| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
Mevalonic acid
Mevalonic acid is a lipid of Fatty Acyls (FA) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.
Here are additional resources we collected from PubChem and MeSH for Mevalonic acid
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Mevalonic acid
PubChem Biomolecular Interactions and Pathways
NCBI Entrez Crosslinks
All references with Mevalonic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wani TA et al. | The effects of rosuvastatin on the serum cortisol, serum lipid, and serum mevalonic acid levels in the healthy Indian male population. | 2010 | AAPS PharmSciTech | pmid:20300897 |
| Fukunaga M et al. | Mast cell death induced by 24(S),25-epoxycholesterol. | 2010 | Exp. Cell Res. | pmid:20854813 |
| Deichmann R et al. | Coenzyme q10 and statin-induced mitochondrial dysfunction. | 2010 | Ochsner J | pmid:21603349 |
| Hamdy RC | Zoledronic acid: clinical utility and patient considerations in osteoporosis and low bone mass. | 2010 | Drug Des Devel Ther | pmid:21151620 |
| Stapleton PA et al. | Hypercholesterolemia and microvascular dysfunction: interventional strategies. | 2010 | J Inflamm (Lond) | pmid:21087503 |
| Martin DM et al. | Functional annotation, genome organization and phylogeny of the grapevine (Vitis vinifera) terpene synthase gene family based on genome assembly, FLcDNA cloning, and enzyme assays. | 2010 | BMC Plant Biol. | pmid:20964856 |
| González-Candelas L et al. | A transcriptomic approach highlights induction of secondary metabolism in citrus fruit in response to Penicillium digitatum infection. | 2010 | BMC Plant Biol. | pmid:20807411 |
| Palozza P et al. | Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signaling in cancer cell lines. | 2010 | Carcinogenesis | pmid:20699249 |
| Klawitter J et al. | Effects of lovastatin on breast cancer cells: a proteo-metabonomic study. | 2010 | Breast Cancer Res. | pmid:20205716 |
| Catros V et al. | [Tgammadelta lymphocytes in oncology: unconventional killer lymphocytes]. | 2010 | Med Sci (Paris) | pmid:20188051 |
| Pontillo A et al. | The inhibition of mevalonate pathway induces upregulation of NALP3 expression: new insight in the pathogenesis of mevalonate kinase deficiency. | 2010 | Eur. J. Hum. Genet. | pmid:20179743 |
| Yamauchi N | The pathway of leucine to mevalonate in halophilic archaea: efficient incorporation of leucine into isoprenoidal lipid with the involvement of isovaleryl-CoA dehydrogenase in Halobacterium salinarum. | 2010 | Biosci. Biotechnol. Biochem. | pmid:20139592 |
| Olson AL et al. | NMR dynamics investigation of ligand-induced changes of main and side-chain arginine N-H's in human phosphomevalonate kinase. | 2010 | J. Am. Chem. Soc. | pmid:20112895 |
| Kowluru A et al. | Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells. | 2010 | Diabetes | pmid:20071600 |
| Kiran U et al. | Structural and functional characterization of HMG-COA reductase from Artemisia annua. | 2010 | Bioinformation | pmid:21364776 |
| Acquavella N et al. | Effect of simvastatin on endothelial cell apoptosis mediated by Fas and TNF-alpha. | 2010 | Cytokine | pmid:19932975 |
| Massaro M et al. | Statins inhibit cyclooxygenase-2 and matrix metalloproteinase-9 in human endothelial cells: anti-angiogenic actions possibly contributing to plaque stability. | 2010 | Cardiovasc. Res. | pmid:19946014 |
| Kojima Y et al. | Pitavastatin decreases the expression of endothelial lipase both in vitro and in vivo. | 2010 | Cardiovasc. Res. | pmid:20045866 |
| Rossi J et al. | Laminar shear stress prevents simvastatin-induced adhesion molecule expression in cytokine activated endothelial cells. | 2010 | Eur. J. Pharmacol. | pmid:20863785 |
| Kaneda T et al. | Statins inhibited erythropoietin-induced proliferation of rat vascular smooth muscle cells. | 2010 | Eur. J. Pharmacol. | pmid:20851116 |
| Singh RS et al. | Expression of 3-hydroxy-3-methylglutaryl-CoA reductase, p-hydroxybenzoate-m-geranyltransferase and genes of phenylpropanoid pathway exhibits positive correlation with shikonins content in arnebia [Arnebia euchroma (Royle) Johnston]. | 2010 | BMC Mol. Biol. | pmid:21092138 |
| Barter MJ et al. | Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation. | 2010 | Ann. Rheum. Dis. | pmid:20693272 |
