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Statins inhibit proliferation and induce apoptosis in Barrett's esophageal adenocarcinoma cells. |
2008 |
Am. J. Gastroenterol. |
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Induction of scavenger receptor class B type I is critical for simvastatin enhancement of high-density lipoprotein-induced anti-inflammatory actions in endothelial cells. |
2008 |
J. Immunol. |
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Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation. |
2008 |
Proc. Natl. Acad. Sci. U.S.A. |
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Structure of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate reductase, the terminal enzyme of the non-mevalonate pathway. |
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J. Am. Chem. Soc. |
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7-ketocholesterol, a major oxysterol, promotes pi-induced vascular calcification in cultured smooth muscle cells. |
2008 |
J. Atheroscler. Thromb. |
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Combination therapy in cholesterol reduction: focus on ezetimibe and statins. |
2008 |
Vasc Health Risk Manag |
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Pravastatin improves renal ischemia-reperfusion injury by inhibiting the mevalonate pathway. |
2008 |
Kidney Int. |
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Dynamical modeling of the cholesterol regulatory pathway with Boolean networks. |
2008 |
BMC Syst Biol |
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Investigation of coenzyme Q biosynthesis in human fibroblast and HepG2 cells. |
2008 |
J. Biochem. Biophys. Methods |
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Modulation of osteoclastogenesis by fatty acids. |
2008 |
Endocrinology |
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Genetic evidence for the role of isopentenyl diphosphate isomerases in the mevalonate pathway and plant development in Arabidopsis. |
2008 |
Plant Cell Physiol. |
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Stable carbon isotope discrimination by human 3-hydroxy-3-methylglutaryl-coenzyme A reductase. |
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J. Lipid Res. |
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Statins impair antitumor effects of rituximab by inducing conformational changes of CD20. |
2008 |
PLoS Med. |
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Simvastatin inducing PC3 prostate cancer cell necrosis mediated by calcineurin and mitochondrial dysfunction. |
2008 |
J. Bioenerg. Biomembr. |
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Peroxisomal localization of Arabidopsis isopentenyl diphosphate isomerases suggests that part of the plant isoprenoid mevalonic acid pathway is compartmentalized to peroxisomes. |
2008 |
Plant Physiol. |
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Sławińska A and Kandefer-Szerszeń M |
[The anticancer properties of statins]. |
2008 |
Postepy Hig Med Dosw (Online) |
pmid:18688209
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Acharjee S and Welty FK |
Atorvastatin and cardiovascular risk in the elderly--patient considerations. |
2008 |
Clin Interv Aging |
pmid:18686752
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Journe F et al. |
Farnesol, a mevalonate pathway intermediate, stimulates MCF-7 breast cancer cell growth through farnesoid-X-receptor-mediated estrogen receptor activation. |
2008 |
Breast Cancer Res. Treat. |
pmid:17333335
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Cloning and characterization of mevalonate pathway genes in a natural rubber producing plant, Hevea brasiliensis. |
2008 |
Biosci. Biotechnol. Biochem. |
pmid:18685207
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Laezza C et al. |
The anandamide analog, Met-F-AEA, controls human breast cancer cell migration via the RHOA/RHO kinase signaling pathway. |
2008 |
Endocr. Relat. Cancer |
pmid:18676619
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Bate C et al. |
Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells. |
2008 |
BMC Biol. |
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Dysregulation of the host mevalonate pathway during early bacterial infection activates human TCR gamma delta cells. |
2008 |
Eur. J. Immunol. |
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Matsuda T et al. |
Simvastatin inhibits catecholamine secretion and synthesis induced by acetylcholine via blocking Na+ and Ca2+ influx in bovine adrenal medullary cells. |
2008 |
J. Pharmacol. Exp. Ther. |
pmid:18593956
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Habara K et al. |
Pitavastatin up-regulates the induction of iNOS through enhanced stabilization of its mRNA in pro-inflammatory cytokine-stimulated hepatocytes. |
2008 |
Nitric Oxide |
pmid:17936042
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Effects of HMG-CoA reductase inhibitors (statins) on progression of kidney disease. |
2008 |
Kidney Int. |
pmid:18528321
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Skorupinska-Tudek K et al. |
Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of dolichols in plants. |
