Hao M et al. |
Direct effect of cholesterol on insulin secretion: a novel mechanism for pancreatic beta-cell dysfunction. |
2007 |
Diabetes |
pmid:17575085
|
Parsons RB et al. |
A specific inhibitor of cholesterol biosynthesis, BM15.766, reduces the expression of beta-secretase and the production of amyloid-beta in vitro. |
2007 |
J. Neurochem. |
pmid:17472704
|
Araki S et al. |
Simvastatin enhances induction of inducible nitric oxide synthase in 3T3-L1 adipocytes. |
2007 |
Free Radic. Res. |
pmid:17729120
|
Hargreaves IP |
Coenzyme Q10 in phenylketonuria and mevalonic aciduria. |
2007 |
Mitochondrion |
pmid:17442628
|
Kettawan A et al. |
Protective effects of coenzyme q(10) on decreased oxidative stress resistance induced by simvastatin. |
2007 |
J Clin Biochem Nutr |
pmid:18398496
|
Li M et al. |
Inhibition of serotonin-induced mitogenesis, migration, and ERK MAPK nuclear translocation in vascular smooth muscle cells by atorvastatin. |
2007 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
pmid:17545489
|
Kotamraju S et al. |
Statin-induced breast cancer cell death: role of inducible nitric oxide and arginase-dependent pathways. |
2007 |
Cancer Res. |
pmid:17671209
|
Ostrowski SM et al. |
Statins reduce amyloid-beta production through inhibition of protein isoprenylation. |
2007 |
J. Biol. Chem. |
pmid:17646164
|
Hu WL et al. |
Decreased C-reactive protein-induced resistin production in human monocytes by simvastatin. |
2007 |
Cytokine |
pmid:18023360
|
Neven B et al. |
Allogeneic bone marrow transplantation in mevalonic aciduria. |
2007 |
N. Engl. J. Med. |
pmid:17596604
|
Wong WW et al. |
Determinants of sensitivity to lovastatin-induced apoptosis in multiple myeloma. |
2007 |
Mol. Cancer Ther. |
pmid:17575117
|
Kutrzeba L et al. |
Biosynthesis of salvinorin A proceeds via the deoxyxylulose phosphate pathway. |
2007 |
Phytochemistry |
pmid:17574635
|
Henriksson LM et al. |
Structures of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase provide new insights into catalysis. |
2007 |
J. Biol. Chem. |
pmid:17491006
|
Nakata S et al. |
Statin treatment upregulates vascular neuronal nitric oxide synthase through Akt/NF-kappaB pathway. |
2007 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:17082483
|
Mönkkönen H et al. |
Zoledronic acid-induced IPP/ApppI production in vivo. |
2007 |
Life Sci. |
pmid:17850825
|
Withers ST et al. |
Identification of isopentenol biosynthetic genes from Bacillus subtilis by a screening method based on isoprenoid precursor toxicity. |
2007 |
Appl. Environ. Microbiol. |
pmid:17693564
|
Buhaescu I and Izzedine H |
Mevalonate pathway: a review of clinical and therapeutical implications. |
2007 |
Clin. Biochem. |
pmid:17467679
|
März P et al. |
Statins induce differentiation and cell death in neurons and astroglia. |
2007 |
Glia |
pmid:16998865
|
Riganti C et al. |
Asbestos induces nitric oxide synthesis in mesothelioma cells via Rho signaling inhibition. |
2007 |
Am. J. Respir. Cell Mol. Biol. |
pmid:17322126
|
Habib A et al. |
Modulation of COX-2 expression by statins in human monocytic cells. |
2007 |
FASEB J. |
pmid:17317725
|
Pertusa M et al. |
Transcriptional control of cholesterol biosynthesis in Schwann cells by axonal neuregulin 1. |
2007 |
J. Biol. Chem. |
pmid:17652086
|
Nakajima H et al. |