| Tsuchiya M et al. | Cholesterol biosynthesis pathway intermediates and inhibitors regulate glucose-stimulated insulin secretion and secretory granule formation in pancreatic beta-cells. | 2010 | Endocrinology | pmid:20685866 |
| Chang TH et al. | Structure of a heterotetrameric geranyl pyrophosphate synthase from mint (Mentha piperita) reveals intersubunit regulation. | 2010 | Plant Cell | pmid:20139160 |
| Kassan M et al. | In vitro antioxidant activity of pravastatin provides vascular protection. | 2010 | Eur. J. Pharmacol. | pmid:20044990 |
| Kocsis GF et al. | Expression of genes related to oxidative/nitrosative stress in mouse hearts: effect of preconditioning and cholesterol diet. | 2010 | Med. Sci. Monit. | pmid:20037483 |
| Tekpli X et al. | Membrane remodeling, an early event in benzo[a]pyrene-induced apoptosis. | 2010 | Toxicol. Appl. Pharmacol. | pmid:19931295 |
| Clendening JW et al. | Dysregulation of the mevalonate pathway promotes transformation. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20696928 |
| Rico J et al. | Enhanced production of a plant monoterpene by overexpression of the 3-hydroxy-3-methylglutaryl coenzyme A reductase catalytic domain in Saccharomyces cerevisiae. | 2010 | Appl. Environ. Microbiol. | pmid:20675444 |
| Okamura E et al. | Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20534558 |
| Chen CC et al. | Effect of pravastatin on ventricular arrhythmias in infarcted rats: role of connexin43. | 2010 | J. Appl. Physiol. | pmid:20466804 |
| Norman KL and Sarnow P | Modulation of hepatitis C virus RNA abundance and the isoprenoid biosynthesis pathway by microRNA miR-122 involves distinct mechanisms. | 2010 | J. Virol. | pmid:19846523 |
| Kato S et al. | Lipophilic but not hydrophilic statins selectively induce cell death in gynaecological cancers expressing high levels of HMGCoA reductase. | 2010 | J. Cell. Mol. Med. | pmid:19432822 |
| Jiang XS et al. | Quantitative proteomics analysis of inborn errors of cholesterol synthesis: identification of altered metabolic pathways in DHCR7 and SC5D deficiency. | 2010 | Mol. Cell Proteomics | pmid:20305089 |
| Schramek N et al. | Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study. | 2010 | Phytochemistry | pmid:19932496 |
| Lee SK et al. | Stabilization and translocation of p53 to mitochondria is linked to Bax translocation to mitochondria in simvastatin-induced apoptosis. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20043868 |
| Kudoh T et al. | Mevalonate analogues as substrates of enzymes in the isoprenoid biosynthetic pathway of Streptococcus pneumoniae. | 2010 | Bioorg. Med. Chem. | pmid:20056424 |
| Boo KH et al. | Distribution and biosynthesis of 20-hydroxyecdysone in plants of Achyranthes japonica Nakai. | 2010 | Biosci. Biotechnol. Biochem. | pmid:21071854 |
| Rydgren T and Sandler S | The protective effect of simvastatin against low dose streptozotocin induced type 1 diabetes in mice is independent of inhibition of HMG-CoA reductase. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19150339 |
| Yoon HE and Yang CW | Established and newly proposed mechanisms of chronic cyclosporine nephropathy. | 2009 | Korean J. Intern. Med. | pmid:19543484 |
| Jauhiainen M et al. | Analysis of endogenous ATP analogs and mevalonate pathway metabolites in cancer cell cultures using liquid chromatography-electrospray ionization mass spectrometry. | 2009 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:19665949 |
| Anthony JR et al. | Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene. | 2009 | Metab. Eng. | pmid:18775787 |
| Lorenzen W et al. | Isoprenoids are essential for fruiting body formation in Myxococcus xanthus. | 2009 | J. Bacteriol. | pmid:19617362 |
| Zhao S et al. | Synthesis and HMG-CoA reductase inhibition of 2-cyclopropyl-4-thiophenyl-quinoline mevalonolactones. | 2009 | Bioorg. Med. Chem. | pmid:19879766 |
| Domoki F et al. | Rosuvastatin induces delayed preconditioning against oxygen-glucose deprivation in cultured cortical neurons. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:18971391 |
| Xu Q et al. | Comparative transcripts profiling reveals new insight into molecular processes regulating lycopene accumulation in a sweet orange (Citrus sinensis) red-flesh mutant. | 2009 | BMC Genomics | pmid:19922663 |
| Rothwell C et al. | Cholesterol biosynthesis modulation regulates dengue viral replication. | 2009 | Virology | pmid:19419745 |
