Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Prostatic Neoplasms D011471 126 associated lipids
Refsum Disease D012035 19 associated lipids
Thrombosis D013927 49 associated lipids
Xanthomatosis D014973 17 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

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All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
Sarrabayrouse G et al. Statins stimulate in vitro membrane FasL expression and lymphocyte apoptosis through RhoA/ROCK pathway in murine melanoma cells. 2007 Neoplasia pmid:18084615
Malenda A et al. Statins impair glucose uptake in tumor cells. 2012 Neoplasia pmid:22577346
Dimitroulakos J et al. Microarray and biochemical analysis of lovastatin-induced apoptosis of squamous cell carcinomas. 2002 Jul-Aug Neoplasia pmid:12082550
Kimachi K et al. Zoledronic acid inhibits RANK expression and migration of osteoclast precursors during osteoclastogenesis. 2011 Naunyn Schmiedebergs Arch. Pharmacol. pmid:21225243
Werner M et al. Simvastatin-induced compartmentalisation of doxorubicin sharpens up nuclear topoisomerase II inhibition in human rhabdomyosarcoma cells. 2013 Naunyn Schmiedebergs Arch. Pharmacol. pmid:23564041
Ro DK et al. Production of the antimalarial drug precursor artemisinic acid in engineered yeast. 2006 Nature pmid:16612385
Liu Y et al. Caenorhabditis elegans pathways that surveil and defend mitochondria. 2014 Nature pmid:24695221
Zeng H et al. mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function. 2013 Nature pmid:23812589
Goldstein JL and Brown MS Regulation of the mevalonate pathway. 1990 Nature pmid:1967820
Palinski W Immunomodulation: a new role for statins? 2000 Nat. Med. pmid:11100105
Yeger-Lotem E et al. Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity. 2009 Nat. Genet. pmid:19234470
Sorrentino G et al. Metabolic control of YAP and TAZ by the mevalonate pathway. 2014 Nat. Cell Biol. pmid:24658687
Parrales A et al. DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway. 2016 Nat. Cell Biol. pmid:27775703
Dueber JE et al. Synthetic protein scaffolds provide modular control over metabolic flux. 2009 Nat. Biotechnol. pmid:19648908
Cárdenas PD et al. GAME9 regulates the biosynthesis of steroidal alkaloids and upstream isoprenoids in the plant mevalonate pathway. 2016 Nat Commun pmid:26876023
Xu L et al. [Effects of simvastatin on DNA synthesis in rat cardiac fibroblasts]. 2006 Nan Fang Yi Ke Da Xue Xue Bao pmid:16503530
Haas D and Hoffmann GF Mevalonate kinase deficiency and autoinflammatory disorders. 2007 N. Engl. J. Med. pmid:17596600
Arkwright PD et al. Mevalonic aciduria cured by bone marrow transplantation. 2007 N. Engl. J. Med. pmid:17898110
Neven B et al. Allogeneic bone marrow transplantation in mevalonic aciduria. 2007 N. Engl. J. Med. pmid:17596604
Hoffmann G et al. Mevalonic aciduria--an inborn error of cholesterol and nonsterol isoprene biosynthesis. 1986 N. Engl. J. Med. pmid:3012338
Polidoro S et al. Effects of bisphosphonate treatment on DNA methylation in osteonecrosis of the jaw. 2013 Mutat. Res. pmid:23892139
Baker SK Molecular clues into the pathogenesis of statin-mediated muscle toxicity. 2005 Muscle Nerve pmid:15712281
Chen Q et al. Molecular Cloning, Characterization, and Functional Analysis of Acetyl-CoA C-Acetyltransferase and Mevalonate Kinase Genes Involved in Terpene Trilactone Biosynthesis from Ginkgo biloba. 2017 Molecules pmid:28045448
Cheng S et al. Cloning, Expression Profiling and Functional Analysis of CnHMGS, a Gene Encoding 3-hydroxy-3-Methylglutaryl Coenzyme A Synthase from Chamaemelum nobile. 2016 Molecules pmid:27005600
Du X et al. Nitric Oxide Plays a Central Role in Water Stress-Induced Tanshinone Production in Salvia miltiorrhiza Hairy Roots. 2015 Molecules pmid:25919278
Coxon FP et al. Protein synthesis is required for caspase activation and induction of apoptosis by bisphosphonate drugs. 1998 Mol. Pharmacol. pmid:9765505