Induction of mitochondria-dependent apoptosis through the inhibition of mevalonate pathway in human breast cancer cells by YM529, a new third generation bisphosphonate. |
2007 |
Cancer Lett. |
pmid:17316980
|
Saha RN and Pahan K |
Regulation of inducible nitric oxide synthase gene in glial cells. |
2006 May-Jun |
Antioxid. Redox Signal. |
pmid:16771683
|
Seong K et al. |
Cryptic promoter activity in the coding region of the HMG-CoA reductase gene in Fusarium graminearum. |
2006 |
Fungal Genet. Biol. |
pmid:16377218
|
Haratake A et al. |
Acceleration of de novo cholesterol synthesis in the epidermis influences desquamation of the stratum corneum in aged mice. |
2006 |
Skin Pharmacol Physiol |
pmid:16778459
|
Dincer M et al. |
Statins may decrease skeletal-related events in breast cancer patients with bone metastases. |
2006 |
Med. Hypotheses |
pmid:16844315
|
Kwintkiewicz J et al. |
Mevastatin inhibits proliferation of rat ovarian theca-interstitial cells by blocking the mitogen-activated protein kinase pathway. |
2006 |
Fertil. Steril. |
pmid:16963032
|
Pozo M et al. |
Simvastatin inhibits the migration and adhesion of monocytic cells and disorganizes the cytoskeleton of activated endothelial cells. |
2006 |
Eur. J. Pharmacol. |
pmid:16973154
|
Piotrowski PC et al. |
Statins inhibit growth of human endometrial stromal cells independently of cholesterol availability. |
2006 |
Biol. Reprod. |
pmid:16571871
|
Sakoda K et al. |
Simvastatin decreases IL-6 and IL-8 production in epithelial cells. |
2006 |
J. Dent. Res. |
pmid:16723648
|
Kanellis J et al. |
Activators of the energy sensing kinase AMPK inhibit random cell movement and chemotaxis in U937 cells. |
2006 |
Immunol. Cell Biol. |
pmid:16405649
|
Polo MP and de Bravo MG |
Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2. |
2006 |
Biochem. Cell Biol. |
pmid:16462894
|
Hampel D et al. |
Biosynthesis of mono- and sesquiterpenes in strawberry fruits and foliage: 2H labeling studies. |
2006 |
J. Agric. Food Chem. |
pmid:16478276
|
Ro DK et al. |
Production of the antimalarial drug precursor artemisinic acid in engineered yeast. |
2006 |
Nature |
pmid:16612385
|
Sjögren B et al. |
Cholesterol depletion reduces serotonin binding and signaling via human 5-HT(7(a)) receptors. |
2006 |
Eur. J. Pharmacol. |
pmid:17064686
|
Ohm TG and Meske V |
Cholesterol, statins and tau. |
2006 |
Acta Neurol. Scand., Suppl.c |
pmid:16866917
|
Crisby M |
The role of pleiotropic effects of statins in dementia. |
2006 |
Acta Neurol. Scand., Suppl.c |
pmid:16866920
|
Chana RS and Brunskill NJ |
Thiazolidinediones inhibit albumin uptake by proximal tubular cells through a mechanism independent of peroxisome proliferator activated receptor gamma. |
2006 |
Am. J. Nephrol. |
pmid:16508249
|
Macreadie IG et al. |
Growth inhibition of Candida species and Aspergillus fumigatus by statins. |
2006 |
FEMS Microbiol. Lett. |
pmid:16907733
|
Kosztáczky B et al. |
Neuropeptides induced a pronounced and statin-sensitive dysregulation of mevalonate cycle in human monocytes of patients with hypercholesterolemia. |
2006 |
Neuropeptides |
pmid:17049599
|
Ridsdale A et al. |
Cholesterol is required for efficient endoplasmic reticulum-to-Golgi transport of secretory membrane proteins. |
2006 |
Mol. Biol. Cell |
pmid:16452637
|
Gómez-Hernández A et al. |
