| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Hypergammaglobulinemia | D006942 | 9 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Hypothyroidism | D007037 | 32 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Lipid Metabolism, Inborn Errors | D008052 | 26 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Peutz-Jeghers Syndrome | D010580 | 2 associated lipids |
Mevalonic acid
Mevalonic acid is a lipid of Fatty Acyls (FA) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.
Here are additional resources we collected from PubChem and MeSH for Mevalonic acid
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Mevalonic acid
PubChem Biomolecular Interactions and Pathways
NCBI Entrez Crosslinks
All references with Mevalonic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hecht S et al. | Studies on the nonmevalonate pathway to terpenes: the role of the GcpE (IspG) protein. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11752431 |
| Han YS et al. | Biosynthesis of anthraquinones in cell cultures of Cinchona 'Robusta' proceeds via the methylerythritol 4-phosphate pathway. | 2002 | Phytochemistry | pmid:11754943 |
| Ferri N et al. | Effect of S(-) perillic acid on protein prenylation and arterial smooth muscle cell proliferation. | 2001 | Biochem. Pharmacol. | pmid:11755117 |
| Izumo N et al. | Lipophilic statins can be osteogenic by promoting osteoblastic calcification in a Cbfa1- and BMP-2-independent manner. | 2001 | Methods Find Exp Clin Pharmacol | pmid:11771853 |
| Richard SB et al. | Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway. | 2002 | J. Biol. Chem. | pmid:11786530 |
| Brämswig S et al. | Carbamazepine increases atherogenic lipoproteins: mechanism of action in male adults. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11788421 |
| Holstein SA et al. | Consequences of mevalonate depletion. Differential transcriptional, translational, and post-translational up-regulation of Ras, Rap1a, RhoA, AND RhoB. | 2002 | J. Biol. Chem. | pmid:11788600 |
| pmid:11794213 | ||||
| Hurtado-Guerrrero R et al. | Kinetic properties and inhibition of Trypanosoma cruzi 3-hydroxy-3-methylglutaryl CoA reductase. | 2002 | FEBS Lett. | pmid:11801242 |
| pmid:11810250 | ||||
| Rohdich F et al. | Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of IspH (LytB) protein. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11818558 |
| Goodman ZD and Lequire VS | Transfer of esterified cholesterol from serum lipoproteins to the liver. | 1975 | Biochim. Biophys. Acta | pmid:1182142 |
| pmid:11829504 | ||||
| Thiel R and Adam KP | Incorporation of [1-(13)C]1-deoxy-D-xylulose into isoprenoids of the liverwort Conocephalum conicum. | 2002 | Phytochemistry | pmid:11830134 |
| Chmielewski M et al. | Diurnal rhythm of cholesterol biosynthesis in experimental chronic renal failure. | 2001 | Mol. Cell. Biochem. | pmid:11855739 |
| Eisenreich W et al. | Biosynthesis of zeaxanthin via mevalonate in Paracoccus species strain PTA-3335. A product-based retrobiosynthetic study. | 2002 | J. Org. Chem. | pmid:11856031 |
| pmid:11856612 | ||||
| Kalinowski L et al. | Increased nitric oxide bioavailability in endothelial cells contributes to the pleiotropic effect of cerivastatin. | 2002 | Circulation | pmid:11864921 |
| Yokoyama K et al. | HMG-CoA reductase inhibitors suppress intracellular calcium mobilization and membrane current induced by lysophosphatidylcholine in endothelial cells. | 2002 | Circulation | pmid:11864926 |
| Fu Z et al. | The structure of a binary complex between a mammalian mevalonate kinase and ATP: insights into the reaction mechanism and human inherited disease. | 2002 | J. Biol. Chem. | pmid:11877411 |
