Huang SH et al. |
Imaging of zebrafish in vivo with second-harmonic generation reveals shortened sarcomeres associated with myopathy induced by statin. |
2011 |
PLoS ONE |
pmid:21966365
|
Aliferis KA and Jabaji S |
FT-ICR/MS and GC-EI/MS metabolomics networking unravels global potato sprout's responses to Rhizoctonia solani infection. |
2012 |
PLoS ONE |
pmid:22880040
|
Van Laar TA et al. |
Effect of levels of acetate on the mevalonate pathway of Borrelia burgdorferi. |
2012 |
PLoS ONE |
pmid:22675445
|
Liu D et al. |
The genome of Ganoderma lucidum provides insights into triterpenes biosynthesis and wood degradation [corrected]. |
2012 |
PLoS ONE |
pmid:22567134
|
Yang J et al. |
Enhancing production of bio-isoprene using hybrid MVA pathway and isoprene synthase in E. coli. |
2012 |
PLoS ONE |
pmid:22558074
|
Bergman P et al. |
Studies on the antibacterial effects of statins--in vitro and in vivo. |
2011 |
PLoS ONE |
pmid:21912631
|
Tsang A et al. |
Francisella tularensis 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase: kinetic characterization and phosphoregulation. |
2011 |
PLoS ONE |
pmid:21694781
|
Maekawa T et al. |
Chronic oral infection with Porphyromonas gingivalis accelerates atheroma formation by shifting the lipid profile. |
2011 |
PLoS ONE |
pmid:21625524
|
Zhou K et al. |
Metabolite profiling identified methylerythritol cyclodiphosphate efflux as a limiting step in microbial isoprenoid production. |
2012 |
PLoS ONE |
pmid:23133596
|
Salunkhe VA et al. |
Rosuvastatin Treatment Affects Both Basal and Glucose-Induced Insulin Secretion in INS-1 832/13 Cells. |
2016 |
PLoS ONE |
pmid:26986474
|
Zhu J et al. |
Mevalonate-Farnesal Biosynthesis in Ticks: Comparative Synganglion Transcriptomics and a New Perspective. |
2016 |
PLoS ONE |
pmid:26959814
|
Smith R et al. |
Simvastatin inhibits glucose metabolism and legumain activity in human myotubes. |
2014 |
PLoS ONE |
pmid:24416446
|
Ghavami S et al. |
Mevalonate cascade regulation of airway mesenchymal cell autophagy and apoptosis: a dual role for p53. |
2011 |
PLoS ONE |
pmid:21304979
|
Head BP et al. |
Loss of caveolin-1 accelerates neurodegeneration and aging. |
2010 |
PLoS ONE |
pmid:21203469
|
Huang Y et al. |
De Novo Transcriptome and Expression Profile Analysis to Reveal Genes and Pathways Potentially Involved in Cantharidin Biosynthesis in the Blister Beetle Mylabris cichorii. |
2016 |
PLoS ONE |
pmid:26752526
|
Chen X et al. |
Statistical experimental design guided optimization of a one-pot biphasic multienzyme total synthesis of amorpha-4,11-diene. |
2013 |
PLoS ONE |
pmid:24278153
|
Nyati P et al. |
Negative Feedbacks by Isoprenoids on a Mevalonate Kinase Expressed in the Corpora Allata of Mosquitoes. |
2015 |
PLoS ONE |
pmid:26566274
|
Liu Q et al. |
Dynamics of lamin-A processing following precursor accumulation. |
2010 |
PLoS ONE |
pmid:20526372
|
Hofberger JA et al. |
Large-Scale Evolutionary Analysis of Genes and Supergene Clusters from Terpenoid Modular Pathways Provides Insights into Metabolic Diversification in Flowering Plants. |
2015 |
PLoS ONE |
pmid:26046541
|
Panicker SP et al. |
Sterol intermediates of cholesterol biosynthesis inhibit hair growth and trigger an innate immune response in cicatricial alopecia. |
2012 |
PLoS ONE |
pmid:22685570
|
Hirota Y et al. |
Functional characterization of the vitamin K2 biosynthetic enzyme UBIAD1. |
2015 |
PLoS ONE |
pmid:25874989
|
Jawaid S et al. |
Kinetic characterization and phosphoregulation of the Francisella tularensis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase). |
2009 |
PLoS ONE |
pmid:20011597
|
Liu Q et al. |
Reconstitution of the costunolide biosynthetic pathway in yeast and Nicotiana benthamiana. |
2011 |
PLoS ONE |
pmid:21858047
|
Xiao H et al. |
Inhibition of Rho and Rac geranylgeranylation by atorvastatin is critical for preservation of endothelial junction integrity. |
2013 |
PLoS ONE |
pmid:23555637
|
Chang TI et al. |
The effect of statin on epithelial-mesenchymal transition in peritoneal mesothelial cells. |
2014 |
PLoS ONE |
pmid:25275561
|
Jouneau S et al. |
Anti-inflammatory effect of fluvastatin on IL-8 production induced by Pseudomonas aeruginosa and Aspergillus fumigatus antigens in cystic fibrosis. |
2011 |
PLoS ONE |
pmid:21826199
