| MeSH term | MeSH ID | Detail |
|---|---|---|
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
Mevalonic acid
Mevalonic acid is a lipid of Fatty Acyls (FA) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.
Here are additional resources we collected from PubChem and MeSH for Mevalonic acid
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Mevalonic acid
PubChem Biomolecular Interactions and Pathways
NCBI Entrez Crosslinks
All references with Mevalonic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Rao KS and Olson RE | The effect of exogenous cholesterol on the synthesis in vivo of cholesterol, ubiquinone, and squalene in rat liver. | 1967 | Biochem. Biophys. Res. Commun. | pmid:6030977 |
| Keller RK and Simonet WS | Near normal levels of isoprenoid lipids in severe mevalonic aciduria. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3365255 |
| Bhat CS and Ramasarma T | Rhythmic activity of utilization of mevalonate for biogenesis of cholesterol. | 1977 | Biochem. Biophys. Res. Commun. | pmid:836326 |
| Sekler MS and Simoni RD | Mutation in the lumenal part of the membrane domain of HMG-CoA reductase alters its regulated degradation. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7818519 |
| Zanotti I et al. | Pitavastatin increases ABCA1-mediated lipid efflux from Fu5AH rat hepatoma cells. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15358158 |
| Gaskin F and Clayton RB | Decreased availability of hepatic NADPH in stressed mice. | 1972 | Biochem. Biophys. Res. Commun. | pmid:4400445 |
| Swell L et al. | Rapid feedback inhibition of endogenous cholic and chenodeoxycholic acid synthesis by exogenous chenodeoxycholic acid in man. | 1975 | Biochem. Biophys. Res. Commun. | pmid:1147960 |
| Tatsuno I et al. | Geranylgeranylpyrophosphate, a metabolite of mevalonate, regulates the cell cycle progression and DNA synthesis in human lymphocytes. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9425279 |
| Dunnington DJ et al. | Stimulation of anchorage independent proliferation of human adrenocortical carcinoma cells by inhibition of cholesterol biosynthesis. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2590222 |
| Alvarez de Sotomayor M and Andriantsitohaina R | Simvastatin and Ca(2+) signaling in endothelial cells: involvement of rho protein. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11162544 |
| Flach J et al. | The mevalonate/isoprenoid pathway inhibitor apomine (SR-45023A) is antiproliferative and induces apoptosis similar to farnesol. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10733934 |
| Shang F et al. | Simvastatin inhibits lipopolysaccharide-induced tumor necrosis factor-alpha expression in neonatal rat cardiomyocytes: The role of reactive oxygen species. | 2006 | Biochem. Biophys. Res. Commun. | pmid:17094942 |
| Chesterton CJ | The subcellular site of cholesterol synthesis in rat liver. | 1966 | Biochem. Biophys. Res. Commun. | pmid:5971766 |
| Polo MP and de Bravo MG | Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2. | 2006 | Biochem. Cell Biol. | pmid:16462894 |
| Polo MP et al. | Effect of ethanol on cell growth and cholesterol metabolism in cultured Hep G2 cells. | 2003 | Biochem. Cell Biol. | pmid:14663504 |
| Silber JR et al. | The effect of mevalonic acid deprivation on enzymes of DNA replication in cells emerging from quiescence. | 1992 | Biochem. J. | pmid:1281982 |
| Malathi P and Ganguly J | Studies on metabolism of vitamin A. 8. Effect of ascorbate on isoprenoid metabolism in vitamin A-deficient rats. | 1964 | Biochem. J. | pmid:5837438 |