| Blanco-Colio LM et al. | 3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation. | 2002 | Atherosclerosis | pmid:11882313 |
| Ledoux S et al. | Lovastatin enhances ecto-5'-nucleotidase activity and cell surface expression in endothelial cells: implication of rho-family GTPases. | 2002 | Circ. Res. | pmid:11884371 |
| Paris D et al. | Statins inhibit A beta-neurotoxicity in vitro and A beta-induced vasoconstriction and inflammation in rat aortae. | 2002 | Atherosclerosis | pmid:11888511 |
| Gubina E et al. | CD43 polarization in unprimed T cells can be dissociated from raft coalescence by inhibition of HMG CoA reductase. | 2002 | Blood | pmid:11895788 |
| pmid:1193282 | ||||
| pmid:1193283 | ||||
| Virtanen SS et al. | Alendronate inhibits invasion of PC-3 prostate cancer cells by affecting the mevalonate pathway. | 2002 | Cancer Res. | pmid:11980672 |
| pmid:11987326 | ||||
| pmid:11995814 | ||||
| Masferrer A et al. | Overexpression of Arabidopsis thaliana farnesyl diphosphate synthase (FPS1S) in transgenic Arabidopsis induces a cell death/senescence-like response and reduced cytokinin levels. | 2002 | Plant J. | pmid:12000449 |
| pmid:12002344 | ||||
| Okada K et al. | Antisense and chemical suppression of the nonmevalonate pathway affects ent-kaurene biosynthesis in Arabidopsis. | 2002 | Planta | pmid:12029484 |
| pmid:12031835 | ||||
| Hamano Y et al. | Growth-phase dependent expression of the mevalonate pathway in a terpenoid antibiotic-producing Streptomyces strain. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12036054 |
| Marino M et al. | Age-related changes of cholesterol and dolichol biosynthesis in rat liver. | 2002 | Mech. Ageing Dev. | pmid:12044967 |
| pmid:12059229 | ||||
| Che P et al. | Metabolic and environmental regulation of 3-methylcrotonyl-coenzyme A carboxylase expression in Arabidopsis. | 2002 | Plant Physiol. | pmid:12068107 |
| Konrad Z and Eichler J | Lipid modification of proteins in Archaea: attachment of a mevalonic acid-based lipid moiety to the surface-layer glycoprotein of Haloferax volcanii follows protein translocation. | 2002 | Biochem. J. | pmid:12069685 |
| Dimitroulakos J et al. | Microarray and biochemical analysis of lovastatin-induced apoptosis of squamous cell carcinomas. | 2002 Jul-Aug | Neoplasia | pmid:12082550 |
| pmid:12091000 | ||||
| Sul D and Kaneshiro ES | Pneumocystis carinii f. sp. carinii synthesizes de novo four homologs of ubiquinone. | 2001 Mar-Apr | J. Eukaryot. Microbiol. | pmid:12095106 |
| Porter KE et al. | Simvastatin inhibits human saphenous vein neointima formation via inhibition of smooth muscle cell proliferation and migration. | 2002 | J. Vasc. Surg. | pmid:12096273 |
| Newton CJ et al. | Statin-induced apoptosis of vascular endothelial cells is blocked by dexamethasone. | 2002 | J. Endocrinol. | pmid:12098658 |
| Sutherlin A et al. | Enterococcus faecalis 3-hydroxy-3-methylglutaryl coenzyme A synthase, an enzyme of isopentenyl diphosphate biosynthesis. | 2002 | J. Bacteriol. | pmid:12107122 |
| Kumar B et al. | Mevastatin induces degeneration and decreases viability of cAMP-induced differentiated neuroblastoma cells in culture by inhibiting proteasome activity, and mevalonic acid lactone prevents these effects. | 2002 | J. Neurosci. Res. | pmid:12111853 |
| Fang TY and Baisted DJ | 2,3-Oxidosqualene cyclase and cycloartenol-s-adenosylmethionine methyltransferase activities in vivo in the cotyledon and axis tissues of germinating pea seeds. | 1975 | Biochem. J. | pmid:1212194 |
