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Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus. |
2007 |
PLoS Pathog. |
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Atorvastatin inhibits angiotensin-converting enzyme induction in differentiating human macrophages. |
2007 |
Am. J. Physiol. Heart Circ. Physiol. |
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J. Lipid Res. |
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Direct effect of cholesterol on insulin secretion: a novel mechanism for pancreatic beta-cell dysfunction. |
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Diabetes |
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2007 |
J. Inherit. Metab. Dis. |
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Statins decrease TNF-alpha-induced osteoprotegerin production by endothelial cells and smooth muscle cells in vitro. |
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Biochem. Pharmacol. |
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Statins induce S1P1 receptors and enhance endothelial nitric oxide production in response to high-density lipoproteins. |
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A specific inhibitor of cholesterol biosynthesis, BM15.766, reduces the expression of beta-secretase and the production of amyloid-beta in vitro. |
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Simvastatin enhances induction of inducible nitric oxide synthase in 3T3-L1 adipocytes. |
2007 |
Free Radic. Res. |
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Coenzyme Q10 in phenylketonuria and mevalonic aciduria. |
2007 |
Mitochondrion |
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Protective effects of coenzyme q(10) on decreased oxidative stress resistance induced by simvastatin. |
2007 |
J Clin Biochem Nutr |
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Simvastatin reduces MMP1 expression in human smooth muscle cells cultured on polymerized collagen by inhibiting Rac1 activation. |
2007 |
Arterioscler. Thromb. Vasc. Biol. |
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Inhibition of serotonin-induced mitogenesis, migration, and ERK MAPK nuclear translocation in vascular smooth muscle cells by atorvastatin. |
2007 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
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Chemical phenotypes of the hmg1 and hmg2 mutants of Arabidopsis demonstrate the in-planta role of HMG-CoA reductase in triterpene biosynthesis. |
2007 |
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Up-regulation of an N-terminal truncated 3-hydroxy-3-methylglutaryl CoA reductase enhances production of essential oils and sterols in transgenic Lavandula latifolia. |
2007 |
Plant Biotechnol. J. |
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Pravastatin induces rat aortic endothelial cell proliferation and migration via activation of PI3K/Akt/mTOR/p70 S6 kinase signaling. |
2007 |
J. Pharmacol. Sci. |
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Statin-mediated cytoprotection of human vascular endothelial cells: a role for Kruppel-like factor 2-dependent induction of heme oxygenase-1. |
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J. Thromb. Haemost. |
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2007 |
N. Engl. J. Med. |
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Preemptive HMG-CoA reductase inhibition provides graft-versus-host disease protection by Th-2 polarization while sparing graft-versus-leukemia activity. |
2007 |
Blood |
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Activation of the integrated stress response regulates lovastatin-induced apoptosis. |
2007 |
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Statin-induced breast cancer cell death: role of inducible nitric oxide and arginase-dependent pathways. |
2007 |
Cancer Res. |
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Statins reduce amyloid-beta production through inhibition of protein isoprenylation. |
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J. Biol. Chem. |
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Decreased C-reactive protein-induced resistin production in human monocytes by simvastatin. |
2007 |
Cytokine |
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2007 |
N. Engl. J. Med. |
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Determinants of sensitivity to lovastatin-induced apoptosis in multiple myeloma. |
2007 |
Mol. Cancer Ther. |
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Biosynthesis of salvinorin A proceeds via the deoxyxylulose phosphate pathway. |
2007 |
Phytochemistry |
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Biosynthetic origins of the isoprene units of gaudichaudianic acid in Piper gaudichaudianum (Piperaceae). |
2007 |
Phytochemistry |
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A mutation in zebrafish hmgcr1b reveals a role for isoprenoids in vertebrate heart-tube formation. |