|
Kanugula AK et al. |
Fluvastatin mediated breast cancer cell death: a proteomic approach to identify differentially regulated proteins in MDA-MB-231 cells. |
2014 |
PLoS ONE |
pmid:25268751
|
Rodriguez SB and Leyh TS |
An enzymatic platform for the synthesis of isoprenoid precursors. |
2014 |
PLoS ONE |
pmid:25153179
|
Sivanandhan G et al. |
Enhanced biosynthesis of withanolides by elicitation and precursor feeding in cell suspension culture of Withania somnifera (L.) Dunal in shake-flask culture and bioreactor. |
2014 |
PLoS ONE |
pmid:25089711
|
Ranji P et al. |
Loss of HMG-CoA reductase in C. elegans causes defects in protein prenylation and muscle mitochondria. |
2014 |
PLoS ONE |
pmid:24918786
|
Rojo-Arreola L et al. |
Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis. |
2014 |
PLoS ONE |
pmid:24489942
|
Leszczynska A et al. |
Investigating the effects of statins on cellular lipid metabolism using a yeast expression system. |
2009 |
PLoS ONE |
pmid:20041128
|
Poggi A et al. |
Selective role of mevalonate pathway in regulating perforin but not FasL and TNFalpha release in human Natural Killer cells. |
2013 |
PLoS ONE |
pmid:23667543
|
Tsuruta H et al. |
High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli. |
2009 |
PLoS ONE |
pmid:19221601
|
Song AA et al. |
Overexpressing 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) in the lactococcal mevalonate pathway for heterologous plant sesquiterpene production. |
2012 |
PLoS ONE |
pmid:23300671
|
Riganti C et al. |
Zoledronic acid restores doxorubicin chemosensitivity and immunogenic cell death in multidrug-resistant human cancer cells. |
2013 |
PLoS ONE |
pmid:23593363
|
Partow S et al. |
Reconstruction and evaluation of the synthetic bacterial MEP pathway in Saccharomyces cerevisiae. |
2012 |
PLoS ONE |
pmid:23285068
|
Yang D et al. |
Different roles of the mevalonate and methylerythritol phosphate pathways in cell growth and tanshinone production of Salvia miltiorrhiza hairy roots. |
2012 |
PLoS ONE |
pmid:23209548
|
Roy A et al. |
Sodium phenylbutyrate controls neuroinflammatory and antioxidant activities and protects dopaminergic neurons in mouse models of Parkinson's disease. |
2012 |
PLoS ONE |
pmid:22723850
|
Fatima T et al. |
Fatty acid composition of developing sea buckthorn (Hippophae rhamnoides L.) berry and the transcriptome of the mature seed. |
2012 |
PLoS ONE |
pmid:22558083
|
Vallianou I et al. |
Camphene, a plant-derived monoterpene, reduces plasma cholesterol and triglycerides in hyperlipidemic rats independently of HMG-CoA reductase activity. |
2011 |
PLoS ONE |
pmid:22073134
|
Ye J |
Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus. |
2007 |
PLoS Pathog. |
pmid:17784784
|
Odom AR |
Five questions about non-mevalonate isoprenoid biosynthesis. |
2011 |
PLoS Pathog. |
pmid:22216001
|
Sławińska A and Kandefer-Szerszeń M |
[The anticancer properties of statins]. |
2008 |
Postepy Hig Med Dosw (Online) |
pmid:18688209
|
Burgazli KM et al. |
The impact of statins on FGF-2-stimulated human umbilical vein endothelial cells. |
2014 |
Postgrad Med |
pmid:24393759
|
Endo A |
A historical perspective on the discovery of statins. |
2010 |
Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. |
pmid:20467214
|
Forman BM et al. |
The orphan nuclear receptor LXRalpha is positively and negatively regulated by distinct products of mevalonate metabolism. |
1997 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:9380679
|
Arebalo RE et al. |
In vivo regulation of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A reductase: immunotitration of the enzyme after short-term mevalonate or cholesterol feeding. |
1982 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:6948302
|
Pronin AN and Gautam N |
Interaction between G-protein beta and gamma subunit types is selective. |
1992 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:1631113
|
Liu GC et al. |
Measurement of cholesterol synthesis in man by isotope kinetics of squalene. |
1975 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:1060141
|
Kotti T et al. |
Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation. |
2008 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:18685105
|
Epstein WW et al. |
Quantitation of prenylcysteines by a selective cleavage reaction. |