| Konrad Z and Eichler J | Lipid modification of proteins in Archaea: attachment of a mevalonic acid-based lipid moiety to the surface-layer glycoprotein of Haloferax volcanii follows protein translocation. | 2002 | Biochem. J. | pmid:12069685 |
| DE WAARD A and POPJAK G | Studies on the biosynthesis of cholesterol. 9. Formation of phosphorylated derivatives of mevalonic acid in liver-enzyme preparations. | 1959 | Biochem. J. | pmid:13815126 |
| Wood SG and Gottlieb D | Evidence from mycelial studies for differences in the sterol biosynthetic pathway of Rhizoctonia solani and Phytophthora cinnamomi. | 1978 | Biochem. J. | pmid:637849 |
| Wood SG and Gottlieb D | Evidence from cell-free systems for differences in the sterol biosynthetic pathway of Rhizoctonia solani and Phytophthora cinnamomi. | 1978 | Biochem. J. | pmid:637850 |
| Smith AG and Goad LJ | Sterol biosynthesis by the sea urchin Echinus esculentus. | 1974 | Biochem. J. | pmid:4441383 |
| Rasmussen LM et al. | Diverse effects of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase on the expression of VCAM-1 and E-selectin in endothelial cells. | 2001 | Biochem. J. | pmid:11716764 |
| DIPLOCK AT et al. | VITAMIN A AND ISOPRENOID SYNTHESIS IN THE RAT. | 1965 | Biochem. J. | pmid:14333548 |
| GOODWIN TW and WILLIAMS RJ | A MECHANISM FOR THE CYCLIZATION OF AN ACYCLIC PRECURSOR TO FORM BETA-CAROTENE. | 1965 | Biochem. J. | pmid:14342248 |
| Metz SA et al. | Modulation of insulin secretion from normal rat islets by inhibitors of the post-translational modifications of GTP-binding proteins. | 1993 | Biochem. J. | pmid:8216234 |
| Graham JM and Green C | The binding of sterols in cellular membranes. | 1967 | Biochem. J. | pmid:6032974 |
| Iglesias J and Gibbons GF | Regulation of hepatic cholesterol biosynthesis. Effects of a cytochrome P-450 inhibitor on the formation and metabolism of oxygenated sterol products of lanosterol. | 1989 | Biochem. J. | pmid:2604729 |
| Hitchcock CA et al. | Interaction of azole antifungal antibiotics with cytochrome P-450-dependent 14 alpha-sterol demethylase purified from Candida albicans. | 1990 | Biochem. J. | pmid:2180400 |
| Ranganathan S and Ramasarma T | The regulation of the biosynthesis of ubiquinone in the rat. | 1975 | Biochem. J. | pmid:1156398 |
| Smith AG and Goad LJ | Sterol biosynthesis in the echinoderm Asterias rubens. | 1975 | Biochem. J. | pmid:1147897 |
| Cohen LH and Griffioen M | Regulation of 3-hydroxy-3-methylglutaryl-CoA reductase mRNA contents in human hepatoma cell line Hep G2 by distinct classes of mevalonate-derived metabolites. | 1988 | Biochem. J. | pmid:2848511 |
| Konrad M and Merz WE | Long-term effect of cyclic AMP on N-glycosylation is caused by an increase in the activity of the cis-prenyltransferase. | 1996 | Biochem. J. | pmid:8687403 |
| Gough DP and Hemming FW | The characterization and stereochemistry of biosynthesis of dolichols in rat liver. | 1970 | Biochem. J. | pmid:4319540 |
| Stone KJ and Hemming FW | The incorporation of [2-14C, 4R-3H1] mevalonate and [2-14C, 4S-3H1] mevalonate into squalene, ubiquinone and ergosterol of Aspergillus fumigatus Fresenius. | 1965 | Biochem. J. | pmid:4284430 |
| Walton MJ and Pennock JF | Some studies on the biosynthesis of ubiguinone, isoprenoid alcohols, squalene and sterols by marine invertebrates. | 1972 | Biochem. J. | pmid:4403925 |
| Green TR and Baisted DJ | Development of the activities of enzymes of the isoprenoid pathway during early stages of pea-seed germination. | 1972 | Biochem. J. | pmid:4348263 |