| Christ M et al. | Glucose increases endothelial-dependent superoxide formation in coronary arteries by NAD(P)H oxidase activation: attenuation by the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor atorvastatin. | 2002 | Diabetes | pmid:12145183 |
| pmid:12162608 | ||||
| Zager RA et al. | The mevalonate pathway during acute tubular injury: selected determinants and consequences. | 2002 | Am. J. Pathol. | pmid:12163393 |
| Li L et al. | Inhibitory effect of fluvastatin on lysophosphatidylcholine-induced nonselective cation current in Guinea pig ventricular myocytes. | 2002 | Mol. Pharmacol. | pmid:12181436 |
| Kandoussi A et al. | HMG-CoA reductase inhibition and PPAR- alpha activation both inhibit cyclosporin A induced endothelin-1 secretion in cultured endothelial cells. | 2002 | Clin. Sci. | pmid:12193060 |
| Fahien LA and MacDonald MJ | The succinate mechanism of insulin release. | 2002 | Diabetes | pmid:12196457 |
| Miyazaki A et al. | Effects of pravastatin sodium on mevalonate metabolism in common marmosets. | 2002 | J. Biochem. | pmid:12204108 |
| pmid:12208479 | ||||
| Kasahara H et al. | Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of gibberellins in Arabidopsis. | 2002 | J. Biol. Chem. | pmid:12228237 |
| Amin R et al. | Inhibition of glucose- and calcium-induced insulin secretion from betaTC3 cells by novel inhibitors of protein isoprenylation. | 2002 | J. Pharmacol. Exp. Ther. | pmid:12235236 |
| Miyashita Y et al. | Oxysterol-induced apoptosis of vascular smooth muscle cells is reduced by HMG-CoA reductase inhibitor, pravastatin. | 2002 | J. Atheroscler. Thromb. | pmid:12238640 |
| pmid:12352324 | ||||
| Kuzuyama T | Mevalonate and nonmevalonate pathways for the biosynthesis of isoprene units. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12353619 |
| Pappu AS et al. | Feedback inhibition of the cholesterol biosynthetic pathway in patients with Smith-Lemli-Opitz syndrome as demonstrated by urinary mevalonate excretion. | 2002 | J. Lipid Res. | pmid:12364550 |
| Hümbelin M et al. | Genetics of isoprenoid biosynthesis in Paracoccus zeaxanthinifaciens. | 2002 | Gene | pmid:12384294 |
| Stamatakis K et al. | Isoprenylation of RhoB is necessary for its degradation. A novel determinant in the complex regulation of RhoB expression by the mevalonate pathway. | 2002 | J. Biol. Chem. | pmid:12384510 |
| Frenkel J et al. | Lack of isoprenoid products raises ex vivo interleukin-1beta secretion in hyperimmunoglobulinemia D and periodic fever syndrome. | 2002 | Arthritis Rheum. | pmid:12384940 |
| Mason JC et al. | Statin-induced expression of decay-accelerating factor protects vascular endothelium against complement-mediated injury. | 2002 | Circ. Res. | pmid:12386146 |
| Carnesecchi S et al. | Perturbation by geraniol of cell membrane permeability and signal transduction pathways in human colon cancer cells. | 2002 | J. Pharmacol. Exp. Ther. | pmid:12388655 |
| Nishikimi T et al. | Cerivastatin, a hydroxymethylglutaryl coenzyme A reductase inhibitor, inhibits cardiac myocyte hypertrophy induced by endothelin. | 2002 | Eur. J. Pharmacol. | pmid:12398901 |
| Ropero S et al. | Cholesterol cell content modulates GTPase activity of G proteins in GH4C1 cell membranes. | 2003 | Cell. Signal. | pmid:12401528 |
| Parhami F et al. | Role of the cholesterol biosynthetic pathway in osteoblastic differentiation of marrow stromal cells. | 2002 | J. Bone Miner. Res. | pmid:12412807 |
| Wagner AH et al. | 3-hydroxy-3-methylglutaryl coenzyme A reductase-independent inhibition of CD40 expression by atorvastatin in human endothelial cells. | 2002 | Arterioscler. Thromb. Vasc. Biol. | pmid:12426205 |
| Holstein SA et al. | Isoprenoids influence expression of Ras and Ras-related proteins. | 2002 | Biochemistry | pmid:12427032 |
