| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
Mevalonic acid
Mevalonic acid is a lipid of Fatty Acyls (FA) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.
Here are additional resources we collected from PubChem and MeSH for Mevalonic acid
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Mevalonic acid
PubChem Biomolecular Interactions and Pathways
NCBI Entrez Crosslinks
All references with Mevalonic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kistowska M et al. | Dysregulation of the host mevalonate pathway during early bacterial infection activates human TCR gamma delta cells. | 2008 | Eur. J. Immunol. | pmid:18624305 |
| pmid:18635753 | ||||
| pmid:18653353 | ||||
| Lüdke SM et al. | Stable carbon isotope discrimination by human 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | 2008 | J. Lipid Res. | pmid:18669481 |
| Laezza C et al. | The anandamide analog, Met-F-AEA, controls human breast cancer cell migration via the RHOA/RHO kinase signaling pathway. | 2008 | Endocr. Relat. Cancer | pmid:18676619 |
| Oliveira KA et al. | Simvastatin inducing PC3 prostate cancer cell necrosis mediated by calcineurin and mitochondrial dysfunction. | 2008 | J. Bioenerg. Biomembr. | pmid:18679777 |
| Pscheidt B and Glieder A | Yeast cell factories for fine chemical and API production. | 2008 | Microb. Cell Fact. | pmid:18684335 |
| Kotti T et al. | Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18685105 |
| Sando T et al. | Cloning and characterization of mevalonate pathway genes in a natural rubber producing plant, Hevea brasiliensis. | 2008 | Biosci. Biotechnol. Biochem. | pmid:18685207 |
| Acharjee S and Welty FK | Atorvastatin and cardiovascular risk in the elderly--patient considerations. | 2008 | Clin Interv Aging | pmid:18686752 |
| Sławińska A and Kandefer-Szerszeń M | [The anticancer properties of statins]. | 2008 | Postepy Hig Med Dosw (Online) | pmid:18688209 |
| pmid:18692592 | ||||
| Ness GC et al. | Feedback regulation of hepatic 3-hydroxy-3-methylglutaryl-CoA reductase activity by dietary cholesterol is not due to altered mRNA levels. | 1991 | J. Biol. Chem. | pmid:1869523 |
| Begley M et al. | Analysis of the isoprenoid biosynthesis pathways in Listeria monocytogenes reveals a role for the alternative 2-C-methyl-D-erythritol 4-phosphate pathway in murine infection. | 2008 | Infect. Immun. | pmid:18765739 |
| Kaliszewski P et al. | Rsp5p ubiquitin ligase and the transcriptional activators Spt23p and Mga2p are involved in co-regulation of biosynthesis of end products of the mevalonate pathway and triacylglycerol in yeast Saccharomyces cerevisiae. | 2008 | Biochim. Biophys. Acta | pmid:18771750 |
| Anthony JR et al. | Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene. | 2009 | Metab. Eng. | pmid:18775787 |
| Habeos IG et al. | Simvastatin activates Keap1/Nrf2 signaling in rat liver. | 2008 | J. Mol. Med. | pmid:18787804 |
| Bate C et al. | Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells. | 2008 | BMC Biol. | pmid:18789130 |
| Baba TT et al. | Simvastatin suppresses the differentiation of C2C12 myoblast cells via a Rac pathway. | 2008 | J. Muscle Res. Cell. Motil. | pmid:18792797 |
| Olson AL et al. | Substrate induced structural and dynamics changes in human phosphomevalonate kinase and implications for mechanism. | 2009 | Proteins | pmid:18798562 |
| Voynova NE et al. | Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure. | 2008 | Arch. Biochem. Biophys. | pmid:18823933 |
| Sepp-Lorenzino L et al. | Cell-cycle-dependent, differential prenylation of proteins. | 1991 | Eur. J. Biochem. | pmid:1889420 |
| Xiang Z and Reeves SA | Simvastatin induces cell death in a mouse cerebellar slice culture (CSC) model of developmental myelination. | 2009 | Exp. Neurol. | pmid:18929563 |
