Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Adrenoleukodystrophy D000326 29 associated lipids
Refsum Disease D012035 19 associated lipids
Leukemia D007938 74 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Hypertension D006973 115 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Glioblastoma D005909 27 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

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All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
Li Z et al. Effect of temperature on postillumination isoprene emission in oak and poplar. 2011 Plant Physiol. pmid:21177471
Singh NK et al. 12/15-Lipoxygenase gene knockout severely impairs ischemia-induced angiogenesis due to lack of Rac1 farnesylation. 2011 Blood pmid:21841162
Yu F et al. Zingiber zerumbet CYP71BA1 catalyzes the conversion of α-humulene to 8-hydroxy-α-humulene in zerumbone biosynthesis. 2011 Cell. Mol. Life Sci. pmid:20730551
Luo H et al. Analysis of the transcriptome of Panax notoginseng root uncovers putative triterpene saponin-biosynthetic genes and genetic markers. 2011 BMC Genomics pmid:22369100
Youn YN et al. Impact of High-Dose Statin Pretreatment in Patients with Stable Angina during Off-Pump Coronary Artery Bypass. 2011 Korean J Thorac Cardiovasc Surg pmid:22263153
Odom AR Five questions about non-mevalonate isoprenoid biosynthesis. 2011 PLoS Pathog. pmid:22216001
Rauthan M and Pilon M The mevalonate pathway in C. elegans. 2011 Lipids Health Dis pmid:22204706
Barrero RA et al. De novo assembly of Euphorbia fischeriana root transcriptome identifies prostratin pathway related genes. 2011 BMC Genomics pmid:22151917
Leszczynska A et al. Different statins produce highly divergent changes in gene expression profiles of human hepatoma cells: a pilot study. 2011 Acta Biochim. Pol. pmid:22132374
Nes WD Biosynthesis of cholesterol and other sterols. 2011 Chem. Rev. pmid:21902244
Bergman P et al. Studies on the antibacterial effects of statins--in vitro and in vivo. 2011 PLoS ONE pmid:21912631
Emma F et al. Renal mitochondrial cytopathies. 2011 Int J Nephrol pmid:21811680
Ageenko NV et al. Expression of Pigment Cell-Specific Genes in the Ontogenesis of the Sea Urchin Strongylocentrotus intermedius. 2011 Evid Based Complement Alternat Med pmid:21804858
Cheng G et al. Mitochondria-targeted nitroxides exacerbate fluvastatin-mediated cytostatic and cytotoxic effects in breast cancer cells. 2011 Cancer Biol. Ther. pmid:21799303
Katuru R et al. Mevalonate depletion mediates the suppressive impact of geranylgeraniol on murine B16 melanoma cells. 2011 Exp. Biol. Med. (Maywood) pmid:21540247
Peng LF et al. Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits 3-hydroxy-3-methylglutaryl-coenzyme A synthase. 2011 J. Infect. Dis. pmid:21791663
Bajgain P et al. Transcriptome characterization and polymorphism detection between subspecies of big sagebrush (Artemisia tridentata). 2011 BMC Genomics pmid:21767398
Scheller EL et al. Zoledronic acid inhibits macrophage SOCS3 expression and enhances cytokine production. 2011 J. Cell. Biochem. pmid:21751240
Sun S and McKenna CE Farnesyl pyrophosphate synthase modulators: a patent review (2006 - 2010). 2011 Expert Opin Ther Pat pmid:21702715
Rizzo WB The role of fatty aldehyde dehydrogenase in epidermal structure and function. 2011 Dermatoendocrinol pmid:21695018
Waldron J and Webster C Liquid chromatography-tandem mass spectrometry method for the measurement of serum mevalonic acid: a novel marker of hydroxymethylglutaryl coenzyme A reductase inhibition by statins. 2011 Ann. Clin. Biochem. pmid:21355014
Tsang A et al. Francisella tularensis 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase: kinetic characterization and phosphoregulation. 2011 PLoS ONE pmid:21694781
Sivy TL et al. Evidence of isoprenoid precursor toxicity in Bacillus subtilis. 2011 Biosci. Biotechnol. Biochem. pmid:22146731
Han J et al. Alteration of enzyme expressions in mevalonate pathway: possible role for cardiovascular remodeling in spontaneously hypertensive rats. 2011 Circ. J. pmid:21467659