Atorvastatin reduces the expression of prostaglandin E2 receptors in human carotid atherosclerotic plaques and monocytic cells: potential implications for plaque stabilization. |
2006 |
J. Cardiovasc. Pharmacol. |
pmid:16424787
|
Kinderlerer AR et al. |
Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis. |
2006 |
Arthritis Res. Ther. |
pmid:16859540
|
Kotti TJ et al. |
Brain cholesterol turnover required for geranylgeraniol production and learning in mice. |
2006 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:16505352
|
Sato M et al. |
Effects of exogenous mevalonic acid on sterol lipid classes in Larix kaempferi callus. |
2006 |
J Oleo Sci |
pmid:17693695
|
Kuzina V et al. |
Relationships among the biosyntheses of ubiquinone, carotene, sterols, and triacylglycerols in Zygomycetes. |
2006 |
Arch. Microbiol. |
pmid:17009023
|
Li JQ et al. |
Atorvastatin reduces plasminogen activator inhibitor-1 expression in adipose tissue of atherosclerotic rabbits. |
2006 |
Clin. Chim. Acta |
pmid:16507303
|
Parsons RB et al. |
Statins inhibit the dimerization of beta-secretase via both isoprenoid- and cholesterol-mediated mechanisms. |
2006 |
Biochem. J. |
pmid:16803455
|
Brinkkoetter PT et al. |
Atorvastatin interferes with activation of human CD4(+) T cells via inhibition of small guanosine triphosphatase (GTPase) activity and caspase-independent apoptosis. |
2006 |
Clin. Exp. Immunol. |
pmid:17100774
|
Mandey SH et al. |
A role for geranylgeranylation in interleukin-1beta secretion. |
2006 |
Arthritis Rheum. |
pmid:17075828
|
Ural AU et al. |
In vitro synergistic cytoreductive effects of zoledronic acid and radiation on breast cancer cells. |
2006 |
Breast Cancer Res. |
pmid:16925824
|
van Hellemond JJ and Tielens AG |
Adaptations in the lipid metabolism of the protozoan parasite Trypanosoma brucei. |
2006 |
FEBS Lett. |
pmid:16920110
|
Saini GS et al. |
Validation of the LC-MS/MS method for the quantification of mevalonic acid in human plasma and determination of the matrix effect. |
2006 |
J. Lipid Res. |
pmid:16861623
|
Yi P et al. |
The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Ggamma1. |
2006 |
Science |
pmid:16857902
|
Dimitroulakos J et al. |
Strategies to enhance epidermal growth factor inhibition: targeting the mevalonate pathway. |
2006 |
Clin. Cancer Res. |
pmid:16857822
|
Xu H et al. |
HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced "inside-out" signaling to extracellular matrix by preventing RhoA activation. |
2006 |
Am. J. Physiol. Renal Physiol. |
pmid:16774905
|
Kawasaki T et al. |
Biosynthesis of a natural polyketide-isoprenoid hybrid compound, furaquinocin A: identification and heterologous expression of the gene cluster. |
2006 |
J. Bacteriol. |
pmid:16452404
|
Haas D and Hoffmann GF |
Mevalonate kinase deficiencies: from mevalonic aciduria to hyperimmunoglobulinemia D syndrome. |
2006 |
Orphanet J Rare Dis |
pmid:16722536
|
Solito E et al. |
Post-translational modification plays an essential role in the translocation of annexin A1 from the cytoplasm to the cell surface. |
2006 |
FASEB J. |
pmid:16720734
|
Chemler JA et al. |
Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae. |
2006 |
Microb. Cell Fact. |
pmid:16719921
|
Silvander M et al. |
A new water-based topical carrier with polar skin-lipids. |
2006 |
Lipids Health Dis |
pmid:16672068
|
Coward WR et al. |
