Ogunwobi OO and Beales IL |
Statins inhibit proliferation and induce apoptosis in Barrett's esophageal adenocarcinoma cells. |
2008 |
Am. J. Gastroenterol. |
pmid:18371146
|
Kimura T et al. |
Induction of scavenger receptor class B type I is critical for simvastatin enhancement of high-density lipoprotein-induced anti-inflammatory actions in endothelial cells. |
2008 |
J. Immunol. |
pmid:18981156
|
Rekittke I et al. |
Structure of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate reductase, the terminal enzyme of the non-mevalonate pathway. |
2008 |
J. Am. Chem. Soc. |
pmid:19035630
|
Sharyo S et al. |
Pravastatin improves renal ischemia-reperfusion injury by inhibiting the mevalonate pathway. |
2008 |
Kidney Int. |
pmid:18509318
|
Kervizic G and Corcos L |
Dynamical modeling of the cholesterol regulatory pathway with Boolean networks. |
2008 |
BMC Syst Biol |
pmid:19025648
|
Udagawa H et al. |
Increase of serum cholesterol levels by heat-moisture-treated high-amylose cornstarch in rats fed a high-cholesterol diet. |
2008 |
Lipids |
pmid:18509689
|
Tekle M et al. |
Investigation of coenzyme Q biosynthesis in human fibroblast and HepG2 cells. |
2008 |
J. Biochem. Biophys. Methods |
pmid:17916383
|
Cornish J et al. |
Modulation of osteoclastogenesis by fatty acids. |
2008 |
Endocrinology |
pmid:18617622
|
Okada K et al. |
Genetic evidence for the role of isopentenyl diphosphate isomerases in the mevalonate pathway and plant development in Arabidopsis. |
2008 |
Plant Cell Physiol. |
pmid:18303110
|
Lüdke SM et al. |
Stable carbon isotope discrimination by human 3-hydroxy-3-methylglutaryl-coenzyme A reductase. |
2008 |
J. Lipid Res. |
pmid:18669481
|
Carrasco MP et al. |
Hexadecylphosphocholine interferes with the intracellular transport of cholesterol in HepG2 cells. |
2008 |
FEBS J. |
pmid:18312412
|
Winiarska M et al. |
Statins impair antitumor effects of rituximab by inducing conformational changes of CD20. |
2008 |
PLoS Med. |
pmid:18366248
|
Oliveira KA et al. |
Simvastatin inducing PC3 prostate cancer cell necrosis mediated by calcineurin and mitochondrial dysfunction. |
2008 |
J. Bioenerg. Biomembr. |
pmid:18679777
|
Chana RS et al. |
Statins but not thiazolidinediones attenuate albumin-mediated chemokine production by proximal tubular cells independently of endocytosis. |
2008 |
Am. J. Nephrol. |
pmid:18535368
|
Abumweis SS et al. |
Plant sterols/stanols as cholesterol lowering agents: A meta-analysis of randomized controlled trials. |
2008 |
Food Nutr Res |
pmid:19109655
|
Sapir-Mir M et al. |
Peroxisomal localization of Arabidopsis isopentenyl diphosphate isomerases suggests that part of the plant isoprenoid mevalonic acid pathway is compartmentalized to peroxisomes. |
2008 |
Plant Physiol. |
pmid:18988695
|
Sławińska A and Kandefer-Szerszeń M |
[The anticancer properties of statins]. |
2008 |
Postepy Hig Med Dosw (Online) |
pmid:18688209
|
Acharjee S and Welty FK |
Atorvastatin and cardiovascular risk in the elderly--patient considerations. |
2008 |
Clin Interv Aging |
pmid:18686752
|
Journe F et al. |
Farnesol, a mevalonate pathway intermediate, stimulates MCF-7 breast cancer cell growth through farnesoid-X-receptor-mediated estrogen receptor activation. |
2008 |
Breast Cancer Res. Treat. |
pmid:17333335
|
Sando T et al. |
Cloning and characterization of mevalonate pathway genes in a natural rubber producing plant, Hevea brasiliensis. |
