| MeSH term | MeSH ID | Detail |
|---|---|---|
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Refsum Disease | D012035 | 19 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Smith-Lemli-Opitz Syndrome | D019082 | 7 associated lipids |
Mevalonic acid
Mevalonic acid is a lipid of Fatty Acyls (FA) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.
Here are additional resources we collected from PubChem and MeSH for Mevalonic acid
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Mevalonic acid
PubChem Biomolecular Interactions and Pathways
NCBI Entrez Crosslinks
All references with Mevalonic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hu ZY et al. | Neurosteroids: oligodendrocyte mitochondria convert cholesterol to pregnenolone. | 1987 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3479785 |
| Forman BM et al. | The orphan nuclear receptor LXRalpha is positively and negatively regulated by distinct products of mevalonate metabolism. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9380679 |
| Arebalo RE et al. | In vivo regulation of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A reductase: immunotitration of the enzyme after short-term mevalonate or cholesterol feeding. | 1982 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6948302 |
| Liu GC et al. | Measurement of cholesterol synthesis in man by isotope kinetics of squalene. | 1975 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1060141 |
| Kotti T et al. | Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18685105 |
| Epstein WW et al. | Quantitation of prenylcysteines by a selective cleavage reaction. | 1991 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1946384 |
| Mizuno T et al. | A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21. | 1991 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1907371 |
| Roullet JB et al. | Mevalonate availability and cardiovascular functions. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8265617 |
| Shi Z and Ruvkun G | The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22396595 |
| Parker TS et al. | Mevalonic acid in human plasma: relationship of concentration and circadian rhythm to cholesterol synthesis rates in man. | 1982 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6953446 |
| Lange BM and Croteau R | Isopentenyl diphosphate biosynthesis via a mevalonate-independent pathway: isopentenyl monophosphate kinase catalyzes the terminal enzymatic step. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10570138 |
| Sinensky M and Logel J | Defective macromolecule biosynthesis and cell-cycle progression in a mammalian cell starved for mevalonate. | 1985 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2582409 |
| Rauthan M et al. | The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23530189 |
| Cuthbert JA and Lipsky PE | Modulation of human lymphocyte responses by low density lipoproteins (LDL): enhancement but not immunosuppression is mediated by LDL receptors. | 1984 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6087331 |
| Tianero MD et al. | Metabolic model for diversity-generating biosynthesis. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26831074 |
| Yasmin S et al. | Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22106303 |
| Larson RA et al. | Neutrophils are required for the DNA synthetic response of human lymphocytes to mevalonic acid: evidence suggesting that a nonsterol product of mevalonate is involved. | 1982 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6953445 |
| Goldstein JL and Brown MS | Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol. | 1973 | Proc. Natl. Acad. Sci. U.S.A. | pmid:4355366 |
| Kopito RR and Brunengraber H | (R)-mevalonate excretion in human and rat urines. | 1980 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6255462 |
| Quesney-Huneeus V et al. | Essential role for mevalonate synthesis in DNA replication. | 1979 | Proc. Natl. Acad. Sci. U.S.A. | pmid:291922 |
| Laffitte BA et al. | LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11149950 |
| Henry LK et al. | Orthologs of the archaeal isopentenyl phosphate kinase regulate terpenoid production in plants. | 2015 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26216978 |
| Venkateshwaran M et al. | A role for the mevalonate pathway in early plant symbiotic signaling. | 2015 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26199419 |
| Brown MS and Goldstein JL | Familial hypercholesterolemia: defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity. | 1974 | Proc. Natl. Acad. Sci. U.S.A. | pmid:4362634 |
| Giron MD et al. | Mevalonate-mediated suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase function in alpha-toxin-perforated cells. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8022795 |
| Parmryd I et al. | Protein prenylation in spinach chloroplasts. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10468564 |
| Lai RK et al. | The gamma subunit of transducin is farnesylated. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2217200 |
| Sapir A et al. | Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25187565 |
| Farnsworth CC et al. | C terminus of the small GTP-binding protein smg p25A contains two geranylgeranylated cysteine residues and a methyl ester. | 1991 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1906176 |
| Kinsella BT et al. | Posttranslational modification of Ha-ras p21 by farnesyl versus geranylgeranyl isoprenoids is determined by the COOH-terminal amino acid. | 1991 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1924354 |
| Casey PJ et al. | p21ras is modified by a farnesyl isoprenoid. | 1989 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2682646 |
| Kawata M et al. | Posttranslationally processed structure of the human platelet protein smg p21B: evidence for geranylgeranylation and carboxyl methylation of the C-terminal cysteine. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2123345 |
| Mumby SM et al. | G protein gamma subunits contain a 20-carbon isoprenoid. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2116011 |
| Wang Z et al. | Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24367099 |
| Khosravi-Far R et al. | Isoprenoid modification of rab proteins terminating in CC or CXC motifs. | 1991 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1648736 |
| Ness GC et al. | Stimulation of hepatic beta-hydroxy-beta-methylglutaryl coenzyme A reductase activity in hypophysectomized rats by L-triiodothyronine. | 1973 | Proc. Natl. Acad. Sci. U.S.A. | pmid:4521209 |
| Clendening JW et al. | Dysregulation of the mevalonate pathway promotes transformation. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20696928 |
| Okamura E et al. | Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20534558 |
| Loiseau L et al. | ErpA, an iron sulfur (Fe S) protein of the A-type essential for respiratory metabolism in Escherichia coli. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17698959 |
| Rohdich F et al. | Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of IspH (LytB) protein. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11818558 |
| Hecht S et al. | Studies on the nonmevalonate pathway to terpenes: the role of the GcpE (IspG) protein. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11752431 |
| Kaneda K et al. | An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11158573 |
| Ohyama K et al. | Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19139393 |
| Rao S et al. | Lovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10393901 |
| Takahashi S et al. | A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9707569 |
| Chang TY et al. | Isolation and partial characterization of a cholesterol-requiring mutant of Chinese hamster ovary cells. | 1977 | Proc. Natl. Acad. Sci. U.S.A. | pmid:265577 |
| McNamara DJ et al. | Measurement of daily cholesterol synthesis rates in man by assay of the fractional conversion of mevalonic acid to cholesterol. | 1977 | Proc. Natl. Acad. Sci. U.S.A. | pmid:268653 |
| James G et al. | Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8633088 |
| Balasubramaniam S et al. | Regulation of cholesterol synthesis in rat adrenal gland through coordinate control of 3-hydroxy-3-methylglutaryl coenzyme A synthase and reductase activities. | 1977 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16260 |
| Beg ZH et al. | In vivo modulation of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A reductase, reductase kinase, and reductase kinase kinase by mevalonolactone. | 1984 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6594693 |