1991 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:1946384
|
Mizuno T et al. |
A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21. |
1991 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:1907371
|
Roullet JB et al. |
Mevalonate availability and cardiovascular functions. |
1993 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:8265617
|
Jakóbisiak M et al. |
Cell cycle-specific effects of lovastatin. |
1991 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:1673788
|
Jackson JH et al. |
Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation. |
1990 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:2183224
|
Parker TS et al. |
Mevalonic acid in human plasma: relationship of concentration and circadian rhythm to cholesterol synthesis rates in man. |
1982 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:6953446
|
Lange BM and Croteau R |
Isopentenyl diphosphate biosynthesis via a mevalonate-independent pathway: isopentenyl monophosphate kinase catalyzes the terminal enzymatic step. |
1999 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:10570138
|
Sinensky M and Logel J |
Defective macromolecule biosynthesis and cell-cycle progression in a mammalian cell starved for mevalonate. |
1985 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:2582409
|
Rauthan M et al. |
The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway. |
2013 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:23530189
|
Tianero MD et al. |
Metabolic model for diversity-generating biosynthesis. |
2016 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:26831074
|
Yasmin S et al. |
Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus. |
2012 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:22106303
|
Larson RA et al. |
Neutrophils are required for the DNA synthetic response of human lymphocytes to mevalonic acid: evidence suggesting that a nonsterol product of mevalonate is involved. |
1982 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:6953445
|
Goldstein JL and Brown MS |
Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol. |
1973 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:4355366
|
Quesney-Huneeus V et al. |
Essential role for mevalonate synthesis in DNA replication. |
1979 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:291922
|
Laffitte BA et al. |
LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. |
2001 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:11149950
|
Henry LK et al. |
Orthologs of the archaeal isopentenyl phosphate kinase regulate terpenoid production in plants. |
2015 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:26216978
|
Venkateshwaran M et al. |
A role for the mevalonate pathway in early plant symbiotic signaling. |
2015 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:26199419
|
Autefage H et al. |
Sparse feature selection methods identify unexpected global cellular response to strontium-containing materials. |
2015 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:25831522
|
Polotskaia A et al. |
Proteome-wide analysis of mutant p53 targets in breast cancer identifies new levels of gain-of-function that influence PARP, PCNA, and MCM4. |
2015 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:25733866
|
Fisher JE et al. |
Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. |
1999 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:9874784
|
Parmryd I et al. |
Protein prenylation in spinach chloroplasts. |
1999 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:10468564
|
Lai RK et al. |
The gamma subunit of transducin is farnesylated. |
1990 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:2217200
|
Sapir A et al. |
Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging. |
2014 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:25187565
|
Sinensky M et al. |
Somatic cell genetic analysis of regulation of expression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. |
1980 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:6935672
|
Farnsworth CC et al. |
C terminus of the small GTP-binding protein smg p25A contains two geranylgeranylated cysteine residues and a methyl ester. |
1991 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:1906176