| RodrÃguez-Concepción M and Boronat A | Elucidation of the methylerythritol phosphate pathway for isoprenoid biosynthesis in bacteria and plastids. A metabolic milestone achieved through genomics. | 2002 | Plant Physiol. | pmid:12427975 |
| Wang W et al. | Cerivastatin enhances the cytotoxicity of 5-fluorouracil on chemosensitive and resistant colorectal cancer cell lines. | 2002 | FEBS Lett. | pmid:12435585 |
| pmid:12444096 | ||||
| Martin PD et al. | Pharmacodynamic effects and pharmacokinetics of a new HMG-CoA reductase inhibitor, rosuvastatin, after morning or evening administration in healthy volunteers. | 2002 | Br J Clin Pharmacol | pmid:12445025 |
| Nagata N et al. | Mevalonic acid partially restores chloroplast and etioplast development in Arabidopsis lacking the non-mevalonate pathway. | 2002 | Planta | pmid:12447549 |
| Phillips GT and Clifford KH | Stereochemistry of a methyl-group rearrangement during the biosynthesis of lanosterol. | 1976 | Eur. J. Biochem. | pmid:1245185 |
| Arkwright PD et al. | Hyper IgD syndrome (HIDS) associated with in vitro evidence of defective monocyte TNFRSF1A shedding and partial response to TNF receptor blockade with etanercept. | 2002 | Clin. Exp. Immunol. | pmid:12452839 |
| pmid:12467639 | ||||
| Naidu A et al. | Secretion of apolipoprotein E by brain glia requires protein prenylation and is suppressed by statins. | 2002 | Brain Res. | pmid:12468034 |
| Choi M et al. | Extracellular signal-regulated kinase inhibition by statins inhibits neutrophil activation by ANCA. | 2003 | Kidney Int. | pmid:12472772 |
| Alla S et al. | [Mevalonolactone: a volatile compound produced by Psammotettix alienus (Dhb)]. | 2002 | C. R. Biol. | pmid:12481687 |
| pmid:12492458 | ||||
| pmid:12499535 | ||||
| pmid:12503192 | ||||
| pmid:12504097 | ||||
| pmid:12509999 | ||||
| Kalinowski L et al. | Cerivastatin potentiates nitric oxide release and enos expression through inhibition of isoprenoids synthesis. | 2002 | J. Physiol. Pharmacol. | pmid:12512694 |
| Flores-Sánchez IJ et al. | Biosynthesis of sterols and triterpenes in cell suspension cultures of Uncaria tomentosa. | 2002 | Plant Cell Physiol. | pmid:12514247 |
| Miyazawa Y et al. | Amyloplast formation in cultured tobacco BY-2 cells requires a high cytokinin content. | 2002 | Plant Cell Physiol. | pmid:12514251 |
| Peffley DM and Gayen AK | Plant-derived monoterpenes suppress hamster kidney cell 3-hydroxy-3-methylglutaryl coenzyme a reductase synthesis at the post-transcriptional level. | 2003 | J. Nutr. | pmid:12514264 |
| Kreck M et al. | Biogenetic studies in Syringa vulgaris L.: synthesis and bioconversion of deuterium-labeled precursors into lilac aldehydes and lilac alcohols. | 2003 | J. Agric. Food Chem. | pmid:12517111 |
| Wiss O | Influence of a lipogenic diet on the cholesterol synthesis in rats in vivo. | 1976 | Biochem. Biophys. Res. Commun. | pmid:1252232 |
| Kuzuyama T et al. | Detection of the mevalonate pathway in Streptomyces species using the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene. | 2002 | J. Antibiot. | pmid:12523826 |
| pmid:12525568 | ||||
| pmid:12528472 | ||||
| Shimada Y et al. | Organ-specific expression of brassinosteroid-biosynthetic genes and distribution of endogenous brassinosteroids in Arabidopsis. | 2003 | Plant Physiol. | pmid:12529536 |
| Sever N et al. | Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain. | 2003 | Mol. Cell | pmid:12535518 |
| Gober HJ et al. | Human T cell receptor gammadelta cells recognize endogenous mevalonate metabolites in tumor cells. | 2003 | J. Exp. Med. | pmid:12538656 |
| pmid:12543573 | ||||
| pmid:12563048 |