Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Cell Transformation, Neoplastic D002471 126 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Adenocarcinoma D000230 166 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

Download all related citations
Per page 10 20 50 100 | Total 2899
Authors Title Published Journal PubMed Link
Rydgren T and Sandler S The protective effect of simvastatin against low dose streptozotocin induced type 1 diabetes in mice is independent of inhibition of HMG-CoA reductase. 2009 Biochem. Biophys. Res. Commun. pmid:19150339
Yoon HE and Yang CW Established and newly proposed mechanisms of chronic cyclosporine nephropathy. 2009 Korean J. Intern. Med. pmid:19543484
Jauhiainen M et al. Analysis of endogenous ATP analogs and mevalonate pathway metabolites in cancer cell cultures using liquid chromatography-electrospray ionization mass spectrometry. 2009 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:19665949
Anthony JR et al. Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene. 2009 Metab. Eng. pmid:18775787
Lorenzen W et al. Isoprenoids are essential for fruiting body formation in Myxococcus xanthus. 2009 J. Bacteriol. pmid:19617362
Zhao S et al. Synthesis and HMG-CoA reductase inhibition of 2-cyclopropyl-4-thiophenyl-quinoline mevalonolactones. 2009 Bioorg. Med. Chem. pmid:19879766
Domoki F et al. Rosuvastatin induces delayed preconditioning against oxygen-glucose deprivation in cultured cortical neurons. 2009 Am. J. Physiol., Cell Physiol. pmid:18971391
Xu Q et al. Comparative transcripts profiling reveals new insight into molecular processes regulating lycopene accumulation in a sweet orange (Citrus sinensis) red-flesh mutant. 2009 BMC Genomics pmid:19922663
Rothwell C et al. Cholesterol biosynthesis modulation regulates dengue viral replication. 2009 Virology pmid:19419745
Ledezma E et al. Potentiated cytotoxic effects of statins and ajoene in murine melanoma cells. 2009 Melanoma Res. pmid:19276863
Maeda T and Horiuchi N Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation. 2009 J. Biochem. pmid:19254925
Dje N'Guessan P et al. Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells. 2009 Arterioscler. Thromb. Vasc. Biol. pmid:19122173
Iriti M and Faoro F Chemical diversity and defence metabolism: how plants cope with pathogens and ozone pollution. 2009 Int J Mol Sci pmid:20111684
Jawaid S et al. Kinetic characterization and phosphoregulation of the Francisella tularensis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase). 2009 PLoS ONE pmid:20011597
Raemer PC et al. Statins inhibit NK-cell cytotoxicity by interfering with LFA-1-mediated conjugate formation. 2009 Eur. J. Immunol. pmid:19424968
Chang PK et al. Cyclopiazonic acid biosynthesis of Aspergillus flavus and Aspergillus oryzae. 2009 Toxins (Basel) pmid:22069533
Kirmizis D and Chatzidimitriou D Pleiotropic vasoprotective effects of statins: the chicken or the egg? 2009 Drug Des Devel Ther pmid:19920934
Brahmachari S et al. Sodium benzoate, a metabolite of cinnamon and a food additive, reduces microglial and astroglial inflammatory responses. 2009 J. Immunol. pmid:19812204
de Souza W and Rodrigues JC Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs. 2009 Interdiscip Perspect Infect Dis pmid:19680554
Zeki AA et al. Simvastatin inhibits airway hyperreactivity: implications for the mevalonate pathway and beyond. 2009 Am. J. Respir. Crit. Care Med. pmid:19608720
Minichsdorfer C and Hohenegger M Autocrine amplification loop in statin-induced apoptosis of human melanoma cells. 2009 Br. J. Pharmacol. pmid:19563533
Perttilä J et al. OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. 2009 J. Mol. Med. pmid:19554302
Montoya CJ et al. Antiretroviral effect of lovastatin on HIV-1-infected individuals without highly active antiretroviral therapy (The LIVE study): a phase-II randomized clinical trial. 2009 Trials pmid:19538732
Li J et al. Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells. 2009 J. Immunol. pmid:19494338
Suzuki M et al. Complete blockage of the mevalonate pathway results in male gametophyte lethality. 2009 J. Exp. Bot. pmid:19363204
