Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Cell Transformation, Neoplastic D002471 126 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Adenocarcinoma D000230 166 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

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All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
pmid:8341325
Li G and Stahl PD Post-translational processing and membrane association of the two early endosome-associated rab GTP-binding proteins (rab4 and rab5). 1993 Arch. Biochem. Biophys. pmid:8346922
Dahl NK et al. Abnormal regulation of low density lipoprotein-sensitive events in a cholesterol transport mutant. 1993 J. Biol. Chem. pmid:8349588
Mancini J et al. Mevalonic aciduria in 3 siblings: a new recognizable metabolic encephalopathy. 1993 May-Jun Pediatr. Neurol. pmid:8352861
Jones MP et al. Cholesterol 7 alpha-hydroxylase: evidence for transcriptional regulation by cholesterol or metabolic products of cholesterol in the rat. 1993 J. Lipid Res. pmid:8354954
Vlahcevic ZR et al. Role of newly synthesized cholesterol or its metabolites on the regulation of bile acid biosynthesis after short-term biliary diversion in the rat. 1993 Hepatology pmid:8359807
Bhat CS and Ramasarma T Rhythmic activity of utilization of mevalonate for biogenesis of cholesterol. 1977 Biochem. Biophys. Res. Commun. pmid:836326
Giroux LM et al. Simvastatin inhibits the oxidation of low-density lipoproteins by activated human monocyte-derived macrophages. 1993 Biochim. Biophys. Acta pmid:8380338
Hoffmann GF et al. Clinical and biochemical phenotype in 11 patients with mevalonic aciduria. 1993 Pediatrics pmid:8386351
Parker RA et al. Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. 1993 J. Biol. Chem. pmid:8388388
Davies JE and Ng LL Simvastatin and intracellular pH regulation by the Na+/H+ antiport of SV40-virus-transformed human MRC5 fibroblasts. 1993 Clin. Sci. pmid:8392920
Keller RK and Vilsaint F Regulation of isoprenoid metabolism in rat liver: near constant chain lengths of dolichyl phosphate and ubiquinone are maintained during greatly altered rates of cholesterogenesis. 1993 Biochim. Biophys. Acta pmid:8399346
pmid:8403532
Arellano R and Grinstein S Role of isoprenylation in intracellular pH regulation of granulocytes. 1993 FEBS Lett. pmid:8405466
Horbach S et al. Isoprenoid biosynthesis in bacteria: two different pathways? 1993 FEMS Microbiol. Lett. pmid:8405922
pmid:8406993
Swiezewska E et al. Biosynthesis of ubiquinone and plastoquinone in the endoplasmic reticulum-Golgi membranes of spinach leaves. 1993 J. Biol. Chem. pmid:8419349
O'Donnell MP et al. Lovastatin inhibits proliferation of rat mesangial cells. 1993 J. Clin. Invest. pmid:8423236
Farrell FX et al. Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated. 1993 Biochem. J. pmid:8424780
Li G et al. Blockade of mevalonate production by lovastatin attenuates bombesin and vasopressin potentiation of nutrient-induced insulin secretion in HIT-T15 cells. Probable involvement of small GTP-binding proteins. 1993 Biochem. J. pmid:8424783
pmid:8435109
Miura S et al. Inhibition of protein prenylation by patulin. 1993 FEBS Lett. pmid:8436232
pmid:8446927
Schwartz CC et al. Cholesterol kinetics in subjects with bile fistula. Positive relationship between size of the bile acid precursor pool and bile acid synthetic rate. 1993 J. Clin. Invest. pmid:8450070
Rilling HC et al. Differential prenylation of proteins as a function of mevalonate concentration in CHO cells. 1993 Arch. Biochem. Biophys. pmid:8460935
Doyle JW et al. Effects of growth factors on cell cycle arrest in dolichyl phosphate-depleted cultures. 1993 J. Cell. Physiol. pmid:8468363
pmid:8482726
Seo S et al. Effect of sterol biosynthesis inhibitor, SSF-109, on cholesterol synthesis in isolated rat hepatocytes. 1993 Steroids pmid:8484187
Randall SK et al. Protein isoprenylation in suspension-cultured tobacco cells. 1993 Plant Cell pmid:8485402
pmid:8491791
Burt VT et al. The formation of menaquinone-4 (vitamin K) and its oxide in some marine invertebrates. 1977 Biochem. J. pmid:849285
Cox AD et al. The carboxyl-terminal CXXX sequence of Gi alpha, but not Rab5 or Rab11, supports Ras processing and transforming activity. 1993 J. Biol. Chem. pmid:8505289
pmid:8507210
Kocarek TA et al. Regulation of phenobarbital-inducible cytochrome P450 2B1/2 mRNA by lovastatin and oxysterols in primary cultures of adult rat hepatocytes. 1993 Toxicol. Appl. Pharmacol. pmid:8511800
Massy ZA et al. Inhibition of the mevalonate pathway: benefits beyond cholesterol reduction? 1996 Lancet pmid:8538301
Luján HD et al. Isoprenylation of proteins in the protozoan Giardia lamblia. 1995 Mol. Biochem. Parasitol. pmid:8538683
Bischoff KM and Rodwell VW 3-Hydroxy-3-methylglutaryl-coenzyme A reductase from Haloferax volcanii: purification, characterization, and expression in Escherichia coli. 1996 J. Bacteriol. pmid:8550415
Rea TJ et al. Lack of correlation between ACAT mRNA expression and cholesterol esterification in primary liver cells. 1996 Biochim. Biophys. Acta pmid:8555254
Weber C et al. Lovastatin induces differentiation of Mono Mac 6 cells. 1995 Cell Biochem. Funct. pmid:8565148
Viganõ T et al. Mevalonate pathway and isoprenoids regulate human bronchial myocyte proliferation. 1995 Eur. J. Pharmacol. pmid:8566171
Tachibana A et al. Evidence for farnesol-mediated isoprenoid synthesis regulation in a halophilic archaeon, Haloferax volcanii. 1996 FEBS Lett. pmid:8566226
Parmryd I et al. Identification of spinach farnesyl protein transferase. Dithiothreitol as an acceptor in vitro. 1995 Eur. J. Biochem. pmid:8575428
Biardi L and Krisans SK Compartmentalization of cholesterol biosynthesis. Conversion of mevalonate to farnesyl diphosphate occurs in the peroxisomes. 1996 J. Biol. Chem. pmid:8576183
Kikuchi A et al. Purification and properties of Rab3A. 1995 Meth. Enzymol. pmid:8583939
pmid:8592143
Lewis LS Statins, cholesterol, and mevalonate pathways? 1996 Lancet pmid:8596303
Fraser PD et al. Carotenoid biosynthesis in wild type and mutant strains of Mucor circinelloides. 1996 Biochim. Biophys. Acta pmid:8600974
Gibbons GF Existence of metabolic reservoirs in the later stages of the cholesterol biosynthetic pathway. 1977 Biochem. Biophys. Res. Commun. pmid:861038
pmid:8611028
Veerkamp JH et al. Effects of HMG-CoA reductase inhibitors on growth and differentiation of cultured rat skeletal muscle cells. 1996 Biochim. Biophys. Acta pmid:8611662