|
Kinsella BT et al. |
Posttranslational modification of Ha-ras p21 by farnesyl versus geranylgeranyl isoprenoids is determined by the COOH-terminal amino acid. |
1991 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:1924354
|
Xiong M et al. |
Scalable production of mechanically tunable block polymers from sugar. |
2014 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:24912182
|
Casey PJ et al. |
p21ras is modified by a farnesyl isoprenoid. |
1989 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:2682646
|
Kawata M et al. |
Posttranslationally processed structure of the human platelet protein smg p21B: evidence for geranylgeranylation and carboxyl methylation of the C-terminal cysteine. |
1990 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:2123345
|
Mumby SM et al. |
G protein gamma subunits contain a 20-carbon isoprenoid. |
1990 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:2116011
|
Stone KJ and Strominger JL |
Inhibition of sterol biosynthesis by bacitracin. |
1972 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:4338587
|
Kotti TJ et al. |
Brain cholesterol turnover required for geranylgeraniol production and learning in mice. |
2006 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:16505352
|
Wang Z et al. |
Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility. |
2014 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:24367099
|
Khosravi-Far R et al. |
Isoprenoid modification of rab proteins terminating in CC or CXC motifs. |
1991 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:1648736
|
Ness GC et al. |
Stimulation of hepatic beta-hydroxy-beta-methylglutaryl coenzyme A reductase activity in hypophysectomized rats by L-triiodothyronine. |
1973 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:4521209
|
Clendening JW et al. |
Dysregulation of the mevalonate pathway promotes transformation. |
2010 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:20696928
|
Okamura E et al. |
Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway. |
2010 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:20534558
|
Loiseau L et al. |
ErpA, an iron sulfur (Fe S) protein of the A-type essential for respiratory metabolism in Escherichia coli. |
2007 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:17698959
|
Arebalo RE et al. |
In vivo regulation of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A reductase: enzyme phosphorylation as an early regulatory response after intragastric administration of mevalonolactone. |
1980 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:6256737
|
Dudareva N et al. |
The nonmevalonate pathway supports both monoterpene and sesquiterpene formation in snapdragon flowers. |
2005 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:15630092
|
Hecht S et al. |
Studies on the nonmevalonate pathway to terpenes: the role of the GcpE (IspG) protein. |
2001 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:11752431
|
Money T et al. |
Biosynthesis of the indole alkaloids. |
1965 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:5222559
|
Kaneda K et al. |
An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190. |
2001 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:11158573
|
Ohyama K et al. |
Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis. |
2009 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:19139393
|
Lange BM et al. |
A family of transketolases that directs isoprenoid biosynthesis via a mevalonate-independent pathway. |
1998 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:9482845
|
Rao S et al. |
Lovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase. |
1999 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:10393901
|
Takahashi S et al. |
A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis. |
1998 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:9707569
|
James G et al. |
Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells. |
1996 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:8633088
|
Beg ZH et al. |
In vivo modulation of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A reductase, reductase kinase, and reductase kinase kinase by mevalonolactone. |
1984 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:6594693
|