Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Cell Transformation, Neoplastic D002471 126 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Adenocarcinoma D000230 166 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

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All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
Kotti T et al. Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation. 2008 Proc. Natl. Acad. Sci. U.S.A. pmid:18685105
Rekittke I et al. Structure of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate reductase, the terminal enzyme of the non-mevalonate pathway. 2008 J. Am. Chem. Soc. pmid:19035630
Saito E et al. 7-ketocholesterol, a major oxysterol, promotes pi-induced vascular calcification in cultured smooth muscle cells. 2008 J. Atheroscler. Thromb. pmid:18603819
Grigore L et al. Combination therapy in cholesterol reduction: focus on ezetimibe and statins. 2008 Vasc Health Risk Manag pmid:18561502
Sharyo S et al. Pravastatin improves renal ischemia-reperfusion injury by inhibiting the mevalonate pathway. 2008 Kidney Int. pmid:18509318
Kervizic G and Corcos L Dynamical modeling of the cholesterol regulatory pathway with Boolean networks. 2008 BMC Syst Biol pmid:19025648
Udagawa H et al. Increase of serum cholesterol levels by heat-moisture-treated high-amylose cornstarch in rats fed a high-cholesterol diet. 2008 Lipids pmid:18509689
Tekle M et al. Investigation of coenzyme Q biosynthesis in human fibroblast and HepG2 cells. 2008 J. Biochem. Biophys. Methods pmid:17916383
Cornish J et al. Modulation of osteoclastogenesis by fatty acids. 2008 Endocrinology pmid:18617622
Okada K et al. Genetic evidence for the role of isopentenyl diphosphate isomerases in the mevalonate pathway and plant development in Arabidopsis. 2008 Plant Cell Physiol. pmid:18303110
Lüdke SM et al. Stable carbon isotope discrimination by human 3-hydroxy-3-methylglutaryl-coenzyme A reductase. 2008 J. Lipid Res. pmid:18669481
Carrasco MP et al. Hexadecylphosphocholine interferes with the intracellular transport of cholesterol in HepG2 cells. 2008 FEBS J. pmid:18312412
Winiarska M et al. Statins impair antitumor effects of rituximab by inducing conformational changes of CD20. 2008 PLoS Med. pmid:18366248
Oliveira KA et al. Simvastatin inducing PC3 prostate cancer cell necrosis mediated by calcineurin and mitochondrial dysfunction. 2008 J. Bioenerg. Biomembr. pmid:18679777
Chana RS et al. Statins but not thiazolidinediones attenuate albumin-mediated chemokine production by proximal tubular cells independently of endocytosis. 2008 Am. J. Nephrol. pmid:18535368
Abumweis SS et al. Plant sterols/stanols as cholesterol lowering agents: A meta-analysis of randomized controlled trials. 2008 Food Nutr Res pmid:19109655
Sławińska A and Kandefer-Szerszeń M [The anticancer properties of statins]. 2008 Postepy Hig Med Dosw (Online) pmid:18688209
Acharjee S and Welty FK Atorvastatin and cardiovascular risk in the elderly--patient considerations. 2008 Clin Interv Aging pmid:18686752
Journe F et al. Farnesol, a mevalonate pathway intermediate, stimulates MCF-7 breast cancer cell growth through farnesoid-X-receptor-mediated estrogen receptor activation. 2008 Breast Cancer Res. Treat. pmid:17333335
Sando T et al. Cloning and characterization of mevalonate pathway genes in a natural rubber producing plant, Hevea brasiliensis. 2008 Biosci. Biotechnol. Biochem. pmid:18685207
Laezza C et al. The anandamide analog, Met-F-AEA, controls human breast cancer cell migration via the RHOA/RHO kinase signaling pathway. 2008 Endocr. Relat. Cancer pmid:18676619
Bate C et al. Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells. 2008 BMC Biol. pmid:18789130
Kistowska M et al. Dysregulation of the host mevalonate pathway during early bacterial infection activates human TCR gamma delta cells. 2008 Eur. J. Immunol. pmid:18624305
Matsuda T et al. Simvastatin inhibits catecholamine secretion and synthesis induced by acetylcholine via blocking Na+ and Ca2+ influx in bovine adrenal medullary cells. 2008 J. Pharmacol. Exp. Ther. pmid:18593956
