Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Prostatic Neoplasms D011471 126 associated lipids
Refsum Disease D012035 19 associated lipids
Thrombosis D013927 49 associated lipids
Xanthomatosis D014973 17 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

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Per page 10 20 50 100 | Total 2899
Authors Title Published Journal PubMed Link
Ota K et al. Effect of pitavastatin on transactivation of human serum paraoxonase 1 gene. 2005 Metab. Clin. Exp. pmid:15690306
Cuzzopoli M et al. Effect of nephrectomy and cholesterol feeding on the metabolism of intravenously administered DL-mevalonate in the rat. 1972 Metab. Clin. Exp. pmid:4641957
Lala A et al. Apolipoprotein E genotype and cholesterogenesis in polygenic hypercholesterolemia. 1998 Metab. Clin. Exp. pmid:9440485
Bortz WM On the control of cholesterol synthesis. 1973 Metab. Clin. Exp. pmid:4206254
Watts GF et al. Direct correlation between cholesterol synthesis and hepatic secretion of apolipoprotein B-100 in normolipidemic subjects. 1995 Metab. Clin. Exp. pmid:7637647
Golper TA and Swartz SH Impaired renal mevalonate metabolism in nephrotic syndrome: a stimulus for increased hepatic cholesterogenesis independent of GFR and hypoalbuminemia. 1982 Metab. Clin. Exp. pmid:7078427
Lindenthal B and von Bergmann K Urinary excretion and serum concentration of mevalonic acid during acute intake of alcohol. 2000 Metab. Clin. Exp. pmid:10647065
Beg ZH et al. Modulation of the enzymic activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase by multiple kinase systems involving reversible phosphorylation: a review. 1987 Metab. Clin. Exp. pmid:3306282
AZARNOFF DL et al. STUDIES WITH ETHYL CHLOROPHENOXYISOBUTYRATE (CLOFIBRATE). 1965 Metab. Clin. Exp. pmid:14327272
Ellsworth JL and Starr JR Inhibition of acyl coenzyme A:cholesterol acyltransferase blocks esterification but not uptake of cholesterol in Caco-2 cells. 1998 Metab. Clin. Exp. pmid:9500571
Sodhi HS et al. Effects of chlorophenoxyisobutyrate on the synthesis and metabolism of cholesterol in man. 1971 Metab. Clin. Exp. pmid:5550302
Barter PJ and Lally JI In vitro exchanges of esterified cholesterol between serum lipoprotein fractions: studies of humans and rabbits. 1979 Metab. Clin. Exp. pmid:216885
Sodhi HS and Kudchodkar BJ Synthesis of cholesterol in hypercholesterolemia and its relationship to plasma trigylcerides. 1973 Metab. Clin. Exp. pmid:4351067
Jenkins DJ et al. Effect of a very-high-fiber vegetable, fruit, and nut diet on serum lipids and colonic function. 2001 Metab. Clin. Exp. pmid:11288049
Ledezma E et al. Potentiated cytotoxic effects of statins and ajoene in murine melanoma cells. 2009 Melanoma Res. pmid:19276863
Saito A et al. Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells. 2008 Melanoma Res. pmid:18337644
Kocsis GF et al. Expression of genes related to oxidative/nitrosative stress in mouse hearts: effect of preconditioning and cholesterol diet. 2010 Med. Sci. Monit. pmid:20037483
Simpkins C Thyroid hormone in biological rhythms. 1983 Med. Hypotheses pmid:6318057
Dincer M et al. Statins may decrease skeletal-related events in breast cancer patients with bone metastases. 2006 Med. Hypotheses pmid:16844315
McCarty MF Current prospects for controlling cancer growth with non-cytotoxic agents--nutrients, phytochemicals, herbal extracts, and available drugs. 2001 Med. Hypotheses pmid:11425277
Catros V et al. [Tgammadelta lymphocytes in oncology: unconventional killer lymphocytes]. 2010 Med Sci (Paris) pmid:20188051
Camps D [Controversies regarding the use of statins in the acute coronary syndrome]. 2010 Aug-Sep Med Intensiva pmid:20538377
Marino M et al. Age-related changes of cholesterol and dolichol biosynthesis in rat liver. 2002 Mech. Ageing Dev. pmid:12044967