2008 |
Biosci. Biotechnol. Biochem. |
pmid:18685207
|
Laezza C et al. |
The anandamide analog, Met-F-AEA, controls human breast cancer cell migration via the RHOA/RHO kinase signaling pathway. |
2008 |
Endocr. Relat. Cancer |
pmid:18676619
|
Bate C et al. |
Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells. |
2008 |
BMC Biol. |
pmid:18789130
|
Habara K et al. |
Pitavastatin up-regulates the induction of iNOS through enhanced stabilization of its mRNA in pro-inflammatory cytokine-stimulated hepatocytes. |
2008 |
Nitric Oxide |
pmid:17936042
|
Fried LF |
Effects of HMG-CoA reductase inhibitors (statins) on progression of kidney disease. |
2008 |
Kidney Int. |
pmid:18528321
|
Skorupinska-Tudek K et al. |
Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of dolichols in plants. |
2008 |
J. Biol. Chem. |
pmid:18502754
|
Zhang X et al. |
Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. |
2008 |
J. Immunol. |
pmid:18453621
|
Aprigliano I et al. |
Atorvastatin induces apoptosis by a caspase-9-dependent pathway: an in vitro study on activated rat hepatic stellate cells. |
2008 |
Liver Int. |
pmid:18339080
|
Akisato Y et al. |
[Effect of pitavastatin on macrophage cholesterol metabolism]. |
2008 |
Yakugaku Zasshi |
pmid:18311054
|
Burke LP and Kukoly CA |
Statins induce lethal effects in acute myeloblastic leukemia [corrected] cells within 72 hours. |
2008 |
Leuk. Lymphoma |
pmid:18231920
|
Glynn SA et al. |
The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, simvastatin, lovastatin and mevastatin inhibit proliferation and invasion of melanoma cells. |
2008 |
BMC Cancer |
pmid:18199328
|
Galichet A et al. |
Farnesylation directs AtIPT3 subcellular localization and modulates cytokinin biosynthesis in Arabidopsis. |
2008 |
Plant Physiol. |
pmid:18184738
|
Kodaman PH and Duleba AJ |
Statins in the treatment of polycystic ovary syndrome. |
2008 |
Semin. Reprod. Med. |
pmid:18181091
|
Wilson GJ et al. |
Effects of beta-hydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: A review. |
2008 |
Nutr Metab (Lond) |
pmid:18173841
|
Mathew B and Biju R |
Neuroprotective effects of garlic a review. |
2008 |
Libyan J Med |
pmid:21499478
|
Yoshida T et al. |
Determination of key intermediates in cholesterol and bile acid biosynthesis by stable isotope dilution mass spectrometry. |
2008 |
Anal Chem Insights |
pmid:19609389
|
Saito A et al. |
Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells. |
2008 |
Melanoma Res. |
pmid:18337644
|
Baba TT et al. |
Simvastatin suppresses the differentiation of C2C12 myoblast cells via a Rac pathway. |
2008 |
J. Muscle Res. Cell. Motil. |
pmid:18792797
|
Habeos IG et al. |
Simvastatin activates Keap1/Nrf2 signaling in rat liver. |
2008 |
J. Mol. Med. |
pmid:18787804
|
Osman L et al. |
Atorvastatin accelerates extracellular nucleotide degradation in human endothelial cells. |
2008 |
Mol. Cell. Biochem. |
pmid:18158588
|
Paintlia AS et al. |
Inhibition of rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis. |
2008 |
Mol. Pharmacol. |
pmid:18239032
|
Martin-Ventura JL et al. |
LDL induces parathyroid hormone-related protein expression in vascular smooth muscle cells: Modulation by simvastatin. |
2008 |
Atherosclerosis |
pmid:18378243
|
Baldi A and Dixit VK |
Yield enhancement strategies for artemisinin production by suspension cultures of Artemisia annua. |
2008 |