2007 |
Curr. Biol. |
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The combination of Ezetimibe and Statin: a new treatment for hypercholesterolemia. |
2007 |
Heart Int |
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Structures of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase provide new insights into catalysis. |
2007 |
J. Biol. Chem. |
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Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase blunts factor VIIa/tissue factor and prothrombinase activities via effects on membrane phosphatidylserine. |
2007 |
Arterioscler. Thromb. Vasc. Biol. |
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Statin treatment upregulates vascular neuronal nitric oxide synthase through Akt/NF-kappaB pathway. |
2007 |
Arterioscler. Thromb. Vasc. Biol. |
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ErpA, an iron sulfur (Fe S) protein of the A-type essential for respiratory metabolism in Escherichia coli. |
2007 |
Proc. Natl. Acad. Sci. U.S.A. |
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Zoledronic acid-induced IPP/ApppI production in vivo. |
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Life Sci. |
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Identification of isopentenol biosynthetic genes from Bacillus subtilis by a screening method based on isoprenoid precursor toxicity. |
2007 |
Appl. Environ. Microbiol. |
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Mevalonate pathway: a review of clinical and therapeutical implications. |
2007 |
Clin. Biochem. |
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Statins induce differentiation and cell death in neurons and astroglia. |
2007 |
Glia |
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Am. J. Respir. Cell Mol. Biol. |
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Modulation of COX-2 expression by statins in human monocytic cells. |
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FASEB J. |
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Isoprenoid depletion by statins antagonizes cytokine-induced down-regulation of endothelial nitric oxide expression and increases NO synthase activity in human umbilical vein endothelial cells. |
2007 |
J. Physiol. Pharmacol. |
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Induction of mitochondria-dependent apoptosis through the inhibition of mevalonate pathway in human breast cancer cells by YM529, a new third generation bisphosphonate. |
2007 |
Cancer Lett. |
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Action profiles of statins and calcineurin inhibitors during human mixed lymphocyte reaction. |
2007 |
Clin. Immunol. |
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Common musculoskeletal adverse effects of oral treatment with once weekly alendronate and risedronate in patients with osteoporosis and ways for their prevention. |
2007 Apr-Jun |
J Musculoskelet Neuronal Interact |
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Incadronate induces cell detachment and apoptosis in prostatic PC-3 cells. |
2007 Mar-Apr |
Anticancer Res. |
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Increased beta-carotene production in recombinant Escherichia coli harboring an engineered isoprenoid precursor pathway with mevalonate addition. |
2007 May-Jun |
Biotechnol. Prog. |
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Simvastatin inhibits cytokine production and nuclear factor-kB activation in interleukin 1beta-stimulated synoviocytes from rheumatoid arthritis patients. |
2007 Sep-Oct |
Clin. Exp. Rheumatol. |
pmid:18078616
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Statins inhibit proliferation and induce apoptosis in Barrett's esophageal adenocarcinoma cells. |
2008 |
Am. J. Gastroenterol. |
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Induction of scavenger receptor class B type I is critical for simvastatin enhancement of high-density lipoprotein-induced anti-inflammatory actions in endothelial cells. |
2008 |
J. Immunol. |
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Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation. |
2008 |
Proc. Natl. Acad. Sci. U.S.A. |
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Structure of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate reductase, the terminal enzyme of the non-mevalonate pathway. |
2008 |
J. Am. Chem. Soc. |
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7-ketocholesterol, a major oxysterol, promotes pi-induced vascular calcification in cultured smooth muscle cells. |
2008 |
J. Atheroscler. Thromb. |
pmid:18603819
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Combination therapy in cholesterol reduction: focus on ezetimibe and statins. |
2008 |
Vasc Health Risk Manag |
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Pravastatin improves renal ischemia-reperfusion injury by inhibiting the mevalonate pathway. |