| pmid:18941711 | ||||
| Domoki F et al. | Rosuvastatin induces delayed preconditioning against oxygen-glucose deprivation in cultured cortical neurons. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:18971391 |
| Vögeli U and Chappell J | Inhibition of a plant sesquiterpene cyclase by mevinolin. | 1991 | Arch. Biochem. Biophys. | pmid:1898013 |
| Kimura T et al. | Induction of scavenger receptor class B type I is critical for simvastatin enhancement of high-density lipoprotein-induced anti-inflammatory actions in endothelial cells. | 2008 | J. Immunol. | pmid:18981156 |
| Sapir-Mir M et al. | Peroxisomal localization of Arabidopsis isopentenyl diphosphate isomerases suggests that part of the plant isoprenoid mevalonic acid pathway is compartmentalized to peroxisomes. | 2008 | Plant Physiol. | pmid:18988695 |
| Winegar DA et al. | Isoprenylation of rap2 proteins in platelets and human erythroleukemia cells. | 1991 | J. Biol. Chem. | pmid:1900292 |
| Monzack EL et al. | Efficacy of simvastatin treatment of valvular interstitial cells varies with the extracellular environment. | 2009 | Arterioscler. Thromb. Vasc. Biol. | pmid:19023089 |
| Kervizic G and Corcos L | Dynamical modeling of the cholesterol regulatory pathway with Boolean networks. | 2008 | BMC Syst Biol | pmid:19025648 |
| GarcÃa I et al. | QSAR and complex network study of the chiral HMGR inhibitor structural diversity. | 2009 | Bioorg. Med. Chem. | pmid:19026553 |
| Balibar CJ et al. | The mevalonate pathway of Staphylococcus aureus. | 2009 | J. Bacteriol. | pmid:19028897 |
| Sanford J et al. | Gamma-subunits of G proteins, but not their alpha- or beta-subunits, are polyisoprenylated. Studies on post-translational modifications using in vitro translation with rabbit reticulocyte lysates. | 1991 | J. Biol. Chem. | pmid:1903391 |
| Rekittke I et al. | Structure of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate reductase, the terminal enzyme of the non-mevalonate pathway. | 2008 | J. Am. Chem. Soc. | pmid:19035630 |
| pmid:19053515 | ||||
| pmid:19053857 | ||||
| Fujimoto M et al. | Fluvastatin inhibits mast cell degranulation without changing the cytoplasmic Ca2+ level. | 2009 | Eur. J. Pharmacol. | pmid:19059394 |
| Farnsworth CC et al. | C terminus of the small GTP-binding protein smg p25A contains two geranylgeranylated cysteine residues and a methyl ester. | 1991 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1906176 |
| Mizuno T et al. | A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21. | 1991 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1907371 |
| pmid:19083230 | ||||
| Roitelman J et al. | Involvement of calcium in the mevalonate-accelerated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase. | 1991 | J. Biol. Chem. | pmid:1908464 |
| pmid:191001 | ||||
| Abumweis SS et al. | Plant sterols/stanols as cholesterol lowering agents: A meta-analysis of randomized controlled trials. | 2008 | Food Nutr Res | pmid:19109655 |
| Schwartz YSh et al. | Cholesterol-induced stimulation of postinflammatory liver fibrosis. | 2008 | Bull. Exp. Biol. Med. | pmid:19110552 |
| Lindemann CJ et al. | Determination of mevalonolactone in capsules by capillary gas-liquid chromatography. | 1991 | J Pharm Biomed Anal | pmid:1911983 |
| Dje N'Guessan P et al. | Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells. | 2009 | Arterioscler. Thromb. Vasc. Biol. | pmid:19122173 |
| Deshpande G et al. | Ggamma1, a downstream target for the hmgcr-isoprenoid biosynthetic pathway, is required for releasing the Hedgehog ligand and directing germ cell migration. | 2009 | PLoS Genet. | pmid:19132091 |
| Ohyama K et al. | Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19139393 |