Bioresour. Technol. |
pmid:17804216
|
Park SY et al. |
Inhibitory effect of simvastatin on the TNF-alpha- and angiotensin II-induced monocyte adhesion to endothelial cells is mediated through the suppression of geranylgeranyl isoprenoid-dependent ROS generation. |
2008 |
Arch. Pharm. Res. |
pmid:18365690
|
Begley M et al. |
Analysis of the isoprenoid biosynthesis pathways in Listeria monocytogenes reveals a role for the alternative 2-C-methyl-D-erythritol 4-phosphate pathway in murine infection. |
2008 |
Infect. Immun. |
pmid:18765739
|
Simonen M et al. |
High-content assay to study protein prenylation. |
2008 |
J Biomol Screen |
pmid:18509097
|
Tarhzaoui K et al. |
Effect of rosuvastatin on capillary filtration of albumin and blood pressure in rats with streptozotocin-induced diabetes. |
2008 |
Diabetes Res. Clin. Pract. |
pmid:18406000
|
Zhuge B et al. |
Bioconversion of lovastatin to a novel statin by Amycolatopsis sp. |
2008 |
Appl. Microbiol. Biotechnol. |
pmid:18368405
|
Voynova NE et al. |
Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure. |
2008 |
Arch. Biochem. Biophys. |
pmid:18823933
|
Pscheidt B and Glieder A |
Yeast cell factories for fine chemical and API production. |
2008 |
Microb. Cell Fact. |
pmid:18684335
|
Schwartz YSh et al. |
Cholesterol-induced stimulation of postinflammatory liver fibrosis. |
2008 |
Bull. Exp. Biol. Med. |
pmid:19110552
|
Yu F et al. |
Isolation and functional characterization of a beta-eudesmol synthase, a new sesquiterpene synthase from Zingiber zerumbet Smith. |
2008 |
FEBS Lett. |
pmid:18242187
|
de Ruyck J and Wouters J |
Structure-based drug design targeting biosynthesis of isoprenoids: a crystallographic state of the art of the involved enzymes. |
2008 |
Curr. Protein Pept. Sci. |
pmid:18393884
|
Lazzerini PE et al. |
Simvastatin inhibits cytokine production and nuclear factor-kB activation in interleukin 1beta-stimulated synoviocytes from rheumatoid arthritis patients. |
2007 Sep-Oct |
Clin. Exp. Rheumatol. |
pmid:18078616
|
Yoon SH et al. |
Increased beta-carotene production in recombinant Escherichia coli harboring an engineered isoprenoid precursor pathway with mevalonate addition. |
2007 May-Jun |
Biotechnol. Prog. |
pmid:17500531
|
Matsunaga S et al. |
Incadronate induces cell detachment and apoptosis in prostatic PC-3 cells. |
2007 Mar-Apr |
Anticancer Res. |
pmid:17465222
|
Bock O et al. |
Common musculoskeletal adverse effects of oral treatment with once weekly alendronate and risedronate in patients with osteoporosis and ways for their prevention. |
2007 Apr-Jun |
J Musculoskelet Neuronal Interact |
pmid:17627083
|
Kuroda M et al. |
Sesquiterpene farnesol inhibits recycling of the C55 lipid carrier of the murein monomer precursor contributing to increased susceptibility to beta-lactams in methicillin-resistant Staphylococcus aureus. |
2007 |
J. Antimicrob. Chemother. |
pmid:17242033
|
Tanaka T et al. |
Lipophilic statins suppress cytotoxicity by freshly isolated natural killer cells through modulation of granule exocytosis. |
2007 |
Int. Immunol. |
pmid:17182966
|
Nishimoto T et al. |
Protective effects of a squalene synthase inhibitor, lapaquistat acetate (TAK-475), on statin-induced myotoxicity in guinea pigs. |
2007 |
Toxicol. Appl. Pharmacol. |
pmid:17599378
|
Hao M et al. |
Direct effect of cholesterol on insulin secretion: a novel mechanism for pancreatic beta-cell dysfunction. |