Song JX et al. Simvastatin reduces lipoprotein-associated phospholipase A2 in lipopolysaccharide-stimulated human monocyte-derived macrophages through inhibition of the mevalonate-geranylgeranyl pyrophosphate-RhoA-p38 mitogen-activated protein kinase pathway. 2011 J. Cardiovasc. Pharmacol. pmid:21052011
Siddals KW et al. Apposite insulin-like growth factor (IGF) receptor glycosylation is critical to the maintenance of vascular smooth muscle phenotype in the presence of factors promoting osteogenic differentiation and mineralization. 2011 J. Biol. Chem. pmid:21454560
Brock NL et al. Biosynthesis of sesqui- and diterpenes by the gibberellin producer Fusarium fujikuroi. 2011 Chembiochem pmid:21990128
Soliman SS et al. Chemical inhibitors suggest endophytic fungal paclitaxel is derived from both mevalonate and non-mevalonate-like pathways. 2011 J. Nat. Prod. pmid:22103292
Mongélard G et al. Measurement of carbon flux through the MEP pathway for isoprenoid synthesis by (31)P-NMR spectroscopy after specific inhibition of 2-C-methyl-d-erythritol 2,4-cyclodiphosphate reductase. Effect of light and temperature. 2011 Plant Cell Environ. pmid:21443577
Zhang B et al. A second target of the antimalarial and antibacterial agent fosmidomycin revealed by cellular metabolic profiling. 2011 Biochemistry pmid:21438569
Henneman L et al. Inhibition of the isoprenoid biosynthesis pathway; detection of intermediates by UPLC-MS/MS. 2011 Biochim. Biophys. Acta pmid:21237288
Kim RH et al. Bisphosphonates induce senescence in normal human oral keratinocytes. 2011 J. Dent. Res. pmid:21427353
Kyathanahalli CN and Kowluru A A farnesylated G-protein suppresses Akt phosphorylation in INS 832/13 cells and normal rat islets: regulation by pertussis toxin and PGEâ‚‚. 2011 Biochem. Pharmacol. pmid:21406184
Zhao Y et al. Statins downregulate K6a promoter activity: a possible therapeutic avenue for pachyonychia congenita. 2011 J. Invest. Dermatol. pmid:21390048
Blankier S et al. The role of atorvastatin in regulating the immune response leading to vascular damage in a model of Kawasaki disease. 2011 Clin. Exp. Immunol. pmid:21361911
Ghavami S et al. Mevalonate cascade regulation of airway mesenchymal cell autophagy and apoptosis: a dual role for p53. 2011 PLoS ONE pmid:21304979
Ignea C et al. Improving yeast strains using recyclable integration cassettes, for the production of plant terpenoids. 2011 Microb. Cell Fact. pmid:21276210
Tuckow AP et al. Simvastatin represses protein synthesis in the muscle-derived C₂C₁₂ cell line with a concomitant reduction in eukaryotic initiation factor 2B expression. 2011 Am. J. Physiol. Endocrinol. Metab. pmid:21224482
Tsubaki M et al. Blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathways by statins reduces the expression of bFGF, HGF, and TGF-β as angiogenic factors in mouse osteosarcoma. 2011 Cytokine pmid:21292498
Sawai S and Saito K Triterpenoid biosynthesis and engineering in plants. 2011 Front Plant Sci pmid:22639586
Hong C et al. Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. 2011 J. Lipid Res. pmid:21187453
Nishikawa Y et al. Host cholesterol synthesis contributes to growth of intracellular Toxoplasma gondii in macrophages. 2011 J. Vet. Med. Sci. pmid:21187676
Tsuyuki R et al. Enhancement of trichothecene production in Fusarium graminearum by cobalt chloride. 2011 J. Agric. Food Chem. pmid:21299216
Li YY et al. Zoledronic acid induces cell-cycle prolongation in murine lung cancer cells by perturbing cyclin and Ras expression. 2011 Anticancer Drugs pmid:20926944
Nilsson S et al. Mevalonate pathway inhibitors affect anticancer drug-induced cell death and DNA damage response of human sarcoma cells. 2011 Cancer Lett. pmid:21356574
Liu Q et al. Reconstitution of the costunolide biosynthetic pathway in yeast and Nicotiana benthamiana. 2011 PLoS ONE pmid:21858047
Epplen R et al. Differential effects of ibandronate, docetaxel and farnesol treatment alone and in combination on the growth of prostate cancer cell lines. 2011 Acta Oncol pmid:20429730
Jouneau S et al. Anti-inflammatory effect of fluvastatin on IL-8 production induced by Pseudomonas aeruginosa and Aspergillus fumigatus antigens in cystic fibrosis. 2011 PLoS ONE pmid:21826199
