Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Prostatic Neoplasms D011471 126 associated lipids
Refsum Disease D012035 19 associated lipids
Thrombosis D013927 49 associated lipids
Xanthomatosis D014973 17 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

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All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
Alonso-Gutierrez J et al. Metabolic engineering of Escherichia coli for limonene and perillyl alcohol production. 2013 Metab. Eng. pmid:23727191
Theesfeld CL and Hampton RY Insulin-induced gene protein (INSIG)-dependent sterol regulation of Hmg2 endoplasmic reticulum-associated degradation (ERAD) in yeast. 2013 J. Biol. Chem. pmid:23306196
van der Burgh R et al. Mevalonate kinase deficiency, a metabolic autoinflammatory disease. 2013 Clin. Immunol. pmid:23110805
Hosaka A et al. Statins reduce amyloid β-peptide production by modulating amyloid precursor protein maturation and phosphorylation through a cholesterol-independent mechanism in cultured neurons. 2013 Neurochem. Res. pmid:23269484
Qi XF et al. HMG-CoA reductase inhibitors induce apoptosis of lymphoma cells by promoting ROS generation and regulating Akt, Erk and p38 signals via suppression of mevalonate pathway. 2013 Cell Death Dis pmid:23449454
Tricarico PM et al. Temperature and drug treatments in mevalonate kinase deficiency: an ex vivo study. 2013 Biomed Res Int pmid:24073415
Tyurin M Gene replacement and elimination using λRed- and FLP-based tool to re-direct carbon flux in acetogen biocatalyst during continuous CO₂/H₂ blend fermentation. 2013 J. Ind. Microbiol. Biotechnol. pmid:23649912
Martín-Navarro CM et al. Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and application of statins as a novel effective therapeutic approach against Acanthamoeba infections. 2013 Antimicrob. Agents Chemother. pmid:23114753
Zhang J et al. Statins directly suppress cytokine production in murine intraepithelial lymphocytes. 2013 Cytokine pmid:23290865
Rauthan M et al. The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23530189
Citron CA and Dickschat JS The stereochemical course of tricho-acorenol biosynthesis. 2013 Org. Biomol. Chem. pmid:24084795
Blanc M et al. The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response. 2013 Immunity pmid:23273843
Wang C et al. Engineered heterologous FPP synthases-mediated Z,E-FPP synthesis in E. coli. 2013 Metab. Eng. pmid:23608473
Yu W et al. The mevalonate auxotrophic mutant of Staphylococcus aureus can adapt to mevalonate depletion. 2013 Antimicrob. Agents Chemother. pmid:23959312
Szűcs G et al. Cardioprotection by farnesol: role of the mevalonate pathway. 2013 Cardiovasc Drugs Ther pmid:23673412
Ramak P et al. Inhibition of the mevalonate pathway enhances carvacrol biosynthesis and DXR gene expression in shoot cultures of Satureja khuzistanica Jamzad. 2013 J. Plant Physiol. pmid:23611428
Chen X et al. Statistical experimental design guided optimization of a one-pot biphasic multienzyme total synthesis of amorpha-4,11-diene. 2013 PLoS ONE pmid:24278153
Chang WC et al. Current development in isoprenoid precursor biosynthesis and regulation. 2013 Curr Opin Chem Biol pmid:23891475
Gopalan A et al. Simvastatin inhibition of mevalonate pathway induces apoptosis in human breast cancer cells via activation of JNK/CHOP/DR5 signaling pathway. 2013 Cancer Lett. pmid:22960596
Onono F et al. Efficient use of exogenous isoprenols for protein isoprenylation by MDA-MB-231 cells is regulated independently of the mevalonate pathway. 2013 J. Biol. Chem. pmid:23908355
Gopalan A et al. Eliminating drug resistant breast cancer stem-like cells with combination of simvastatin and gamma-tocotrienol. 2013 Cancer Lett. pmid:23063651
Liu J et al. Overproduction of geraniol by enhanced precursor supply in Saccharomyces cerevisiae. 2013 J. Biotechnol. pmid:24161921
Lee SK and Kim YS Phosphorylation of eIF2α attenuates statin-induced apoptosis by inhibiting the stabilization and translocation of p53 to the mitochondria. 2013 Int. J. Oncol. pmid:23354132
Valente AJ et al. Interleukin-18 enhances IL-18R/Nox1 binding, and mediates TRAF3IP2-dependent smooth muscle cell migration. Inhibition by simvastatin. 2013 Cell. Signal. pmid:23541442