2007 |
Diabetes |
pmid:17575085
|
Parsons RB et al. |
A specific inhibitor of cholesterol biosynthesis, BM15.766, reduces the expression of beta-secretase and the production of amyloid-beta in vitro. |
2007 |
J. Neurochem. |
pmid:17472704
|
Araki S et al. |
Simvastatin enhances induction of inducible nitric oxide synthase in 3T3-L1 adipocytes. |
2007 |
Free Radic. Res. |
pmid:17729120
|
Haas D and Hoffmann GF |
Mevalonate kinase deficiency and autoinflammatory disorders. |
2007 |
N. Engl. J. Med. |
pmid:17596600
|
Hargreaves IP |
Coenzyme Q10 in phenylketonuria and mevalonic aciduria. |
2007 |
Mitochondrion |
pmid:17442628
|
Maurer-Stroh S et al. |
Towards complete sets of farnesylated and geranylgeranylated proteins. |
2007 |
PLoS Comput. Biol. |
pmid:17411337
|
Llorente A et al. |
Cholesterol regulates prostasome release from secretory lysosomes in PC-3 human prostate cancer cells. |
2007 |
Eur. J. Cell Biol. |
pmid:17601634
|
Kettawan A et al. |
Protective effects of coenzyme q(10) on decreased oxidative stress resistance induced by simvastatin. |
2007 |
J Clin Biochem Nutr |
pmid:18398496
|
Jahangir T and Sultana S |
Perillyl Alcohol Protects Against Fe-NTA-Induced Nephrotoxicity and Early Tumor Promotional Events in Rat Experimental Model. |
2007 |
Evid Based Complement Alternat Med |
pmid:18227911
|
Li M et al. |
Inhibition of serotonin-induced mitogenesis, migration, and ERK MAPK nuclear translocation in vascular smooth muscle cells by atorvastatin. |
2007 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
pmid:17545489
|
Hamadmad SN and Hohl RJ |
Lovastatin suppresses erythropoietin receptor surface expression through dual inhibition of glycosylation and geranylgeranylation. |
2007 |
Biochem. Pharmacol. |
pmid:17586475
|
Muñoz-Bertomeu J et al. |
Up-regulation of an N-terminal truncated 3-hydroxy-3-methylglutaryl CoA reductase enhances production of essential oils and sterols in transgenic Lavandula latifolia. |
2007 |
Plant Biotechnol. J. |
pmid:17714440
|
Merrell MA et al. |
Inhibition of the mevalonate pathway and activation of p38 MAP kinase are independently regulated by nitrogen-containing bisphosphonates in breast cancer cells. |
2007 |
Eur. J. Pharmacol. |
pmid:17640631
|
Niknejad N et al. |
Activation of the integrated stress response regulates lovastatin-induced apoptosis. |
2007 |
J. Biol. Chem. |
pmid:17699156
|
Kotamraju S et al. |
Statin-induced breast cancer cell death: role of inducible nitric oxide and arginase-dependent pathways. |
2007 |
Cancer Res. |
pmid:17671209
|
Ostrowski SM et al. |
Statins reduce amyloid-beta production through inhibition of protein isoprenylation. |
2007 |
J. Biol. Chem. |
pmid:17646164
|
Hu WL et al. |
Decreased C-reactive protein-induced resistin production in human monocytes by simvastatin. |
2007 |
Cytokine |
pmid:18023360
|
Neven B et al. |
Allogeneic bone marrow transplantation in mevalonic aciduria. |
2007 |
N. Engl. J. Med. |
pmid:17596604
|
Wong WW et al. |
Determinants of sensitivity to lovastatin-induced apoptosis in multiple myeloma. |
2007 |
Mol. Cancer Ther. |
pmid:17575117
|
Kutrzeba L et al. |
Biosynthesis of salvinorin A proceeds via the deoxyxylulose phosphate pathway. |
2007 |
Phytochemistry |
pmid:17574635
|
Wong J et al. |
Synthesis of the oxysterol, 24(S), 25-epoxycholesterol, parallels cholesterol production and may protect against cellular accumulation of newly-synthesized cholesterol. |