Choi YS et al. Effects of short-term cholestyramine feeding on cholesterol metabolism in differently aged rats. 1987 Mech. Ageing Dev. pmid:3431166
Andersson M et al. Age-dependent modifications in the metabolism of mevalonate pathway lipids in rat brain. 1995 Mech. Ageing Dev. pmid:8789251
Guella G et al. Structures, biological activities and phylogenetic relationships of terpenoids from marine ciliates of the genus Euplotes. 2010 Mar Drugs pmid:20714425
de Oliveira LS et al. New Insights on the terpenome of the red seaweed Laurencia dendroidea (Florideophyceae, Rhodophyta). 2015 Mar Drugs pmid:25675000
Bevilacqua M et al. Bisphosphonates and atherosclerosis: why? 2005 Lupus pmid:16218486
Aprigliano I et al. Atorvastatin induces apoptosis by a caspase-9-dependent pathway: an in vitro study on activated rat hepatic stellate cells. 2008 Liver Int. pmid:18339080
Keizer HG The "Mevalonate hypothesis": a cholesterol-independent alternative for the etiology of atherosclerosis. 2012 Lipids Health Dis pmid:23122424
Rauthan M and Pilon M The mevalonate pathway in C. elegans. 2011 Lipids Health Dis pmid:22204706
Chen Y et al. Mevalonate inhibits acid sphingomyelinase activity, increases sphingomyelin levels and inhibits cell proliferation of HepG2 and Caco-2 cells. 2015 Lipids Health Dis pmid:26493087
Ohukainen P If the wheel ain't broke, don't reinvent it. 2013 Lipids Health Dis pmid:23577775
Wong J et al. Synthesis of the oxysterol, 24(S), 25-epoxycholesterol, parallels cholesterol production and may protect against cellular accumulation of newly-synthesized cholesterol. 2007 Lipids Health Dis pmid:17408498
Silvander M et al. A new water-based topical carrier with polar skin-lipids. 2006 Lipids Health Dis pmid:16672068
Udagawa H et al. Increase of serum cholesterol levels by heat-moisture-treated high-amylose cornstarch in rats fed a high-cholesterol diet. 2008 Lipids pmid:18509689
Montero-Villegas S et al. Inhibition of Mevalonate Pathway and Synthesis of the Storage Lipids in Human Liver-Derived and Non-liver Cell Lines by Lippia alba Essential Oils. 2017 Lipids pmid:27905068
Wali VB et al. Suppression in mevalonate synthesis mediates antitumor effects of combined statin and gamma-tocotrienol treatment. 2009 Lipids pmid:19777282
Satoh T et al. The effects of pravastatin, an HMG-CoA reductase inhibitor, on cell viability and DNA production of rat hepatocytes. 1996 Life Sci. pmid:8831797
Dick M et al. Statin therapy influences endothelial cell morphology and F-actin cytoskeleton structure when exposed to static and laminar shear stress conditions. 2013 Life Sci. pmid:23517776
Mönkkönen H et al. Zoledronic acid-induced IPP/ApppI production in vivo. 2007 Life Sci. pmid:17850825
Mathew B and Biju R Neuroprotective effects of garlic a review. 2008 Libyan J Med pmid:21499478
Burke LP and Kukoly CA Statins induce lethal effects in acute myeloblastic leukemia [corrected] cells within 72 hours. 2008 Leuk. Lymphoma pmid:18231920
Betteridge DJ et al. Compactin inhibits cholesterol synthesis in lymphocytes and intestinal mucosa from patients with familial hypercholesterolaemia. 1978 Dec 23-30 Lancet pmid:82843
Lewis LS Statins, cholesterol, and mevalonate pathways? 1996 Lancet pmid:8596303
Buchwald H Cholesterol inhibition, cancer, and chemotherapy. 1992 Lancet pmid:1349377
Massy ZA et al. Inhibition of the mevalonate pathway: benefits beyond cholesterol reduction? 1996 Lancet pmid:8538301
Yoon HE and Yang CW Established and newly proposed mechanisms of chronic cyclosporine nephropathy. 2009 Korean J. Intern. Med. pmid:19543484
Youn YN et al. Impact of High-Dose Statin Pretreatment in Patients with Stable Angina during Off-Pump Coronary Artery Bypass. 2011 Korean J Thorac Cardiovasc Surg pmid:22263153
Christensen M et al. Simvastatin protection against acute immune-mediated glomerulonephritis in mice. 2006 Kidney Int. pmid:16407885