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J. Biol. Chem. |
pmid:18502754
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Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. |
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J. Immunol. |
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Atorvastatin induces apoptosis by a caspase-9-dependent pathway: an in vitro study on activated rat hepatic stellate cells. |
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Liver Int. |
pmid:18339080
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The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, simvastatin, lovastatin and mevastatin inhibit proliferation and invasion of melanoma cells. |
2008 |
BMC Cancer |
pmid:18199328
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Galichet A et al. |
Farnesylation directs AtIPT3 subcellular localization and modulates cytokinin biosynthesis in Arabidopsis. |
2008 |
Plant Physiol. |
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Kodaman PH and Duleba AJ |
Statins in the treatment of polycystic ovary syndrome. |
2008 |
Semin. Reprod. Med. |
pmid:18181091
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Wilson GJ et al. |
Effects of beta-hydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: A review. |
2008 |
Nutr Metab (Lond) |
pmid:18173841
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Mathew B and Biju R |
Neuroprotective effects of garlic a review. |
2008 |
Libyan J Med |
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Determination of key intermediates in cholesterol and bile acid biosynthesis by stable isotope dilution mass spectrometry. |
2008 |
Anal Chem Insights |
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Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells. |
2008 |
Melanoma Res. |
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Simvastatin suppresses the differentiation of C2C12 myoblast cells via a Rac pathway. |
2008 |
J. Muscle Res. Cell. Motil. |
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Simvastatin activates Keap1/Nrf2 signaling in rat liver. |
2008 |
J. Mol. Med. |
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Atorvastatin accelerates extracellular nucleotide degradation in human endothelial cells. |
2008 |
Mol. Cell. Biochem. |
pmid:18158588
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LDL induces parathyroid hormone-related protein expression in vascular smooth muscle cells: Modulation by simvastatin. |
2008 |
Atherosclerosis |
pmid:18378243
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Baldi A and Dixit VK |
Yield enhancement strategies for artemisinin production by suspension cultures of Artemisia annua. |
2008 |
Bioresour. Technol. |
pmid:17804216
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Inhibitory effect of simvastatin on the TNF-alpha- and angiotensin II-induced monocyte adhesion to endothelial cells is mediated through the suppression of geranylgeranyl isoprenoid-dependent ROS generation. |
2008 |
Arch. Pharm. Res. |
pmid:18365690
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Begley M et al. |
Analysis of the isoprenoid biosynthesis pathways in Listeria monocytogenes reveals a role for the alternative 2-C-methyl-D-erythritol 4-phosphate pathway in murine infection. |
2008 |
Infect. Immun. |
pmid:18765739
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Tarhzaoui K et al. |
Effect of rosuvastatin on capillary filtration of albumin and blood pressure in rats with streptozotocin-induced diabetes. |
2008 |
Diabetes Res. Clin. Pract. |
pmid:18406000
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Zhuge B et al. |
Bioconversion of lovastatin to a novel statin by Amycolatopsis sp. |
2008 |
Appl. Microbiol. Biotechnol. |
pmid:18368405
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Kaliszewski P et al. |
Rsp5p ubiquitin ligase and the transcriptional activators Spt23p and Mga2p are involved in co-regulation of biosynthesis of end products of the mevalonate pathway and triacylglycerol in yeast Saccharomyces cerevisiae. |
2008 |
Biochim. Biophys. Acta |
pmid:18771750
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Voynova NE et al. |
Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure. |
2008 |
Arch. Biochem. Biophys. |
pmid:18823933
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Pscheidt B and Glieder A |
Yeast cell factories for fine chemical and API production. |
2008 |
Microb. Cell Fact. |
pmid:18684335
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Cholesterol-induced stimulation of postinflammatory liver fibrosis. |
2008 |
Bull. Exp. Biol. Med. |
pmid:19110552
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Liang YJ et al. |
Simvastatin inhibits C-reactive protein-induced pro-inflammatory changes in endothelial cells by decreasing mevalonate pathway products. |
2008 |
Cardiology |
pmid:18057884
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de Ruyck J and Wouters J |
Structure-based drug design targeting biosynthesis of isoprenoids: a crystallographic state of the art of the involved enzymes. |
2008 |
Curr. Protein Pept. Sci. |
pmid:18393884
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