2007 |
Lipids Health Dis |
pmid:17408498
|
Hunter WN |
The non-mevalonate pathway of isoprenoid precursor biosynthesis. |
2007 |
J. Biol. Chem. |
pmid:17442674
|
Takeda I et al. |
Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. |
2007 |
Cancer Sci. |
pmid:17428261
|
Roelofs AJ et al. |
Apomine enhances the antitumor effects of lovastatin on myeloma cells by down-regulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase. |
2007 |
J. Pharmacol. Exp. Ther. |
pmid:17412884
|
Sgraja T et al. |
Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase. |
2007 |
BMC Struct. Biol. |
pmid:17397541
|
Henriksson LM et al. |
Structures of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase provide new insights into catalysis. |
2007 |
J. Biol. Chem. |
pmid:17491006
|
Nakata S et al. |
Statin treatment upregulates vascular neuronal nitric oxide synthase through Akt/NF-kappaB pathway. |
2007 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:17082483
|
Loiseau L et al. |
ErpA, an iron sulfur (Fe S) protein of the A-type essential for respiratory metabolism in Escherichia coli. |
2007 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:17698959
|
Mönkkönen H et al. |
Zoledronic acid-induced IPP/ApppI production in vivo. |
2007 |
Life Sci. |
pmid:17850825
|
Towler MJ and Weathers PJ |
Evidence of artemisinin production from IPP stemming from both the mevalonate and the nonmevalonate pathways. |
2007 |
Plant Cell Rep. |
pmid:17710406
|
Withers ST et al. |
Identification of isopentenol biosynthetic genes from Bacillus subtilis by a screening method based on isoprenoid precursor toxicity. |
2007 |
Appl. Environ. Microbiol. |
pmid:17693564
|
Buhaescu I and Izzedine H |
Mevalonate pathway: a review of clinical and therapeutical implications. |
2007 |
Clin. Biochem. |
pmid:17467679
|
März P et al. |
Statins induce differentiation and cell death in neurons and astroglia. |
2007 |
Glia |
pmid:16998865
|
Riganti C et al. |
Asbestos induces nitric oxide synthesis in mesothelioma cells via Rho signaling inhibition. |
2007 |
Am. J. Respir. Cell Mol. Biol. |
pmid:17322126
|
Habib A et al. |
Modulation of COX-2 expression by statins in human monocytic cells. |
2007 |
FASEB J. |
pmid:17317725
|
Pertusa M et al. |
Transcriptional control of cholesterol biosynthesis in Schwann cells by axonal neuregulin 1. |
2007 |
J. Biol. Chem. |
pmid:17652086
|
Andreassi JL et al. |
Crystal structure of the Streptococcus pneumoniae mevalonate kinase in complex with diphosphomevalonate. |
2007 |
Protein Sci. |
pmid:17400916
|
Lee MH et al. |
Simvastatin suppresses self-renewal of mouse embryonic stem cells by inhibiting RhoA geranylgeranylation. |
2007 |
Stem Cells |
pmid:17464088
|
Nakajima H et al. |
Induction of mitochondria-dependent apoptosis through the inhibition of mevalonate pathway in human breast cancer cells by YM529, a new third generation bisphosphonate. |
2007 |
Cancer Lett. |
pmid:17316980
|
Kinjoh T et al. |
Control of juvenile hormone biosynthesis in Bombyx mori: cloning of the enzymes in the mevalonate pathway and assessment of their developmental expression in the corpora allata. |
2007 |
Insect Biochem. Mol. Biol. |
pmid:17628279
|
Takahashi HK et al. |
Action profiles of statins and calcineurin inhibitors during human mixed lymphocyte reaction. |
2007 |
Clin. Immunol. |
pmid:17482516
|