Paintlia AS et al. Inhibition of rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis. 2008 Mol. Pharmacol. pmid:18239032
Reszka AA et al. Nitrogen-bisphosphonates block retinoblastoma phosphorylation and cell growth by inhibiting the cholesterol biosynthetic pathway in a keratinocyte model for esophageal irritation. 2001 Mol. Pharmacol. pmid:11160853
Li L et al. Inhibitory effect of fluvastatin on lysophosphatidylcholine-induced nonselective cation current in Guinea pig ventricular myocytes. 2002 Mol. Pharmacol. pmid:12181436
Hooff GP et al. Modulation of cholesterol, farnesylpyrophosphate, and geranylgeranylpyrophosphate in neuroblastoma SH-SY5Y-APP695 cells: impact on amyloid beta-protein production. 2010 Mol. Neurobiol. pmid:20405344
Boucher Y et al. Origins and evolution of isoprenoid lipid biosynthesis in archaea. 2004 Mol. Microbiol. pmid:15066037
Agabiti SS et al. Molecular mechanisms linking geranylgeranyl diphosphate synthase to cell survival and proliferation. 2016 Mol. Membr. Biol. pmid:27537059
Nwokoro NA et al. Genetic disorders of cholesterol biosynthesis in mice and humans. 2001 Sep-Oct Mol. Genet. Metab. pmid:11592808
García-Román N et al. Lovastatin induces apoptosis of spontaneously immortalized rat brain neuroblasts: involvement of nonsterol isoprenoid biosynthesis inhibition. 2001 Mol. Cell. Neurosci. pmid:11178870
Martín D et al. Inhibition of vitellogenin production by allatostatin in the German cockroach. 1996 Mol. Cell. Endocrinol. pmid:8892320
Lasa M et al. Lovastatin decreases prolactin and growth hormone gene expression in GH4C1 cells through a cAMP dependent mechanism. 1997 Mol. Cell. Endocrinol. pmid:9220025
Couillaud F Evidence for regulation of juvenile hormone biosynthesis operating before mevalonate in locust corpora allata. 1991 Mol. Cell. Endocrinol. pmid:1815999
Gertler FB et al. Developmental and metabolic regulation of the Drosophila melanogaster 3-hydroxy-3-methylglutaryl coenzyme A reductase. 1988 Mol. Cell. Biol. pmid:3136321
Kim R et al. Prenylation of mammalian Ras protein in Xenopus oocytes. 1990 Mol. Cell. Biol. pmid:2233726
Masuda A et al. Chinese hamster cell mutant resistant to ML236B (Compactin) is defective in endocytosis of low-density lipo-protein. 1982 Mol. Cell. Biol. pmid:7162516
Zelcer N et al. The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway. 2014 Mol. Cell. Biol. pmid:24449766
Dimster-Denk D and Rine J Transcriptional regulation of a sterol-biosynthetic enzyme by sterol levels in Saccharomyces cerevisiae. 1996 Mol. Cell. Biol. pmid:8754796
Lambert M and Bui ND Dexamethasone-induced decrease in HMG-CoA reductase and protein-farnesyl transferase activities does not impair ras processing in AR 4-2J cells. 1999 Mol. Cell. Biochem. pmid:10706000
Chmielewski M et al. Diurnal rhythm of cholesterol biosynthesis in experimental chronic renal failure. 2001 Mol. Cell. Biochem. pmid:11855739
Kaul D and Kaur M Receptor-Ck regulates the expression of cyclin-dependent kinase inhibitors (p16; p27). 1999 Mol. Cell. Biochem. pmid:10569199
Kaur M et al. Receptor-Ck-dependent regulation of genes involved in the cell cycle. 1998 Mol. Cell. Biochem. pmid:9562250
Osman L et al. Atorvastatin accelerates extracellular nucleotide degradation in human endothelial cells. 2008 Mol. Cell. Biochem. pmid:18158588
Goldman AR et al. The Primary Effect on the Proteome of ARID1A-mutated Ovarian Clear Cell Carcinoma is Downregulation of the Mevalonate Pathway at the Post-transcriptional Level. 2016 Mol. Cell Proteomics pmid:27654507
Jiang XS et al. Quantitative proteomics analysis of inborn errors of cholesterol synthesis: identification of altered metabolic pathways in DHCR7 and SC5D deficiency. 2010 Mol. Cell Proteomics pmid:20305089
Sever N et al. Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain. 2003 Mol. Cell pmid:12535518