| Ledezma E et al. | Potentiated cytotoxic effects of statins and ajoene in murine melanoma cells. | 2009 | Melanoma Res. | pmid:19276863 |
| Maeda T and Horiuchi N | Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation. | 2009 | J. Biochem. | pmid:19254925 |
| Dje N'Guessan P et al. | Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells. | 2009 | Arterioscler. Thromb. Vasc. Biol. | pmid:19122173 |
| Iriti M and Faoro F | Chemical diversity and defence metabolism: how plants cope with pathogens and ozone pollution. | 2009 | Int J Mol Sci | pmid:20111684 |
| Jawaid S et al. | Kinetic characterization and phosphoregulation of the Francisella tularensis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase). | 2009 | PLoS ONE | pmid:20011597 |
| Raemer PC et al. | Statins inhibit NK-cell cytotoxicity by interfering with LFA-1-mediated conjugate formation. | 2009 | Eur. J. Immunol. | pmid:19424968 |
| Chang PK et al. | Cyclopiazonic acid biosynthesis of Aspergillus flavus and Aspergillus oryzae. | 2009 | Toxins (Basel) | pmid:22069533 |
| Kirmizis D and Chatzidimitriou D | Pleiotropic vasoprotective effects of statins: the chicken or the egg? | 2009 | Drug Des Devel Ther | pmid:19920934 |
| Eldor R and Raz I | American Diabetes Association indications for statins in diabetes: is there evidence? | 2009 | Diabetes Care | pmid:19875586 |
| Massonnet B et al. | Pharmacological inhibitors of the mevalonate pathway activate pro-IL-1 processing and IL-1 release by human monocytes. | 2009 | Eur. Cytokine Netw. | pmid:19825520 |
| Wang W et al. | Global characterization of Artemisia annua glandular trichome transcriptome using 454 pyrosequencing. | 2009 | BMC Genomics | pmid:19818120 |
| Brahmachari S et al. | Sodium benzoate, a metabolite of cinnamon and a food additive, reduces microglial and astroglial inflammatory responses. | 2009 | J. Immunol. | pmid:19812204 |
| de Souza W and Rodrigues JC | Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs. | 2009 | Interdiscip Perspect Infect Dis | pmid:19680554 |
| Zeki AA et al. | Simvastatin inhibits airway hyperreactivity: implications for the mevalonate pathway and beyond. | 2009 | Am. J. Respir. Crit. Care Med. | pmid:19608720 |
| Minichsdorfer C and Hohenegger M | Autocrine amplification loop in statin-induced apoptosis of human melanoma cells. | 2009 | Br. J. Pharmacol. | pmid:19563533 |
| Perttilä J et al. | OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. | 2009 | J. Mol. Med. | pmid:19554302 |
| Montoya CJ et al. | Antiretroviral effect of lovastatin on HIV-1-infected individuals without highly active antiretroviral therapy (The LIVE study): a phase-II randomized clinical trial. | 2009 | Trials | pmid:19538732 |
| Li J et al. | Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells. | 2009 | J. Immunol. | pmid:19494338 |
| Suzuki M et al. | Complete blockage of the mevalonate pathway results in male gametophyte lethality. | 2009 | J. Exp. Bot. | pmid:19363204 |
| Balibar CJ et al. | The mevalonate pathway of Staphylococcus aureus. | 2009 | J. Bacteriol. | pmid:19028897 |
| Khan MA et al. | Statins impair CD1d-mediated antigen presentation through the inhibition of prenylation. | 2009 | J. Immunol. | pmid:19342651 |
| Alvarez Y et al. | Cyclooxygenase-2 induced by zymosan in human monocyte-derived dendritic cells shows high stability, and its expression is enhanced by atorvastatin. | 2009 | J. Pharmacol. Exp. Ther. | pmid:19318593 |
| Niessen J et al. | Human platelets express organic anion-transporting peptide 2B1, an uptake transporter for atorvastatin. | 2009 | Drug Metab. Dispos. | pmid:19237515 |
| Lachmann HJ and Hawkins PN | Developments in the scientific and clinical understanding of autoinflammatory disorders. | 2009 | Arthritis Res. Ther. | pmid:19232070 |
| Kim WY et al. | Statins decrease dendritic arborization in rat sympathetic neurons by blocking RhoA activation. | 2009 | J. Neurochem. | pmid:19209406 |
| Zeiser R et al. | Regulation of different inflammatory diseases by impacting the mevalonate pathway. | 2009 | Immunology | pmid:19191903 |
| Yeger-Lotem E et al. | Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity. | 2009 | Nat. Genet. | pmid:19234470 |
| Knight LA et al. | Activity of mevalonate pathway inhibitors against breast and ovarian cancers in the ATP-based tumour chemosensitivity assay. | 2009 | BMC Cancer | pmid:19175937 |
