Wani TA et al. |
The effects of rosuvastatin on the serum cortisol, serum lipid, and serum mevalonic acid levels in the healthy Indian male population. |
2010 |
AAPS PharmSciTech |
pmid:20300897
|
Fukunaga M et al. |
Mast cell death induced by 24(S),25-epoxycholesterol. |
2010 |
Exp. Cell Res. |
pmid:20854813
|
Deichmann R et al. |
Coenzyme q10 and statin-induced mitochondrial dysfunction. |
2010 |
Ochsner J |
pmid:21603349
|
Hamdy RC |
Zoledronic acid: clinical utility and patient considerations in osteoporosis and low bone mass. |
2010 |
Drug Des Devel Ther |
pmid:21151620
|
Stapleton PA et al. |
Hypercholesterolemia and microvascular dysfunction: interventional strategies. |
2010 |
J Inflamm (Lond) |
pmid:21087503
|
Martin DM et al. |
Functional annotation, genome organization and phylogeny of the grapevine (Vitis vinifera) terpene synthase gene family based on genome assembly, FLcDNA cloning, and enzyme assays. |
2010 |
BMC Plant Biol. |
pmid:20964856
|
González-Candelas L et al. |
A transcriptomic approach highlights induction of secondary metabolism in citrus fruit in response to Penicillium digitatum infection. |
2010 |
BMC Plant Biol. |
pmid:20807411
|
Palozza P et al. |
Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signaling in cancer cell lines. |
2010 |
Carcinogenesis |
pmid:20699249
|
Klawitter J et al. |
Effects of lovastatin on breast cancer cells: a proteo-metabonomic study. |
2010 |
Breast Cancer Res. |
pmid:20205716
|
Catros V et al. |
[Tgammadelta lymphocytes in oncology: unconventional killer lymphocytes]. |
2010 |
Med Sci (Paris) |
pmid:20188051
|
Pontillo A et al. |
The inhibition of mevalonate pathway induces upregulation of NALP3 expression: new insight in the pathogenesis of mevalonate kinase deficiency. |
2010 |
Eur. J. Hum. Genet. |
pmid:20179743
|
Yamauchi N |
The pathway of leucine to mevalonate in halophilic archaea: efficient incorporation of leucine into isoprenoidal lipid with the involvement of isovaleryl-CoA dehydrogenase in Halobacterium salinarum. |
2010 |
Biosci. Biotechnol. Biochem. |
pmid:20139592
|
Olson AL et al. |
NMR dynamics investigation of ligand-induced changes of main and side-chain arginine N-H's in human phosphomevalonate kinase. |
2010 |
J. Am. Chem. Soc. |
pmid:20112895
|
Kowluru A et al. |
Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells. |
2010 |
Diabetes |
pmid:20071600
|
Kiran U et al. |
Structural and functional characterization of HMG-COA reductase from Artemisia annua. |
2010 |
Bioinformation |
pmid:21364776
|
Acquavella N et al. |
Effect of simvastatin on endothelial cell apoptosis mediated by Fas and TNF-alpha. |
2010 |
Cytokine |
pmid:19932975
|
Massaro M et al. |
Statins inhibit cyclooxygenase-2 and matrix metalloproteinase-9 in human endothelial cells: anti-angiogenic actions possibly contributing to plaque stability. |
2010 |
Cardiovasc. Res. |
pmid:19946014
|
Kojima Y et al. |
Pitavastatin decreases the expression of endothelial lipase both in vitro and in vivo. |
2010 |
Cardiovasc. Res. |
pmid:20045866
|
Rossi J et al. |
Laminar shear stress prevents simvastatin-induced adhesion molecule expression in cytokine activated endothelial cells. |
2010 |
Eur. J. Pharmacol. |
pmid:20863785
|
Kaneda T et al. |
Statins inhibited erythropoietin-induced proliferation of rat vascular smooth muscle cells. |
2010 |
Eur. J. Pharmacol. |
pmid:20851116
|
Singh RS et al. |
Expression of 3-hydroxy-3-methylglutaryl-CoA reductase, p-hydroxybenzoate-m-geranyltransferase and genes of phenylpropanoid pathway exhibits positive correlation with shikonins content in arnebia [Arnebia euchroma (Royle) Johnston]. |
2010 |
BMC Mol. Biol. |
pmid:21092138
|
Barter MJ et al. |
Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation. |
2010 |
Ann. Rheum. Dis. |
pmid:20693272
|
Tsuchiya M et al. |
Cholesterol biosynthesis pathway intermediates and inhibitors regulate glucose-stimulated insulin secretion and secretory granule formation in pancreatic beta-cells. |
2010 |
Endocrinology |
pmid:20685866
|
Chang TH et al. |
Structure of a heterotetrameric geranyl pyrophosphate synthase from mint (Mentha piperita) reveals intersubunit regulation. |
2010 |
Plant Cell |
pmid:20139160
|
Kassan M et al. |