| Burt VT et al. | The formation of menaquinone-4 (vitamin K) and its oxide in some marine invertebrates. | 1977 | Biochem. J. | pmid:849285 |
| Higgins MJ and Kekwick RG | An investigation into the role of malonyl-coenzyme A in isoprenoid biosynthesis. | 1973 | Biochem. J. | pmid:4579226 |
| Gibbons GF and Mitropoulos KA | The effect of carbon monoxide on the nature of the accumulated 4,4-dimethyl sterol precursors of cholesterol during its biosynthesis from (2-14C)mevalonic acid in vitro. | 1973 | Biochem. J. | pmid:4724584 |
| Fang TY and Baisted DJ | 2,3-Oxidosqualene cyclase and cycloartenol-s-adenosylmethionine methyltransferase activities in vivo in the cotyledon and axis tissues of germinating pea seeds. | 1975 | Biochem. J. | pmid:1212194 |
| Beedle AS et al. | Some properties and a suggested reclassification of mevaldate reductase. | 1974 | Biochem. J. | pmid:4463942 |
| Martin HG and Thorne KJ | Synthesis of radioactive dolichol from (4S-3H)mevalonate in the regenerating rat liver. | 1974 | Biochem. J. | pmid:4822733 |
| Greenwood DR and Rees HH | Mechanism of hydroxylation at C-22 during the biosynthesis of ecdysteroids in the locust Schistocerca gregaria. | 1982 | Biochem. J. | pmid:7165737 |
| Smith AG and Goad LJ | Sterol biosynthesis in the starfish Asterias rubens and Henricia sanguinolenta. | 1971 | Biochem. J. | pmid:5126917 |
| Gibbons GF and Mitropoulos KA | Inhibition of cholesterol biosynthesis by carbon monoxide: accumulation of lanosterol and 24,25-dihydrolanosterol. | 1972 | Biochem. J. | pmid:5073750 |
| McDermott JC et al. | Carotenoid biosynthesis in a Flavobacterium sp.: stereochemistry of hydrogen elimination in the desaturation of phytoene to lycopene, rubixanthin and zeaxanthin. | 1973 | Biochem. J. | pmid:4762756 |
| Ranganathan S and Ramasarma T | Inhibition of the biosynthesis of sterols by phenyl and phenolic compounds in rat liver. | 1973 | Biochem. J. | pmid:4749274 |
| Gray JC and Kekwick RG | Mevalonate kinase in green leaves and etiolated cotyledons of the french bean Phaseolus vulgaris. | 1973 | Biochem. J. | pmid:4723778 |
| Bassett RA et al. | Biosynthesis of ergotamine by Claviceps purpurea (Fr.) Tul. | 1973 | Biochem. J. | pmid:4723222 |
| Gregory KW et al. | Diurnal variations in rat liver 3-hydroxy-3-methylglutaryl-Coenzyme A reductase activity in relation to feeding. | 1972 | Biochem. J. | pmid:4656802 |
| Beedle AS et al. | Studies on the biosynthesis of tetrahymanol in Tetrahymena pyriformis. The mechanism of inhibition by cholesterol. | 1974 | Biochem. J. | pmid:4140721 |
| Goodwin TW | Recent developments in the study of the biosynthesis of carotenoids. | 1972 | Biochem. J. | pmid:5085548 |
| Mitropoulos KA and Myant NB | Evidence that the oxidation of the side chain of cholesterol by liver mitochondria is stereospecific, and that the immediate product of cleavage is propionate. | 1965 | Biochem. J. | pmid:5881647 |
| Durr IF and Habbal MZ | The biosynthesis of C 55 polyprenols by a cell-free preparation of Lactobacillus plantarum. | 1972 | Biochem. J. | pmid:5076663 |
| Leijten L et al. | Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in mouse uterine epithelial cells. | 1987 | Biochem. J. | pmid:3032158 |
| Kam NT et al. | Effect of lovastatin on acyl-CoA: cholesterol O-acyltransferase (ACAT) activity and the basolateral-membrane secretion of newly synthesized lipids by CaCo-2 cells. | 1990 | Biochem. J. | pmid:2268271 |