| Deshpande G et al. | Ggamma1, a downstream target for the hmgcr-isoprenoid biosynthetic pathway, is required for releasing the Hedgehog ligand and directing germ cell migration. | 2009 | PLoS Genet. | pmid:19132091 |
| Mansouri H et al. | Effects of gibberellic acid on primary terpenoids and delta-tetrahydrocannabinol in Cannabis sativa at flowering stage. | 2009 | J Integr Plant Biol | pmid:19522814 |
| Monzack EL et al. | Efficacy of simvastatin treatment of valvular interstitial cells varies with the extracellular environment. | 2009 | Arterioscler. Thromb. Vasc. Biol. | pmid:19023089 |
| Xiang Z and Reeves SA | Simvastatin induces cell death in a mouse cerebellar slice culture (CSC) model of developmental myelination. | 2009 | Exp. Neurol. | pmid:18929563 |
| Olson AL et al. | Substrate induced structural and dynamics changes in human phosphomevalonate kinase and implications for mechanism. | 2009 | Proteins | pmid:18798562 |
| Sillero MA et al. | Synthesis of ATP derivatives of compounds of the mevalonate pathway (isopentenyl di- and triphosphate; geranyl di- and triphosphate, farnesyl di- and triphosphate, and dimethylallyl diphosphate) catalyzed by T4 RNA ligase, T4 DNA ligase and other ligases Potential relationship with the effect of bisphosphonates on osteoclasts. | 2009 | Biochem. Pharmacol. | pmid:19414000 |
| Dueber JE et al. | Synthetic protein scaffolds provide modular control over metabolic flux. | 2009 | Nat. Biotechnol. | pmid:19648908 |
| Leszczynska A et al. | Investigating the effects of statins on cellular lipid metabolism using a yeast expression system. | 2009 | PLoS ONE | pmid:20041128 |
| Tsuruta H et al. | High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli. | 2009 | PLoS ONE | pmid:19221601 |
| Fujimoto M et al. | Fluvastatin inhibits mast cell degranulation without changing the cytoplasmic Ca2+ level. | 2009 | Eur. J. Pharmacol. | pmid:19059394 |
| Sun X et al. | Identified biosynthetic pathway of aspergiolide A and a novel strategy to increase its production in a marine-derived fungus Aspergillus glaucus by feeding of biosynthetic precursors and inhibitors simultaneously. | 2009 | Bioresour. Technol. | pmid:19386490 |
| Sidorkiewicz M et al. | Mevalonate pathway modulation is associated with hepatitis C virus RNA presence in peripheral blood mononuclear cells. | 2009 | Virus Res. | pmid:19540284 |
| Bełtowski J et al. | Adverse effects of statins - mechanisms and consequences. | 2009 | Curr Drug Saf | pmid:19534648 |
| GarcÃa I et al. | QSAR and complex network study of the chiral HMGR inhibitor structural diversity. | 2009 | Bioorg. Med. Chem. | pmid:19026553 |
| Ohyama K et al. | Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19139393 |
| Kroll J et al. | Establishment of a novel anabolism-based addiction system with an artificially introduced mevalonate pathway: complete stabilization of plasmids as universal application in white biotechnology. | 2009 | Metab. Eng. | pmid:19558962 |
| Alagna F et al. | Comparative 454 pyrosequencing of transcripts from two olive genotypes during fruit development. | 2009 | BMC Genomics | pmid:19709400 |
| Wali VB et al. | Suppression in mevalonate synthesis mediates antitumor effects of combined statin and gamma-tocotrienol treatment. | 2009 | Lipids | pmid:19777282 |
| Winiarska M et al. | Statins impair antitumor effects of rituximab by inducing conformational changes of CD20. | 2008 | PLoS Med. | pmid:18366248 |
| Skorupinska-Tudek K et al. | Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of dolichols in plants. | 2008 | J. Biol. Chem. | pmid:18502754 |
| Zhang X et al. | Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. | 2008 | J. Immunol. | pmid:18453621 |
| Baba TT et al. | Simvastatin suppresses the differentiation of C2C12 myoblast cells via a Rac pathway. | 2008 | J. Muscle Res. Cell. Motil. | pmid:18792797 |
| Habeos IG et al. | Simvastatin activates Keap1/Nrf2 signaling in rat liver. | 2008 | J. Mol. Med. | pmid:18787804 |
| Osman L et al. | Atorvastatin accelerates extracellular nucleotide degradation in human endothelial cells. | 2008 | Mol. Cell. Biochem. | pmid:18158588 |
| Begley M et al. | Analysis of the isoprenoid biosynthesis pathways in Listeria monocytogenes reveals a role for the alternative 2-C-methyl-D-erythritol 4-phosphate pathway in murine infection. | 2008 | Infect. Immun. | pmid:18765739 |