2008 |
Kidney Int. |
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Dynamical modeling of the cholesterol regulatory pathway with Boolean networks. |
2008 |
BMC Syst Biol |
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Tekle M et al. |
Investigation of coenzyme Q biosynthesis in human fibroblast and HepG2 cells. |
2008 |
J. Biochem. Biophys. Methods |
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Cornish J et al. |
Modulation of osteoclastogenesis by fatty acids. |
2008 |
Endocrinology |
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Genetic evidence for the role of isopentenyl diphosphate isomerases in the mevalonate pathway and plant development in Arabidopsis. |
2008 |
Plant Cell Physiol. |
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Stable carbon isotope discrimination by human 3-hydroxy-3-methylglutaryl-coenzyme A reductase. |
2008 |
J. Lipid Res. |
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Statins impair antitumor effects of rituximab by inducing conformational changes of CD20. |
2008 |
PLoS Med. |
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Oliveira KA et al. |
Simvastatin inducing PC3 prostate cancer cell necrosis mediated by calcineurin and mitochondrial dysfunction. |
2008 |
J. Bioenerg. Biomembr. |
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Abumweis SS et al. |
Plant sterols/stanols as cholesterol lowering agents: A meta-analysis of randomized controlled trials. |
2008 |
Food Nutr Res |
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Sapir-Mir M et al. |
Peroxisomal localization of Arabidopsis isopentenyl diphosphate isomerases suggests that part of the plant isoprenoid mevalonic acid pathway is compartmentalized to peroxisomes. |
2008 |
Plant Physiol. |
pmid:18988695
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Sławińska A and Kandefer-Szerszeń M |
[The anticancer properties of statins]. |
2008 |
Postepy Hig Med Dosw (Online) |
pmid:18688209
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Acharjee S and Welty FK |
Atorvastatin and cardiovascular risk in the elderly--patient considerations. |
2008 |
Clin Interv Aging |
pmid:18686752
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Journe F et al. |
Farnesol, a mevalonate pathway intermediate, stimulates MCF-7 breast cancer cell growth through farnesoid-X-receptor-mediated estrogen receptor activation. |
2008 |
Breast Cancer Res. Treat. |
pmid:17333335
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Sando T et al. |
Cloning and characterization of mevalonate pathway genes in a natural rubber producing plant, Hevea brasiliensis. |
2008 |
Biosci. Biotechnol. Biochem. |
pmid:18685207
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Laezza C et al. |
The anandamide analog, Met-F-AEA, controls human breast cancer cell migration via the RHOA/RHO kinase signaling pathway. |
2008 |
Endocr. Relat. Cancer |
pmid:18676619
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Bate C et al. |
Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells. |
2008 |
BMC Biol. |
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Kistowska M et al. |
Dysregulation of the host mevalonate pathway during early bacterial infection activates human TCR gamma delta cells. |
2008 |
Eur. J. Immunol. |
pmid:18624305
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Matsuda T et al. |
Simvastatin inhibits catecholamine secretion and synthesis induced by acetylcholine via blocking Na+ and Ca2+ influx in bovine adrenal medullary cells. |
2008 |
J. Pharmacol. Exp. Ther. |
pmid:18593956
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Habara K et al. |
Pitavastatin up-regulates the induction of iNOS through enhanced stabilization of its mRNA in pro-inflammatory cytokine-stimulated hepatocytes. |
2008 |
Nitric Oxide |
pmid:17936042
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Fried LF |
Effects of HMG-CoA reductase inhibitors (statins) on progression of kidney disease. |
2008 |
Kidney Int. |
pmid:18528321
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Skorupinska-Tudek K et al. |
Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of dolichols in plants. |
2008 |
J. Biol. Chem. |
pmid:18502754
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Zhang X et al. |
Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. |
2008 |
J. Immunol. |
pmid:18453621
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Atorvastatin induces apoptosis by a caspase-9-dependent pathway: an in vitro study on activated rat hepatic stellate cells. |
2008 |
Liver Int. |
pmid:18339080
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Burke LP and Kukoly CA |
Statins induce lethal effects in acute myeloblastic leukemia [corrected] cells within 72 hours. |
2008 |
Leuk. Lymphoma |
pmid:18231920
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Glynn SA et al. |
