Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Cell Transformation, Neoplastic D002471 126 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Adenocarcinoma D000230 166 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 | Total 25

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All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
Liu YJ et al. Simvastatin ameliorates rat cerebrovascular remodeling during hypertension via inhibition of volume-regulated chloride channel. 2010 Hypertension pmid:20644009
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Rico J et al. Enhanced production of a plant monoterpene by overexpression of the 3-hydroxy-3-methylglutaryl coenzyme A reductase catalytic domain in Saccharomyces cerevisiae. 2010 Appl. Environ. Microbiol. pmid:20675444
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Tsuchiya M et al. Cholesterol biosynthesis pathway intermediates and inhibitors regulate glucose-stimulated insulin secretion and secretory granule formation in pancreatic beta-cells. 2010 Endocrinology pmid:20685866
Barter MJ et al. Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation. 2010 Ann. Rheum. Dis. pmid:20693272
Clendening JW et al. Dysregulation of the mevalonate pathway promotes transformation. 2010 Proc. Natl. Acad. Sci. U.S.A. pmid:20696928
Palozza P et al. Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signaling in cancer cell lines. 2010 Carcinogenesis pmid:20699249
Guella G et al. Structures, biological activities and phylogenetic relationships of terpenoids from marine ciliates of the genus Euplotes. 2010 Mar Drugs pmid:20714425
Yang L et al. [Effects of clinically effective dose of lovastatin on prostate cancer PC3 cells]. 2010 Beijing Da Xue Xue Bao pmid:20721249
Jarrell KF et al. S-layer glycoproteins and flagellins: reporters of archaeal posttranslational modifications. 2010 Archaea pmid:20721273
Yu F et al. Zingiber zerumbet CYP71BA1 catalyzes the conversion of α-humulene to 8-hydroxy-α-humulene in zerumbone biosynthesis. 2011 Cell. Mol. Life Sci. pmid:20730551
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González-Candelas L et al. A transcriptomic approach highlights induction of secondary metabolism in citrus fruit in response to Penicillium digitatum infection. 2010 BMC Plant Biol. pmid:20807411
Kaneda T et al. Statins inhibited erythropoietin-induced proliferation of rat vascular smooth muscle cells. 2010 Eur. J. Pharmacol. pmid:20851116
Fukunaga M et al. Mast cell death induced by 24(S),25-epoxycholesterol. 2010 Exp. Cell Res. pmid:20854813
Rossi J et al. Laminar shear stress prevents simvastatin-induced adhesion molecule expression in cytokine activated endothelial cells. 2010 Eur. J. Pharmacol. pmid:20863785
Musso A et al. Relevance of the mevalonate biosynthetic pathway in the regulation of bone marrow mesenchymal stromal cell-mediated effects on T-cell proliferation and B-cell survival. 2011 Haematologica pmid:20884711
Nagata Y et al. Effects of simvastatin (MK-733) on branched pathway of mevalonate. 1990 Jpn. J. Pharmacol. pmid:2090840
Li YY et al. Zoledronic acid induces cell-cycle prolongation in murine lung cancer cells by perturbing cyclin and Ras expression. 2011 Anticancer Drugs pmid:20926944
Miziorko HM Enzymes of the mevalonate pathway of isoprenoid biosynthesis. 2011 Arch. Biochem. Biophys. pmid:20932952
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Kim KH et al. Generation of human chiral metabolites of simvastatin and lovastatin by bacterial CYP102A1 mutants. 2011 Drug Metab. Dispos. pmid:20962060
Martin DM et al. Functional annotation, genome organization and phylogeny of the grapevine (Vitis vinifera) terpene synthase gene family based on genome assembly, FLcDNA cloning, and enzyme assays. 2010 BMC Plant Biol. pmid:20964856