In vitro antioxidant activity of pravastatin provides vascular protection. |
2010 |
Eur. J. Pharmacol. |
pmid:20044990
|
Kocsis GF et al. |
Expression of genes related to oxidative/nitrosative stress in mouse hearts: effect of preconditioning and cholesterol diet. |
2010 |
Med. Sci. Monit. |
pmid:20037483
|
Tekpli X et al. |
Membrane remodeling, an early event in benzo[a]pyrene-induced apoptosis. |
2010 |
Toxicol. Appl. Pharmacol. |
pmid:19931295
|
Clendening JW et al. |
Dysregulation of the mevalonate pathway promotes transformation. |
2010 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:20696928
|
Rico J et al. |
Enhanced production of a plant monoterpene by overexpression of the 3-hydroxy-3-methylglutaryl coenzyme A reductase catalytic domain in Saccharomyces cerevisiae. |
2010 |
Appl. Environ. Microbiol. |
pmid:20675444
|
Okamura E et al. |
Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway. |
2010 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:20534558
|
Chen CC et al. |
Effect of pravastatin on ventricular arrhythmias in infarcted rats: role of connexin43. |
2010 |
J. Appl. Physiol. |
pmid:20466804
|
Norman KL and Sarnow P |
Modulation of hepatitis C virus RNA abundance and the isoprenoid biosynthesis pathway by microRNA miR-122 involves distinct mechanisms. |
2010 |
J. Virol. |
pmid:19846523
|
Kato S et al. |
Lipophilic but not hydrophilic statins selectively induce cell death in gynaecological cancers expressing high levels of HMGCoA reductase. |
2010 |
J. Cell. Mol. Med. |
pmid:19432822
|
Jiang XS et al. |
Quantitative proteomics analysis of inborn errors of cholesterol synthesis: identification of altered metabolic pathways in DHCR7 and SC5D deficiency. |
2010 |
Mol. Cell Proteomics |
pmid:20305089
|
Schramek N et al. |
Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study. |
2010 |
Phytochemistry |
pmid:19932496
|
Lee SK et al. |
Stabilization and translocation of p53 to mitochondria is linked to Bax translocation to mitochondria in simvastatin-induced apoptosis. |
2010 |
Biochem. Biophys. Res. Commun. |
pmid:20043868
|
Kudoh T et al. |
Mevalonate analogues as substrates of enzymes in the isoprenoid biosynthetic pathway of Streptococcus pneumoniae. |
2010 |
Bioorg. Med. Chem. |
pmid:20056424
|
Boo KH et al. |
Distribution and biosynthesis of 20-hydroxyecdysone in plants of Achyranthes japonica Nakai. |
2010 |
Biosci. Biotechnol. Biochem. |
pmid:21071854
|
Rydgren T and Sandler S |
The protective effect of simvastatin against low dose streptozotocin induced type 1 diabetes in mice is independent of inhibition of HMG-CoA reductase. |
2009 |
Biochem. Biophys. Res. Commun. |
pmid:19150339
|
Yoon HE and Yang CW |
Established and newly proposed mechanisms of chronic cyclosporine nephropathy. |
2009 |
Korean J. Intern. Med. |
pmid:19543484
|
Jauhiainen M et al. |
Analysis of endogenous ATP analogs and mevalonate pathway metabolites in cancer cell cultures using liquid chromatography-electrospray ionization mass spectrometry. |
2009 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
pmid:19665949
|
Anthony JR et al. |
Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene. |
2009 |
Metab. Eng. |
pmid:18775787
|
Lorenzen W et al. |
Isoprenoids are essential for fruiting body formation in Myxococcus xanthus. |
2009 |
J. Bacteriol. |
pmid:19617362
|
Zhao S et al. |
Synthesis and HMG-CoA reductase inhibition of 2-cyclopropyl-4-thiophenyl-quinoline mevalonolactones. |
2009 |
Bioorg. Med. Chem. |
pmid:19879766
|
Domoki F et al. |
Rosuvastatin induces delayed preconditioning against oxygen-glucose deprivation in cultured cortical neurons. |
2009 |
Am. J. Physiol., Cell Physiol. |
pmid:18971391
|
Xu Q et al. |
Comparative transcripts profiling reveals new insight into molecular processes regulating lycopene accumulation in a sweet orange (Citrus sinensis) red-flesh mutant. |
2009 |
BMC Genomics |
pmid:19922663
|
Rothwell C et al. |
Cholesterol biosynthesis modulation regulates dengue viral replication. |
2009 |
Virology |
pmid:19419745
|
Ledezma E et al. |
Potentiated cytotoxic effects of statins and ajoene in murine melanoma cells. |
2009 |
Melanoma Res. |
pmid:19276863
|
Maeda T and Horiuchi N |
Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation. |
2009 |
J. Biochem. |
pmid:19254925