Lin Y et al. Triterpenic Acids Present in Hawthorn Lower Plasma Cholesterol by Inhibiting Intestinal ACAT Activity in Hamsters. 2011 Evid Based Complement Alternat Med pmid:19228775
Murtola TJ et al. Comparative effects of high and low-dose simvastatin on prostate epithelial cells: the role of LDL. 2011 Eur. J. Pharmacol. pmid:22040920
Issat T et al. Antitumor effects of the combination of cholesterol reducing drugs. 2011 Oncol. Rep. pmid:21491092
Varman AM et al. Statistics-based model for prediction of chemical biosynthesis yield from Saccharomyces cerevisiae. 2011 Microb. Cell Fact. pmid:21689458
Castella B et al. Immune modulation by zoledronic acid in human myeloma: an advantageous cross-talk between Vγ9Vδ2 T cells, αβ CD8+ T cells, regulatory T cells, and dendritic cells. 2011 J. Immunol. pmid:21753152
Okada K The biosynthesis of isoprenoids and the mechanisms regulating it in plants. 2011 Biosci. Biotechnol. Biochem. pmid:21737944
Kim YS et al. Increase of lycopene production by supplementing auxiliary carbon sources in metabolically engineered Escherichia coli. 2011 Appl. Microbiol. Biotechnol. pmid:21246354
Jang HJ et al. Retinoid production using metabolically engineered Escherichia coli with a two-phase culture system. 2011 Microb. Cell Fact. pmid:21801353
Schaafsma D et al. Simvastatin inhibits TGFβ1-induced fibronectin in human airway fibroblasts. 2011 Respir. Res. pmid:21864337
Leichner GS et al. Metabolically regulated endoplasmic reticulum-associated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase: evidence for requirement of a geranylgeranylated protein. 2011 J. Biol. Chem. pmid:21778231
Simkin AJ et al. Peroxisomal localisation of the final steps of the mevalonic acid pathway in planta. 2011 Planta pmid:21655959
Yanae M et al. Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma. 2011 J. Exp. Clin. Cancer Res. pmid:21831290
Maki KC et al. Effects of soy protein on lipoprotein lipids and fecal bile acid excretion in men and women with moderate hypercholesterolemia. 2010 Nov-Dec J Clin Lipidol pmid:21122701
Camps D [Controversies regarding the use of statins in the acute coronary syndrome]. 2010 Aug-Sep Med Intensiva pmid:20538377
Omar SH Oleuropein in olive and its pharmacological effects. 2010 Apr-Jun Sci Pharm pmid:21179340
Fukunaga M et al. Mast cell death induced by 24(S),25-epoxycholesterol. 2010 Exp. Cell Res. pmid:20854813
Bouvier-Navé P et al. Involvement of the phospholipid sterol acyltransferase1 in plant sterol homeostasis and leaf senescence. 2010 Plant Physiol. pmid:19923239
Deichmann R et al. Coenzyme q10 and statin-induced mitochondrial dysfunction. 2010 Ochsner J pmid:21603349
Stapleton PA et al. Hypercholesterolemia and microvascular dysfunction: interventional strategies. 2010 J Inflamm (Lond) pmid:21087503
Martin DM et al. Functional annotation, genome organization and phylogeny of the grapevine (Vitis vinifera) terpene synthase gene family based on genome assembly, FLcDNA cloning, and enzyme assays. 2010 BMC Plant Biol. pmid:20964856
González-Candelas L et al. A transcriptomic approach highlights induction of secondary metabolism in citrus fruit in response to Penicillium digitatum infection. 2010 BMC Plant Biol. pmid:20807411
Jarrell KF et al. S-layer glycoproteins and flagellins: reporters of archaeal posttranslational modifications. 2010 Archaea pmid:20721273
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Guella G et al. Structures, biological activities and phylogenetic relationships of terpenoids from marine ciliates of the genus Euplotes. 2010 Mar Drugs pmid:20714425
Jana S and Shekhawat GS Anethum graveolens: An Indian traditional medicinal herb and spice. 2010 Pharmacogn Rev pmid:22228959
Zheng Z et al. Improvement of retinal vascular injury in diabetic rats by statins is associated with the inhibition of mitochondrial reactive oxygen species pathway mediated by peroxisome proliferator-activated receptor gamma coactivator 1alpha. 2010 Diabetes pmid:20566666
Liu Q et al. Dynamics of lamin-A processing following precursor accumulation. 2010 PLoS ONE pmid:20526372
Aoyama T et al. Pharmacokinetic/pharmacodynamic modeling and simulation of rosuvastatin using an extension of the indirect response model by incorporating a circadian rhythm. 2010 Biol. Pharm. Bull. pmid:20522984