Song JX et al. Simvastatin reduces lipoprotein-associated phospholipase A2 in lipopolysaccharide-stimulated human monocyte-derived macrophages through inhibition of the mevalonate-geranylgeranyl pyrophosphate-RhoA-p38 mitogen-activated protein kinase pathway. 2011 J. Cardiovasc. Pharmacol. pmid:21052011
Maltese WA et al. Post-translational modification of low molecular mass GTP-binding proteins by isoprenoid. 1990 J. Biol. Chem. pmid:2105317
Boo KH et al. Distribution and biosynthesis of 20-hydroxyecdysone in plants of Achyranthes japonica Nakai. 2010 Biosci. Biotechnol. Biochem. pmid:21071854
Stapleton PA et al. Hypercholesterolemia and microvascular dysfunction: interventional strategies. 2010 J Inflamm (Lond) pmid:21087503
Singh RS et al. Expression of 3-hydroxy-3-methylglutaryl-CoA reductase, p-hydroxybenzoate-m-geranyltransferase and genes of phenylpropanoid pathway exhibits positive correlation with shikonins content in arnebia [Arnebia euchroma (Royle) Johnston]. 2010 BMC Mol. Biol. pmid:21092138
Kindt E et al. The validation of a simple LC/MS/MS method for determining the level of mevalonic acid in human plasma. 2011 Biomed. Chromatogr. pmid:21110384
Rosenwald AG and Krag SS Lec9 CHO glycosylation mutants are defective in the synthesis of dolichol. 1990 J. Lipid Res. pmid:2111370
Maki KC et al. Effects of soy protein on lipoprotein lipids and fecal bile acid excretion in men and women with moderate hypercholesterolemia. 2010 Nov-Dec J Clin Lipidol pmid:21122701
Hagemenas FC et al. The effects of simvastatin on plasma lipoproteins and cholesterol homeostasis in patients with heterozygous familial hypercholesterolaemia. 1990 Eur. J. Clin. Invest. pmid:2112479
Hamada M et al. Antithrombotic properties of pravastatin reducing intra-thrombus fibrin deposition under high shear blood flow conditions. 2011 Thromb. Haemost. pmid:21136018
Llacuna L et al. Targeting cholesterol at different levels in the mevalonate pathway protects fatty liver against ischemia-reperfusion injury. 2011 J. Hepatol. pmid:21145825
Hamdy RC Zoledronic acid: clinical utility and patient considerations in osteoporosis and low bone mass. 2010 Drug Des Devel Ther pmid:21151620
Mumby SM et al. G protein gamma subunits contain a 20-carbon isoprenoid. 1990 Proc. Natl. Acad. Sci. U.S.A. pmid:2116011
Li Z et al. Effect of temperature on postillumination isoprene emission in oak and poplar. 2011 Plant Physiol. pmid:21177471
Omar SH Oleuropein in olive and its pharmacological effects. 2010 Apr-Jun Sci Pharm pmid:21179340
Hong C et al. Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. 2011 J. Lipid Res. pmid:21187453
Nishikawa Y et al. Host cholesterol synthesis contributes to growth of intracellular Toxoplasma gondii in macrophages. 2011 J. Vet. Med. Sci. pmid:21187676
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pmid:2119580
Zeki AA et al. Statin drugs, metabolic pathways, and asthma: a therapeutic opportunity needing further research. 2011 Drug Metab Lett pmid:21198438
Maltese WA and Sheridan KM Isoprenoid modification of G25K (Gp), a low molecular mass GTP-binding protein distinct from p21ras. 1990 J. Biol. Chem. pmid:2120220
Head BP et al. Loss of caveolin-1 accelerates neurodegeneration and aging. 2010 PLoS ONE pmid:21203469
Relja B et al. Simvastatin modulates the adhesion and growth of hepatocellular carcinoma cells via decrease of integrin expression and ROCK. 2011 Int. J. Oncol. pmid:21206971
Redding-Johanson AM et al. Targeted proteomics for metabolic pathway optimization: application to terpene production. 2011 Metab. Eng. pmid:21215324
Tuckow AP et al. Simvastatin represses protein synthesis in the muscle-derived C₂C₁₂ cell line with a concomitant reduction in eukaryotic initiation factor 2B expression. 2011 Am. J. Physiol. Endocrinol. Metab. pmid:21224482