Balibar CJ et al. The mevalonate pathway of Staphylococcus aureus. 2009 J. Bacteriol. pmid:19028897
Khan MA et al. Statins impair CD1d-mediated antigen presentation through the inhibition of prenylation. 2009 J. Immunol. pmid:19342651
Alvarez Y et al. Cyclooxygenase-2 induced by zymosan in human monocyte-derived dendritic cells shows high stability, and its expression is enhanced by atorvastatin. 2009 J. Pharmacol. Exp. Ther. pmid:19318593
Niessen J et al. Human platelets express organic anion-transporting peptide 2B1, an uptake transporter for atorvastatin. 2009 Drug Metab. Dispos. pmid:19237515
Knight LA et al. Activity of mevalonate pathway inhibitors against breast and ovarian cancers in the ATP-based tumour chemosensitivity assay. 2009 BMC Cancer pmid:19175937
Deshpande G et al. Ggamma1, a downstream target for the hmgcr-isoprenoid biosynthetic pathway, is required for releasing the Hedgehog ligand and directing germ cell migration. 2009 PLoS Genet. pmid:19132091
Monzack EL et al. Efficacy of simvastatin treatment of valvular interstitial cells varies with the extracellular environment. 2009 Arterioscler. Thromb. Vasc. Biol. pmid:19023089
Xiang Z and Reeves SA Simvastatin induces cell death in a mouse cerebellar slice culture (CSC) model of developmental myelination. 2009 Exp. Neurol. pmid:18929563
Olson AL et al. Substrate induced structural and dynamics changes in human phosphomevalonate kinase and implications for mechanism. 2009 Proteins pmid:18798562
Sillero MA et al. Synthesis of ATP derivatives of compounds of the mevalonate pathway (isopentenyl di- and triphosphate; geranyl di- and triphosphate, farnesyl di- and triphosphate, and dimethylallyl diphosphate) catalyzed by T4 RNA ligase, T4 DNA ligase and other ligases Potential relationship with the effect of bisphosphonates on osteoclasts. 2009 Biochem. Pharmacol. pmid:19414000
Dueber JE et al. Synthetic protein scaffolds provide modular control over metabolic flux. 2009 Nat. Biotechnol. pmid:19648908
Leszczynska A et al. Investigating the effects of statins on cellular lipid metabolism using a yeast expression system. 2009 PLoS ONE pmid:20041128
Fujimoto M et al. Fluvastatin inhibits mast cell degranulation without changing the cytoplasmic Ca2+ level. 2009 Eur. J. Pharmacol. pmid:19059394
Sun X et al. Identified biosynthetic pathway of aspergiolide A and a novel strategy to increase its production in a marine-derived fungus Aspergillus glaucus by feeding of biosynthetic precursors and inhibitors simultaneously. 2009 Bioresour. Technol. pmid:19386490
García I et al. QSAR and complex network study of the chiral HMGR inhibitor structural diversity. 2009 Bioorg. Med. Chem. pmid:19026553
Ohyama K et al. Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis. 2009 Proc. Natl. Acad. Sci. U.S.A. pmid:19139393
Alagna F et al. Comparative 454 pyrosequencing of transcripts from two olive genotypes during fruit development. 2009 BMC Genomics pmid:19709400
Wali VB et al. Suppression in mevalonate synthesis mediates antitumor effects of combined statin and gamma-tocotrienol treatment. 2009 Lipids pmid:19777282
Tekle M et al. Investigation of coenzyme Q biosynthesis in human fibroblast and HepG2 cells. 2008 J. Biochem. Biophys. Methods pmid:17916383
Cornish J et al. Modulation of osteoclastogenesis by fatty acids. 2008 Endocrinology pmid:18617622
Winiarska M et al. Statins impair antitumor effects of rituximab by inducing conformational changes of CD20. 2008 PLoS Med. pmid:18366248
Journe F et al. Farnesol, a mevalonate pathway intermediate, stimulates MCF-7 breast cancer cell growth through farnesoid-X-receptor-mediated estrogen receptor activation. 2008 Breast Cancer Res. Treat. pmid:17333335
Habara K et al. Pitavastatin up-regulates the induction of iNOS through enhanced stabilization of its mRNA in pro-inflammatory cytokine-stimulated hepatocytes. 2008 Nitric Oxide pmid:17936042
Skorupinska-Tudek K et al. Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of dolichols in plants. 2008 J. Biol. Chem. pmid:18502754
Zhang X et al. Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. 2008 J. Immunol. pmid:18453621