Jameson JM et al. A role for the mevalonate pathway in the induction of subtype cross-reactive immunity to influenza A virus by human gammadelta T lymphocytes. 2010 Cell. Immunol. pmid:20483407
Yamauchi N The pathway of leucine to mevalonate in halophilic archaea: efficient incorporation of leucine into isoprenoidal lipid with the involvement of isovaleryl-CoA dehydrogenase in Halobacterium salinarum. 2010 Biosci. Biotechnol. Biochem. pmid:20139592
Olson AL et al. NMR dynamics investigation of ligand-induced changes of main and side-chain arginine N-H's in human phosphomevalonate kinase. 2010 J. Am. Chem. Soc. pmid:20112895
Kowluru A et al. Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells. 2010 Diabetes pmid:20071600
Kiran U et al. Structural and functional characterization of HMG-COA reductase from Artemisia annua. 2010 Bioinformation pmid:21364776
Domoki F et al. Rosuvastatin induces delayed preconditioning against L-glutamate excitotoxicity in cultured cortical neurons. 2010 Neurochem. Int. pmid:19931334
De Leo L et al. Targeting farnesyl-transferase as a novel therapeutic strategy for mevalonate kinase deficiency: in vitro and in vivo approaches. 2010 Pharmacol. Res. pmid:20206266
Tisch D and Schmoll M Light regulation of metabolic pathways in fungi. 2010 Appl. Microbiol. Biotechnol. pmid:19915832
Kojima Y et al. Pitavastatin decreases the expression of endothelial lipase both in vitro and in vivo. 2010 Cardiovasc. Res. pmid:20045866
Liu YJ et al. Simvastatin ameliorates rat cerebrovascular remodeling during hypertension via inhibition of volume-regulated chloride channel. 2010 Hypertension pmid:20644009
Mitrofan LM et al. Lysosomal-mitochondrial axis in zoledronic acid-induced apoptosis in human follicular lymphoma cells. 2010 J. Biol. Chem. pmid:19875454
Rossi J et al. Laminar shear stress prevents simvastatin-induced adhesion molecule expression in cytokine activated endothelial cells. 2010 Eur. J. Pharmacol. pmid:20863785
Kaneda T et al. Statins inhibited erythropoietin-induced proliferation of rat vascular smooth muscle cells. 2010 Eur. J. Pharmacol. pmid:20851116
Singh RS et al. Expression of 3-hydroxy-3-methylglutaryl-CoA reductase, p-hydroxybenzoate-m-geranyltransferase and genes of phenylpropanoid pathway exhibits positive correlation with shikonins content in arnebia [Arnebia euchroma (Royle) Johnston]. 2010 BMC Mol. Biol. pmid:21092138
Chang TH et al. Structure of a heterotetrameric geranyl pyrophosphate synthase from mint (Mentha piperita) reveals intersubunit regulation. 2010 Plant Cell pmid:20139160
Quist-Paulsen P Statins and inflammation: an update. 2010 Curr. Opin. Cardiol. pmid:20421792
Kassan M et al. In vitro antioxidant activity of pravastatin provides vascular protection. 2010 Eur. J. Pharmacol. pmid:20044990
Kocsis GF et al. Expression of genes related to oxidative/nitrosative stress in mouse hearts: effect of preconditioning and cholesterol diet. 2010 Med. Sci. Monit. pmid:20037483
Hooff GP et al. Modulation of cholesterol, farnesylpyrophosphate, and geranylgeranylpyrophosphate in neuroblastoma SH-SY5Y-APP695 cells: impact on amyloid beta-protein production. 2010 Mol. Neurobiol. pmid:20405344
Woo IS et al. Farnesyl diphosphate synthase attenuates paclitaxel-induced apoptotic cell death in human glioblastoma U87MG cells. 2010 Neurosci. Lett. pmid:20298756
Asadollahi MA et al. Enhancement of farnesyl diphosphate pool as direct precursor of sesquiterpenes through metabolic engineering of the mevalonate pathway in Saccharomyces cerevisiae. 2010 Biotechnol. Bioeng. pmid:20091767
Lee SK et al. Stabilization and translocation of p53 to mitochondria is linked to Bax translocation to mitochondria in simvastatin-induced apoptosis. 2010 Biochem. Biophys. Res. Commun. pmid:20043868
Kudoh T et al. Mevalonate analogues as substrates of enzymes in the isoprenoid biosynthetic pathway of Streptococcus pneumoniae. 2010 Bioorg. Med. Chem. pmid:20056424
Boo KH et al. Distribution and biosynthesis of 20-hydroxyecdysone in plants of Achyranthes japonica Nakai. 2010 Biosci. Biotechnol. Biochem. pmid:21071854