Habara K et al. Pitavastatin up-regulates the induction of iNOS through enhanced stabilization of its mRNA in pro-inflammatory cytokine-stimulated hepatocytes. 2008 Nitric Oxide pmid:17936042
Fried LF Effects of HMG-CoA reductase inhibitors (statins) on progression of kidney disease. 2008 Kidney Int. pmid:18528321
Skorupinska-Tudek K et al. Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of dolichols in plants. 2008 J. Biol. Chem. pmid:18502754
Zhang X et al. Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. 2008 J. Immunol. pmid:18453621
Aprigliano I et al. Atorvastatin induces apoptosis by a caspase-9-dependent pathway: an in vitro study on activated rat hepatic stellate cells. 2008 Liver Int. pmid:18339080
Akisato Y et al. [Effect of pitavastatin on macrophage cholesterol metabolism]. 2008 Yakugaku Zasshi pmid:18311054
Burke LP and Kukoly CA Statins induce lethal effects in acute myeloblastic leukemia [corrected] cells within 72 hours. 2008 Leuk. Lymphoma pmid:18231920
Glynn SA et al. The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, simvastatin, lovastatin and mevastatin inhibit proliferation and invasion of melanoma cells. 2008 BMC Cancer pmid:18199328
Galichet A et al. Farnesylation directs AtIPT3 subcellular localization and modulates cytokinin biosynthesis in Arabidopsis. 2008 Plant Physiol. pmid:18184738
Kodaman PH and Duleba AJ Statins in the treatment of polycystic ovary syndrome. 2008 Semin. Reprod. Med. pmid:18181091
Baba TT et al. Simvastatin suppresses the differentiation of C2C12 myoblast cells via a Rac pathway. 2008 J. Muscle Res. Cell. Motil. pmid:18792797
Habeos IG et al. Simvastatin activates Keap1/Nrf2 signaling in rat liver. 2008 J. Mol. Med. pmid:18787804
Osman L et al. Atorvastatin accelerates extracellular nucleotide degradation in human endothelial cells. 2008 Mol. Cell. Biochem. pmid:18158588
Paintlia AS et al. Inhibition of rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis. 2008 Mol. Pharmacol. pmid:18239032
Martin-Ventura JL et al. LDL induces parathyroid hormone-related protein expression in vascular smooth muscle cells: Modulation by simvastatin. 2008 Atherosclerosis pmid:18378243
Baldi A and Dixit VK Yield enhancement strategies for artemisinin production by suspension cultures of Artemisia annua. 2008 Bioresour. Technol. pmid:17804216
Begley M et al. Analysis of the isoprenoid biosynthesis pathways in Listeria monocytogenes reveals a role for the alternative 2-C-methyl-D-erythritol 4-phosphate pathway in murine infection. 2008 Infect. Immun. pmid:18765739
Simonen M et al. High-content assay to study protein prenylation. 2008 J Biomol Screen pmid:18509097
Tarhzaoui K et al. Effect of rosuvastatin on capillary filtration of albumin and blood pressure in rats with streptozotocin-induced diabetes. 2008 Diabetes Res. Clin. Pract. pmid:18406000
Kaliszewski P et al. Rsp5p ubiquitin ligase and the transcriptional activators Spt23p and Mga2p are involved in co-regulation of biosynthesis of end products of the mevalonate pathway and triacylglycerol in yeast Saccharomyces cerevisiae. 2008 Biochim. Biophys. Acta pmid:18771750
Voynova NE et al. Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure. 2008 Arch. Biochem. Biophys. pmid:18823933
Pscheidt B and Glieder A Yeast cell factories for fine chemical and API production. 2008 Microb. Cell Fact. pmid:18684335
Schwartz YSh et al. Cholesterol-induced stimulation of postinflammatory liver fibrosis. 2008 Bull. Exp. Biol. Med. pmid:19110552
Liang YJ et al. Simvastatin inhibits C-reactive protein-induced pro-inflammatory changes in endothelial cells by decreasing mevalonate pathway products. 2008 Cardiology pmid:18057884
Yu F et al. Isolation and functional characterization of a beta-eudesmol synthase, a new sesquiterpene synthase from Zingiber zerumbet Smith. 2008 FEBS Lett. pmid:18242187
de Ruyck J and Wouters J Structure-based drug design targeting biosynthesis of isoprenoids: a crystallographic state of the art of the involved enzymes. 2008 Curr. Protein Pept. Sci. pmid:18393884