Statin-induced proinflammatory response in mitogen-activated peripheral blood mononuclear cells through the activation of caspase-1 and IL-18 secretion in monocytes. |
2006 |
J. Immunol. |
pmid:16621994
|
Neville-Webbe HL et al. |
Mechanisms of the synergistic interaction between the bisphosphonate zoledronic acid and the chemotherapy agent paclitaxel in breast cancer cells in vitro. |
2006 |
Tumour Biol. |
pmid:16582586
|
Rattan R et al. |
Rho/ROCK pathway as a target of tumor therapy. |
2006 |
J. Neurosci. Res. |
pmid:16385577
|
Wang J et al. |
Anti-inflammatory effect of pitavastatin on NF-kappaB activated by TNF-alpha in hepatocellular carcinoma cells. |
2006 |
Biol. Pharm. Bull. |
pmid:16595893
|
Benetka W et al. |
Farnesylation or geranylgeranylation? Efficient assays for testing protein prenylation in vitro and in vivo. |
2006 |
BMC Biochem. |
pmid:16507103
|
Xu L et al. |
[Effects of simvastatin on DNA synthesis in rat cardiac fibroblasts]. |
2006 |
Nan Fang Yi Ke Da Xue Xue Bao |
pmid:16503530
|
Riganti C et al. |
Statins revert doxorubicin resistance via nitric oxide in malignant mesothelioma. |
2006 |
Int. J. Cancer |
pmid:16450390
|
Ramasubbu K and Mann DL |
The emerging role of statins in the treatment of heart failure. |
2006 |
J. Am. Coll. Cardiol. |
pmid:16412858
|
Christensen M et al. |
Simvastatin protection against acute immune-mediated glomerulonephritis in mice. |
2006 |
Kidney Int. |
pmid:16407885
|
González-Fernández L et al. |
Cleavage of focal adhesion proteins and PKCdelta during lovastatin-induced apoptosis in spontaneously immortalized rat brain neuroblasts. |
2006 |
FEBS J. |
pmid:16367743
|
Zahiri HS et al. |
Coenzyme Q10 production in recombinant Escherichia coli strains engineered with a heterologous decaprenyl diphosphate synthase gene and foreign mevalonate pathway. |
2006 |
Metab. Eng. |
pmid:16815062
|
Pappu AS et al. |
Increased nonsterol isoprenoids, dolichol and ubiquinone, in the Smith-Lemli-Opitz syndrome: effects of dietary cholesterol. |
2006 |
J. Lipid Res. |
pmid:16983147
|
Yoon SH et al. |
Enhanced lycopene production in Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate. |
2006 |
Biotechnol. Bioeng. |
pmid:16547999
|
Nagashima T et al. |
Apoptosis of rheumatoid synovial cells by statins through the blocking of protein geranylgeranylation: a potential therapeutic approach to rheumatoid arthritis. |
2006 |
Arthritis Rheum. |
pmid:16447234
|
Yokota K et al. |
Simvastatin inhibits production of interleukin 6 (IL-6) and IL-8 and cell proliferation induced by tumor necrosis factor-alpha in fibroblast-like synoviocytes from patients with rheumatoid arthritis. |
2006 |
J. Rheumatol. |
pmid:16511915
|
Grochowski LL et al. |
Methanocaldococcus jannaschii uses a modified mevalonate pathway for biosynthesis of isopentenyl diphosphate. |
2006 |
J. Bacteriol. |
pmid:16621811
|
Alegret M and Silvestre JS |
Pleiotropic effects of statins and related pharmacological experimental approaches. |
2006 |
Methods Find Exp Clin Pharmacol |
pmid:17200729
|
Muñoz-GarcÃa B et al. |
Fn14 is upregulated in cytokine-stimulated vascular smooth muscle cells and is expressed in human carotid atherosclerotic plaques: modulation by atorvastatin. |
2006 |
Stroke |
pmid:16809572
|
Shang F et al. |