The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, simvastatin, lovastatin and mevastatin inhibit proliferation and invasion of melanoma cells. |
2008 |
BMC Cancer |
pmid:18199328
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Galichet A et al. |
Farnesylation directs AtIPT3 subcellular localization and modulates cytokinin biosynthesis in Arabidopsis. |
2008 |
Plant Physiol. |
pmid:18184738
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Kodaman PH and Duleba AJ |
Statins in the treatment of polycystic ovary syndrome. |
2008 |
Semin. Reprod. Med. |
pmid:18181091
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Wilson GJ et al. |
Effects of beta-hydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: A review. |
2008 |
Nutr Metab (Lond) |
pmid:18173841
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Mathew B and Biju R |
Neuroprotective effects of garlic a review. |
2008 |
Libyan J Med |
pmid:21499478
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Yoshida T et al. |
Determination of key intermediates in cholesterol and bile acid biosynthesis by stable isotope dilution mass spectrometry. |
2008 |
Anal Chem Insights |
pmid:19609389
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Saito A et al. |
Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells. |
2008 |
Melanoma Res. |
pmid:18337644
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Baba TT et al. |
Simvastatin suppresses the differentiation of C2C12 myoblast cells via a Rac pathway. |
2008 |
J. Muscle Res. Cell. Motil. |
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Habeos IG et al. |
Simvastatin activates Keap1/Nrf2 signaling in rat liver. |
2008 |
J. Mol. Med. |
pmid:18787804
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Atorvastatin accelerates extracellular nucleotide degradation in human endothelial cells. |
2008 |
Mol. Cell. Biochem. |
pmid:18158588
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Paintlia AS et al. |
Inhibition of rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis. |
2008 |
Mol. Pharmacol. |
pmid:18239032
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Martin-Ventura JL et al. |
LDL induces parathyroid hormone-related protein expression in vascular smooth muscle cells: Modulation by simvastatin. |
2008 |
Atherosclerosis |
pmid:18378243
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Park SY et al. |
Inhibitory effect of simvastatin on the TNF-alpha- and angiotensin II-induced monocyte adhesion to endothelial cells is mediated through the suppression of geranylgeranyl isoprenoid-dependent ROS generation. |
2008 |
Arch. Pharm. Res. |
pmid:18365690
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Begley M et al. |
Analysis of the isoprenoid biosynthesis pathways in Listeria monocytogenes reveals a role for the alternative 2-C-methyl-D-erythritol 4-phosphate pathway in murine infection. |
2008 |
Infect. Immun. |
pmid:18765739
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Simonen M et al. |
High-content assay to study protein prenylation. |
2008 |
J Biomol Screen |
pmid:18509097
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Tarhzaoui K et al. |
Effect of rosuvastatin on capillary filtration of albumin and blood pressure in rats with streptozotocin-induced diabetes. |
2008 |
Diabetes Res. Clin. Pract. |
pmid:18406000
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Zhuge B et al. |
Bioconversion of lovastatin to a novel statin by Amycolatopsis sp. |
2008 |
Appl. Microbiol. Biotechnol. |
pmid:18368405
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Kaliszewski P et al. |
Rsp5p ubiquitin ligase and the transcriptional activators Spt23p and Mga2p are involved in co-regulation of biosynthesis of end products of the mevalonate pathway and triacylglycerol in yeast Saccharomyces cerevisiae. |
2008 |
Biochim. Biophys. Acta |
pmid:18771750
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Voynova NE et al. |
Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure. |
2008 |
Arch. Biochem. Biophys. |
pmid:18823933
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Pscheidt B and Glieder A |
Yeast cell factories for fine chemical and API production. |
2008 |
Microb. Cell Fact. |
pmid:18684335
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Schwartz YSh et al. |
Cholesterol-induced stimulation of postinflammatory liver fibrosis. |
2008 |
Bull. Exp. Biol. Med. |
pmid:19110552
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Liang YJ et al. |
Simvastatin inhibits C-reactive protein-induced pro-inflammatory changes in endothelial cells by decreasing mevalonate pathway products. |
2008 |
Cardiology |
pmid:18057884
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de Ruyck J and Wouters J |
Structure-based drug design targeting biosynthesis of isoprenoids: a crystallographic state of the art of the involved enzymes. |
2008 |
Curr. Protein Pept. Sci. |
pmid:18393884
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