| Rydgren T and Sandler S | The protective effect of simvastatin against low dose streptozotocin induced type 1 diabetes in mice is independent of inhibition of HMG-CoA reductase. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19150339 |
| Knight LA et al. | Activity of mevalonate pathway inhibitors against breast and ovarian cancers in the ATP-based tumour chemosensitivity assay. | 2009 | BMC Cancer | pmid:19175937 |
| Fujiyama A et al. | S-farnesylation and methyl esterification of C-terminal domain of yeast RAS2 protein prior to fatty acid acylation. | 1991 | J. Biol. Chem. | pmid:1917931 |
| Cuthbert JA and Lipsky PE | Negative regulation of cell proliferation by mevalonate or one of the mevalonate phosphates. | 1991 | J. Biol. Chem. | pmid:1917936 |
| Löw P et al. | The mevalonate pathway in the bloodstream form of Trypanosoma brucei. Identification of dolichols containing 11 and 12 isoprene residues. | 1991 | J. Biol. Chem. | pmid:1918042 |
| Zeiser R et al. | Regulation of different inflammatory diseases by impacting the mevalonate pathway. | 2009 | Immunology | pmid:19191903 |
| pmid:19198899 | ||||
| Kim WY et al. | Statins decrease dendritic arborization in rat sympathetic neurons by blocking RhoA activation. | 2009 | J. Neurochem. | pmid:19209406 |
| pmid:19219049 | ||||
| Tsuruta H et al. | High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli. | 2009 | PLoS ONE | pmid:19221601 |
| Lin Y et al. | Triterpenic Acids Present in Hawthorn Lower Plasma Cholesterol by Inhibiting Intestinal ACAT Activity in Hamsters. | 2011 | Evid Based Complement Alternat Med | pmid:19228775 |
| Lachmann HJ and Hawkins PN | Developments in the scientific and clinical understanding of autoinflammatory disorders. | 2009 | Arthritis Res. Ther. | pmid:19232070 |
| Yeger-Lotem E et al. | Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity. | 2009 | Nat. Genet. | pmid:19234470 |
| Niessen J et al. | Human platelets express organic anion-transporting peptide 2B1, an uptake transporter for atorvastatin. | 2009 | Drug Metab. Dispos. | pmid:19237515 |
| Kinsella BT et al. | Posttranslational modification of Ha-ras p21 by farnesyl versus geranylgeranyl isoprenoids is determined by the COOH-terminal amino acid. | 1991 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1924354 |
| pmid:19254730 | ||||
| Maeda T and Horiuchi N | Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation. | 2009 | J. Biochem. | pmid:19254925 |
| Ledezma E et al. | Potentiated cytotoxic effects of statins and ajoene in murine melanoma cells. | 2009 | Melanoma Res. | pmid:19276863 |
| Ellsworth JL et al. | Evidence for sterol-independent regulation of low-density lipoprotein receptor activity in Hep-G2 cells. | 1991 | Biochem. J. | pmid:1930137 |
| Alvarez Y et al. | Cyclooxygenase-2 induced by zymosan in human monocyte-derived dendritic cells shows high stability, and its expression is enhanced by atorvastatin. | 2009 | J. Pharmacol. Exp. Ther. | pmid:19318593 |
| Khan MA et al. | Statins impair CD1d-mediated antigen presentation through the inhibition of prenylation. | 2009 | J. Immunol. | pmid:19342651 |
| pmid:19346993 | ||||
| pmid:19360315 | ||||
| Suzuki M et al. | Complete blockage of the mevalonate pathway results in male gametophyte lethality. | 2009 | J. Exp. Bot. | pmid:19363204 |
| pmid:19384817 | ||||
| Sun X et al. | Identified biosynthetic pathway of aspergiolide A and a novel strategy to increase its production in a marine-derived fungus Aspergillus glaucus by feeding of biosynthetic precursors and inhibitors simultaneously. | 2009 | Bioresour. Technol. | pmid:19386490 |
| Scoppola A et al. | Quantitation of plasma mevalonic acid using gas chromatography-electron capture mass spectrometry. | 1991 | J. Lipid Res. | pmid:1940620 |