Simvastatin inhibits lipopolysaccharide-induced tumor necrosis factor-alpha expression in neonatal rat cardiomyocytes: The role of reactive oxygen species. |
2006 |
Biochem. Biophys. Res. Commun. |
pmid:17094942
|
Issat T et al. |
Berberine, a natural cholesterol reducing product, exerts antitumor cytostatic/cytotoxic effects independently from the mevalonate pathway. |
2006 |
Oncol. Rep. |
pmid:17089049
|
Kuwana M |
Potential benefit of statins for vascular disease in systemic sclerosis. |
2006 |
Curr Opin Rheumatol |
pmid:17053504
|
Thompson K et al. |
Alkylamines cause Vgamma9Vdelta2 T-cell activation and proliferation by inhibiting the mevalonate pathway. |
2006 |
Blood |
pmid:16179378
|
van Beek E et al. |
Independent pathways in the modulation of osteoclastic resorption by intermediates of the mevalonate biosynthetic pathway: the role of the retinoic acid receptor. |
2006 |
Bone |
pmid:16165408
|
Hamadmad SN et al. |
Erythropoietin receptor signal transduction requires protein geranylgeranylation. |
2006 |
J. Pharmacol. Exp. Ther. |
pmid:16203826
|
Qiu Y and Li D |
Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase. |
2006 |
Org. Lett. |
pmid:16524256
|
Qiu Y and Li D |
Inhibition of mevalonate 5-diphosphate decarboxylase by fluorinated substrate analogs. |
2006 |
Biochim. Biophys. Acta |
pmid:16626865
|
Beckman JA and Creager MA |
The nonlipid effects of statins on endothelial function. |
2006 |
Trends Cardiovasc. Med. |
pmid:16781949
|
Caruso MG and Notarnicola M |
Biochemical changes of mevalonate pathway in human colorectal cancer. |
2005 Sep-Oct |
Anticancer Res. |
pmid:16101154
|
Nawarskas JJ |
HMG-CoA reductase inhibitors and coenzyme Q10. |
2005 Mar-Apr |
Cardiol Rev |
pmid:15705257
|
Akiyama K et al. |
Antitumor effect of geranylamine derivatives on human hepatoma. |
2005 Jan-Feb |
In Vivo |
pmid:15796170
|
Mokashi V et al. |
Supernatant protein factor stimulates HMG-CoA reductase in cell culture and in vitro. |
2005 |
Arch. Biochem. Biophys. |
pmid:15581604
|
Han KH et al. |
HMG-CoA reductase inhibition reduces monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated monocyte recruitment in vivo. |
2005 |
Circulation |
pmid:15781755
|
Bevilacqua M et al. |
Bisphosphonates and atherosclerosis: why? |
2005 |
Lupus |
pmid:16218486
|
Kim J et al. |
4,8-Dimethyldecanal, the aggregation pheromone of Tribolium castaneum, is biosynthesized through the fatty acid pathway. |
2005 |
J. Chem. Ecol. |
pmid:16222778
|
Viereck V et al. |
Atorvastatin stimulates the production of osteoprotegerin by human osteoblasts. |
2005 |
J. Cell. Biochem. |
pmid:16152630
|
Okada K and Hase T |
Cyanobacterial non-mevalonate pathway: (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase interacts with ferredoxin in Thermosynechococcus elongatus BP-1. |
2005 |
J. Biol. Chem. |
pmid:15792953
|
Mantha AJ et al. |
Targeting the mevalonate pathway inhibits the function of the epidermal growth factor receptor. |
2005 |
Clin. Cancer Res. |
pmid:15788691
|
McCarey DW et al. |
Do the pleiotropic effects of statins in the vasculature predict a role in inflammatory diseases? |
2005 |
Arthritis Res. Ther. |
pmid:15743490
|
Zeng L et al. |
HMG CoA reductase inhibition modulates VEGF-induced endothelial cell hyperpermeability by preventing RhoA activation and myosin regulatory light chain phosphorylation. |
2005 |
FASEB J. |
pmid:16160062
|