|
Dje N'Guessan P et al. |
Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells. |
2009 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:19122173
|
Iriti M and Faoro F |
Chemical diversity and defence metabolism: how plants cope with pathogens and ozone pollution. |
2009 |
Int J Mol Sci |
pmid:20111684
|
Jawaid S et al. |
Kinetic characterization and phosphoregulation of the Francisella tularensis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase). |
2009 |
PLoS ONE |
pmid:20011597
|
Raemer PC et al. |
Statins inhibit NK-cell cytotoxicity by interfering with LFA-1-mediated conjugate formation. |
2009 |
Eur. J. Immunol. |
pmid:19424968
|
Chang PK et al. |
Cyclopiazonic acid biosynthesis of Aspergillus flavus and Aspergillus oryzae. |
2009 |
Toxins (Basel) |
pmid:22069533
|
Kirmizis D and Chatzidimitriou D |
Pleiotropic vasoprotective effects of statins: the chicken or the egg? |
2009 |
Drug Des Devel Ther |
pmid:19920934
|
Eldor R and Raz I |
American Diabetes Association indications for statins in diabetes: is there evidence? |
2009 |
Diabetes Care |
pmid:19875586
|
Massonnet B et al. |
Pharmacological inhibitors of the mevalonate pathway activate pro-IL-1 processing and IL-1 release by human monocytes. |
2009 |
Eur. Cytokine Netw. |
pmid:19825520
|
Wang W et al. |
Global characterization of Artemisia annua glandular trichome transcriptome using 454 pyrosequencing. |
2009 |
BMC Genomics |
pmid:19818120
|
Brahmachari S et al. |
Sodium benzoate, a metabolite of cinnamon and a food additive, reduces microglial and astroglial inflammatory responses. |
2009 |
J. Immunol. |
pmid:19812204
|
de Souza W and Rodrigues JC |
Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs. |
2009 |
Interdiscip Perspect Infect Dis |
pmid:19680554
|
Zeki AA et al. |
Simvastatin inhibits airway hyperreactivity: implications for the mevalonate pathway and beyond. |
2009 |
Am. J. Respir. Crit. Care Med. |
pmid:19608720
|
Minichsdorfer C and Hohenegger M |
Autocrine amplification loop in statin-induced apoptosis of human melanoma cells. |
2009 |
Br. J. Pharmacol. |
pmid:19563533
|
Perttilä J et al. |
OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. |
2009 |
J. Mol. Med. |
pmid:19554302
|
Montoya CJ et al. |
Antiretroviral effect of lovastatin on HIV-1-infected individuals without highly active antiretroviral therapy (The LIVE study): a phase-II randomized clinical trial. |
2009 |
Trials |
pmid:19538732
|
Li J et al. |
Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells. |
2009 |
J. Immunol. |
pmid:19494338
|
Suzuki M et al. |
Complete blockage of the mevalonate pathway results in male gametophyte lethality. |
2009 |
J. Exp. Bot. |
pmid:19363204
|
Balibar CJ et al. |
The mevalonate pathway of Staphylococcus aureus. |
2009 |
J. Bacteriol. |
pmid:19028897
|
Khan MA et al. |
Statins impair CD1d-mediated antigen presentation through the inhibition of prenylation. |
2009 |
J. Immunol. |
pmid:19342651
|
Alvarez Y et al. |
Cyclooxygenase-2 induced by zymosan in human monocyte-derived dendritic cells shows high stability, and its expression is enhanced by atorvastatin. |
2009 |
J. Pharmacol. Exp. Ther. |
pmid:19318593
|
Niessen J et al. |
Human platelets express organic anion-transporting peptide 2B1, an uptake transporter for atorvastatin. |
2009 |
Drug Metab. Dispos. |
pmid:19237515
|
Lachmann HJ and Hawkins PN |
Developments in the scientific and clinical understanding of autoinflammatory disorders. |
2009 |
Arthritis Res. Ther. |
pmid:19232070
|
Kim WY et al. |
Statins decrease dendritic arborization in rat sympathetic neurons by blocking RhoA activation. |
2009 |
J. Neurochem. |
pmid:19209406
|
Zeiser R et al. |
Regulation of different inflammatory diseases by impacting the mevalonate pathway. |
2009 |
Immunology |
pmid:19191903
|
Yeger-Lotem E et al. |
Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity. |
2009 |
Nat. Genet. |
pmid:19234470
|
Knight LA et al. |
Activity of mevalonate pathway inhibitors against breast and ovarian cancers in the ATP-based tumour chemosensitivity assay. |
2009 |
BMC Cancer |
pmid:19175937
|
Deshpande G et al. |
Ggamma1, a downstream target for the hmgcr-isoprenoid biosynthetic pathway, is required for releasing the Hedgehog ligand and directing germ cell migration. |