Xiao H et al. Inhibition of Rho and Rac geranylgeranylation by atorvastatin is critical for preservation of endothelial junction integrity. 2013 PLoS ONE pmid:23555637
Villanueva JA et al. Resveratrol potentiates effect of simvastatin on inhibition of mevalonate pathway in human endometrial stromal cells. 2013 J. Clin. Endocrinol. Metab. pmid:23386644
May B et al. Biosynthesis of sesquiterpenes in grape berry exocarp of Vitis vinifera L.: evidence for a transport of farnesyl diphosphate precursors from plastids to the cytosol. 2013 Phytochemistry pmid:23954075
Zeng H et al. mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function. 2013 Nature pmid:23812589
Chen B et al. Alteration of mevalonate pathway related enzyme expressions in pressure overload-induced cardiac hypertrophy and associated heart failure with preserved ejection fraction. 2013 Cell. Physiol. Biochem. pmid:24356578
Dellas N et al. Discovery of a metabolic alternative to the classical mevalonate pathway. 2013 Elife pmid:24327557
Bruzzese F et al. Panobinostat synergizes with zoledronic acid in prostate cancer and multiple myeloma models by increasing ROS and modulating mevalonate and p38-MAPK pathways. 2013 Cell Death Dis pmid:24157872
Dick M et al. Statin therapy influences endothelial cell morphology and F-actin cytoskeleton structure when exposed to static and laminar shear stress conditions. 2013 Life Sci. pmid:23517776
Fang SY et al. Pleiotropic vascular protective effects of statins in perioperative medicine. 2013 Acta Anaesthesiol Taiwan pmid:24148741
Maciejak A et al. The effects of statins on the mevalonic acid pathway in recombinant yeast strains expressing human HMG-CoA reductase. 2013 BMC Biotechnol. pmid:24128347
Polidoro S et al. Effects of bisphosphonate treatment on DNA methylation in osteonecrosis of the jaw. 2013 Mutat. Res. pmid:23892139
Santolaria T et al. Repeated systemic administrations of both aminobisphosphonates and human Vγ9Vδ2 T cells efficiently control tumor development in vivo. 2013 J. Immunol. pmid:23836057
Werner M et al. Simvastatin-induced compartmentalisation of doxorubicin sharpens up nuclear topoisomerase II inhibition in human rhabdomyosarcoma cells. 2013 Naunyn Schmiedebergs Arch. Pharmacol. pmid:23564041
Zhu Y et al. Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases. 2013 Cell Death Dis pmid:23559002
Lee NY and Kang YS The effects of bisphosphonates on taurine transport in retinal capillary endothelial cells under high glucose conditions. 2013 Adv. Exp. Med. Biol. pmid:23392871
Corcos L and Le Jossic-Corcos C Statins: perspectives in cancer therapeutics. 2013 Dig Liver Dis pmid:23490341
Lesma E et al. Chromatin remodeling by rosuvastatin normalizes TSC2-/meth cell phenotype through the expression of tuberin. 2013 J. Pharmacol. Exp. Ther. pmid:23426956
Doblas VG et al. The SUD1 gene encodes a putative E3 ubiquitin ligase and is a positive regulator of 3-hydroxy-3-methylglutaryl coenzyme a reductase activity in Arabidopsis. 2013 Plant Cell pmid:23404890
Lazzerini PE et al. Rosuvastatin inhibits spontaneous and IL-1β-induced interleukin-6 production from human cultured osteoblastic cells. 2013 Joint Bone Spine pmid:22999910
Freed-Pastor WA et al. Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. 2012 Cell pmid:22265415
Angaman DM et al. Precursor uptake assays and metabolic analyses in isolated tomato fruit chromoplasts. 2012 Plant Methods pmid:22243738
Guo H et al. Rosuvastatin may modulate insulin signaling and inhibit atherogenesis beyond its plasma cholesterol-lowering effect in insulin-resistant mice. 2012 Cardiovasc Drugs Ther pmid:22918601
Nürenberg G and Volmer DA The analytical determination of isoprenoid intermediates from the mevalonate pathway. 2012 Anal Bioanal Chem pmid:21789486
Wu S et al. Engineering triterpene metabolism in tobacco. 2012 Planta pmid:22729821
Roy A et al. Sodium phenylbutyrate controls neuroinflammatory and antioxidant activities and protects dopaminergic neurons in mouse models of Parkinson's disease. 2012 PLoS ONE pmid:22723850
Ghavami S et al. Apoptosis, autophagy and ER stress in mevalonate cascade inhibition-induced cell death of human atrial fibroblasts. 2012 Cell Death Dis pmid:22717585