| GOSSELIN L and POPJAK G | Studies on biosynthesis of cholesterol. 8. The effect of Mg2+ and Mn2+ ions and of adenosine triphosphate on enzymic activity of microsomes in sterol biosynthesis from mevalonic acid. | 1959 | Biochem. J. | pmid:13651113 |
| Thorne KJ and Barker DC | The bactoprenol content of plasma and mesosome membranes from Lactobacillus casei. | 1971 | Biochem. J. | pmid:5001951 |
| Skilleter DN and Kekwick RG | The enzymes forming isopentenyl pyrophosphate from 5-phosphomevalonate (mevalonate 5-phosphate) in the latex of Hevea brasiliensis. | 1971 | Biochem. J. | pmid:4333851 |
| Goodwin TW | Biosynthesis of carotenoids and plant triterpenes. | 1971 | Biochem. J. | pmid:4331177 |
| Bloxham DP and Akhtar M | Studies on the control of cholesterol biosynthesis: the adenosine 3':5'-cyclic monophosphate-dependent accumulation of a steroid carboxylic acid. | 1971 | Biochem. J. | pmid:4331371 |
| Olson RJ et al. | Alterations in cholesterol and fatty acid biosynthesis in rat liver homogenates by aryloxy acids. | 1974 | Biochem. J. | pmid:4441387 |
| Tefft RE et al. | Aspects of the stereochemistry of torularhodin biosynthesis. | 1970 | Biochem. J. | pmid:5465554 |
| Castagnoli N et al. | Biosynthesis of N-(alpha-hydroxyethyl) lysergamide, a metabolite of Claviceps paspali Stevens and Hall. | 1970 | Biochem. J. | pmid:5419742 |
| Gough DP and Hemming FW | The stereochemistry of betulaprenol biosynthesis. | 1970 | Biochem. J. | pmid:4315982 |
| Krishnaiah KV and Ramasarma T | Effect of alpha-p-chlorophenoxyisobutyrate on the metabolism of isoprenoid compounds in the rat. | 1970 | Biochem. J. | pmid:5435680 |
| Sargent JR et al. | Metabolism of mevalonic acid in the liver of the dogfish Scyliorhinus caniculus. | 1970 | Biochem. J. | pmid:5420034 |
| Boogaard A et al. | Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in human hepatoma cell line Hep G2. Effects of inhibitors of cholesterol synthesis on enzyme activity. | 1987 | Biochem. J. | pmid:3036060 |
| Stone KJ and Hemming FW | The stereochemistry of hexahydroprenol, ubiquinone and ergosterol biosynthesis in the mycelium of Aspergillus fumigatus Fresenius. | 1967 | Biochem. J. | pmid:4292001 |
| Goto T et al. | Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist. | 2011 | Biochem. J. | pmid:21605082 |
| Cornforth JW and Cornforth RH | Chemistry of mevalonic acid. | 1969 | Biochem. J. | pmid:5807184 |
| Rudney H | The biosynthesis of terpenoid quinones. | 1969 | Biochem. J. | pmid:4308944 |
| Noddle RC and Robinson DR | Biosynthesis of abscisic acid: incorporation of radioactivity from [2-14C]mevalonic acid by intact fruit. | 1969 | Biochem. J. | pmid:4308332 |
| Barr RM and Hemming FW | Polyprenol phosphate as an acceptor of mannose from guanosine diphosphate mannose in Aspergillus niger. | 1972 | Biochem. J. | pmid:5073732 |
| Parsons RB et al. | Statins inhibit the dimerization of beta-secretase via both isoprenoid- and cholesterol-mediated mechanisms. | 2006 | Biochem. J. | pmid:16803455 |
| Atkin SD et al. | The role of cytochrome P-450 in cholesterol biogenesis and catabolism. | 1972 | Biochem. J. | pmid:5084788 |
| Williams RJ et al. | The stereospecific biosynthesis of phytoene and polyunsaturated carotenes. | 1967 | Biochem. J. | pmid:6049923 |
| Wellburn AR and Hemming FW | The subcellular distribution and biosynthesis of castaprenols and plastoquinone in the leaves of Aesculus hippocastanum. | 1967 | Biochem. J. | pmid:6068175 |
| Threlfall DR et al. | Biosynthesis of the prenyl side chains of plastoquinone and related compounds in maize and barley shoots. | 1967 | Biochem. J. | pmid:6049407 |
