Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Cell Transformation, Neoplastic D002471 126 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Adenocarcinoma D000230 166 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 | Total 25

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Authors Title Published Journal PubMed Link
Dueber JE et al. Synthetic protein scaffolds provide modular control over metabolic flux. 2009 Nat. Biotechnol. pmid:19648908
Hidaka Y et al. Regulation of squalene epoxidase in HepG2 cells. 1990 J. Lipid Res. pmid:1964954
Weerasinghe S and Samantha Dassanayake R Simulation of structural and functional properties of mevalonate diphosphate decarboxylase (MVD). 2010 J Mol Model pmid:19653015
Jauhiainen M et al. Analysis of endogenous ATP analogs and mevalonate pathway metabolites in cancer cell cultures using liquid chromatography-electrospray ionization mass spectrometry. 2009 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:19665949
Goldstein JL and Brown MS Regulation of the mevalonate pathway. 1990 Nature pmid:1967820
de Souza W and Rodrigues JC Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs. 2009 Interdiscip Perspect Infect Dis pmid:19680554
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Alagna F et al. Comparative 454 pyrosequencing of transcripts from two olive genotypes during fruit development. 2009 BMC Genomics pmid:19709400
Jakoi L and Quarfordt SH Alterations of rat hepatic cholesterogenesis by heterologous lipoproteins. 1977 J. Biol. Chem. pmid:197106
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Kumagai H et al. Method of search for microbial inhibitors of mevalonate biosynthesis using animal cells. 1990 J. Antibiot. pmid:1972152
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Morrone D et al. Increasing diterpene yield with a modular metabolic engineering system in E. coli: comparison of MEV and MEP isoprenoid precursor pathway engineering. 2010 Appl. Microbiol. Biotechnol. pmid:19777230
Wali VB et al. Suppression in mevalonate synthesis mediates antitumor effects of combined statin and gamma-tocotrienol treatment. 2009 Lipids pmid:19777282
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Brahmachari S et al. Sodium benzoate, a metabolite of cinnamon and a food additive, reduces microglial and astroglial inflammatory responses. 2009 J. Immunol. pmid:19812204
Coscia M et al. Zoledronic acid repolarizes tumour-associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway. 2010 J. Cell. Mol. Med. pmid:19818098
Wang W et al. Global characterization of Artemisia annua glandular trichome transcriptome using 454 pyrosequencing. 2009 BMC Genomics pmid:19818120
Räikkönen J et al. Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells. 2010 Biochem. Pharmacol. pmid:19819230
Massonnet B et al. Pharmacological inhibitors of the mevalonate pathway activate pro-IL-1 processing and IL-1 release by human monocytes. 2009 Eur. Cytokine Netw. pmid:19825520
Norman KL and Sarnow P Modulation of hepatitis C virus RNA abundance and the isoprenoid biosynthesis pathway by microRNA miR-122 involves distinct mechanisms. 2010 J. Virol. pmid:19846523
Mitrofan LM et al. Lysosomal-mitochondrial axis in zoledronic acid-induced apoptosis in human follicular lymphoma cells. 2010 J. Biol. Chem. pmid:19875454
Eldor R and Raz I American Diabetes Association indications for statins in diabetes: is there evidence? 2009 Diabetes Care pmid:19875586
Zhao S et al. Synthesis and HMG-CoA reductase inhibition of 2-cyclopropyl-4-thiophenyl-quinoline mevalonolactones. 2009 Bioorg. Med. Chem. pmid:19879766
Shoff SM et al. Concentration-dependent increase of murine P388 and B16 population doubling time by the acyclic monoterpene geraniol. 1991 Cancer Res. pmid:1988098
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Keung WM Human liver alcohol dehydrogenases catalyze the oxidation of the intermediary alcohols of the shunt pathway of mevalonate metabolism. 1991 Biochem. Biophys. Res. Commun. pmid:1993065
Tekpli X et al. Membrane remodeling, an early event in benzo[a]pyrene-induced apoptosis. 2010 Toxicol. Appl. Pharmacol. pmid:19931295