2009 |
PLoS Genet. |
pmid:19132091
|
Mansouri H et al. |
Effects of gibberellic acid on primary terpenoids and delta-tetrahydrocannabinol in Cannabis sativa at flowering stage. |
2009 |
J Integr Plant Biol |
pmid:19522814
|
Monzack EL et al. |
Efficacy of simvastatin treatment of valvular interstitial cells varies with the extracellular environment. |
2009 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:19023089
|
Xiang Z and Reeves SA |
Simvastatin induces cell death in a mouse cerebellar slice culture (CSC) model of developmental myelination. |
2009 |
Exp. Neurol. |
pmid:18929563
|
Olson AL et al. |
Substrate induced structural and dynamics changes in human phosphomevalonate kinase and implications for mechanism. |
2009 |
Proteins |
pmid:18798562
|
Sillero MA et al. |
Synthesis of ATP derivatives of compounds of the mevalonate pathway (isopentenyl di- and triphosphate; geranyl di- and triphosphate, farnesyl di- and triphosphate, and dimethylallyl diphosphate) catalyzed by T4 RNA ligase, T4 DNA ligase and other ligases Potential relationship with the effect of bisphosphonates on osteoclasts. |
2009 |
Biochem. Pharmacol. |
pmid:19414000
|
Dueber JE et al. |
Synthetic protein scaffolds provide modular control over metabolic flux. |
2009 |
Nat. Biotechnol. |
pmid:19648908
|
Leszczynska A et al. |
Investigating the effects of statins on cellular lipid metabolism using a yeast expression system. |
2009 |
PLoS ONE |
pmid:20041128
|
Tsuruta H et al. |
High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli. |
2009 |
PLoS ONE |
pmid:19221601
|
Fujimoto M et al. |
Fluvastatin inhibits mast cell degranulation without changing the cytoplasmic Ca2+ level. |
2009 |
Eur. J. Pharmacol. |
pmid:19059394
|
Sun X et al. |
Identified biosynthetic pathway of aspergiolide A and a novel strategy to increase its production in a marine-derived fungus Aspergillus glaucus by feeding of biosynthetic precursors and inhibitors simultaneously. |
2009 |
Bioresour. Technol. |
pmid:19386490
|
Sidorkiewicz M et al. |
Mevalonate pathway modulation is associated with hepatitis C virus RNA presence in peripheral blood mononuclear cells. |
2009 |
Virus Res. |
pmid:19540284
|
Bełtowski J et al. |
Adverse effects of statins - mechanisms and consequences. |
2009 |
Curr Drug Saf |
pmid:19534648
|
GarcÃa I et al. |
QSAR and complex network study of the chiral HMGR inhibitor structural diversity. |
2009 |
Bioorg. Med. Chem. |
pmid:19026553
|
Ohyama K et al. |
Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis. |
2009 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:19139393
|
Kroll J et al. |
Establishment of a novel anabolism-based addiction system with an artificially introduced mevalonate pathway: complete stabilization of plasmids as universal application in white biotechnology. |
2009 |
Metab. Eng. |
pmid:19558962
|
Alagna F et al. |
Comparative 454 pyrosequencing of transcripts from two olive genotypes during fruit development. |
2009 |
BMC Genomics |
pmid:19709400
|
Wali VB et al. |
Suppression in mevalonate synthesis mediates antitumor effects of combined statin and gamma-tocotrienol treatment. |
2009 |
Lipids |
pmid:19777282
|
Winiarska M et al. |
Statins impair antitumor effects of rituximab by inducing conformational changes of CD20. |
2008 |
PLoS Med. |
pmid:18366248
|
Skorupinska-Tudek K et al. |
Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of dolichols in plants. |
2008 |
J. Biol. Chem. |
pmid:18502754
|
Zhang X et al. |
Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. |
2008 |
J. Immunol. |
pmid:18453621
|
Baba TT et al. |
Simvastatin suppresses the differentiation of C2C12 myoblast cells via a Rac pathway. |
2008 |
J. Muscle Res. Cell. Motil. |
pmid:18792797
|
Habeos IG et al. |
Simvastatin activates Keap1/Nrf2 signaling in rat liver. |
2008 |
J. Mol. Med. |
pmid:18787804
|
Osman L et al. |
Atorvastatin accelerates extracellular nucleotide degradation in human endothelial cells. |
2008 |
Mol. Cell. Biochem. |
pmid:18158588
|
Begley M et al. |
Analysis of the isoprenoid biosynthesis pathways in Listeria monocytogenes reveals a role for the alternative 2-C-methyl-D-erythritol 4-phosphate pathway in murine infection. |
2008 |
Infect. Immun. |
pmid:18765739
|