Kimachi K et al. Zoledronic acid inhibits RANK expression and migration of osteoclast precursors during osteoclastogenesis. 2011 Naunyn Schmiedebergs Arch. Pharmacol. pmid:21225243
pmid:21229242
Jones TL and Spiegel AM Isoprenylation of an inhibitory G protein alpha subunit occurs only upon mutagenesis of the carboxyl terminus. 1990 J. Biol. Chem. pmid:2123186
pmid:21233409
Kawata M et al. Posttranslationally processed structure of the human platelet protein smg p21B: evidence for geranylgeranylation and carboxyl methylation of the C-terminal cysteine. 1990 Proc. Natl. Acad. Sci. U.S.A. pmid:2123345
Henneman L et al. Inhibition of the isoprenoid biosynthesis pathway; detection of intermediates by UPLC-MS/MS. 2011 Biochim. Biophys. Acta pmid:21237288
Wang Y et al. Identification of the principal catalytically important acidic residue of 3-hydroxy-3-methylglutaryl coenzyme A reductase. 1990 J. Biol. Chem. pmid:2123872
Mohr C et al. Morphological alterations of Xenopus oocytes induced by valine-14 p21rho depend on isoprenylation and are inhibited by Clostridium botulinum C3 ADP-ribosyltransferase. 1990 FEBS Lett. pmid:2124543
Kim YS et al. Increase of lycopene production by supplementing auxiliary carbon sources in metabolically engineered Escherichia coli. 2011 Appl. Microbiol. Biotechnol. pmid:21246354
Kones R Rosuvastatin, inflammation, C-reactive protein, JUPITER, and primary prevention of cardiovascular disease--a perspective. 2010 Drug Des Devel Ther pmid:21267417
pmid:21268200
Honour JW Steroid assays in paediatric endocrinology. 2010 J Clin Res Pediatr Endocrinol pmid:21274330
Ignea C et al. Improving yeast strains using recyclable integration cassettes, for the production of plant terpenoids. 2011 Microb. Cell Fact. pmid:21276210
Tsubaki M et al. Blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathways by statins reduces the expression of bFGF, HGF, and TGF-β as angiogenic factors in mouse osteosarcoma. 2011 Cytokine pmid:21292498
Tsuyuki R et al. Enhancement of trichothecene production in Fusarium graminearum by cobalt chloride. 2011 J. Agric. Food Chem. pmid:21299216
Ghavami S et al. Mevalonate cascade regulation of airway mesenchymal cell autophagy and apoptosis: a dual role for p53. 2011 PLoS ONE pmid:21304979
Keyhani J and Keyhani E Mevalonic acid as a precursor of the alkyl sidechain of heme a of cytochrome c oxidase in yeast Saccharomyces cerevisiae. 1978 FEBS Lett. pmid:213310
Yokota K et al. Geranylgeranyl-pyrophosphate regulates secretion of pentraxin 3 and monocyte chemoattractant protein-1 from rheumatoid fibroblast-like synoviocytes in distinct manners. 2011 Jan-Feb Clin. Exp. Rheumatol. pmid:21345291
Waldron J and Webster C Liquid chromatography-tandem mass spectrometry method for the measurement of serum mevalonic acid: a novel marker of hydroxymethylglutaryl coenzyme A reductase inhibition by statins. 2011 Ann. Clin. Biochem. pmid:21355014
Nilsson S et al. Mevalonate pathway inhibitors affect anticancer drug-induced cell death and DNA damage response of human sarcoma cells. 2011 Cancer Lett. pmid:21356574
Blankier S et al. The role of atorvastatin in regulating the immune response leading to vascular damage in a model of Kawasaki disease. 2011 Clin. Exp. Immunol. pmid:21361911
Kiran U et al. Structural and functional characterization of HMG-COA reductase from Artemisia annua. 2010 Bioinformation pmid:21364776
Zhao Y et al. Statins downregulate K6a promoter activity: a possible therapeutic avenue for pachyonychia congenita. 2011 J. Invest. Dermatol. pmid:21390048
Jiang Q et al. Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide. 2012 Int. J. Cancer pmid:21400505