| Akhtar M et al. | The role of a cholesta-8,14-dien-3-beta-ol system in cholesterol biosynthesis. | 1969 | Biochem. J. | pmid:5783476 |
| De Matteis F | Stimulation of liver cholesterol synthesis by actinomycin D. | 1968 | Biochem. J. | pmid:5696865 |
| Williamson IP and Kekwick RG | The formation of 5-phosphomevalonate by mevalonate kinase in Hevea brasiliensis latex. | 1965 | Biochem. J. | pmid:5862423 |
| Overton KH and Roberts FM | Biosynthesis of trans, trans- and cis, trans-farnesols by soluble enzymes from tissue cultures of Andrographis paniculata. | 1974 | Biochem. J. | pmid:4468823 |
| Joshi VC et al. | Biosynthetic relationship between ubichromenol and ubiquinone. | 1964 | Biochem. J. | pmid:5838088 |
| Shama Bhat C and Ramasarma T | Inhibition of rat liver mevalonate pyrophosphate decarboxylase and mevalonate phosphate kinase by phenyl and phenolic compounds. | 1979 | Biochem. J. | pmid:226078 |
| Montalvetti A et al. | Characterization and regulation of Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase. | 2000 | Biochem. J. | pmid:10861207 |
| Madyastha KM et al. | Carboxyl group methylation of loganic acid by a cell-free enzyme preparation from Vinca rosea. | 1972 | Biochem. J. | pmid:4404427 |
| Banthorpe DV et al. | Biosynthesis of geraniol and nerol and beta-D-glucosides in Pelargonium graveolens and Rosa dilecta. | 1972 | Biochem. J. | pmid:4348258 |
| BRAITHWAITE GD and GOODWIN TW | Studies in carotenogenesis. 26. The incorporation of [C14] acetate, [C14] mevalonate and C14-labelled carbon dioxide into beta-carotene by the fungus Phycomyces blakesleeanus. | 1960 | Biochem. J. | pmid:13849152 |
| Rohmer M et al. | Isoprenoid biosynthesis in bacteria: a novel pathway for the early steps leading to isopentenyl diphosphate. | 1993 | Biochem. J. | pmid:8240251 |
| GOODWIN TW | Studies in carotenogenesis. 25. The incorporation of 14CO2, [2-14C] acetate and [2-14C]mevalonate into beta-carotene by illuminated etiolated maize seedings. | 1958 | Biochem. J. | pmid:13607416 |
| Farrell FX et al. | Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated. | 1993 | Biochem. J. | pmid:8424780 |
| Barr RM and Hemming FW | Polyprenols of Aspergillus niger. Their characterization, biosynthesis and subcellular distribution. | 1972 | Biochem. J. | pmid:5073731 |
| Goodwin TW and Williams RJ | A mechanism for the biosynthesis of alpha-carotene. | 1965 | Biochem. J. | pmid:5881648 |
| Walton TJ et al. | Biosynthesis of xanthophylls in higher plants: stereochemistry of hydroxylation at C-3. | 1969 | Biochem. J. | pmid:5801311 |
| Grönroos E et al. | Leukotriene D4-induced mobilization of intracellular Ca2+ in epithelial cells is critically dependent on activation of the small GTP-binding protein Rho. | 1996 | Biochem. J. | pmid:8645211 |
| Booth R et al. | The effect of dietary cholesterol on cholesterol biosynthesis and other processes in mammalian liver. | 1971 | Biochem. J. | pmid:5124798 |
| Cohen LH et al. | Effects of compactin, mevalonate and low-density lipoprotein on 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity and low-density-lipoprotein-receptor activity in the human hepatoma cell line Hep G2. | 1984 | Biochem. J. | pmid:6089762 |
| Li G et al. | Blockade of mevalonate production by lovastatin attenuates bombesin and vasopressin potentiation of nutrient-induced insulin secretion in HIT-T15 cells. Probable involvement of small GTP-binding proteins. | 1993 | Biochem. J. | pmid:8424783 |