| Elmberger PG et al. | Effects of pravastatin and cholestyramine on products of the mevalonate pathway in familial hypercholesterolemia. | 1991 | J. Lipid Res. | pmid:1940625 |
| Sillero MA et al. | Synthesis of ATP derivatives of compounds of the mevalonate pathway (isopentenyl di- and triphosphate; geranyl di- and triphosphate, farnesyl di- and triphosphate, and dimethylallyl diphosphate) catalyzed by T4 RNA ligase, T4 DNA ligase and other ligases Potential relationship with the effect of bisphosphonates on osteoclasts. | 2009 | Biochem. Pharmacol. | pmid:19414000 |
| pmid:19414014 | ||||
| Rothwell C et al. | Cholesterol biosynthesis modulation regulates dengue viral replication. | 2009 | Virology | pmid:19419745 |
| Raemer PC et al. | Statins inhibit NK-cell cytotoxicity by interfering with LFA-1-mediated conjugate formation. | 2009 | Eur. J. Immunol. | pmid:19424968 |
| pmid:19428716 | ||||
| Kato S et al. | Lipophilic but not hydrophilic statins selectively induce cell death in gynaecological cancers expressing high levels of HMGCoA reductase. | 2010 | J. Cell. Mol. Med. | pmid:19432822 |
| Epstein WW et al. | Quantitation of prenylcysteines by a selective cleavage reaction. | 1991 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1946384 |
| Li J et al. | Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells. | 2009 | J. Immunol. | pmid:19494338 |
| pmid:19508172 | ||||
| Mansouri H et al. | Effects of gibberellic acid on primary terpenoids and delta-tetrahydrocannabinol in Cannabis sativa at flowering stage. | 2009 | J Integr Plant Biol | pmid:19522814 |
| Bełtowski J et al. | Adverse effects of statins - mechanisms and consequences. | 2009 | Curr Drug Saf | pmid:19534648 |
| pmid:1953779 | ||||
| Montoya CJ et al. | Antiretroviral effect of lovastatin on HIV-1-infected individuals without highly active antiretroviral therapy (The LIVE study): a phase-II randomized clinical trial. | 2009 | Trials | pmid:19538732 |
| Sidorkiewicz M et al. | Mevalonate pathway modulation is associated with hepatitis C virus RNA presence in peripheral blood mononuclear cells. | 2009 | Virus Res. | pmid:19540284 |
| Hashimoto F and Hayashi H | Identification of intermediates after inhibition of cholesterol synthesis by aminotriazole treatment in vivo. | 1991 | Biochim. Biophys. Acta | pmid:1954238 |
| Yoon HE and Yang CW | Established and newly proposed mechanisms of chronic cyclosporine nephropathy. | 2009 | Korean J. Intern. Med. | pmid:19543484 |
| Perttilä J et al. | OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. | 2009 | J. Mol. Med. | pmid:19554302 |
| Kroll J et al. | Establishment of a novel anabolism-based addiction system with an artificially introduced mevalonate pathway: complete stabilization of plasmids as universal application in white biotechnology. | 2009 | Metab. Eng. | pmid:19558962 |
| Minichsdorfer C and Hohenegger M | Autocrine amplification loop in statin-induced apoptosis of human melanoma cells. | 2009 | Br. J. Pharmacol. | pmid:19563533 |
| Zeki AA et al. | Simvastatin inhibits airway hyperreactivity: implications for the mevalonate pathway and beyond. | 2009 | Am. J. Respir. Crit. Care Med. | pmid:19608720 |
| Yoshida T et al. | Determination of key intermediates in cholesterol and bile acid biosynthesis by stable isotope dilution mass spectrometry. | 2008 | Anal Chem Insights | pmid:19609389 |
| Lorenzen W et al. | Isoprenoids are essential for fruiting body formation in Myxococcus xanthus. | 2009 | J. Bacteriol. | pmid:19617362 |
| Yang Z et al. | Synergistic actions of atorvastatin with gamma-tocotrienol and celecoxib against human colon cancer HT29 and HCT116 cells. | 2010 | Int. J. Cancer | pmid:19626588 |