Kyathanahalli CN and Kowluru A A farnesylated G-protein suppresses Akt phosphorylation in INS 832/13 cells and normal rat islets: regulation by pertussis toxin and PGEâ‚‚. 2011 Biochem. Pharmacol. pmid:21406184
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Kim RH et al. Bisphosphonates induce senescence in normal human oral keratinocytes. 2011 J. Dent. Res. pmid:21427353
Zhang B et al. A second target of the antimalarial and antibacterial agent fosmidomycin revealed by cellular metabolic profiling. 2011 Biochemistry pmid:21438569
Mongélard G et al. Measurement of carbon flux through the MEP pathway for isoprenoid synthesis by (31)P-NMR spectroscopy after specific inhibition of 2-C-methyl-d-erythritol 2,4-cyclodiphosphate reductase. Effect of light and temperature. 2011 Plant Cell Environ. pmid:21443577
Siddals KW et al. Apposite insulin-like growth factor (IGF) receptor glycosylation is critical to the maintenance of vascular smooth muscle phenotype in the presence of factors promoting osteogenic differentiation and mineralization. 2011 J. Biol. Chem. pmid:21454560
Han J et al. Alteration of enzyme expressions in mevalonate pathway: possible role for cardiovascular remodeling in spontaneously hypertensive rats. 2011 Circ. J. pmid:21467659
Issat T et al. Antitumor effects of the combination of cholesterol reducing drugs. 2011 Oncol. Rep. pmid:21491092
Mathew B and Biju R Neuroprotective effects of garlic a review. 2008 Libyan J Med pmid:21499478
Sakamoto K et al. Simvastatin suppresses dexamethasone-induced secretion of plasminogen activator inhibitor-1 in human bone marrow adipocytes. 2011 BMC Musculoskelet Disord pmid:21524281
Kishi T Mevalonate pathway is a novel target for hypertension. 2011 Circ. J. pmid:21532185
Katuru R et al. Mevalonate depletion mediates the suppressive impact of geranylgeraniol on murine B16 melanoma cells. 2011 Exp. Biol. Med. (Maywood) pmid:21540247
Scheller EL et al. Bisphosphonates inhibit expression of p63 by oral keratinocytes. 2011 J. Dent. Res. pmid:21551338
Barta ML et al. Crystal structures of Staphylococcus epidermidis mevalonate diphosphate decarboxylase bound to inhibitory analogs reveal new insight into substrate binding and catalysis. 2011 J. Biol. Chem. pmid:21561869
Jeon JG et al. Natural products in caries research: current (limited) knowledge, challenges and future perspective. 2011 Caries Res. pmid:21576957
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Deichmann R et al. Coenzyme q10 and statin-induced mitochondrial dysfunction. 2010 Ochsner J pmid:21603349
Goto T et al. Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist. 2011 Biochem. J. pmid:21605082
Gibson KM et al. 3-Hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured fibroblasts from patients with mevalonate kinase deficiency: differential response to lipid supplied by fetal bovine serum in tissue culture medium. 1990 J. Lipid Res. pmid:2160511
Banfi C et al. Statins prevent tissue factor induction by protease-activated receptors 1 and 2 in human umbilical vein endothelial cells in vitro. 2011 J. Thromb. Haemost. pmid:21605334
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Maekawa T et al. Chronic oral infection with Porphyromonas gingivalis accelerates atheroma formation by shifting the lipid profile. 2011 PLoS ONE pmid:21625524
Simkin AJ et al. Peroxisomal localisation of the final steps of the mevalonic acid pathway in planta. 2011 Planta pmid:21655959
pmid:21667041
Martinez-Moya P et al. Proteomic analysis of the carotenogenic yeast Xanthophyllomyces dendrorhous. 2011 BMC Microbiol. pmid:21669001
Rossoni LV et al. Acute simvastatin increases endothelial nitric oxide synthase phosphorylation via AMP-activated protein kinase and reduces contractility of isolated rat mesenteric resistance arteries. 2011 Clin. Sci. pmid:21671887