synthesis in vitro and in vivo by ML-236A and ML-236B, competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. 1977 Eur. J. Biochem. pmid:908337
Crick DC et al. Geranylgeraniol promotes entry of UT-2 cells into the cell cycle in the absence of mevalonate. 1997 Exp. Cell Res. pmid:9087171
pmid:9089010
Cartwright IJ et al. Investigation of the role of lipids in the assembly of very low density lipoproteins in rabbit hepatocytes. 1997 J. Lipid Res. pmid:9101434
Khan SA and Nyce JW Effects of ubiquinone and mevalonic acid on hepatic peroxisomal enzymes induced by dehydroepiandrosterone. 1997 Pharmacol. Toxicol. pmid:9101583
Sinensky M Isolation of a mammalian cell mutant resistant to 25-hydroxy cholesterol. 1977 Biochem. Biophys. Res. Commun. pmid:911332
Tamai I et al. Intestinal brush-border membrane transport of monocarboxylic acids mediated by proton-coupled transport and anion antiport mechanisms. 1997 J. Pharm. Pharmacol. pmid:9120761
Padayatty SJ et al. Lovastatin-induced apoptosis in prostate stromal cells. 1997 J. Clin. Endocrinol. Metab. pmid:9141529
Herawati E and Ishizaki A Optimization of the culture medium for growth and the kinetics of lactate fermentation by Pediococcus sp. ISK-1. 1997 Biosci. Biotechnol. Biochem. pmid:9145518
Anouja F et al. The cytotoxicity of the parvovirus minute virus of mice nonstructural protein NS1 is related to changes in the synthesis and phosphorylation of cell proteins. 1997 J. Virol. pmid:9151861
Amin D et al. RPR 107393, a potent squalene synthase inhibitor and orally effective cholesterol-lowering agent: comparison with inhibitors of HMG-CoA reductase. 1997 J. Pharmacol. Exp. Ther. pmid:9152381
He L et al. Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo. 1997 J. Nutr. pmid:9164984
Fuhrman B et al. Hypocholesterolemic effect of lycopene and beta-carotene is related to suppression of cholesterol synthesis and augmentation of LDL receptor activity in macrophages. 1997 Biochem. Biophys. Res. Commun. pmid:9168909
Raiteri M et al. Pharmacological control of the mevalonate pathway: effect on arterial smooth muscle cell proliferation. 1997 J. Pharmacol. Exp. Ther. pmid:9190847
pmid:9191394
Chan PC et al. Lovastatin increases surface low density lipoprotein receptor expression by retarding the receptor internalization rate in proliferating lymphocytes. 1997 Biochem. Biophys. Res. Commun. pmid:9196047
Spencer TA et al. Feasibility of an immunoassay for mevalonolactone. 1997 Bioorg. Med. Chem. pmid:9208099
pmid:921298
Lasa M et al. Lovastatin decreases prolactin and growth hormone gene expression in GH4C1 cells through a cAMP dependent mechanism. 1997 Mol. Cell. Endocrinol. pmid:9220025
Flint OP et al. Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro. 1997 Toxicol. Appl. Pharmacol. pmid:9221828
Flint OP et al. HMG CoA reductase inhibitor-induced myotoxicity: pravastatin and lovastatin inhibit the geranylgeranylation of low-molecular-weight proteins in neonatal rat muscle cell culture. 1997 Toxicol. Appl. Pharmacol. pmid:9221829
pmid:9226547
Paton VG et al. Cloning and subcellular localization of hamster and rat isopentenyl diphosphate dimethylallyl diphosphate isomerase. A PTS1 motif targets the enzyme to peroxisomes. 1997 J. Biol. Chem. pmid:9228075
Pomerantz KB et al. G-protein-mediated signaling in cholesterol-enriched arterial smooth muscle cells. 2. Role of protein kinase C-delta in the regulation of eicosanoid production. 1997 Biochemistry pmid:9235999
Cenedella RJ Posttranscriptional regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in lens epithelial cells by mevalonate-derived nonsterols. 1997 Exp. Eye Res. pmid:9237866