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Massaro M et al. Statins inhibit cyclooxygenase-2 and matrix metalloproteinase-9 in human endothelial cells: anti-angiogenic actions possibly contributing to plaque stability. 2010 Cardiovasc. Res. pmid:19946014
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Thelin A et al. Covalent binding of dolichyl phosphate to proteins in rat liver. 1991 Eur. J. Biochem. pmid:1999193
Jawaid S et al. Kinetic characterization and phosphoregulation of the Francisella tularensis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase). 2009 PLoS ONE pmid:20011597
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Hancock JF et al. Methylation and proteolysis are essential for efficient membrane binding of prenylated p21K-ras(B). 1991 EMBO J. pmid:2001678
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Kocsis GF et al. Expression of genes related to oxidative/nitrosative stress in mouse hearts: effect of preconditioning and cholesterol diet. 2010 Med. Sci. Monit. pmid:20037483
Leszczynska A et al. Investigating the effects of statins on cellular lipid metabolism using a yeast expression system. 2009 PLoS ONE pmid:20041128
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Lee SK et al. Stabilization and translocation of p53 to mitochondria is linked to Bax translocation to mitochondria in simvastatin-induced apoptosis. 2010 Biochem. Biophys. Res. Commun. pmid:20043868
Kassan M et al. In vitro antioxidant activity of pravastatin provides vascular protection. 2010 Eur. J. Pharmacol. pmid:20044990
Kojima Y et al. Pitavastatin decreases the expression of endothelial lipase both in vitro and in vivo. 2010 Cardiovasc. Res. pmid:20045866
Kudoh T et al. Mevalonate analogues as substrates of enzymes in the isoprenoid biosynthetic pathway of Streptococcus pneumoniae. 2010 Bioorg. Med. Chem. pmid:20056424
Kowluru A et al. Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells. 2010 Diabetes pmid:20071600
Kitten GT and Nigg EA The CaaX motif is required for isoprenylation, carboxyl methylation, and nuclear membrane association of lamin B2. 1991 J. Cell Biol. pmid:2007618
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Asadollahi MA et al. Enhancement of farnesyl diphosphate pool as direct precursor of sesquiterpenes through metabolic engineering of the mevalonate pathway in Saccharomyces cerevisiae. 2010 Biotechnol. Bioeng. pmid:20091767
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Iriti M and Faoro F Chemical diversity and defence metabolism: how plants cope with pathogens and ozone pollution. 2009 Int J Mol Sci pmid:20111684
Olson AL et al. NMR dynamics investigation of ligand-induced changes of main and side-chain arginine N-H's in human phosphomevalonate kinase. 2010 J. Am. Chem. Soc. pmid:20112895
Behr P et al. Effect of 7 beta-hydroxycholesterol on astrocyte primary cultures and derived spontaneously transformed cell lines. Cytotoxicity and cholesterogenesis. 1991 FEBS Lett. pmid:2013313
Chang TH et al. Structure of a heterotetrameric geranyl pyrophosphate synthase from mint (Mentha piperita) reveals intersubunit regulation. 2010 Plant Cell pmid:20139160
Yamauchi N The pathway of leucine to mevalonate in halophilic archaea: efficient incorporation of leucine into isoprenoidal lipid with the involvement of isovaleryl-CoA dehydrogenase in Halobacterium salinarum. 2010 Biosci. Biotechnol. Biochem. pmid:20139592
Pontillo A et al. The inhibition of mevalonate pathway induces upregulation of NALP3 expression: new insight in the pathogenesis of mevalonate kinase deficiency. 2010 Eur. J. Hum. Genet. pmid:20179743
Catros V et al. [Tgammadelta lymphocytes in oncology: unconventional killer lymphocytes]. 2010 Med Sci (Paris) pmid:20188051
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Klawitter J et al. Effects of lovastatin on breast cancer cells: a proteo-metabonomic study. 2010 Breast Cancer Res. pmid:20205716
De Leo L et al. Targeting farnesyl-transferase as a novel therapeutic strategy for mevalonate kinase deficiency: in vitro and in vivo approaches. 2010 Pharmacol. Res. pmid:20206266
Woo IS et al. Farnesyl diphosphate synthase attenuates paclitaxel-induced apoptotic cell death in human glioblastoma U87MG cells. 2010 Neurosci. Lett. pmid:20298756
Wani TA et al. The effects of rosuvastatin on the serum cortisol, serum lipid, and serum mevalonic acid levels in the healthy Indian male population. 2010 AAPS PharmSciTech pmid:20300897
Jiang XS et al. Quantitative proteomics analysis of inborn errors of cholesterol synthesis: identification of altered metabolic pathways in DHCR7 and SC5D deficiency. 2010 Mol. Cell Proteomics pmid:20305089
Faust JR and Dice JF Evidence for isopentenyladenine modification on a cell cycle-regulated protein. 1991 J. Biol. Chem. pmid:2033083
Esemuede N et al. Lovastatin inhibits thrombospondin-1-induced smooth muscle cell chemotaxis. 2011 J. Surg. Res. pmid:20338582
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Clendening JW et al. Exploiting the mevalonate pathway to distinguish statin-sensitive multiple myeloma. 2010 Blood pmid:20360469
Hooff GP et al. Isoprenoids, small GTPases and Alzheimer's disease. 2010 Biochim. Biophys. Acta pmid:20382260
Lefurgy ST et al. Probing ligand-binding pockets of the mevalonate pathway enzymes from Streptococcus pneumoniae. 2010 J. Biol. Chem. pmid:20404339
Hooff GP et al. Modulation of cholesterol, farnesylpyrophosphate, and geranylgeranylpyrophosphate in neuroblastoma SH-SY5Y-APP695 cells: impact on amyloid beta-protein production. 2010 Mol. Neurobiol. pmid:20405344
Snoeren TA et al. The herbivore-induced plant volatile methyl salicylate negatively affects attraction of the parasitoid Diadegma semiclausum. 2010 J. Chem. Ecol. pmid:20407809
Quist-Paulsen P Statins and inflammation: an update. 2010 Curr. Opin. Cardiol. pmid:20421792
Epplen R et al. Differential effects of ibandronate, docetaxel and farnesol treatment alone and in combination on the growth of prostate cancer cell lines. 2011 Acta Oncol pmid:20429730
Huang M et al. Variation of herbivore-induced volatile terpenes among Arabidopsis ecotypes depends on allelic differences and subcellular targeting of two terpene synthases, TPS02 and TPS03. 2010 Plant Physiol. pmid:20463089
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Chen CC et al. Effect of pravastatin on ventricular arrhythmias in infarcted rats: role of connexin43. 2010 J. Appl. Physiol. pmid:20466804
Endo A A historical perspective on the discovery of statins. 2010 Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. pmid:20467214
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Hughes M et al. Neurite-like structures induced by mevalonate pathway blockade are due to the stability of cell adhesion foci and are enhanced by the presence of APP. 2010 J. Neurochem. pmid:20477946
Jameson JM et al. A role for the mevalonate pathway in the induction of subtype cross-reactive immunity to influenza A virus by human gammadelta T lymphocytes. 2010 Cell. Immunol. pmid:20483407
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Aoyama T et al. Pharmacokinetic/pharmacodynamic modeling and simulation of rosuvastatin using an extension of the indirect response model by incorporating a circadian rhythm. 2010 Biol. Pharm. Bull. pmid:20522984
Liu Q et al. Dynamics of lamin-A processing following precursor accumulation. 2010 PLoS ONE pmid:20526372
Björkhem-Bergman L et al. Lovastatin prevents carcinogenesis in a rat model for liver cancer. Effects of ubiquinone supplementation. 2010 Anticancer Res. pmid:20530415
Okamura E et al. Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway. 2010 Proc. Natl. Acad. Sci. U.S.A. pmid:20534558
Camps D [Controversies regarding the use of statins in the acute coronary syndrome]. 2010 Aug-Sep Med Intensiva pmid:20538377
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Wang C et al. Farnesol production from Escherichia coli by harnessing the exogenous mevalonate pathway. 2010 Biotechnol. Bioeng. pmid:20552672
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Zheng Z et al. Improvement of retinal vascular injury in diabetic rats by statins is associated with the inhibition of mitochondrial reactive oxygen species pathway mediated by peroxisome proliferator-activated receptor gamma coactivator 1alpha. 2010 Diabetes pmid:20566666
Barrett-Bee K et al. Biochemical changes associated with the antifungal action of the triazole ICI 153,066 on Candida albicans and Trichophyton quinckeanum. 1991 FEMS Microbiol. Lett. pmid:2060756